CN104998225A

CN104998225A - Medicinal preparation for treatment of constipation

Info

Publication number: CN104998225A
Application number: CN201510362966.4A
Authority: CN
Inventors: 徐国华
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-28
Filing date: 2015-06-28
Publication date: 2015-10-28

Abstract

Belonging to the field of Chinese medicinal preparations, the invention in particular provides a drug, which can achieve the purpose of treatment of constipation by clearing away heat and toxic materials. The active ingredients contained by the drug are prepared from the following raw materials by weight: 18 parts of Fibraurea tinctoria Lour, 20 parts of Solanum torvum Swartz, 10 parts of codonopsis pilosula, 18 parts of astragalus, 10 parts of bighead atractylodes rhizome, 15 parts of pomegranate peel, 9 parts of Aconitum carmichaelii, 2 parts of rhizoma zingiberis preparata, 12 parts of sophora flavescens, 2 parts of cinnamon, 12 parts of psoralea corylifolia, 5 parts of radix aucklandiae, 6 parts of radix bupleuri, 12 parts of white paeony root, 5 parts of Amomum villosum, 3 parts of licorice. And a corresponding preparation method is employed. The Chinese medicinal composition has constipation treatment effect.

Description

A kind of pharmaceutical preparation for the treatment of constipation

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical preparation for the treatment of constipation and its preparation method and application.

Background technology

Constipation mainly refers to that defecation frequency reduces, feces amount reduces, dry and hard, the defecation effort of feces etc.The prevalence of constipation in crowd up to 27%, but only has sub-fraction constipation person to go to a doctor.Constipation can affect the people of each age group.Constipation often shows as: awareness of defecation is few, just secondary also few; Defecation is difficult, effort; Defecation is not smooth; Constipation with dry stool, hard just, defecation is not felt only; Constipation is with stomachache or abdominal discomfort.Some patients is also with Behavioral disturbances such as insomnia, agitation, dreaminess, depression, anxieties.Because constipation is a kind of comparatively general symptom, symptoms of varying severity, most people usually do not go specially to comprehend, and think that constipation is not disease, need not treat, but the harm of in fact constipation are very large.

Summary of the invention

Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of pharmaceutical preparation for the treatment of constipation and its preparation method and application.

Technical scheme: the object of the invention is by following scheme realize:

Be used for the treatment of a pharmaceutical preparation for constipation, its active component is prepared from by the raw material of following weight: fibraurea recisa 18 parts, Herba Cancriniae lasiocarpae 20 parts, Radix Codonopsis 10 parts, the Radix Astragali 18 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Granati 15 parts, Radix Aconiti Lateralis Preparata 9 parts, Rhizoma Zingiberis Preparatum 2 parts, Radix Sophorae Flavescentis 12 parts, Cortex Cinnamomi 2 parts, Fructus Psoraleae 12 parts, the Radix Aucklandiae 5 parts, Radix Bupleuri 6 parts, the Radix Paeoniae Alba 12 parts, Fructus Amomi 5 parts, 3 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of constipation, dosage form is granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of constipation, preparation method step is: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of constipation, preparation method decocts with water in process, and first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.

The described pharmaceutical preparation being used for the treatment of constipation, preparation method spray drying condition is: inlet temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.

Be used for the treatment of the application of pharmaceutical preparation in preparation treatment constipation medicine of constipation.

Resina garciniae is linked as Menispermaceae fibraurea recisa platymiscium fibraurea recisa Fibraurea tinctoria Lour., is used as medicine with root and stem.The whole year can adopt, and cleans section, clearing away heat-damp and promoting diuresis, removing toxic substances.For preventing epidemic cerebrospinal meningitis, fever and headache, acute tonsillitis, pharyngolaryngitis, eye conjunctivitis, acute gastroenteritis, dysentery, jaundice; Root: furuncle is controlled in external, burn and scald.

Herba Cancriniae lasiocarpae is the plant that Compositae Herba Cancriniae lasiocarpae belongs to.The leaf of Herba Cancriniae lasiocarpae and headdress flower (head inflorescence) composition containing a kind of analgesic, can be used for alleviating the pain of tooth, be therefore otherwise known as Herba monochasmatis.Originate in the torrid areas of Brazil, being introduced a fine variety to cultivating all over the world, using as ornamental plant and medicinal herbs.Annual herb plant, can become perennial plant in the area of warmer climate.Plant is small-sized, upright, and growth fast, is bloomed time in autumn, and headdress flower is in golden yellow and red: removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For tonsillitis, pharyngolaryngitis, lymphadenitis, toothache, stomachache, traumatic injury.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect:

The traditional Chinese medical science thinks that heat-clearing and toxic substances removing and tonifying QI to produce body fluid are answered in constipation.Fibraurea recisa, Herba Cancriniae lasiocarpae, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Granati, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Preparatum, Radix Sophorae Flavescentis, Cortex Cinnamomi, Fructus Psoraleae, the Radix Aucklandiae, Radix Bupleuri, the Radix Paeoniae Alba, Fructus Amomi, Radix Glycyrrhizae heat-clearing and toxic substances removing in we, expel the heat-evil logical abdomen, full side's compatibility, bring out the best in each other, play the power of heat-clearing and toxic substances removing altogether, be used for the treatment of constipation.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, embodiment is prepared

Embodiment 1: get fibraurea recisa 18g, Herba Cancriniae lasiocarpae 20g, Radix Codonopsis 10g, Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 10g, Pericarpium Granati 15g, Radix Aconiti Lateralis Preparata 9g, Rhizoma Zingiberis Preparatum 2g, Radix Sophorae Flavescentis 12g, Cortex Cinnamomi 2g, Fructus Psoraleae 12g, Radix Aucklandiae 5g, Radix Bupleuri 6g, Radix Paeoniae Alba 12g, Fructus Amomi 5g, Radix Glycyrrhizae 3g merges, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.10, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.30 to relative density when 65 DEG C, (condition is inlet temperature is 120 DEG C to spraying dry, leaving air temp is 80 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add starch 50g, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.

Embodiment 2: get fibraurea recisa 18g, Herba Cancriniae lasiocarpae 20g, Radix Codonopsis 10g, Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 10g, Pericarpium Granati 15g, Radix Aconiti Lateralis Preparata 9g, Rhizoma Zingiberis Preparatum 2g, Radix Sophorae Flavescentis 12g, Cortex Cinnamomi 2g, Fructus Psoraleae 12g, Radix Aucklandiae 5g, Radix Bupleuri 6g, Radix Paeoniae Alba 12g, Fructus Amomi 5g, Radix Glycyrrhizae 3g merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 100 DEG C to spraying dry, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), add dextrin 50g, dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.

Embodiment 3: get fibraurea recisa 18g, Herba Cancriniae lasiocarpae 20g, Radix Codonopsis 10g, Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 10g, Pericarpium Granati 15g, Radix Aconiti Lateralis Preparata 9g, Rhizoma Zingiberis Preparatum 2g, Radix Sophorae Flavescentis 12g, Cortex Cinnamomi 2g, Fructus Psoraleae 12g, Radix Aucklandiae 5g, Radix Bupleuri 6g, Radix Paeoniae Alba 12g, Fructus Amomi 5g, Radix Glycyrrhizae 3g merges, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.20, adding 95% (v/v) ethanol makes alcohol content reach 65% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 110 DEG C to spraying dry, leaving air temp is 85 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), then add lactose 50g, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 50-80 DEG C of drying, 60 order granulate, obtain granule.

2, clinical observation material

2.1 sample preparations: prepare clinical trial sample by above-described embodiment granule method, specification is 10g/ bag, is 18g/ bag containing crude drug amount.

2.2 clinical datas: observe 60 routine constipation patients altogether, wherein male patient 30 example, female patient 30 example.Age 17-45 year, 28.5 years old mean age.Diagnostic criteria (1) weekly defecation is less than 3 times.(2) the hard number of times just of row is more than 25%.(3) number of times only do not felt of defecation is more than 25%.(4) defecation of Overexertion more than 25%.(5) need to point defecation assisting.

2.3 efficacy assessment standards:

(1) cure: within 2 days, defecation once, and just matter turns profit, and unobstructed during solution, short-term is without recurrence.(2), effectively: defecation within 3 days, just matter turns profit, and defecation owes smooth.(3), invalid: symptom is without improvement.

2.4 Therapeutic Method: treatment group is taken and prepared clinical trial sample by above-described embodiment 3, every natural gift three oral meals 30 days were 1 course for the treatment of.

2.5 therapeutic outcomes: in Clinical practice the present invention, take medicine 60 routine constipation patients, take medicine after 1 course for the treatment of, symptom is alleviated to some extent, and take medicine after 2 courses for the treatment of, symptom is obviously improved.In the routine patient of clinical experiment 60, cure 21 examples, effective 32 examples, invalid 7 examples, total effective rate is 88.33%.

Claims

1. be used for the treatment of a medicine for constipation, it is characterized in that its active component is prepared from by the raw material of following weight: fibraurea recisa 18 parts, Herba Cancriniae lasiocarpae 20 parts, Radix Codonopsis 10 parts, the Radix Astragali 18 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Granati 15 parts, Radix Aconiti Lateralis Preparata 9 parts, Rhizoma Zingiberis Preparatum 2 parts, Radix Sophorae Flavescentis 12 parts, Cortex Cinnamomi 2 parts, Fructus Psoraleae 12 parts, the Radix Aucklandiae 5 parts, Radix Bupleuri 6 parts, the Radix Paeoniae Alba 12 parts, Fructus Amomi 5 parts, 3 parts, Radix Glycyrrhizae.

2. be used for the treatment of the medicine of constipation as claimed in claim 1, it is characterized in that dosage form is granule, tablet, capsule.

3. be used for the treatment of the medicine of constipation as claimed in claim 1, it is characterized in that preparation method comprises the steps: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.

4. be used for the treatment of the medicine of constipation as claimed in claim 1, it is characterized in that preparation method decocts with water in process, first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.

5. be used for the treatment of the medicine of constipation as claimed in claim 1, it is characterized in that preparation method spray drying condition is: inlet temperature is 100-120 DEG C, leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.

6. a kind of application of medicine in treatment constipation medicine being used for the treatment of constipation as claimed in claim 1.