CN103405640A - Preparation method of bowel clearing granules before late pregnancy labor induction - Google Patents
Preparation method of bowel clearing granules before late pregnancy labor induction Download PDFInfo
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- CN103405640A CN103405640A CN2013103601477A CN201310360147A CN103405640A CN 103405640 A CN103405640 A CN 103405640A CN 2013103601477 A CN2013103601477 A CN 2013103601477A CN 201310360147 A CN201310360147 A CN 201310360147A CN 103405640 A CN103405640 A CN 103405640A
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Abstract
The invention discloses a preparation method of bowel clearing granules before late pregnancy labor induction, which aims to solve the problem of bowel clearing before late pregnancy labor induction. The invention is characterized by comprising the following active pharmaceutical ingredients in parts by weight: Horseweed herb, Fructus Cinnamomi, ternate buttercup root, Trachelospermum jasminoides, Asarum maximum Hemsl., rhizoma polygonati, fructus psoraleae, dried orange peel, sunflower, Turbo cornutus Solander, plant soot and magnesium sulfate. The preparation method comprises the following steps: (1) extracting volatile oils from fructus psoraleae, Fructus Cinnamomi and Asarum maximum Hemsl. coarse powders for later use; (2) pulverizing Turbo cornutus Solander and plant soot into fine powders for later use; (3) decocting horseweed herb, ternate buttercup root, Trachelospermum jasminoides, rhizoma polygonati, sunflower and dried orange peel with water 2 times, filtering, merging the filtrates, concentrating the filtrate, adding ethanol to precipitate, taking the supernatant, recovering the ethanol, and concentrating to obtain a thick paste; and (4) adding the volatile oils obtained in the step 1, the fine powders obtained in the step 2, and magnesium sulfate into the thick paste obtained in the step 3, stirring uniformly, granulating, and drying. The clinical experiment proves that the invention has the characteristic of favorable bowel clearing effect before late pregnancy labor induction, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of for the preoperative bowel relieving preparation method of granules of Induced Labor in Late Pregnancy.
Background technology
Intestinal is prepared to comprise before Induced Labor in Late Pregnancy stimulates enterokinesia, softening and remove feces, gets rid of the enteral pneumatosis, prevents that the patient from can not control defecation and increase opportunities for contamination because anaesthetizing rear Sphincter ani chalasia; Reduce simultaneously the enteral pneumatosis full and have feces and affect operation technique.Clinical practice confirms, can also alleviate hands postoperative abdominal distention discomfort by Oral Rhubarb, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid intestinal tract cleaning.Traditional method is that the art proxima luce (prox. luc) advances without the slag liquid food, preoperative late oral purgative (as: mannitol), and art is used 0.2% suds cleansing enema once morning again.There is following defect in this kind intestinal stand-by mode: 1. mannitol is a kind of hyperosmotic dehydration agent, and intestinal stimulates strong, and patient's emotion, sleep state are had a significant effect; 2. the last coloclysis time of Traditional Method is art 6am in morning, and 8am enters operating room, during do not have time enough thoroughly emptying by intestinal, in art, easily pollute; 3. can not produce beneficial effect to post-operative recovery.
At present, also there is report to use Chinese medicine preparation to carry out preoperative intervention bowel relieving, as oral above-mentioned Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid, but medicine great majority used are all the purgatives medicine things such as Radix Et Rhizoma Rhei, take rear zest strong, patient's emotion, sleep state are had a significant effect, and Semen Platycladi etc. the cathartic medicine is wayward rushes down the lower time.So lack now a kind of preoperative intervention bowel relieving that is applicable to, rush down effectively lower and can not affect sleep again, for post-operative recovery, can produce the medicine of beneficial effect.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little medicine for the preoperative intervention of Induced Labor in Late Pregnancy of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the preoperative intervention of Induced Labor in Late Pregnancy is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Horseweed Herbs, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Caulis Trachelospermis, 3 ~ 10 parts of large Herba Swertiae heteranthaes, 6 ~ 12 parts of Rhizoma Polygonatis, 6 ~ 12 parts of Fructus Psoraleaes, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Flos Helianthis, 1 ~ 5 part of Turbo cornutus Solander, 3 ~ 10 parts of Pulvis Fumi Carbonisatuss, 10 ~ 25 parts, magnesium sulfate.
Chinese medicine of the present invention can be prepared from by following method:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large Herba Swertiae heteranthae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make to contain alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Wherein said: Horseweed Herb, for Compositae Herba Erigerontis aceris platymiscium Horseweed Herb Erigeron canadensis L., be used as medicine with herb or bright leaf.Property mildly bitter flavor, suffering, cool.But the merit clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.
Fructus cinnamomi immaturus, be the tender fruit of the children of canella Cortex Cinnamomi.Gas fragrance, distinguish the flavor of micro-sweet.Nature and flavor Wen Xingan, return the stomach warp.But merit warming spleen and stomach for dispelling cold.
Radix Ranunculi Ternati, be the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..The nature and flavor sweet, acrid, warm.Return liver, lung meridian.But the merit eliminating stagnation, detumescence.
Caulis Trachelospermi, be the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, be slightly cold.GUIXIN, liver, kidney channel.But the merit dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.
Large Herba Swertiae heteranthae, be aristolochiaceae plant the become mildewed herb of Herba Asari or root, rhizome.The nature and flavor suffering; Temperature.But merit warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.
Rhizoma Polygonati, be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.But the merit boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor are hot, bitter, temperature.Return kidney, spleen channel.But the merit warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
Pericarpium Citri Reticulatae, be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Flos Helianthi, be the flower of feverfew Helianthi Helianthus annuus L..Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, be the operculum of covering of Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.But merit clearing away damp-heat; Remove phlegm-fire; Separate sore.Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Pulvis Fumi Carbonisatus, for weeds invest the cigarette China ink of depositing in the bottom of a pan or chimney after burning.The nature and flavor suffering, temperature.Merit can be stopped blooding, antidiarrheal.
Composition principle: Induced Labor in Late Pregnancy is preoperative will carry out intestinal processing, namely bowel relieving.Traditional method is that the art proxima luce (prox. luc) advances without the slag liquid food, preoperative late oral purgative (as: mannitol or Chinese medicine cathartic prescription), and art morning, 0.2% suds (or normal saline) cleansing enema was once again.There is following defect in this kind intestinal stand-by mode: 1. mannitol or Chinese medicine cathartic prescription, and intestinal stimulates strong, and patient's emotion, sleep state are had a significant effect; 2. the last coloclysis time of Traditional Method is art 6am in morning, and 8am enters operating room, during do not have time enough thoroughly emptying by intestinal, in art, easily pollute; 3. can not produce beneficial effect to post-operative recovery.We be take magnesium sulfate and are cathartic, coordinate the medicine of fugitive stable enterokinesia, and suitable reduction intestinal contents reaction sensitivity that intestinal is stimulated, lax intestinal smooth.Like this, the magnesium sulfate that enters on the one hand intestinal is difficult for absorbing at intestinal, forms hyperosmotic state, completes the catharsis effect; The lax intestinal smooth of the medicine of fugitive stable enterokinesia, alleviate awareness of defecation on the other hand, to guarantee Sleeping.Simultaneously, other pharmaceutical components in we complete and invigorate blood circulation, eliminate the phlegm, the effect of eliminating stagnation, dredging collateral, promote the Induced Labor in Late Pregnancy post-operative recovery.
Compared with prior art, the present invention has following characteristics.
1, Horseweed Herb and Fructus cinnamomi immaturus coordinate for monarch drug, the inventor studies discovery: the mixing water decocting liquid of Horseweed Herb and Fructus cinnamomi immaturus is wriggled without obvious inhibitory action to the isolated mouse ileum, but when gastrointestinal smooth muscle is in the excitatory state under the magnesium sulfate stimulation, remarkable relexation is arranged.Its mechanism of action may be relevant to the smooth muscle relaxation of Horseweed Herb total flavones water soluble part, but this kind effect coordinates with Fructus cinnamomi immaturus and can only for the intestinal wall smooth muscle under excited state, come into force.Under this dosage, the pharmacological action time of Horseweed Herb is about 8 ~ 10 hours, namely takes medicine night, can alleviate the awareness of defecation under the magnesium sulfate stimulation, and guarantee suitable sleep, after art drug effect in morning is lost, can complete the effect of cleaning intestinal.
2, Radix Ranunculi Ternati mass dissipating and swelling eliminating, Caulis Trachelospermi dredging collateral reducing swelling and alleviating pain, alleviate the discomfort that postoperative pelvic cavity excitation causes.
3, Rhizoma Polygonati boosting qi and nourishing yin, the Fructus Psoraleae nourishing the liver and kidney, Pericarpium Citri Reticulatae invigorating the spleen and benefiting QI diuretic, the postoperative function of intestinal canal that is conducive to recovers, and shortens fasting time, is conducive to early recovery.
4, the large Herba Swertiae heteranthae motionless blood of invigorating blood circulation, and the strong muscle effect of dredging collateral is arranged.
5, inventor's experimentation shows: low dose of Turbo cornutus Solander can be stablized intestinal mucosa effectively.
6, Flos Helianthi is using corrigent, and this medicine can obviously strengthen small intestinal and shrink, and lasting medicine, utilizes low dose of Flos Helianthi to prevent the Horseweed Herb overaction.
7, in the loose dredging collateral medicine of one row, add low dose of Pulvis Fumi Carbonisatus, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
9, adopt the granule dosage form, easy to use.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts of Horseweed Herbs, 10 parts of Fructus cinnamomi immaturus, 6 parts of Radix Ranunculi Ternatis, 10 parts of Caulis Trachelospermis, 6 parts of large Herba Swertiae heteranthaes, 10 parts of Rhizoma Polygonatis, 10 parts of Fructus Psoraleaes, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts of Pulvis Fumi Carbonisatuss, 20 parts, magnesium sulfate.
The preparation method of embodiment 1 is: Horseweed Herb, Fructus cinnamomi immaturus, Radix Ranunculi Ternati, Caulis Trachelospermi, large Herba Swertiae heteranthae, Rhizoma Polygonati, Fructus Psoraleae, Pericarpium Citri Reticulatae, Flos Helianthi, Turbo cornutus Solander, Pulvis Fumi Carbonisatus, magnesium sulfate mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, and twice filtrate is merged into decoction.
Embodiment 2, the crude drug weight proportion: 10 parts of Horseweed Herbs, 6 parts of Fructus cinnamomi immaturus, 3 parts of Radix Ranunculi Ternatis, 6 parts of Caulis Trachelospermis, 3 parts of large Herba Swertiae heteranthaes, 6 parts of Rhizoma Polygonatis, 6 parts of Fructus Psoraleaes, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Helianthis, 1 part of Turbo cornutus Solander, 3 parts of Pulvis Fumi Carbonisatuss, 10 parts, magnesium sulfate.
Embodiment 3, the crude drug weight proportion: 20 parts of Horseweed Herbs, 10 parts of Fructus cinnamomi immaturus, 6 parts of Radix Ranunculi Ternatis, 10 parts of Caulis Trachelospermis, 6 parts of large Herba Swertiae heteranthaes, 10 parts of Rhizoma Polygonatis, 10 parts of Fructus Psoraleaes, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts of Pulvis Fumi Carbonisatuss, 20 parts, magnesium sulfate.
Embodiment 4, the crude drug weight proportion: 30 parts of Horseweed Herbs, 12 parts of Fructus cinnamomi immaturus, 10 parts of Radix Ranunculi Ternatis, 12 parts of Caulis Trachelospermis, 10 parts of large Herba Swertiae heteranthaes, 12 parts of Rhizoma Polygonatis, 12 parts of Fructus Psoraleaes, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Flos Helianthis, 5 parts of Turbo cornutus Solander, 10 parts of Pulvis Fumi Carbonisatuss, 25 parts, magnesium sulfate.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large Herba Swertiae heteranthae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make to contain alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Described magnesium sulfate can be the magnesium sulfate powder, also can be Adlerika.
Effective combination of said medicine, coordinate mutually, effectively reaches the purpose of the preoperative cleaning intestinal of Induced Labor in Late Pregnancy, and do not affect Sleeping, is beneficial to post-operative recovery.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: the Induced Labor in Late Pregnancy that accept for medical treatment year April in March, 2012 ~ 2013 is chosen date for operation and is needed cleansing enema patient 81 examples, and pregnant week is between 28 ~ 37 weeks.
1.1.2 grouping: be divided at random matched group 27 examples, at 19 ~ 42 years old age, the mean age is 27.3 years old.Decoction group 27 examples, 17 ~ 39 years old age, 25.4 years old mean age.Groups of grains 27 examples, 18 ~ 41 years old age, 24.6 years old mean age.Before three groups of patient treatments, compare on age, pregnant week, mean operative time, and the difference not statistically significant (P > 0.05), have comparability.
1.2 method.
1.2.1 administering mode: all case art proxima luce (prox. luc)s advance without the slag liquid food, and matched group is taked conventional method of clyster: preoperative late oral mannitol, art morning, the normal saline cleansing enema was once again.The decoction group adopted embodiment 1 gained decoction oral at preoperative late 8 o'clock, and art normal saline in morning cleansing enema once.Groups of grains adopted embodiment 3 gained particulate orals at preoperative late 8 o'clock, and art normal saline in morning cleansing enema once.
1.2.2 observation index: after the bowel relieving operation, observe patient's defecation frequency, record intestinal tract cleaning and pneumatosis situation in art, and micturition time after operation in patients and untoward reaction are passed judgment on.
1.2.3 intestine cleaning effect evaluation criterion: effectively be intestinal in operation in patients and keep complete relaxed state, pollute without leakage in art; Invalidly be intestinal high level expansion in operation in patients, in art, occur that leakage pollutes.
2 results.
2.1 intestinal tract cleaning situation and transfusion definition situation in art: the effective percentage of matched group, decoction group, groups of grains bowel relieving is 100%.
2.2 three groups of operation in patients between eve defecation, art defecation in morning situation, the postoperative aerofluxus situation of insomnia situation see the following form:
| Group | Number of cases | Defecation at night (inferior) | Art defecation in morning (inferior) | Insomnia (example) | Postoperative aerofluxus (h) |
| Matched group | 27 | 2. 62±0.23 | 2.25±0.32 | 19 | 36.13±11.61 |
| The decoction group | 27 | 0.95±0.22 | 5.72±0.37 | 8 | 25.24±4.62 |
| Groups of grains | 27 | 0. 96±0.44 | 4.73±0.26 | 6 | 24.21±5.38 |
Result shows: apply decoction of the present invention or granule dosage form preoperative night and orally can reduce the defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach as early as possible postoperative aerofluxus, and compare (P<0.05) with matched group.
2.3 before three groups of operation in patients, the nursing intervention satisfaction relatively: the matched group patient is 86.67% to preoperative nursing intervention satisfaction, and the satisfaction of decoction group, groups of grains bowel relieving is 100%.
3. conclusion.
The demonstration of this result of study, the preoperative oral decoction of the present invention or granule intestine cleaning effect are obvious, can effectively reduce the defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach as early as possible postoperative aerofluxus, increase the satisfaction of patient to nursery work.
Claims (2)
1. one kind for the preoperative bowel relieving preparation method of granules of Induced Labor in Late Pregnancy, it is characterized in that, crude drug comprises: the crude drug by following weight proportion is prepared from: 10 ~ 30 parts of Horseweed Herbs, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Caulis Trachelospermis, 3 ~ 10 parts of large Herba Swertiae heteranthaes, 6 ~ 12 parts of Rhizoma Polygonatis, 6 ~ 12 parts of Fructus Psoraleaes, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Flos Helianthis, 1 ~ 5 part of Turbo cornutus Solander, 3 ~ 10 parts of Pulvis Fumi Carbonisatuss, 10 ~ 25 parts, magnesium sulfate are comprised of following steps:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large Herba Swertiae heteranthae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make to contain alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
2. according to claim 1 a kind of for the preoperative bowel relieving preparation method of granules of Induced Labor in Late Pregnancy, it is characterized in that: the simmer down to concentrating under reduced pressure described in described step (3).
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Address after: 261400 Laizhou Yantai people's Hospital, 1817 east culture street, Laizhou, Shandong, Shandong Applicant after: Jiang Chunjie Address before: 261400 Department of Neurology, Laizhou people's Hospital of Laizhou, Shandong Province, Shandong 1817, Yantai Applicant before: Jiang Chunjie |
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