CN103417772B - Gynecological preoperative bowl preparation oral drug - Google Patents
Gynecological preoperative bowl preparation oral drug Download PDFInfo
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- CN103417772B CN103417772B CN201310361394.9A CN201310361394A CN103417772B CN 103417772 B CN103417772 B CN 103417772B CN 201310361394 A CN201310361394 A CN 201310361394A CN 103417772 B CN103417772 B CN 103417772B
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Abstract
The invention discloses gynecological preoperative bowl preparation oral drug and solves the problems in gynecological preoperative treatment. The drug is characterized by being made with, by weight, 10-30 parts of horseweed herb, 6-12 parts of cinnamon seeds, 3-10 parts of Chinese mosla, 6-12 parts of Chinese starjasmine stem, 3-10 parts of loofah sponge, 6-12 parts of Barbary wolfberry fruit, 6-12 parts of Dipsacus root, 6-12 parts of grassleaf sweelflag rhizome, 6-12 parts of sunflower flower, 1-5 parts of Turbo cornutus solander, 3-10 parts of ox horn bone, and 10-25 parts of magnesium sulfate. Clinical experiments show that the gynecological preoperative bowl preparation oral drug has good effect of gynecological preoperative bowel cleansing, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of gynecological preoperative bowl preparation oral drug.
Background technology
Before gynecilogical operation, INTESTINAL CLEANSING comprises stimulates enterokinesia, softening and remove feces, gets rid of enteral pneumatosis, prevents patient from increasing opportunities for contamination because anaesthetizing rear Sphincter ani chalasia and can not controlling defecation; Minimizing enteral pneumatosis fills and has feces and affects operation technique simultaneously.Clinical practice confirms, can also alleviate Post operation abdominal distention discomfort by Oral Rhubarb, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid intestinal tract cleaning.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol), and art uses 0.2% suds cleansing enema once morning again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol is a kind of hyperosmotic dehydration agent, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.
At present, also report is had to use Chinese medicine preparation to carry out preoperative bowel relieving, as oral above-mentioned Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid, but medicine great majority used are all the purgatives medicine things such as Radix Et Rhizoma Rhei, take rear zest strong, patient's emotion, sleep state are had a significant effect, and Semen Platycladi etc. cathartic medicine is wayward rushes down the lower time.So lack now one to be applicable to preoperative bowel relieving, rush down effectively lower and can not sleep be affected again, the medicine of beneficial effect can be produced for post-operative recovery.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little gynecological preoperative bowl preparation oral drug of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of gynecological preoperative bowl preparation oral drug, it is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 10 ~ 30 parts, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Caulis Trachelospermi 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Bos taurus domesticus Gmelin 3 ~ 10 parts, 10 ~ 25 parts, magnesium sulfate.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Caulis Trachelospermi 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Bos taurus domesticus Gmelin 6 parts, 20 parts, magnesium sulfate.
Wherein said: Conyza canadensis (L.) Cronq., is Compositae Herba Erigerontis aceris platymiscium Conyza canadensis (L.) Cronq. Erigeron canadensis L., is used as medicine with herb or fresh leaf.Property mildly bitter flavor, pungent, cool.Merit can clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.
Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are worked hard, temperature.Merit can be driven away summer heat, and invigorates blood circulation, and regulates the flow of vital energy, removing dampness.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, dispels the wind.
Fructus Lycii is the fruit of Solanaceae Lycium Fructus Lycii Polygonatum kingianum Coll.et Hemsl., and merit can mend marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing by spermatogenesis.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.Bitter in the mouth is pungent; Slightly warm in nature.Return liver, kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.
Rhizoma Acori Graminei is the dry rhizome of Rhizoma Acori Graminei Citrus reticulata Blanco, and merit can be whetted the appetite in removing dampness, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, covers operculum for Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.Merit can clearing away damp-heat; Remove phlegm-fire; Separate sore.Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Bos taurus domesticus Gmelin is Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, is used as medicine with the inner hard bone heart of Cornu Bovis seu Bubali.Nature and flavor are bitter, temperature.Merit can be stopped blooding.
Composition principle: gynecilogical operation is preoperative will carry out intestinal process, namely bowel relieving.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol or Chinese medicine cathartic prescription), and art morning, 0.2% suds (or normal saline) cleansing enema was once again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol or Chinese medicine cathartic prescription, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.We are cathartic with magnesium sulfate, coordinate the medicine of fugitive stable enterokinesia, and the reaction sensitivity that suitable reduction intestinal contents stimulates intestinal, lax intestinal smooth.Like this, the magnesium sulfate entering intestinal on the one hand not easily absorbs at intestinal, forms hyperosmotic state, completes catharsis effect; On the other hand the medicine of fugitive stable enterokinesia relaxes intestinal smooth, alleviates awareness of defecation, to ensure Sleeping.Meanwhile, other pharmaceutical components in we complete invigorate blood circulation, eliminate the phlegm, the effect of eliminating stagnation, dredging collateral, promote gynecilogical operation post-operative recovery.
Compared with prior art, the present invention has following characteristics.
1, Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus coordinate for monarch drug, inventor studies discovery: the mixing water decocting liquid of Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus is wriggled without obvious inhibitory action to isolated mouse ileum, but when gastrointestinal smooth muscle is in the excitatory state under magnesium sulfate stimulation, there is remarkable relexation.Its mechanism of action may be relevant to the smooth muscle relaxation of Conyza canadensis (L.) Cronq. total flavones water soluble part, but this kind of effect coordinates can only come into force for the intestinal wall smooth muscle under excited state with Fructus cinnamomi immaturus.Under this dosage, the pharmacological action time of Conyza canadensis (L.) Cronq. is 8 ~ 10 hours, namely takes medicine night, can alleviate the awareness of defecation under magnesium sulfate stimulation, and ensure suitable sleep, after art drug effect in morning is lost, can complete the effect of cleaning intestinal.
2, Herba Moslae Chinensis dehumidifying regulating QI to relieve pain, Caulis Trachelospermi dredging collateral reducing swelling and alleviating pain, alleviates the discomfort that postoperative pelvic cavity excitation causes.
3, Fructus Lycii enriching yin and nourishing kidney, Radix Dipsaci nourishing the liver and kidney, Rhizoma Acori Graminei removing dampness is whetted the appetite, and the postoperative function of intestinal canal that is conducive to recovers, and shortens fasting time, is conducive to early recovery.
4, Retinervus Luffae Fructus is invigorated blood circulation motionless blood, and has the strong muscle effect of dredging collateral.
5, inventor's experimentation shows: low dose of Turbo cornutus Solander can stablize intestinal mucosa effectively.
6, Flos Helianthi is using corrigent, and this medicine obviously can strengthen intestinal contraction, and lasting medicine, utilize low dose of Flos Helianthi to prevent Conyza canadensis (L.) Cronq. overaction.
7, in one row falls apart dredging collateral medicine, add low dose of Bos taurus domesticus Gmelin, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Caulis Trachelospermi 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Bos taurus domesticus Gmelin 6 parts, 20 parts, magnesium sulfate.
The preparation method of embodiment 1 is: Conyza canadensis (L.) Cronq., Fructus cinnamomi immaturus, Herba Moslae Chinensis, Caulis Trachelospermi, Retinervus Luffae Fructus, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, Bos taurus domesticus Gmelin, magnesium sulfate mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate is merged into decoction.
Embodiment 2, crude drug weight proportion: Conyza canadensis (L.) Cronq. 10 parts, Fructus cinnamomi immaturus 6 parts, Herba Moslae Chinensis 3 parts, Caulis Trachelospermi 6 parts, Retinervus Luffae Fructus 3 parts, Fructus Lycii 6 parts, Radix Dipsaci 6 parts, Rhizoma Acori Graminei 6 parts, Flos Helianthi 6 parts, Turbo cornutus Solander 1 part, Bos taurus domesticus Gmelin 3 parts, 10 parts, magnesium sulfate.
Embodiment 3, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Caulis Trachelospermi 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Bos taurus domesticus Gmelin 6 parts, 20 parts, magnesium sulfate.
Embodiment 4, crude drug weight proportion: Conyza canadensis (L.) Cronq. 30 parts, Fructus cinnamomi immaturus 12 parts, Herba Moslae Chinensis 10 parts, Caulis Trachelospermi 12 parts, Retinervus Luffae Fructus 10 parts, Fructus Lycii 12 parts, Radix Dipsaci 12 parts, Rhizoma Acori Graminei 12 parts, Flos Helianthi 12 parts, Turbo cornutus Solander 5 parts, Bos taurus domesticus Gmelin 10 parts, 25 parts, magnesium sulfate.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Bos taurus domesticus Gmelin are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Conyza canadensis (L.) Cronq., Herba Moslae Chinensis, Caulis Trachelospermi, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Described magnesium sulfate can be magnesium sulfate powder, also can be Adlerika.
The efficient combination of said medicine, coordinates mutually, effectively reaches the object of the preoperative cleaning intestinal of gynecilogical operation, and does not affect Sleeping, be beneficial to post-operative recovery.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: the gynecologic surgery preparation that in March, 2012 ~ 2013 are accepted for medical treatment year March needs cleansing enema patient 78 example.
1.1.2 divide into groups: be divided into matched group 26 example at random, decoction group 26 example, groups of grains 26 example.
1.2 method.
1.2.1 administering mode: all case art proxima luce (prox. luc)s enter without slag liquid food, and matched group takes conventional method of clyster: preoperative late oral mannitol, art morning, normal saline cleansing enema was once again.Decoction group preoperative late 8 time adopt embodiment 1 gained decoction oral, art normal saline in morning cleansing enema is once.Groups of grains preoperative late 8 time adopt embodiment 3 gained particulate oral, art normal saline in morning cleansing enema is once.
1.2.2 observation index: after bowel relieving operation, observe patient's defecation frequency, intestinal tract cleaning and pneumatosis situation in record art, and micturition time after operation in patients and untoward reaction are passed judgment on.
1.2.3 intestine cleaning effect evaluation criterion: be effectively intestinal in operation in patients and keep complete relaxed state, and visual area exposes completely; Invalidly be intestinal high level expansion in operation in patients, and visual area is capped.
2 results.
Intestinal tract cleaning situation and transfusion definition situation in 2.1 arts: the effective percentage of matched group, decoction group, groups of grains bowel relieving is 100%.
Between 2.2 3 groups of operation in patients eve, defecation, art defecation in morning situation, insomnia situation postoperative bowel situation saw the following form:
| Group | Number of cases | Defecation at night (secondary) | Art defecation in morning (secondary) | Insomnia (example) | Postoperative bowel (h) |
| Matched group | 26 | 2.62±032 | 2.11±0.11 | 18 | 37.83±7.14 |
| Decoction group | 26 | 0.95±0.23 | 5.53±0.55 | 6 | 23.36±5.62 |
| Groups of grains | 26 | 0.91±0.43 | 4.63±0.23 | 7 | 25.33±8.42 |
Result shows: apply decoction of the present invention or bead dosage form preoperative night orally can reduce defecation frequency at night, increases art defecation in morning, reduces the generation of having a sleepless night, reach postoperative bowel as early as possible, and compare with matched group (P<0.05).
Before 2.3 3 groups of operation in patients, bowel relieving nursing satisfaction compares: matched group patient is 88.46% to preoperative bowel relieving nursing satisfaction, and the satisfaction of decoction group, groups of grains bowel relieving is 100%.
3. conclusion.
This result of study shows, and the preoperative oral decoction of the present invention or granule intestine cleaning effect obviously, can effectively reduce defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach postoperative bowel as early as possible, increases patient to the satisfaction of nursery work.
Claims (2)
1. a gynecological preoperative bowl preparation oral drug, is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 10 ~ 30 parts, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Caulis Trachelospermi 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Bos taurus domesticus Gmelin 3 ~ 10 parts, 10 ~ 25 parts, magnesium sulfate.
2. a kind of gynecological preoperative bowl preparation oral drug according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Caulis Trachelospermi 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Bos taurus domesticus Gmelin 6 parts, 20 parts, magnesium sulfate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310361394.9A CN103417772B (en) | 2013-08-19 | 2013-08-19 | Gynecological preoperative bowl preparation oral drug |
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| CN201310361394.9A CN103417772B (en) | 2013-08-19 | 2013-08-19 | Gynecological preoperative bowl preparation oral drug |
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| CN201510113618.3A Division CN104666674A (en) | 2013-08-19 | 2013-08-19 | Oral drug for gynecologic preoperative bowel preparation |
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| CN103417772A CN103417772A (en) | 2013-12-04 |
| CN103417772B true CN103417772B (en) | 2015-03-11 |
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| CN201310361394.9A Expired - Fee Related CN103417772B (en) | 2013-08-19 | 2013-08-19 | Gynecological preoperative bowl preparation oral drug |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209339A (en) * | 1998-09-18 | 1999-03-03 | 李粤 | Medicine for treating colonitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209339A (en) * | 1998-09-18 | 1999-03-03 | 李粤 | Medicine for treating colonitis |
Non-Patent Citations (1)
| Title |
|---|
| 《口服硫酸镁溶液清洁肠道的效果观察》;赖桂凤等;《包头医学院学报》;20071231;第23卷(第6期);618-619 * |
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