CN105079336A - Pharmaceutical preparation for treating chronic pelvic inflammatory disease - Google Patents
Pharmaceutical preparation for treating chronic pelvic inflammatory disease Download PDFInfo
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- CN105079336A CN105079336A CN201510585771.6A CN201510585771A CN105079336A CN 105079336 A CN105079336 A CN 105079336A CN 201510585771 A CN201510585771 A CN 201510585771A CN 105079336 A CN105079336 A CN 105079336A
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Abstract
The invention belongs to the field of a traditional Chinese medicinal preparation, and in particular provides a pharmaceutical preparation for treating chronic pelvic inflammatory disease, wherein the pharmaceutical preparation is prepared from the following raw materials: 25 parts of north china hound's-tongue root, 20 parts of S. uncinata, 28 parts of ardisia japonica, 15 parts of herb of malay blumea, 25 parts of honeysuckle, 28 parts of caulis spatholobi, 15 parts of herba patriniae, 15 parts of dandelion, 20 parts of rhizoma alismatis, 25 parts of rhizoma rehmannia, 20 parts of bighead atractylodes rhizome, 25 parts of rhizoma corydalis, 20 parts of spina gleditsiae, 15 parts of root of three-nerved spicebush, 15 parts of fennel, 15 parts of fructus forsythiae, 25 parts of herba lycopi, 15 parts of seed of Chinese dodder and 5 parts of liquorice root. The pharmaceutical preparation disclosed by the invention is used for treating chronic pelvic inflammatory disease.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease and its preparation method and application.
Background technology
Chronic pelvic inflammatory disease is most fails thoroughly treatment because of acute pelvic inflammatory disease, or caused by the poor course of disease delay of patient's body constitution, also can because of caused by chlamydia infection.The symptom of chronic pelvic inflammation mainly contains: how not obvious (1) General Symptoms is, sometimes can have low grade fever, and susceptible is tired.The course of disease time is longer, and some patients can have neurasthenia symptom.(2) chronic inflammatory disease formed cicatricial adhesion and pelvic congestion, hypogastric region falling inflation, pain and lumbosacral region can be caused to ache, aggravate before and after fatigue of being everlasting, sexual intercourse, menstruation.(3) due to pelvic congestion, patient can have menstruation to increase, and ovarian function infringement can have menoxenia, can cause infertile when fallopian tube adhesion is blocked.Because the combination of sperm and the ovum process that to be needs one very complicated, sperm arrives intrauterine to be needed to overcome all the difficulties in the way, and screens layer by layer, no matter any one link is out of joint, the effect of obstruction is played in capital, if there is implantation positional fault, also can cause ectopic pregnancy.Guangzhou kindheartedness hospital gynaecologist is introduced, the course for the treatment of of chronic pelvic inflammatory disease is long, therefore treatment is got up more complicated than acute pelvic inflammatory disease, the composite treatment of usual employing Chinese medicine is treated, Chinese medicine composite treatment comprises extract oral, Chinese medicine intravenous drip, herbal enema, acupuncture and moxibustion therapy, abdominal acupoints externally used medicine bag, and vagina receives medicine, fumigation and wash method etc., can also coordinate hot compress and the iontophoresis of Chinese medicine in addition.Often can cause lower abdomen falling inflation, pain, waist and sacrum pain, menorrhagia etc.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic pelvic inflammatory disease safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic pelvic inflammatory disease disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: Radix cynoglossi divaricati 25 parts, refreshing brocade spend 20 parts, Herba Ardisiae Japonicae 28 parts, Herba Blumeae Lacerae 15 parts, Flos Lonicerae 25 parts, Caulis Spatholobi 28 parts, Herba Patriniae 15 parts, Herba Taraxaci 15 parts, Rhizoma Alismatis 20 parts, Radix Rehmanniae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Corydalis 25 parts, Spina Gleditsiae 20 parts, the Radix Linderae 15 parts, Fructus Foeniculi 15 parts, Fructus Forsythiae 15 parts, Herba Lycopi 25 parts, Semen Cuscutae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic pelvic inflammatory disease medicine being used for the treatment of chronic pelvic inflammatory disease.
Radix cynoglossi divaricati is the root of comfrey exhibition branch Herba Carpesii Cernui.Heat-clearing and toxic substances removing.Treating tonsillitis, furuncle carbuncle.
God's brocade flower is Selaginaceae Rock lily plant CUIYUNCAO Selaginellauncinata (Desv.) Spring, with all herbal medicine.The whole year can adopt, using fresh herb or dry.Heat-clearing and toxic substances removing, cough-relieving sore-throat relieving, inducing diuresis and reducing edema, hemostasis and pain-relieving.For influenza, flu, cough, tonsillitis, parotitis, conjunctival congestion and swelling pain, enteritis, dysentery, agalactia; External is controlled skin ulcer and to be swollen furunculosis, and traumatic injury, eczema, burn and scald, knife injury is hemorrhage.
Herba Ardisiae Japonicae, formal name used at school: Ardisiajaponica (Thunb) Blume, belongs to undershrub or semishrub plant, closely overgrows, the repent rhizome of tool; Erect stern reaches 30 centimetres, rarely reaches 40 centimetres, not branch, by trickle pubescence during children, later without hair.Relieving cough and resolving phlegm, removing toxic substances of dispeling the wind, promoting blood circulation and stopping pain.For bronchitis, lobar pneumonia, infantile pneumonia, pulmonary tuberculosis, hepatitis, dysentery, acute nephritis, urinary tract infection, stimulates the menstrual flow, traumatic injury, bones and muscles pain due to rheumatism; Skin itching is controlled in external, dermatitis rhus.The present invention is with all herbal medicine.
Herba Blumeae Lacerae is the herb that Compositae Herba Blumeae Balsamiferae platymiscium is shown in white yellow BlumealaceraDC..Spring and summer is gathered, and clean chopping is dried, or fresh leaf.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: chronic pelvic inflammatory disease belongs to the category of " leukorrhagia " in Chinese medicine, " dysmenorrhea ", " note of the ancient Chinese abdominal mass ".The traditional Chinese medical science is thought, this disease is many because of natural endowment deficiency, maintenance is careless at ordinary times, caused by the unclean or overstrain of vaginal orifice, Radix cynoglossi divaricati of the present invention, god's brocade flower, Herba Ardisiae Japonicae, Herba Blumeae Lacerae, Flos Lonicerae, Caulis Spatholobi, Herba Patriniae, Herba Taraxaci blood circulation promoting and blood stasis dispelling, heat clearing away dredging collateral is monarch drug, Rhizoma Alismatis, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Spina Gleditsiae, the Radix Linderae, Fructus Foeniculi, Fructus Forsythiae, Herba Lycopi, Semen Cuscutae clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and QI regulating is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, blood circulation promoting and blood stasis dispelling, heat clearing away dredging collateral, clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and QI regulating, treatment chronic pelvic inflammatory disease successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Radix cynoglossi divaricati 25g, god's brocade flower 20g, Herba Ardisiae Japonicae 28g, Herba Blumeae Lacerae 15g, Flos Lonicerae 25g, Caulis Spatholobi 28g, Herba Patriniae 15g, Herba Taraxaci 15g, Rhizoma Alismatis 20g, Radix Rehmanniae 25g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Corydalis 25g, Spina Gleditsiae 20g, Radix Linderae 15g, Fructus Foeniculi 15g, Fructus Forsythiae 15g, Herba Lycopi 25g, Semen Cuscutae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Radix cynoglossi divaricati 25g, god's brocade flower 20g, Herba Ardisiae Japonicae 28g, Herba Blumeae Lacerae 15g, Flos Lonicerae 25g, Caulis Spatholobi 28g, Herba Patriniae 15g, Herba Taraxaci 15g, Rhizoma Alismatis 20g, Radix Rehmanniae 25g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Corydalis 25g, Spina Gleditsiae 20g, Radix Linderae 15g, Fructus Foeniculi 15g, Fructus Forsythiae 15g, Herba Lycopi 25g, Semen Cuscutae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Radix cynoglossi divaricati 25g, god's brocade flower 20g, Herba Ardisiae Japonicae 28g, Herba Blumeae Lacerae 15g, Flos Lonicerae 25g, Caulis Spatholobi 28g, Herba Patriniae 15g, Herba Taraxaci 15g, Rhizoma Alismatis 20g, Radix Rehmanniae 25g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Corydalis 25g, Spina Gleditsiae 20g, Radix Linderae 15g, Fructus Foeniculi 15g, Fructus Forsythiae 15g, Herba Lycopi 25g, Semen Cuscutae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment chronic pelvic inflammatory disease of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic pelvic inflammatory disease case 70 example, 25 ~ 45 years old age.The shortest person of the course of disease 6 months, most elder reaches 4 years.
4.2 diagnostic criterias: (1) once had acute pelvic inflammatory disease medical history or pulmonary tuberculosis medical history.(2) clinical manifestation can have Irregular uterine bleeding, lower abdomen falling inflation, and lumbosacral region is uncomfortable, sexual anhedonia.(3) check have the other tissue in palace to thicken and tenderness maybe can be laid one's hand on and enclosed mass.(4) routine blood test and erythrocyte sedimentation rate may be higher.(5) diagnostic curettage prompting endometrial tuberculosis or chronic endometritis.(6) enclosed mass that B-type ultrasonography visible pelvic cavity form is irregular, capsule is uneven in fact or hydrops.(7) adhesion around internal genitalia can be found under peritoneoscope, tissue thickens, enclosed mass is formed; Get tissue in art to make pathologic finding and can make a definite diagnosis further.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptom disappearance, gynecologial examination positive sign disappears, and B ultrasonic display inflammatory mass, pelvic hydrops disappear, and bilateral adnexa is normal; Effective: main clinic symptoms disappears or obviously alleviates, it is thinning that B ultrasonic display inflammatory mass reduces the adnexa thickened, and pelvic hydrops reduces or trend disappears; Invalid: main clinic symptoms and sign unchanged, B ultrasonic display inflammatory mass without change.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 35 | 12 | 21 | 2 | 94.3 |
| Blank group | 35 | 1 | 1 | 32 | 5.7 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic pelvic inflammatory disease, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease, it is characterized in that, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: Radix cynoglossi divaricati 25 parts, refreshing brocade spend 20 parts, Herba Ardisiae Japonicae 28 parts, Herba Blumeae Lacerae 15 parts, Flos Lonicerae 25 parts, Caulis Spatholobi 28 parts, Herba Patriniae 15 parts, Herba Taraxaci 15 parts, Rhizoma Alismatis 20 parts, Radix Rehmanniae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Corydalis 25 parts, Spina Gleditsiae 20 parts, the Radix Linderae 15 parts, Fructus Foeniculi 15 parts, Fructus Forsythiae 15 parts, Herba Lycopi 25 parts, Semen Cuscutae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic pelvic inflammatory disease medicine of chronic pelvic inflammatory disease according to claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105288506A (en) * | 2015-12-03 | 2016-02-03 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation for treating acute pelvic inflammatory disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102872418A (en) * | 2012-10-17 | 2013-01-16 | 薛洪喜 | Medicine for treating pelvic inflammation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102872418A (en) * | 2012-10-17 | 2013-01-16 | 薛洪喜 | Medicine for treating pelvic inflammation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288506A (en) * | 2015-12-03 | 2016-02-03 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation for treating acute pelvic inflammatory disease |
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