CN103656122A - Traditional Chinese medicine for treating externally-contracted heat disease and preparation method thereof - Google Patents
Traditional Chinese medicine for treating externally-contracted heat disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating externally-contracted heat disease and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials: isatis root, mint, radix bupleuri, processed pinellia tuber, licorice, radix scutellariae, balloonflower root, dandelion, notopterygium root, sweet wormwood, gypsum, clematis root, anemarrhena, and honeysuckle flower. The traditional Chinese medicine has a prominent curative effect on patients who have fever caused by viral diseases such as upper respiratory infection, influenza, hand-foot-and-mouth disease or mumps diagnosed by western medicine, and patients who have heat in taiyang, shaoyang or yangming channels in traditional Chinese medicine theory; and through clinical observation the effective rate of the traditional Chinese medicine can reach 96.0%.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors and preparation method thereof.
Background technology
Fever caused by exogenous pathogenic factors, refers to by exopathogen and invades human body, the class disease of generating heat as cardinal symptom of take.This class disease is mainly acute infectious disease in modern medicine, and to comprise generating heat be cardinal symptom, the disease being caused by antibacterial or virus etc.Though this disease has self limiting, but clinical commonly encountered diseases and frequently-occurring disease, affect greatly patient's study and work.
Chinese medicine thinks, fever caused by exogenous pathogenic factors is the healthy energy of human body and the process that warm pathogenic factor fierceness disaccords, and by dialectical, takes eliminating evil, righting to treat, and final human righteousness defeats pathogenic factor gradually and calentura is cured.In this process, because of evil, can just hinder, certainly will produce internal organs, injuries of tissues and organs in various degree, and disorder and the loss of meridians, qi-blood-body fluid.The dialectical method of being familiar with fever caused by exogenous pathogenic factors ancient times has three warmers, four layers, five sections, the saying of the six channels conventionally.Zhang Zhongjing < < Treatise on Febrile Diseases > > be take negative and positive as superclass, with the sun, sun, bright, few positive, lunar, Shao Yintun faints cloudy the six channels as dialectical guiding principle, from the aspects such as advance and retreat emergency of excess and weakness of pathogen and vital QI, diseased region and patient's condition, fever caused by exogenous pathogenic factors is analyzed, is distinguished.As < < Treatise on Febrile Diseases > > have " after typhoid fever is recovered, more heating, Herba Sidae Rhombifoliae soup master it; Floating pulse person, with cure by diaphoresis it; Deep and forceful pulse person, below separates it " different method for the treatment of, to control it according to the state of an illness is dialectical; If after being ill, waste heat is not to the greatest extent, Tianjin wound is not multiple, stomach-QI being unable to descend normally, the empty weak breath of winning, thirsty, red and uncoated tongue, not hungry nausea, controls with < < Treatise on Febrile Diseases > > Zhuye Shigao Tang, Lophatherum and Gypsum Dectoction (Folium Bambusae, Gypsum Fibrosum, the Rhizoma Pinelliae, Radix Ophiopogonis, Radix Ginseng, Radix Glycyrrhizae, Semen oryzae sativae) QI invigorating stomach function regulating and promotes the production of body fluid, and lets out clearly waste heat.To the modern method that also has some typical treatment by Chinese herbs fevers caused by exogenous pathogenic factors, as:
1, Liu of the People's Hospital, Lin County, Shanxi Province builds filial piety and has carried out the clinical application research of YINQIAO Baihu Tang in fever caused by exogenous pathogenic factors.Therapeutic Principle: the pungent table that cools completely, heat-clearing and toxic substances removing.Prescription: Flos Lonicerae 15g, Fructus Forsythiae 15g, Gypsum Fibrosum (being decocted first) 100g, Folium Bambusae 10g, Mentha haplocalyx Briq. 10g, Rhizoma Phragmitis 12g, Niu Fenzi 12g, Radix Bupleuri 12g, Radix Puerariae 12g, Radix Platycodonis 12g, Semen Sojae Preparatum 10g, Radix Glycyrrhizae 10g.(application of YINQIAO Baihu Tang in fever caused by exogenous pathogenic factors, China National folk medicine magazine, the 21st volume the 19th phase 34-34 in 2012)
2, the attached Huguo Temple of the Beijing University of Chinese Medicine Zhang Xiaoyu of the hospital of traditional Chinese hospital has introduced a routine warm class fever caused by exogenous pathogenic factors treatment case.Prescription: Folium Bambusae, method half is multiple, Radix Platycodonis, each 10g of stir-fry Fructus Gardeniae, Gypsum Fibrosum 30g, Flos Lonicerae, Radix Adenophorae (Radix Glehniae), Rhizoma Phragmitis, each 15g of Rhizoma Imperatae, Radix Ophiopogonis, Radix Scrophulariae, Semen Sojae Preparatum, each 12g of Radix Trichosanthis, Radix Glycyrrhizae 6g.(Zhang Xiangsheng treatment fever caused by exogenous pathogenic factors experience is lifted corner, the Shaanxi traditional Chinese medical science, the 32nd volume the 6th phase 720-721 page in 2011)
3, Chinese patent CN03146749.0, with heat clearing away, combine with removing dampness two methods and use treatment fever caused by exogenous pathogenic factors, main body formula includes Herba Artemisiae Annuae, Caulis Bambusae In Taenia, the Rhizoma Pinelliae, Poria, Radix Scutellariae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, BIYUSAN eight kinds of Chinese medicine ingredients altogether, can comprise at most Flos Lonicerae, Radix Paeoniae Rubra, Herba Houttuyniae, Bombyx Batryticatus, Rhizoma Atractylodis, Gypsum Fibrosum six kinds of Chinese crude drugs altogether in auxiliary formula.
4, Chinese patent CN200810137807.4 discloses a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors.It is characterized in that main component is by 50 grams of Concretio Silicea Bambusaes, 25 grams of Arisaema Cum Bile, Bombyx Batryticatus 25,10 grams of gram Herba Plantaginis, 30 grams of Radix Et Rhizoma Rhei（streamed）, 20 grams of Rhizoma Wenyujin Concisum, 10 grams of the Rhizoma Pinelliaes, 25 grams of Periostracum Cicadaes, 2.5 grams, Borneolum Syntheticum, 10 grams of Rhizoma Alismatis, 1.5 grams, Moschus, 25 grams, Cinnabaris, is ground into altogether superfine face by medicine-feeding and mixes, and reserving a little Cinnabaris face is clothing.Another with each 50 grams of Flos Lonicerae, Fructus Forsythiaes, each 30 grams of RADIX PLATYCODI, Fructus Arctii, Herba Menthae, Semen Sojae Preparatum, Radix Glycyrrhizae each 25 each, each 20 grams of mustard fringes, Folium Bambusae grind for thick powder compositions such as (being Lonicerae and Forsythiae Powder).Compound method: decoct the concentrated established law of Lonicerae and Forsythiae Powder with fresh reed root soup, be in harmonious proportion above-mentioned powder, refined honey is the pill that Semen phaseoli radiati is large, and take Cinnabaris face as clothing, and every ball weighs 2 grams.
5, Chinese patent CN201010511320.5 discloses a kind of preparation method of Chinese traditional patent formulation anti-inflammatory antipyretic drop pill, and its prescription is: 400 parts of Folium Isatidiss, 400 parts of Herba Taraxacis, 150 parts of Herba Violaes, 50 parts, Radix Glycyrrhizae.
Visible, Chinese medicine and pharmacy, having accumulated rich experience aspect the viral fever caused by exogenous pathogenic factors for the treatment of, wherein has many dialectical administrated methods to be used so far always, and obtain great development, but administrated method is not quite similar.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors;
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine of fever caused by exogenous pathogenic factors.
The object of the invention is to realize by following technical scheme:
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention is to be prepared from by the raw material that comprises following weight portion:
10～20 parts of 10～20 parts of Rhizoma Pinelliae Preparatum of 5～15 parts of Radix Bupleuri of 20～40 portions of Herba Menthaes of Radix Isatidis
20～40 parts of 5～15 parts of Herba Taraxacis of 10～20 parts of Radix Platycodoniss of 2～10 parts of Radix Scutellariaes of Radix Glycyrrhizae
10～20 parts of 5～15 parts of Radix Clematidis of 10～20 parts of Gypsum Fibrosum of 5～15 portions of Herba Artemisiae Annuaes of Rhizoma Et Radix Notopterygii
5～25 parts of 5～20 portions of Flos Loniceraes of the Rhizoma Anemarrhenae.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
13～18 parts of 13～18 parts of Rhizoma Pinelliae Preparatum of 7～13 parts of Radix Bupleuri of 25～35 portions of Herba Menthaes of Radix Isatidis
25～35 parts of 7～13 parts of Herba Taraxacis of 12～17 parts of Radix Platycodoniss of 4～8 parts of Radix Scutellariaes of Radix Glycyrrhizae
13～18 parts of 7～13 parts of Radix Clematidis of 12～17 parts of Gypsum Fibrosum of 7～13 portions of Herba Artemisiae Annuaes of Rhizoma Et Radix Notopterygii
10～20 parts of 12～17 portions of Flos Loniceraes of the Rhizoma Anemarrhenae.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
6 parts, 15 portions of Radix Glycyrrhizaes of 15 parts of Rhizoma Pinelliae Preparatum of 10 parts of Radix Bupleuri of 30 portions of Herba Menthaes of Radix Isatidis
15 parts of 10 portions of Herba Artemisiae Annuaes of 30 portions of Rhizoma Et Radix Notopterygiis of 10 parts of Herba Taraxacis of 15 parts of Radix Platycodoniss of Radix Scutellariae
15 parts of 10 portions of Flos Loniceraes of 15 parts of Rhizoma Anemarrhenaes of 10 parts of Radix Clematidis of Gypsum Fibrosum.
The Chinese crude drug details adopting in the present invention is as follows:
Radix Isatidis: Isatis indigotica Fort, crucifer, the dry root of Isatis indigotica Fort., has heat-clearing and toxic substances removing, antibacterial, antiviral effect.
Herba Menthae: the dry aerial parts of labiate Herba Menthae Mentha haplocalyx Briq., pungent cool property sweating antipyretic medicine, control influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache, external can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.
Radix Bupleuri: RootofChneseThorowax, samphire, < < Sheng Nong's herbal classic > > begins to be loaded in, for clearind deficient heat Chinese medicine, can be used for that cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.
Rhizoma Pinelliae Preparatum: Rhizoma Pinelliae, the tuber for the aroid Rhizoma Pinelliae, cures mainly drying dampness to eliminate phlegm, for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Radix Glycyrrhizae: the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Radix Scutellariae: Scutellaria baicalensis Georgi, labiate Radix Scutellariae, is used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, and detoxicating functions cures mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia.
Radix Platycodonis: Platycodon grandiforus, campanulaceae Platycodon grandiflouorum plant, is the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.
Herba Taraxaci: feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or belong to the dry herbs of several plants together, the flat sweet and slightly bitter taste of property, has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Rhizoma Et Radix Notopterygii: dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H. T. Chang or Radix et Rhizoma Notopterygii Notopterygium forbesii Boiss..Acrid in the mouth, hardship, warm in nature, loose exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.
Herba Artemisiae Annuae: feverfew Herba Artemisiae annuae Artemisia annua L. dry aerial parts.Bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, three warmers, kidney channel.Clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Gypsum Fibrosum: main chemical compositions is CaSO
4nH
2o, heat clearing and fire purging medicine, acrid in the mouth, sweet, is slightly cold, and attaches to the lung and stomach meridians.Clearly
Diarrhea of heat type fire, relieving restlessness is quenched the thirst, convergence granulation promoting.Normal and Rhizoma Anemarrhenae mutual reinforcement between compatibility, for the syndrome of epidemic febrile disease edema caused by disorder of QI excess-heat.
Radix Clematidis: Clematis chinensis, cohosh, bitter in the mouth is pungent, warm in nature, its root and stem be used as medicine there is rheumatism, effect that the meridian dredging, the bone that disappears are choked.
The Rhizoma Anemarrhenae: the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge., belong to gunpowder under heat clearing away, cure mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness etc.
Flos Lonicerae: caprifoliaceae plant, the flower that the dry flower of Radix Ophiopogonis Lonicera japonica Thunb. Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae Lonicera confusa DC. hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band are just opened, there is heat-clearing and toxic substances removing, the effect of wind-heat dissipating.
Another aspect of the present invention has been to provide the preparation method of active ingredient of Chinese herbs of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole 14 taste medical materials, extracting in water 2-3 time adds the water that is equivalent to 6～10 times of medical material gross weights at every turn, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 60-80 ℃, relative density is 1.10～1.20, adding ethanol is 50%～60% to containing alcohol amount concentration of volume percent, stir, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10～1.20, obtains described active component.
Scheme two: get whole 14 taste medical materials, add 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-4 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains active component.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
For example, can be prepared as various common dosage forms by one of following method:
Method 1: Chinese medicine capsules of the present invention
Get scheme 1 or scheme 2 gained active component, add capsule to commonly use adjuvant, production method is prepared into the capsule of Chinese medicine of the present invention routinely.
Method 2: Chinese medicinal tablet of the present invention
Get scheme 1 or scheme 2 gained active component, add tablet to commonly use adjuvant, production method is prepared into the tablet of Chinese medicine of the present invention routinely.
Method 3: Chinese medicine granules of the present invention
Get scheme 1 or scheme 2 gained active component, add granule to commonly use adjuvant, production method is prepared into the granule of Chinese medicine of the present invention routinely.
Method 4: herb mixture of the present invention
Get scheme 1 or scheme 2 gained active component, add mixture to commonly use adjuvant, production method is prepared into the mixture of Chinese medicine of the present invention routinely.
Method 5: Chinese medicine oral liquid of the present invention
Get scheme 1 or scheme 2 gained active component, add oral liquid to commonly use adjuvant, production method is prepared into the oral liquid of Chinese medicine of the present invention routinely.
Fever caused by exogenous pathogenic factors, because exopathogen is from mouth and nose, fur going from the exterior into the interior damage internal organs, pathogenic factor in the exterior enters between the exterior and the interior, must not declare loosely, qi-blood-body fluid is burnt into the stasis of blood, expectorant, thus with the poison that expels the heat-evil clearly, Replenishing QI and nourishing YIN is dialectical treats, and can prevent and treat complication, prevents that disease is listed as.The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, Flos Lonicerae, Herba Taraxaci have the effect of heat-clearing and toxic substances removing sore-throat relieving, can remove rapidly the epidemic disease due to heat pathogen causing into external heresy, with Radix Isatidis, Radix Platycodonis compatibility anti-bacteria and anti-virus, and can dispel the expectorant stasis of blood of burning and form in gas Tianjin; Coordinate relieving the exterior syndrome with drugs of pungent in flavor and warm in nature dehumidifying medicine Rhizoma Et Radix Notopterygii, the exterior cold of can faling apart, alleviates a body, person's back, joint, myalgia due to calentura again; Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae Preparatum can move back the heat of shaoyang channel; Gypsum Fibrosum, the Rhizoma Anemarrhenae can be removed the large heat of Yangming Channel.All medicines share above, can treating SHAO YANG disease by mediation, declare smooth mechanism of qi, and the three YANG meridians heat of ruling together, removes the various symptoms that cause into external heresy, takes good care of taste, and the anxious card for the treatment of fever caused by exogenous pathogenic factors is had to good curative effect.
A kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors provided by the invention has the following advantages:
1, the present invention removes because of heating that affection due to external wind and heat causes, aversion to cold, thirsty, pharyngalgia, headache, general pain, and the symptoms such as cough have significant curative effect, antipyretic rapidly, difficult repeatedly.
2, clinical test results shows, Chinese medicine of the present invention and matched group ribavirin tablet, quick comparison of phenol ammonia coffee, be obviously better than matched group, and effective percentage reaches 96.0%; And in the clinical process treating, have no toxic and side effects, safe and reliable.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1
Radix Isatidis 300g Herba Menthae 100g Radix Bupleuri 150g Rhizoma Pinelliae Preparatum 150g Radix Glycyrrhizae 60g
Radix Scutellariae 150g Radix Platycodonis 100g Herba Taraxaci 300g Rhizoma Et Radix Notopterygii 100g Herba Artemisiae Annuae 150g
Gypsum Fibrosum 100g Radix Clematidis 150g Rhizoma Anemarrhenae 100g Flos Lonicerae 150g
Get whole 14 taste medical materials, extracting in water 2 times adds respectively the water that is equivalent to 10 times, 8 times amounts of medical material gross weight at every turn, and each extraction time is respectively 3 hours, 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 60 ℃, relative density is 1.20, adds ethanol to being 50% containing alcohol amount, stirs, standing 12 hours, filter, the extractum that when filtrate is concentrated into 60 ℃, relative density is 1.20, obtains described active component.
Embodiment 2
Radix Isatidis 200g Herba Menthae 50g Radix Bupleuri 100g Rhizoma Pinelliae Preparatum 100g Radix Glycyrrhizae 20g
Radix Scutellariae 100g Radix Platycodonis 50g Herba Taraxaci 200g Rhizoma Et Radix Notopterygii 50g Herba Artemisiae Annuae 100g
Gypsum Fibrosum 50g Radix Clematidis 100g Rhizoma Anemarrhenae 50g Flos Lonicerae 50g
Get whole 14 taste medical materials, extracting in water 3 times adds respectively the water that is equivalent to 10 times, 8 times, 6 times amounts of medical material gross weight at every turn, and each extraction time is respectively 3 hours, 2 hours, 1 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.10, adds ethanol to being 60% containing alcohol amount, stirs, standing 24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, obtains described active component.
Above-mentioned active component is mixed with appropriate sucrose, granulation, dry, obtain granule of the present invention.
Embodiment 3
Radix Isatidis 200g Herba Menthae 150g Radix Bupleuri 200g Rhizoma Pinelliae Preparatum 200g Radix Glycyrrhizae 100g
Radix Scutellariae 200g Radix Platycodonis 150g Herba Taraxaci 200g Rhizoma Et Radix Notopterygii 150g Herba Artemisiae Annuae 200g
Gypsum Fibrosum 150g Radix Clematidis 200g Rhizoma Anemarrhenae 200g Flos Lonicerae 200g
Get whole 14 taste medical materials, add 40% alcohol reflux 2 times, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 2 hours, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60 ℃, relative density is 1.25, obtains active component.
Above-mentioned active component is mixed with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.
Embodiment 4
Radix Isatidis 250g Herba Menthae 130g Radix Bupleuri 180g Rhizoma Pinelliae Preparatum 180g Radix Glycyrrhizae 80g
Radix Scutellariae 170g Radix Platycodonis 130g Herba Taraxaci 350g Rhizoma Et Radix Notopterygii 130g Herba Artemisiae Annuae 170g
Gypsum Fibrosum 130g Radix Clematidis 180g Rhizoma Anemarrhenae 170g Flos Lonicerae 250g
Get whole 14 taste medical materials, add 80% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, extraction time is respectively 4 hours, 2 hours, 1 hour, merge extractive liquid,, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, obtains active component.
Above-mentioned active component is mixed with appropriate sucrose, water, obtain oral liquid of the present invention.
Embodiment 5
Radix Isatidis 250g Herba Menthae 70g Radix Bupleuri 130g Rhizoma Pinelliae Preparatum 130g Radix Glycyrrhizae 40g
Radix Scutellariae 120g Radix Platycodonis 70g Herba Taraxaci 250g Rhizoma Et Radix Notopterygii 70g Herba Artemisiae Annuae 120g
Gypsum Fibrosum 70g Radix Clematidis 130g Rhizoma Anemarrhenae 120g Flos Lonicerae 100g
Get whole 14 taste medical materials, extracting in water 3 times adds respectively the water that is equivalent to 8 times, 8 times, 6 times amounts of medical material gross weight at every turn, and each extraction time is respectively 3 hours, 2 hours, 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 70 ℃, relative density is 1.15, adds ethanol to being 60% containing alcohol amount, stirs, standing 18 hours, filter, the extractum that when filtrate is concentrated into 70 ℃, relative density is 1.15, obtains described active component.
By active component vacuum drying under 65 ℃～70 ℃ conditions, pulverized 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, incapsulates, and obtains capsule of the present invention.
Embodiment 6
Radix Isatidis 30g Herba Menthae 10g Radix Bupleuri 15g Rhizoma Pinelliae Preparatum 15g Radix Glycyrrhizae 6g
Radix Scutellariae 15g Radix Platycodonis 10g Herba Taraxaci 30g Rhizoma Et Radix Notopterygii 10g Herba Artemisiae Annuae 15g
Gypsum Fibrosum 10g Radix Clematidis 15g Rhizoma Anemarrhenae 10g Flos Lonicerae 15g
Get whole 14 taste medical materials, clean, drying and sterilizing, pulverizes, and crosses 80 orders～l20 mesh sieve, obtains powder of the present invention.
clinical trial
The present invention is treated to the curative effect of fever caused by exogenous pathogenic factors and carry out clinical observation, by take medicine antipyretic, analgesia, the antiinflammatory situation of Patients Before And After of contrast, check whether fever caused by exogenous pathogenic factors takes a turn for the better and analyze therapeutic effect of the present invention.
1 ureteral calculus diagnosis basis: < < fever caused by exogenous pathogens curative effect determinate standard > > (fever caused by exogenous pathogenic factors)
2 case selections
3～60 years old age, tcm syndrome belong to affection of exogenous wind-cold, in accumulate hot and suffocating card person; Get rid of gestation and women breast-feeding their children, psychotic, merges intentionally, liver, renal function and the serious primary disease person of hemopoietic system, has used other treatment medicine person, allergic constitution or multi-medicament allergy sufferers.
3 medicines
Experimental group: embodiment 2 granules;
Matched group: ribavirin tablet, Shanghai Hua Surname Pharmaceutical Co., Ltd.; Quick of phenol ammonia coffee, Shanghai Xinyi Pharmaceutical Factory.
4 curative effect index
Cure: heat is cool skin to the greatest extent, and nothing repeatedly, cardinal symptom disappears, and abnormal physico-chemical examination index recovers normal;
Effective: heating has been moved back and without repeatedly, cardinal symptom is most of to disappear, and abnormal physico-chemical examination index approaches normal;
Effective: heating is moved back, but also have repeatedly, cardinal symptom partly disappears, and abnormal physico-chemical examination index makes moderate progress;
Invalid: generate heat persistent, symptom is not improved, abnormal physico-chemical examination index is not improved.
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 350, male 178 examples, female's 172 examples; All patients all meet relevant fever caused by exogenous pathogenic factors diagnostic criteria, Chinese medical discrimination is the sun, few sun, (heating is heavy for Yangming Channel calentura, light or the alternate attack of chill and fever of aversion to cold or high fever are thirsty, there is antiperspirant or lossless, pharyngalgia and/or headache, general pain, cough, red tongue, yellow fur, floating and rapid pulse or loud), the patient of the course of disease in 3 days.Case is divided into two groups at random.
Therapeutic Method:
Experimental group: the embodiment of the present invention 2, each serving the medicine with being equivalent to crude drug amount 100g, three times on the one;
Matched group: ribavirin tablet, 3-4 times/day; Quick of phenol ammonia coffee, 3 times/day.
6 results
Therapeutic effect: 350 patients are carried out to clinical treatment, and observing effect is as follows:
Table 1 clinical efficacy table
| ? | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Experimental group | 148 | 12 | 8 | 7 | 96.0 * |
| Matched group | 28 | 22 | 94 | 31 | 82.3 |
Note: experimental group and matched group comparison, * P < 0.05
Table 1 result shows: experimental group and reference group all have more significant effective percentage in treatment fever caused by exogenous pathogenic factors, but the therapeutic effect of medicine of the present invention is compared with quick of phenol ammonia coffee with Western medicine ribavirin tablet, there is significant difference, especially in antipyretic completeness, the present invention antipyretic rear being difficult for repeatedly, Western medicine is only separated exterior heat, easily heating repeatedly, from result, Drug therapy fever caused by exogenous pathogenic factors effect of the present invention is better than control drug.
model case:
The concrete clinical use case of Chinese medicine of the present invention:
1, Chen, man, 21 years old, main suit: generate heat 39.5 ℃, companion's pharyngalgia, cough 2 days.After diagnosing, tcm syndrome belong to affection of exogenous wind-cold, in accumulate hot and suffocating card, cause heating and tonsil inflammation.Give the embodiment of the present invention 3 tablets, one day 3 times, to take after one day, heat retreats to 38.5 ℃, and pharyngalgia slightly alleviates, and takes after 5 days and returns to normal body temperature, does not occur heating repeatedly, and pharyngalgia disappears, and is judged as recovery from illness.
2, Wu, man, 3 years old, main suit: repeatedly generate heat two days, taking Western medicine cannot be thoroughly antipyretic, was reluctant to take food, cough.After diagnosing, tcm syndrome belongs to affection of exogenous wind-cold, causes upper respiratory tract infection, and tonsil is red and swollen.Give the embodiment of the present invention 4 oral liquids, one day 3 times, take after one day, perspire, take temperature and be down to normal value, the minimizing of crying and screaming, advises many hello boiled water, then takes after 2 days, cough and obviously reduce, and not appearance rising repeatedly of body temperature, tonsil is red and swollen to disappear, and is judged as recovery from illness.
3, thank certain, female, 42 years old, main suit: generated heat the day before yesterday suddenly, companion's throat severe pain, dysdipsia, buys ibuprofen by oneself in pharmacy and takes one day, and symptom alleviates, but always at midnight, has a fever suddenly and accompany pharyngalgia to fall asleep again.After diagnosing, be exogenous high fever emergency case.Give the embodiment of the present invention 2 granules, one day 3 times, take two doses, a large amount of diaphoresis, body temperature is down to normal value, then takes after 5 days, and pharyngalgia disappears, and body temperature raises no longer repeatedly, is judged as recovery from illness.
4, Wang, female, 15 years old, main suit: headache, general pain, pharyngalgia 1 day.Through looking into, body temperature is 39.1 ℃, rapid pulse, aversion to cold, and tcm syndrome belongs to fever caused by exogenous pathogenic factors.Give the embodiment of the present invention 5 capsules, one day 3 times, to take after one day, temperature recovery is normal, and whole body is soft tired slightly to be alleviated, and takes after 3 days, does not occur heating repeatedly, and the transference cures such as headache, general pain, pharyngalgia, are judged as recovery from illness.
Claims (7)
1. treat a Chinese medicine for fever caused by exogenous pathogenic factors, it is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
10～20 parts of 10～20 parts of Rhizoma Pinelliae Preparatum of 5～15 parts of Radix Bupleuri of 20～40 portions of Herba Menthaes of Radix Isatidis
20～40 parts of 5～15 parts of Herba Taraxacis of 10～20 parts of Radix Platycodoniss of 2～10 parts of Radix Scutellariaes of Radix Glycyrrhizae
10～20 parts of 5～15 parts of Radix Clematidis of 10～20 parts of Gypsum Fibrosum of 5～15 portions of Herba Artemisiae Annuaes of Rhizoma Et Radix Notopterygii
5～25 parts of 5～20 portions of Flos Loniceraes of the Rhizoma Anemarrhenae.
2. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
13～18 parts of 13～18 parts of Rhizoma Pinelliae Preparatum of 7～13 parts of Radix Bupleuri of 25～35 portions of Herba Menthaes of Radix Isatidis
25～35 parts of 7～13 parts of Herba Taraxacis of 12～17 parts of Radix Platycodoniss of 4～8 parts of Radix Scutellariaes of Radix Glycyrrhizae
13～18 parts of 7～13 parts of Radix Clematidis of 12～17 parts of Gypsum Fibrosum of 7～13 portions of Herba Artemisiae Annuaes of Rhizoma Et Radix Notopterygii
10～20 parts of 12～17 portions of Flos Loniceraes of the Rhizoma Anemarrhenae.
3. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 2, is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
6 parts, 15 portions of Radix Glycyrrhizaes of 15 parts of Rhizoma Pinelliae Preparatum of 10 parts of Radix Bupleuri of 30 portions of Herba Menthaes of Radix Isatidis
15 parts of 10 portions of Herba Artemisiae Annuaes of 30 portions of Rhizoma Et Radix Notopterygiis of 10 parts of Herba Taraxacis of 15 parts of Radix Platycodoniss of Radix Scutellariae
15 parts of 10 portions of Flos Loniceraes of 15 parts of Rhizoma Anemarrhenaes of 10 parts of Radix Clematidis of Gypsum Fibrosum.
4. the Chinese medicine of the treatment fever caused by exogenous pathogenic factors as described in one of claim 1-3, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 14 taste medical materials, extracting in water 2-3 time adds the water that is equivalent to 6～10 times of medical material gross weights at every turn, extracts 1～3 hour; Merge extractive liquid,, the extractum that while being concentrated into 60-80 ℃, relative density is 1.10～1.20, adding ethanol is 50%～60% to containing alcohol amount concentration of volume percent, stir, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10～1.20, obtains described active component.
6. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 14 taste medical materials, add 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-4 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains active component.
7. treat a Chinese medicine preparation for fever caused by exogenous pathogenic factors, comprise the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of any one in claim 1～3 and pharmaceutically acceptable carrier.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412711A (en) * | 2015-11-26 | 2016-03-23 | 严亚木 | Medicine for treating influenza |
| CN106343556A (en) * | 2016-08-26 | 2017-01-25 | 凤阳瑞诚食品科技有限公司 | Nutritious food with efficacies of intestine clearing, throat moistening and Qi smoothening |
| CN106581294A (en) * | 2016-11-30 | 2017-04-26 | 四川旭华制药有限公司 | Antipyretic pharmaceutical composition |
| CN108210582A (en) * | 2018-03-30 | 2018-06-29 | 湖北大顶山制药有限公司 | A kind of Chinese medicinal granule for being used to treat and prevent viral influenza |
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| CN101138614A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Chinese traditional medicine for treating exogenous fever |
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| CN101138614A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Chinese traditional medicine for treating exogenous fever |
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| 甘璐等: "清感退热汤治疗小儿外感发热临床体会", 《陕西中医》, vol. 33, no. 12, 31 December 2012 (2012-12-31) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412711A (en) * | 2015-11-26 | 2016-03-23 | 严亚木 | Medicine for treating influenza |
| CN106343556A (en) * | 2016-08-26 | 2017-01-25 | 凤阳瑞诚食品科技有限公司 | Nutritious food with efficacies of intestine clearing, throat moistening and Qi smoothening |
| CN106581294A (en) * | 2016-11-30 | 2017-04-26 | 四川旭华制药有限公司 | Antipyretic pharmaceutical composition |
| CN108210582A (en) * | 2018-03-30 | 2018-06-29 | 湖北大顶山制药有限公司 | A kind of Chinese medicinal granule for being used to treat and prevent viral influenza |
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