CN105148078A - Medicinal preparation used for treating oral ulcers - Google Patents

Medicinal preparation used for treating oral ulcers Download PDF

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Publication number
CN105148078A
CN105148078A CN201510638259.3A CN201510638259A CN105148078A CN 105148078 A CN105148078 A CN 105148078A CN 201510638259 A CN201510638259 A CN 201510638259A CN 105148078 A CN105148078 A CN 105148078A
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parts
radix
treatment
medicinal
oral ulcer
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卞文青
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卞文青
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Abstract

The invention belongs to the field of Chinese herb preparations, and particularly provides a medicinal preparation used for treating oral ulcers. The medicinal preparation is prepared from 28 parts of sonchus oleraceus L., 25 parts of brachystemma calycinum D., 20 parts of diplazium donianum, 15 parts of rubus delavayi, 25 parts of lonicera japonica, 28 parts of sculellaria barbata, 15 parts of alisma plantago-aquatica, 15 parts of ramulus cinnamomi, 20 parts of radix achyranthis bidentatae, 25 parts of salvia miltiorrhiza, 20 parts of forsythia suspense, 25 parts of folium isatidis, 20 parts of Chinese pulsatilla roots, 15 parts of bamboo leaves, 15 parts of rhizoma cimicifugae, 15 parts of platycodon grandiflorum, 25 parts of scrophularia ningpoensis, 15 parts of cayratia japonica and 5 parts of glycyrrhiza uralensis. The medicinal preparation is capable of treating oral ulcers.

Description

A kind of pharmaceutical preparation being used for the treatment of oral ulcer
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of oral ulcer and its preparation method and application.
Background technology
Oral ulcer is a kind of common ulcerative damages disease betiding oral mucosa, is more common in inside lip, the position such as tongue, tongue abdomen, cheek mucosa, vestibule ditch, soft palate, the mucosa at these positions lack keratinization layer or keratinization poor.Tongue ulcer refers to the oral ulcer betiding tongue, tongue abdominal part position.Sharp ache during oral ulcer outbreak, local causalgia is obvious, and severe patient also can affect diet, speak, and causes very big inconvenience to daily life; Can the General Symptoms such as concurrent halitosis, chronic pharyngitis, constipation, headache, dizziness, nauseating, weak, irritated, heating, lymphadenectasis.For this reason, be bursting to and develop the needs that more medicines for the treatment of oral ulcer safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of oral ulcer disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of oral ulcer, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Picris divaricata 28 parts, Brachystemma calycina D. Don. 25 parts, 20 parts, comb leaf, Rubus delavayi Franch. 15 parts, Flos Lonicerae 25 parts, Herba Scutellariae Barbatae 28 parts, Rhizoma Alismatis 15 parts, Ramulus Cinnamomi 15 parts, Radix Achyranthis Bidentatae 20 parts, Radix Salviae Miltiorrhizae 25 parts, Fructus Forsythiae 20 parts, Folium Isatidis 25 parts, the Radix Pulsatillae 20 parts, 15 parts, Folium Bambusae, Rhizoma Cimicifugae 15 parts, Radix Platycodonis 15 parts, Radix Scrophulariae 25 parts, Herba Cayatiae Japonicae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of oral ulcer, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of oral ulcer, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment stomatocace medicine being used for the treatment of oral ulcer.
Picris divaricata is Compositae sonchus plant Herba Sonchi Oleracei SonchusoleraceusL., with all herbal medicine.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For enteritis, dysentery, acute icteric infectious hepatitis, appendicitis, mastitis, stomatitis, pharyngitis, tonsillitis, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia; Carbuncle pyogenic infections from tumour or sore is controlled in external, otitis media.
Brachystemma calycina D. Don. is Caryophyllaceae Brachystemma calycina D. Don. platymiscium Brachystemma calycina D. Don. BrachystemmacalycinumD.Don, is used as medicine with whole herb with root.The whole year can adopt, and cleans, using fresh herb or dry.Heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral.Root: for diphtheria, rheumatic arthralgia, traumatic injury, menoxenia, weak after being ill.Stem, leaf: carpopedal spasm is controlled in external, fracture.
Comb leaf is the herb of Athyriaceae plant Diplazium donianum (Mett.) Tard. Blet..Latin name: Diplaziumdonianum (Mett.) Tard-Blot. [AspleniumdonianumMett.], clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Cure mainly jaundice due to damp-heat; Venom; Traumatic hemorrhage; Dysmenorrhea.
Rubus delavayi Franch. is the Herb of rosaceous plant SANYE Fructus Rubi corchorifolii Immaturus.Heat-clearing and toxic substances removing, dehumidifying dysentery relieving.Drive ascarid.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, oral ulcer is many to be caused because stomach-fire is excessively prosperous, Picris divaricata of the present invention, Brachystemma calycina D. Don., comb leaf, Rubus delavayi Franch., Flos Lonicerae, Herba Scutellariae Barbatae, Rhizoma Alismatis, Ramulus Cinnamomi, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Fructus Forsythiae, Folium Isatidis, the Radix Pulsatillae, Folium Bambusae, Rhizoma Cimicifugae, Radix Platycodonis, Radix Scrophulariae, Herba Cayatiae Japonicae heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating are monarch drug, Fructus Forsythiae, Folium Isatidis, the Radix Pulsatillae, Folium Bambusae, Rhizoma Cimicifugae, Radix Platycodonis, Radix Scrophulariae, Herba Cayatiae Japonicae pathogenic fire reducing promote the production of body fluid for ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment oral ulcer successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Picris divaricata 28g, Brachystemma calycina D. Don. 25g, comb leaf 20g, Rubus delavayi Franch. 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Rhizoma Alismatis 15g, Ramulus Cinnamomi 15g, Radix Achyranthis Bidentatae 20g, Radix Salviae Miltiorrhizae 25g, Fructus Forsythiae 20g, Folium Isatidis 25g, Radix Pulsatillae 20g, Folium Bambusae 15g, Rhizoma Cimicifugae 15g, Radix Platycodonis 15g, Radix Scrophulariae 25g, Herba Cayatiae Japonicae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Picris divaricata 28g, Brachystemma calycina D. Don. 25g, comb leaf 20g, Rubus delavayi Franch. 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Rhizoma Alismatis 15g, Ramulus Cinnamomi 15g, Radix Achyranthis Bidentatae 20g, Radix Salviae Miltiorrhizae 25g, Fructus Forsythiae 20g, Folium Isatidis 25g, Radix Pulsatillae 20g, Folium Bambusae 15g, Rhizoma Cimicifugae 15g, Radix Platycodonis 15g, Radix Scrophulariae 25g, Herba Cayatiae Japonicae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Picris divaricata 28g, Brachystemma calycina D. Don. 25g, comb leaf 20g, Rubus delavayi Franch. 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Rhizoma Alismatis 15g, Ramulus Cinnamomi 15g, Radix Achyranthis Bidentatae 20g, Radix Salviae Miltiorrhizae 25g, Fructus Forsythiae 20g, Folium Isatidis 25g, Radix Pulsatillae 20g, Folium Bambusae 15g, Rhizoma Cimicifugae 15g, Radix Platycodonis 15g, Radix Scrophulariae 25g, Herba Cayatiae Japonicae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4.1 general data: this Chinese medicine composition is applied to clinical observation oral ulcer case 40 example, wherein man 20 example, female 20 example, 26 ~ 58 years old age.The shortest person of the course of disease 3 months, most elder reaches 10 months, average 6 months.
4.2 diagnostic criterias: (1) occurs ulcer that is single or several diameter 3 ~ 5mm with oral mucosa, and scorching hot pain is cardinal symptom.(2) onset is very fast, healing in general about 7 days, if down here, then the course of disease extends.More normal easily recurrence after.(3) examination of mouth: stomatocace is comparatively shown shallow, circular or oval, quantity 1 ~ 2 at least, more than 10 at most, surface has faint yellow secretions to adhere to, and ulcer surrounding mucosa is mostly congested.(4) should differentiate mutually with inflammation around hu huo syndrome (behcet's syndrome), Periadenitis mucosa and herpetic stomatitis.Syndrome-classification: accumulation of heat in the heart and spleen: pain in mouth, thirsty, halitosis, short urination is yellow, constipation.Aphtha quantity is many, obviously congested around.Red tongue, yellow fur, rapid pulse.Hyperactivity of fire caused by deficiency of YIN: pain in mouth, xerostomia, feverish sensation in the palms and soles, weak.Aphtha 1 ~ 2 or 2 ~ 3, slight congested around.Red tongue, tongue is few, thready and rapid pulse.Deficiency of qi and blood: mouth is not thirsty, or companion's fear of cold, loose stool.Aphtha quantity is few, and surrounding mucosa is not congested.Light red tongue, white and thin fur, thready and weak pulse.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: oral ulcer heals, local is without sense of discomfort.(2) take a turn for the better: although have recurrence during aphtha, quantity reduces, and degree alleviates.(3) invalid: aphtha symptom and ulcer are without significant change.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 20 6 11 3 85
Blank group 20 0 1 19 5
Visible, the medicine that the present invention obtains can safe and effective treatment oral ulcer, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of oral ulcer, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Picris divaricata 28 parts, Brachystemma calycina D. Don. 25 parts, 20 parts, comb leaf, Rubus delavayi Franch. 15 parts, Flos Lonicerae 25 parts, Herba Scutellariae Barbatae 28 parts, Rhizoma Alismatis 15 parts, Ramulus Cinnamomi 15 parts, Radix Achyranthis Bidentatae 20 parts, Radix Salviae Miltiorrhizae 25 parts, Fructus Forsythiae 20 parts, Folium Isatidis 25 parts, the Radix Pulsatillae 20 parts, 15 parts, Folium Bambusae, Rhizoma Cimicifugae 15 parts, Radix Platycodonis 15 parts, Radix Scrophulariae 25 parts, Herba Cayatiae Japonicae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of oral ulcer as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of oral ulcer as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment stomatocace medicine of oral ulcer according to claim 1.
CN201510638259.3A 2015-09-30 2015-09-30 Medicinal preparation used for treating oral ulcers Withdrawn CN105148078A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641520A (en) * 2016-01-27 2016-06-08 郭洪平 Medicine for treating dental ulcers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751443A (en) * 2014-01-06 2014-04-30 崔磊 Traditional Chinese medicine composite powder for treating oral ulcer
CN104189563A (en) * 2014-08-09 2014-12-10 刘兰英 Traditional Chinese medicine for treating oral ulcer and preparation method thereof
CN104274763A (en) * 2014-10-27 2015-01-14 山东大学齐鲁医院 Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation
CN104800807A (en) * 2015-05-05 2015-07-29 淄博齐鼎立专利信息咨询有限公司 Traditional Chinese medicine composition for treating oral ulcer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751443A (en) * 2014-01-06 2014-04-30 崔磊 Traditional Chinese medicine composite powder for treating oral ulcer
CN104189563A (en) * 2014-08-09 2014-12-10 刘兰英 Traditional Chinese medicine for treating oral ulcer and preparation method thereof
CN104274763A (en) * 2014-10-27 2015-01-14 山东大学齐鲁医院 Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation
CN104800807A (en) * 2015-05-05 2015-07-29 淄博齐鼎立专利信息咨询有限公司 Traditional Chinese medicine composition for treating oral ulcer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
蔡琳等: "基于中医传承辅助系统的口疮外用方剂用药规律分析", 《中国实验方剂学杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641520A (en) * 2016-01-27 2016-06-08 郭洪平 Medicine for treating dental ulcers

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