CN103393808B - A kind of medicine for bowel relieving before PA induced labor - Google Patents
A kind of medicine for bowel relieving before PA induced labor Download PDFInfo
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- CN103393808B CN103393808B CN201310361267.9A CN201310361267A CN103393808B CN 103393808 B CN103393808 B CN 103393808B CN 201310361267 A CN201310361267 A CN 201310361267A CN 103393808 B CN103393808 B CN 103393808B
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Abstract
The invention discloses a kind of medicine for bowel relieving before PA induced labor, to solve bowel relieving problem before PA induced labor.It is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq., Fructus cinnamomi immaturus, Herba Trifolii Pratentis, Caulis Trachelospermi, large Herba Swertiae heteranthae, Radix Codonopsis lanceolatae, Fructus Psoraleae, Pericarpium Citri Reticulatae, Flos Helianthi, Turbo cornutus Solander, Herba Taxilli, magnesium sulfate.Clinical trial certificate the present invention has the good feature of intestine cleaning effect before being used for PA induced labor, clinic application, popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of medicine for bowel relieving before PA induced labor.
Background technology
Gestation is full after 28 weeks, due to maternal factors or fetus aspect, starts the means of uterine contraction and termination of pregnancy by artificial method, the Induced Labor in Late Pregnancy art of meaning.Before PA induced labor, INTESTINAL CLEANSING comprises stimulates enterokinesia, softening and remove feces, gets rid of enteral pneumatosis, prevents patient from increasing opportunities for contamination because anaesthetizing rear Sphincter ani chalasia and can not controlling defecation; Minimizing enteral pneumatosis fills and has feces and affects operation technique simultaneously.Clinical practice confirms, can also alleviate Post operation abdominal distention discomfort by Oral Rhubarb, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid intestinal tract cleaning.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol), and art uses 0.2% suds cleansing enema once morning again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol is a kind of hyperosmotic dehydration agent, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.
At present, also report is had to use Chinese medicine preparation to carry out preoperative intervention bowel relieving, as oral above-mentioned Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid, but medicine great majority used are all the purgatives medicine things such as Radix Et Rhizoma Rhei, take rear zest strong, patient's emotion, sleep state are had a significant effect, and Semen Platycladi etc. cathartic medicine is wayward rushes down the lower time.So lack now one to be applicable to preoperative intervention bowel relieving, rush down effectively lower and can not sleep be affected again, the medicine of beneficial effect can be produced for post-operative recovery.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little medicine for bowel relieving before PA induced labor of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for bowel relieving before PA induced labor, it is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 10 ~ 30 parts, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Trifolii Pratentis 3 ~ 10 parts, Caulis Trachelospermi 6 ~ 12 parts, large Herba Swertiae heteranthae 3 ~ 10 parts, Radix Codonopsis lanceolatae 6 ~ 12 parts, Fructus Psoraleae 6 ~ 12 parts, Pericarpium Citri Reticulatae 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Herba Taxilli 3 ~ 10 parts, 10 ~ 25 parts, magnesium sulfate.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Trifolii Pratentis 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Radix Codonopsis lanceolatae 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Herba Taxilli 6 parts, 20 parts, magnesium sulfate.
Wherein said: Conyza canadensis (L.) Cronq., is Compositae Herba Erigerontis aceris platymiscium Conyza canadensis (L.) Cronq. Erigeron canadensis L., is used as medicine with herb or fresh leaf.Property mildly bitter flavor, pungent, cool.Merit can clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.
Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Herba Trifolii Pratentis is the inflorescence of leguminous plant Herba Trifolii Pratentis and wounded in the battle branch and leaf.Sweet in the mouth; Bitter; Cold nature.Return lung meridian.Merit can clearing and antitussive; Mass dissipating and swelling eliminating.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.
Large Herba Swertiae heteranthae, for aristolochiaceae plant becomes mildewed the herb of Herba Asari or root, rhizome.Nature and flavor are pungent; Temperature.Merit can warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.
Radix Codonopsis lanceolatae is the root of Campanulaceae Lac caprae seu ovis.Sweet in the mouth; Pungent; Property is put down.Return spleen; Lung meridian.Merit can supplementing QI and nourishing YIN; Removing toxic substances removing heat from blood; Evacuation of pus; Eliminating stagnation; Lactogenesis.
Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor are pungent, bitter, temperature.Return kidney, spleen channel.Merit can warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.Merit can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, covers operculum for Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.Merit can clearing away damp-heat; Remove phlegm-fire; Separate sore.Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Merit can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Composition principle: will intestinal process be carried out before PA induced labor, namely bowel relieving.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol or Chinese medicine cathartic prescription), and art morning, 0.2% suds (or normal saline) cleansing enema was once again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol or Chinese medicine cathartic prescription, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.We are cathartic with magnesium sulfate, coordinate the medicine of fugitive stable enterokinesia, and the reaction sensitivity that suitable reduction intestinal contents stimulates intestinal, lax intestinal smooth.Like this, the magnesium sulfate entering intestinal on the one hand not easily absorbs at intestinal, forms hyperosmotic state, completes catharsis effect; On the other hand the medicine of fugitive stable enterokinesia relaxes intestinal smooth, alleviates awareness of defecation, to ensure Sleeping.Meanwhile, other pharmaceutical components in we complete invigorate blood circulation, eliminate the phlegm, the effect of eliminating stagnation, dredging collateral, promote late pregnancy PA induced labor post-operative recovery.
Compared with prior art, the present invention has following characteristics.
1, Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus coordinate for monarch drug, inventor studies discovery: the mixing water decocting liquid of Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus is wriggled without obvious inhibitory action to isolated mouse ileum, but when gastrointestinal smooth muscle is in the excitatory state under magnesium sulfate stimulation, there is remarkable relexation.Its mechanism of action may be relevant to the smooth muscle relaxation of Conyza canadensis (L.) Cronq. total flavones water soluble part, but this kind of effect coordinates can only come into force for the intestinal wall smooth muscle under excited state with Fructus cinnamomi immaturus.Under this dosage, the pharmacological action time of Conyza canadensis (L.) Cronq. is 8 ~ 10 hours, namely takes medicine night, can alleviate the awareness of defecation under magnesium sulfate stimulation, and ensure suitable sleep, after art drug effect in morning is lost, can complete the effect of cleaning intestinal.
2, Radix Codonopsis lanceolatae eliminating stagnation, Herba Trifolii Pratentis mass dissipating and swelling eliminating, Caulis Trachelospermi dredging collateral reducing swelling and alleviating pain, alleviates the discomfort that postoperative pelvic cavity excitation causes.
3, Radix Codonopsis lanceolatae boosting qi and nourishing yin, Fructus Psoraleae nourishing the liver and kidney, Pericarpium Citri Reticulatae invigorating the spleen and benefiting QI diuretic, the postoperative function of intestinal canal that is conducive to recovers, and shortens fasting time, is conducive to early recovery.
4, large Herba Swertiae heteranthae is invigorated blood circulation motionless blood, and has the strong muscle effect of dredging collateral.
5, inventor's experimentation shows: low dose of Turbo cornutus Solander can stablize intestinal mucosa effectively.
6, Flos Helianthi is using corrigent, and this medicine obviously can strengthen intestinal contraction, and lasting medicine, utilize low dose of Flos Helianthi to prevent Conyza canadensis (L.) Cronq. overaction.
7, in one row falls apart dredging collateral medicine, add low dose of Herba Taxilli, play assistant and make use, prevent uterine contraction too.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Trifolii Pratentis 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Radix Codonopsis lanceolatae 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Herba Taxilli 6 parts, 20 parts, magnesium sulfate.
The preparation method of embodiment 1 is: Conyza canadensis (L.) Cronq., Fructus cinnamomi immaturus, Herba Trifolii Pratentis, Caulis Trachelospermi, large Herba Swertiae heteranthae, Radix Codonopsis lanceolatae, Fructus Psoraleae, Pericarpium Citri Reticulatae, Flos Helianthi, Turbo cornutus Solander, Herba Taxilli, magnesium sulfate mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate is merged into decoction.
Embodiment 2, crude drug weight proportion: Conyza canadensis (L.) Cronq. 10 parts, Fructus cinnamomi immaturus 6 parts, Herba Trifolii Pratentis 3 parts, Caulis Trachelospermi 6 parts, large Herba Swertiae heteranthae 3 parts, Radix Codonopsis lanceolatae 6 parts, Fructus Psoraleae 6 parts, Pericarpium Citri Reticulatae 6 parts, Flos Helianthi 6 parts, Turbo cornutus Solander 1 part, Herba Taxilli 3 parts, 10 parts, magnesium sulfate.
Embodiment 3, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Trifolii Pratentis 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Radix Codonopsis lanceolatae 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Herba Taxilli 6 parts, 20 parts, magnesium sulfate.
Embodiment 4, crude drug weight proportion: Conyza canadensis (L.) Cronq. 30 parts, Fructus cinnamomi immaturus 12 parts, Herba Trifolii Pratentis 10 parts, Caulis Trachelospermi 12 parts, large Herba Swertiae heteranthae 10 parts, Radix Codonopsis lanceolatae 12 parts, Fructus Psoraleae 12 parts, Pericarpium Citri Reticulatae 12 parts, Flos Helianthi 12 parts, Turbo cornutus Solander 5 parts, Herba Taxilli 10 parts, 25 parts, magnesium sulfate.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large swertia coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Herba Taxilli are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Conyza canadensis (L.) Cronq., Herba Trifolii Pratentis, Caulis Trachelospermi, Radix Codonopsis lanceolatae, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Described magnesium sulfate can be magnesium sulfate powder, also can be Adlerika.
The efficient combination of said medicine, coordinates mutually, clears up the object of intestinal, and does not affect Sleeping, be beneficial to post-operative recovery before effectively reaching PA induced labor.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: the late pregnancy PA induced labor that in March, 2012 ~ 2013 are accepted for medical treatment year April is chosen date for operation and needed cleansing enema patient 60 example, and pregnant week is between 28 ~ 36 weeks.
1.1.2 divide into groups: be divided into matched group 20 example at random, decoction group 20 example, groups of grains 20 example.Compare in age, pregnant week, mean operative time before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 administering mode: all case art proxima luce (prox. luc)s enter without slag liquid food, and matched group takes conventional method of clyster: preoperative late oral mannitol, art morning, normal saline cleansing enema was once again.Decoction group preoperative late 8 time adopt embodiment 1 gained decoction oral, art normal saline in morning cleansing enema is once.Groups of grains preoperative late 8 time adopt embodiment 3 gained particulate oral, art normal saline in morning cleansing enema is once.
1.2.2 observation index: after bowel relieving operation, observe patient's defecation frequency, intestinal tract cleaning and pneumatosis situation in record art, and micturition time after operation in patients and untoward reaction are passed judgment on.
1.2.3 intestine cleaning effect evaluation criterion: be effectively intestinal in operation in patients and keep complete relaxed state, pollute without leakage in art; Invalidly be intestinal high level expansion in operation in patients, in art, occur that leakage is polluted.
2 results.
Intestinal tract cleaning situation and transfusion definition situation in 2.1 arts: the effective percentage of matched group, decoction group, groups of grains bowel relieving is 100%.
Between 2.2 3 groups of operation in patients eve, defecation, art defecation in morning situation, insomnia situation postoperative bowel situation saw the following form:
| Group | Number of cases | Defecation at night (secondary) | Art defecation in morning (secondary) | Insomnia (example) | Postoperative bowel (h) |
| Matched group | 20 | 2.26±0.42 | 2.42±0.23 | 19 | 36.91±11.36 |
| Decoction group | 20 | 0.92±0.32 | 5.37±0.53 | 8 | 25.82±4.66 |
| Groups of grains | 20 | 0.89±0.34 | 4.57±0.32 | 6 | 24.42±5.23 |
Result shows: apply decoction of the present invention or bead dosage form preoperative night orally can reduce defecation frequency at night, increases art defecation in morning, reduces the generation of having a sleepless night, reach postoperative bowel as early as possible, and compare with matched group (P<0.05).
Intervene satisfaction before 2.3 3 groups of operation in patients to compare: matched group patient is 85.00% to preoperative intervention satisfaction, and the satisfaction of decoction group, groups of grains bowel relieving is 100%.
3. conclusion.
This result of study shows, and the preoperative oral decoction of the present invention or granule intestine cleaning effect obviously, can effectively reduce defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach postoperative bowel as early as possible, increases patient to the satisfaction of nursery work.
Claims (1)
1. for a medicine for bowel relieving before PA induced labor, it is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Herba Trifolii Pratentis 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Radix Codonopsis lanceolatae 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Herba Taxilli 6 parts, 20 parts, magnesium sulfate.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510612711.9A CN105079205A (en) | 2013-08-19 | 2013-08-19 | Preparation method of intestine clearing drug orally taken before induction of labor |
| CN201310361267.9A CN103393808B (en) | 2013-08-19 | 2013-08-19 | A kind of medicine for bowel relieving before PA induced labor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310361267.9A CN103393808B (en) | 2013-08-19 | 2013-08-19 | A kind of medicine for bowel relieving before PA induced labor |
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| CN201510612711.9A Division CN105079205A (en) | 2013-08-19 | 2013-08-19 | Preparation method of intestine clearing drug orally taken before induction of labor |
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| Publication Number | Publication Date |
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| CN103393808A CN103393808A (en) | 2013-11-20 |
| CN103393808B true CN103393808B (en) | 2015-09-09 |
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| CN201310361267.9A Expired - Fee Related CN103393808B (en) | 2013-08-19 | 2013-08-19 | A kind of medicine for bowel relieving before PA induced labor |
| CN201510612711.9A Pending CN105079205A (en) | 2013-08-19 | 2013-08-19 | Preparation method of intestine clearing drug orally taken before induction of labor |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510612711.9A Pending CN105079205A (en) | 2013-08-19 | 2013-08-19 | Preparation method of intestine clearing drug orally taken before induction of labor |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150021A (en) * | 1996-01-11 | 1997-05-21 | 李智军 | Bowel clearing agent |
| CN1209339A (en) * | 1998-09-18 | 1999-03-03 | 李粤 | Medicine for treating colonitis |
-
2013
- 2013-08-19 CN CN201310361267.9A patent/CN103393808B/en not_active Expired - Fee Related
- 2013-08-19 CN CN201510612711.9A patent/CN105079205A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150021A (en) * | 1996-01-11 | 1997-05-21 | 李智军 | Bowel clearing agent |
| CN1209339A (en) * | 1998-09-18 | 1999-03-03 | 李粤 | Medicine for treating colonitis |
Non-Patent Citations (3)
| Title |
|---|
| "口服硫酸镁溶液清洁肠道的效果观察";赖桂凤等;《包头医学院学报》;20071231(第6期);第618-619页 * |
| "益脾清肠汤治疗慢性溃疡性结肠炎74例临床观察";陈良金;《时珍 国医国药》;20061231(第11期);第2285页 * |
| 郝建新等.肠宁汤.《脾胃病效方》.科学技术文献出版社,2005,(第1版),第341-342页. * |
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| CN105079205A (en) | 2015-11-25 |
| CN103393808A (en) | 2013-11-20 |
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