CN104523873A - Pharmaceutical composition for treating gout - Google Patents
Pharmaceutical composition for treating gout Download PDFInfo
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- CN104523873A CN104523873A CN201510062971.3A CN201510062971A CN104523873A CN 104523873 A CN104523873 A CN 104523873A CN 201510062971 A CN201510062971 A CN 201510062971A CN 104523873 A CN104523873 A CN 104523873A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract
The invention provides a pharmaceutical composition for treating gout. The pharmaceutical composition is characterized in that the prescription of the pharmaceutical composition contains the ingredients in parts by weight: 1-15 parts of honeysuckle stem, 1-10 parts of giant knotweed, 1-10 parts of poria cocos, 1-10 parts of lycopodium clavatum, 1-10 parts of astragalus root, 1-8 parts of epimedium, 1-8 parts of clematis root, 1-8 parts of plantain seed, 1-8 parts of polygonum multiflorum, 1-8 parts of ledebouriella root and 1-5 parts of glycyrrhiza uralensis. The pharmaceutical composition preparation is prepared from a traditional Chinese medicine composition and a pharmaceutically-acceptable carrier, and dosage forms comprise decoction, pills, capsules, granules, dissolved granules and oral liquid. The composition provided by the invention has a remarkable treatment effect on patients suffering from early-stage and metaphase gout and is free from toxic or side effects.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of gout.
Background technology
Gout be due to produce in body uric acid too much and kidney Scavenging activity decline, uric acid body accumulation, causes urate crystal in joint and each internal organs deposition.Along with improving constantly of people's living standard, the change of dietary structure and living habit (food being rich in nucleoprotein increases), the prolongation of average life, the understanding of the mankind to gout and the raising of diagnostic level, no matter be in American-European countries or in countries in Asia, the prevalence of gout has the trend increased year by year, current China Patients with Hyperuricemia number is more than 1.5 hundred million, wherein patient with gout is more than 7,500 ten thousand people, and increase with annual 0.97% annual rate of growth, gout has become China with the same second largest metabolism class disease of diabetes, and the life and health of people in serious threat.
Ancient Chinese medicine doctor can trace back to "Nei Jing" to the understanding of gout, therebetween the category being attributed to " pyretic arthralgia " more, and its head sees " during Plain Questions four the inverse opinion of thorn ", wherein also proposed the mechanism of pyretic arthralgia formation for " its hot person, yang-energy is many, and cloudy gas is few; pathogenic QI in the body is contained, and sun suffers the moon, therefore is numbness heat." so-called numbness heat, be pyretic arthralgia occur with arthroncus, scorching hot, pain, joint stuffiness, the numbness being clinical manifestation with heating is sick.Modern many doctors, on the basis of forefathers, by broad practice, to the etiology and pathogenesis of gout, TCM Syndrome Features, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs propose many useful opinions and understanding.The sick first professor of Wu thinks that this outbreak is that press from both sides inherent phlegm-damp and mutually hand over work, pathogen must not be fallen apart due to wind-cold damp pathogen resistance numbness passages through which vital energy circulates outward, strongly fragrantly holds back heat-transformation and causes acute articular to swell and ache in skin space between skin and muscles.Due to cold and heat interweave, inner for cold-damp resistance numbness, passages through which vital energy circulates QI and blood is obstructed, table for phlegm-damp hot and suffocating must not pent up fall apart outward, and send out this disease.
The conventional current kind of antigout drug is few clinically at present, and clinical treatment is mainly based on colchicine, nonsteroidal antiinflammatory drug, hormone, promotion urate excretion medicine (as probenecid, sulfinpyrazone and benzbromarone) and suppression uric acid synthetic drug (allopurinol).These medicines are all defectiveness in treatment.Weak curative effect, side effect become greatly the bottleneck of its clinical practice.
Summary of the invention
The present invention aims to provide a kind of pharmaceutical composition for the treatment of gout.
For achieving the above object, a kind of pharmaceutical composition for the treatment of gout of the present invention, its concrete scheme is:
A kind of pharmaceutical composition for the treatment of gout of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Caulis Lonicerae 1-15 part, Rhizoma Polygoni Cuspidati 1-10 part, Poria 1-10 part, Herba Lycopodii 1-10 part, Radix Astragali 1-10 part, Herba Epimedii 1-8 part, Radix Clematidis 1-8 part, Semen Plantaginis 1-8 part, Radix Polygoni Multiflori 1-8 part, Radix Saposhnikoviae 1-8 part, Radix Glycyrrhizae 1-5 part.
A kind of pharmaceutical composition for the treatment of gout of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Caulis Lonicerae 3-10 part, Rhizoma Polygoni Cuspidati 2-8 part, Poria 2-8 part, Herba Lycopodii 2-8 part, Radix Astragali 2-8 part, Herba Epimedii 2-6 part, Radix Clematidis 2-6 part, Semen Plantaginis 2-6 part, Radix Polygoni Multiflori 2-6 part, Radix Saposhnikoviae 2-6 part, Radix Glycyrrhizae 1-3 part.。
The pharmaceutical composition of a kind of gout of the present invention, is characterized in that these pharmaceutical composition parts by weight are counted: Caulis Lonicerae 6 parts, Rhizoma Polygoni Cuspidati 4 parts, 4 parts, Poria, Herba Lycopodii 4 parts, the Radix Astragali 4 parts, Herba Epimedii 3 parts, Radix Clematidis 3 parts, Semen Plantaginis 3 parts, Radix Polygoni Multiflori 3 parts, Radix Saposhnikoviae 3 parts, 1.8 parts, Radix Glycyrrhizae.
The preparation of the Chinese medicine composition described in any one of the present invention, is characterized in that, described preparation is oral formulations.Preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.Further, preparation of the present invention, is characterized in that, described preparation is water decoction.
Preparation of the present invention, is characterized in that, the preparation method of described water decoction is: water crude drug being added 8 ~ 10 times of quality, decocts 1 ~ 2 hour, filters; Medicinal residues add the water of 3 ~ 5 times of quality again, decoct 30 ~ 40 minutes, filter; Merge twice filtrate, to obtain final product.
Preparation of the present invention, is characterized in that, the preparation method of described water decoction is: water crude drug being added 10 times of quality, decocts 1.5 hours, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, to obtain final product.
The application of described Chinese medicine composition of the present invention in preparation treatment gout medicine.
The each component pharmacology analysis of prescription of the present invention:
Caulis Lonicerae: Caulis Lonicerae has another name called large Caulis fici pumilae (Fructus Fici Pumilae), bigcatkin willow rattan, Radix Stephaniae Japonicae, perennial half evergreen voluble shrub, stem hollow, the close raw pubescence of sprout.Sweet in the mouth, cold in nature, there is heat-clearing and toxic substances removing, the curative effect of dispelling wind dredging collateral.Can be used for epidemic febrile disease heating, sore and toxic, toxic-heat and blood stasis, beriberoid pyretic arthralgia.
Rhizoma Polygoni Cuspidati: bitter in the mouth, property is put down, and expelling wind and removing dampness, removing blood stasis stimulates the menstrual flow, anti-inflammatory analgetic.
Poria: sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.
Herba Lycopodii: bitter in the mouth, pungent, warm in nature.Expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Energy invigorating the spleen and replenishing QI, tonifying the lung consolidating superficial resistance, inducing diuresis to remove edema.
Herba Epimedii: acrid in the mouth, warm in nature.Invigorating the liver and kidney, bone and muscle strengthening, supporing yang benefit essence, wind-damp dispelling.
Radix Clematidis: acrid in the mouth, salty, warm in nature.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.
Semen Plantaginis: sweet in the mouth, is slightly cold, clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.
Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, tepor, effects such as there is tonifying liver, kidney tonifying, nourish blood, dispel the wind.
Radix Saposhnikoviae: taste acrid, sweet, warm.Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Radix Glycyrrhizae, sweet in the mouth is put down, and enters spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Beneficial effect of the present invention is: Chinese medicine composition of the present invention, according to " soothing the stagnant liver ", the principle of " disease caused by accumulations of pathogen should be treated with therapy of dispersion ", utilize pharmaceutical composition dispelling wind dredging collateral of the present invention, expelling wind and removing dampness carries out dialectical treating, then takes to adjust rule of life, strikes a proper balance between work and rest, low fat diets etc. are conducive to setting up live and work order that is happy, rule, can reach effect for the treatment of both the principal and secondary aspects of a disease to gout.
Detailed description of the invention
Embodiment is only for further illustrating the present invention below, does not limit the scope of the invention in any form.
Embodiment 1 present composition decoction prescription and preparation method: get Caulis Lonicerae 30 grams, Rhizoma Polygoni Cuspidati 20 grams, 20 grams, Poria, Herba Lycopodii 20 grams, the Radix Astragali 20 grams, Herba Epimedii 15 grams, Radix Clematidis 15 grams, Semen Plantaginis 15 grams, Radix Polygoni Multiflori 15 grams, Radix Saposhnikoviae 15 grams, 9 grams, Radix Glycyrrhizae.Mixing, adds the water of 10 times of quality, decocts 1.5 hours in crude drug, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, make water decoction.
Embodiment 2 present composition decoction prescription and preparation method: Caulis Lonicerae 30 grams, Rhizoma Polygoni Cuspidati 15 grams, 15 grams, Poria, Herba Lycopodii 20 grams, the Radix Astragali 15 grams, Herba Epimedii 10 grams, Radix Clematidis 10 grams, Semen Plantaginis 10 grams, Radix Polygoni Multiflori 10 grams, Radix Saposhnikoviae 10 grams, 6 grams, Radix Glycyrrhizae.Mixing, adds the water of 10 times of quality, decocts 1.5 hours in crude drug, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, make water decoction.
Embodiment 3 present composition capsule prescription and preparation method: get Caulis Lonicerae 30 grams, Rhizoma Polygoni Cuspidati 20 grams, 20 grams, Poria, Herba Lycopodii 20 grams, the Radix Astragali 20 grams, Herba Epimedii 15 grams, Radix Clematidis 15 grams, Semen Plantaginis 15 grams, Radix Polygoni Multiflori 15 grams, Radix Saposhnikoviae 15 grams, 9 grams, Radix Glycyrrhizae.Mixing, adds the water of 10 times of quality, decocts 1.5 hours in crude drug, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.The adjuvant of proper proportion is added in thick paste, adjuvant is intended selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (pre-paying starch), sodium carboxymethyl cellulose (polyvidone), carboxymethylstach sodium (polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose) to stir, obtained soft material.Cross 24 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 24 mesh sieve granulate, additional magnesium stearate (micropowder silica gel) after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 4 present composition granule prescription and preparation method: get Caulis Lonicerae 30 grams, Rhizoma Polygoni Cuspidati 20 grams, 20 grams, Poria, Herba Lycopodii 20 grams, the Radix Astragali 20 grams, Herba Epimedii 15 grams, Radix Clematidis 15 grams, Semen Plantaginis 15 grams, Radix Polygoni Multiflori 15 grams, Radix Saposhnikoviae 15 grams, 9 grams, Radix Glycyrrhizae.Mixing, adds the water of 10 times of quality, decocts 1.5 hours in crude drug, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant is intended selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (pre-paying starch), sodium carboxymethyl cellulose (polyvidone) to stir, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate respectively after dry granule cooling, to obtain final product.
Embodiment 5 present composition electuary prescription and preparation method: get Radix Ginseng 3g, Poria 3 g, Radix Rehmanniae Preparata 3 g, Bulbus Fritillariae Uninbracteatae 3 g, fry Fructus Gardeniae 3 g, the Rhizoma Atractylodis Macrocephalae 4.5 g, Radix Angelicae Sinensis 4.5 g, Radix Bupleuri 2.4 g, Cortex Moutan 2.4 g, Rhizoma Chuanxiong 2.4 g, Pericarpium Citri Reticulatae 2.4 g, Radix Glycyrrhizae 1.5 g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Crushed 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate respectively after dry granule cooling, make powder or graininess electuary.
Embodiment 6 present composition tablet formulation and preparation method: get Radix Ginseng 3g, Poria 3 g, Radix Rehmanniae Preparata 3 g, Bulbus Fritillariae Uninbracteatae 3 g, fry Fructus Gardeniae 3 g, the Rhizoma Atractylodis Macrocephalae 4.5 g, Radix Angelicae Sinensis 4.5 g, Radix Bupleuri 2.4 g, Cortex Moutan 2.4 g, Rhizoma Chuanxiong 2.4 g, Pericarpium Citri Reticulatae 2.4 g, Radix Glycyrrhizae 1.5 g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.The adjuvant of proper proportion is added in thick paste, adjuvant is intended selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (pre-paying starch), sodium carboxymethyl cellulose (polyvidone), carboxymethylstach sodium (polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose) to stir, obtained soft material.Crushed 24 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 24 mesh sieve granulate respectively after dry granule cooling, additional magnesium stearate (micropowder silica gel) tabletting, to obtain final product.
More than describe preferred embodiment of the present invention in detail.Should be appreciated that those of ordinary skill in the art just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (9)
1. treat the pharmaceutical composition of gout for one kind, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Caulis Lonicerae 1-15 part, Rhizoma Polygoni Cuspidati 1-10 part, Poria 1-10 part, Herba Lycopodii 1-10 part, Radix Astragali 1-10 part, Herba Epimedii 1-8 part, Radix Clematidis 1-8 part, Semen Plantaginis 1-8 part, Radix Polygoni Multiflori 1-8 part, Radix Saposhnikoviae 1-8 part, Radix Glycyrrhizae 1-5 part.
2. a kind of pharmaceutical composition for the treatment of gout according to claim 1, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Caulis Lonicerae 3-10 part, Rhizoma Polygoni Cuspidati 2-8 part, Poria 2-8 part, Herba Lycopodii 2-8 part, Radix Astragali 2-8 part, Herba Epimedii 2-6 part, Radix Clematidis 2-6 part, Semen Plantaginis 2-6 part, Radix Polygoni Multiflori 2-6 part, Radix Saposhnikoviae 2-6 part, Radix Glycyrrhizae 1-3 part.
3. the pharmaceutical composition of a kind of gout according to claim 1, is characterized in that these pharmaceutical composition parts by weight are counted: Caulis Lonicerae 6 parts, Rhizoma Polygoni Cuspidati 4 parts, 4 parts, Poria, Herba Lycopodii 4 parts, the Radix Astragali 4 parts, Herba Epimedii 3 parts, Radix Clematidis 3 parts, Semen Plantaginis 3 parts, Radix Polygoni Multiflori 3 parts, Radix Saposhnikoviae 3 parts, 1.8 parts, Radix Glycyrrhizae.
4. the preparation of the Chinese medicine composition according to any one of claim 1-3, is characterized in that, described preparation is oral formulations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is water decoction.
7. preparation according to claim 6, is characterized in that, the preparation method of described water decoction is: water crude drug being added 8 ~ 10 times of quality, decocts 1 ~ 2 hour, filters; Medicinal residues add the water of 3 ~ 5 times of quality again, decoct 30 ~ 40 minutes, filter; Merge twice filtrate, to obtain final product.
8. preparation according to claim 7, is characterized in that, the preparation method of described water decoction is: water crude drug being added 10 times of quality, decocts 1.5 hours, filters; Medicinal residues add the water of 5 times of quality again, decoct 30 minutes, filter; Merge twice filtrate, to obtain final product.
9. the application of the Chinese medicine composition described in any one of claim 1-3 in preparation treatment gout medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105748611A (en) * | 2016-03-28 | 2016-07-13 | 张艳娟 | Pharmaceutical composition for treating hyperuricemia |
| CN105902635A (en) * | 2016-06-29 | 2016-08-31 | 骆彩林 | Wasp medicinal liquor and preparation method thereof |
| CN117338886A (en) * | 2023-08-25 | 2024-01-05 | 黑龙江珍宝岛药业股份有限公司 | Traditional Chinese medicine composition for treating gout and preparation method and application thereof |
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| CN103920117A (en) * | 2014-04-15 | 2014-07-16 | 韩世昌 | Chinese medicinal composition for treating gout and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748611A (en) * | 2016-03-28 | 2016-07-13 | 张艳娟 | Pharmaceutical composition for treating hyperuricemia |
| CN105902635A (en) * | 2016-06-29 | 2016-08-31 | 骆彩林 | Wasp medicinal liquor and preparation method thereof |
| CN117338886A (en) * | 2023-08-25 | 2024-01-05 | 黑龙江珍宝岛药业股份有限公司 | Traditional Chinese medicine composition for treating gout and preparation method and application thereof |
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Application publication date: 20150422 |