Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, the safe and reliable Chinese medicine composition being used for the treatment of asthma.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of a Chinese medicine composition for asthma, the medicament be made up of the crude drug of following weight portion,
Rhizoma Pinelliae 7-11 part, Fructus Aurantii 7-11 part, Radix Saposhnikoviae 7-11 part, Radix Platycodonis 7-11 part, Fructus Schisandrae Chinensis 8-12 part, Herba Artemisiae Annuae 7-11 part, Radix Bupleuri 8-12 part, Radix Astragali 13-17 part, Radix Scutellariae 7-11 part, Rhizoma Phragmitis 13-17 part, coltsfoot 18-22 part, Radix Asteris 18-22 part, Pericarpium Citri Reticulatae 18-22 part, Poria 8-12 part, Cortex Phellodendri 8-12 part, fry Rhizoma Alismatis 13-17 part, Radix Paeoniae Alba 13-17 part, Cortex Magnoliae Officinalis 13-17 part, Radix Et Rhizoma Rhei 8-12 part, Rhizoma Zingiberis 8-12 part, Ramulus Cinnamomi 8-12 part, the Radix Angelicae Dahuricae 9 parts, Radix Angelicae Sinensis 7-11 part, Fructus Amomi Rotundus 8-12 part, Rhizoma Et Radix Notopterygii 8-12 part, Rhizoma Atractylodis 8-12 part, Cortex Lycii 8-12 part, Flos Papaveris rhoeadis pollen 13-17 part, Semen Armeniacae Amarum 13-17 part, Rhizoma Dioscoreae 13-17 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Aconiti Lateralis Preparata 8-12 part, Rhizoma Coptidis 8-12 part.
Preferred weight part of each crude drug is:
The Rhizoma Pinelliae 9 parts, Fructus Aurantii 9 parts, Radix Saposhnikoviae 9 parts, Radix Platycodonis 9 parts, Fructus Schisandrae Chinensis 10 parts, Herba Artemisiae Annuae 9 parts, Radix Bupleuri 10 parts, the Radix Astragali 15 parts, Radix Scutellariae 9 parts, Rhizoma Phragmitis 15 parts, coltsfoot 20 parts, Radix Asteris 20 parts, Pericarpium Citri Reticulatae 20 parts, 10 parts, Poria, Cortex Phellodendri 10 parts, fry Rhizoma Alismatis 15 parts, the Radix Paeoniae Alba 15 parts, Cortex Magnoliae Officinalis 15 parts, Radix Et Rhizoma Rhei 10 parts, Rhizoma Zingiberis 10 parts, Ramulus Cinnamomi 10 parts, the Radix Angelicae Dahuricae 9 parts, Radix Angelicae Sinensis 9 parts, 10 parts, Fructus Amomi Rotundus, Rhizoma Et Radix Notopterygii 10 parts, Rhizoma Atractylodis 10 parts, Cortex Lycii 10 parts, Flos Papaveris rhoeadis pollen 15 parts, 15 parts, Semen Armeniacae Amarum, Rhizoma Dioscoreae 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Aconiti Lateralis Preparata 10 parts, Rhizoma Coptidis 10 parts.
Also contain in prescription of the present invention: Semen Fagopyri Esculenti 7-11 part, Pericarpium Citri junoris 7-11 part, Fructus Crataegi 8-12 part, Fructus Cnidii 8-12 part.
Be preferably: 9 parts, Semen Fagopyri Esculenti, Pericarpium Citri junoris 9 parts, Fructus Crataegi 10 parts, Fructus Cnidii 10 parts.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each crude drug is taken by following parts by weight;
2) above-mentioned each taste material medicine is ground to form mix homogeneously after smalls, then add common carrier, preparations shaping, make pill.
1, pharmacology analysis:
The Rhizoma Pinelliae: acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Fructus Aurantii: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting.
Radix Saposhnikoviae: acrid in the mouth; Sweet; Slightly warm in nature.Yuzhen San (" Waike Zhengzong, Orthodox Manual of External Diseases "), effect dispelling pathogenic wind and eliminating phlegm.
Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.
Fructus Schisandrae Chinensis: control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Herba Artemisiae Annuae: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Clear deficiency-heat thoroughly, removing heat from blood is except steaming.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.
The Radix Astragali: sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis.
Rhizoma Phragmitis: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Coltsfoot: property and flavor of peppery and warm, has nourishing the lung to keep the adverse QI downward, the effect of the antitussive that reduces phlegm.Record in " herbal classic ": to " pathogenic fluid-retention of cold bundle lung meridian is breathed heavily, cough the most suitable ".
Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward; Preventing phlegm from forming and stopping coughing.Main cough; Deficiency of the lung chronic cough; Consumptive lung disease lung abscess; Cough vomiting bloody pus.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Poria: promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieves internal heat anticancer.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.
Fry Rhizoma Alismatis: be partial to and spleen eliminating dampness by diuresis, for phlegm retention, dysentery, the vertigo.
The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.
Cortex Magnoliae Officinalis: bitter; Pungent; Warm in nature.Circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.
Radix Et Rhizoma Rhei: have and attack the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.
Rhizoma Zingiberis: acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Ramulus Cinnamomi: pungent, sweet, tepor, nontoxic.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.
The Radix Angelicae Dahuricae: there is antiinflammatory, antipyretic-antalgic, active eliminating stagnation.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Enrich blood invigorate blood circulation, conditioner body immunity function.
Fructus Amomi Rotundus: cold expelling dampness, alcoholic intoxication, removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.
Rhizoma Et Radix Notopterygii: dispersing wind and cold wets, and pain relieving, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathe heavily.
Rhizoma Atractylodis: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.For dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.
Cortex Lycii: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.
Flos Papaveris rhoeadis pollen: tranquillizing and allaying excitement, QI invigorating of calming the nerves, invigorating middle warmer is healthy and strong, the intestines and stomach coordinating, controls cough, bronchitis, headache, gastropathy has specially good effect.
Semen Armeniacae Amarum: bitter, tepor; Slightly poisonous.Relieving cough and asthma, loosening bowel to relieve constipation.
Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.There are strengthening the spleen and stomach, tonifying the lung kidney, invigorating the spleen and replenishing QI, spleen invigorating tonify deficiency.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic; Reduce phlegm, hidroschesis; Antiabortive; Increase appetite.
Radix Aconiti Lateralis Preparata: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel.Mend fire supporing yang, dispersing cold for relieving pain, belong to drugs for dispelling internal cold.
Rhizoma Coptidis: bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.
Semen Fagopyri Esculenti: the wide intestinal of sending down the abnormal ascending QI, removing food stagnancy is stagnant, and the swollen wind pain of the heat that disappears, except nebulousurine leucorrhea, spleen amasss antidiarrheal.
Pericarpium Citri junoris: the micro-hardship of acrid in the mouth, enters spleen, lung two warp.Regulate the flow of vital energy, reduce phlegm, spleen invigorating, intestinal stasis relieving.
Fructus Crataegi: having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Fructus Cnidii: the total coumarins of Fructus Cnidii has antiasthmatic effect, Neng Shi asthmatic patient pulmonary wheezing sound obviously reduces or disappears, and significantly can increase expiration peak flow rate value, improves lung ventilation function.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: pill: 3-5g/ ball, a ball, every day 2 ball, sooner or later sub-service 7 days is a course for the treatment of.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1) animal acute toxicity test is carried out to medicated powder prepared by the present invention:
Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.
Method and result: get white mice 10, hungry 20 hours, by filling with medicine feed powder 3g every every day, feeding one week continuously, observing 10 days, and mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) long-term toxicity test for animals is carried out to medicated powder prepared by the present invention:
Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.
Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, feed by filling with for 2 times every every day, each 1-3g is not etc., 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) clinical diagnosis: have uncomfortable in chest, cough, expectoration, dyspnea, dizzy, breaking out without any under omen, falling ill before daybreak especially at dead of night.
2) in order to verify clinical efficacy, this prescription is tried out in Affiliated Hospital of Chinese medicine institute first of Anhui Province respectively, and random selecting wherein 50 examples suffers from the patient of asthma.
3) Therapeutic Method: according to drug ratios of the present invention, takes raw material (dose), obtains pill according to conventional formulation mode, and every day 2, ball, point took sooner or later, and taking 7 days is a course for the treatment of, the shortest 2 courses for the treatment of, the longest half a year.
4) efficacy determination:
Recovery from illness: sign and symptom are improved completely, happy, in high spirits; Effective: sign and symptom are significantly improved, happy, spirit very well; Effective: sign and symptom change, random thoughts are slightly uncomfortable, but can accept; Invalid: to treat rear symptom, sign compared with before treatment without any change; Concrete therapeutic outcome is see table 1.
Table 1
Number of cases |
Recovery from illness |
Effective |
Effectively |
Invalid |
Effective percentage (%) |
50 |
6 |
28 |
13 |
3 |
94 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly take by usage and dosage, this medicine should not be taken for a long time in a large number.
5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.
6. prohibit the use when this property of drug changes.
7. please this medicine is placed on the place that child can not contact.
8. as used other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: the present invention selects at Chinese crude drug and compatibility meets Chinese medical discrimination theory, and compound method simply, and have rapid-action, cure rate is high, not easily the advantage such as recurrence.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Rhizoma Pinelliae 9g by following parts by weight, Fructus Aurantii 9g, Radix Saposhnikoviae 9g, Radix Platycodonis 9g, Fructus Schisandrae Chinensis 10g, Herba Artemisiae Annuae 9g, Radix Bupleuri 10g, Radix Astragali 15g, Radix Scutellariae 9g, Rhizoma Phragmitis 15g, coltsfoot 20g, Radix Asteris 20g, Pericarpium Citri Reticulatae 20g, Poria 10g, Cortex Phellodendri 10g, fry Rhizoma Alismatis 15g, Radix Paeoniae Alba 15g, Cortex Magnoliae Officinalis 15g, Radix Et Rhizoma Rhei 10g, Rhizoma Zingiberis 10g, Ramulus Cinnamomi 10g, Radix Angelicae Dahuricae 9g, Radix Angelicae Sinensis 9g, Fructus Amomi Rotundus 10g, Rhizoma Et Radix Notopterygii 10g, Rhizoma Atractylodis 10g, Cortex Lycii 10g, Flos Papaveris rhoeadis pollen 15g, Semen Armeniacae Amarum 15g, Rhizoma Dioscoreae 15g, Rhizoma Atractylodis Macrocephalae 12g, Radix Aconiti Lateralis Preparata 10g, Rhizoma Coptidis 10g.Above-mentioned each taste material medicine is ground to form mix homogeneously after smalls, then adds common carrier, preparations shaping, make pill, 3-5g/ ball, a ball, every day 2 ball, sub-service sooner or later 7 days is a course for the treatment of.
Embodiment 2
Each crude drug is taken: Rhizoma Pinelliae 8g by following parts by weight, Fructus Aurantii 8g, Radix Saposhnikoviae 8g, Radix Platycodonis 8g, Fructus Schisandrae Chinensis 9g, Herba Artemisiae Annuae 8g, Radix Bupleuri 9g, Radix Astragali 14g, Radix Scutellariae 8g, Rhizoma Phragmitis 14g, coltsfoot 19g, Radix Asteris 19g, Pericarpium Citri Reticulatae 19g, Poria 9g, Cortex Phellodendri 9g, fry Rhizoma Alismatis 14g, Radix Paeoniae Alba 14g, Cortex Magnoliae Officinalis 14g, Radix Et Rhizoma Rhei 9g, Rhizoma Zingiberis 9g, Ramulus Cinnamomi 9g, Radix Angelicae Dahuricae 8g, Radix Angelicae Sinensis 8g, Fructus Amomi Rotundus 9g, Rhizoma Et Radix Notopterygii 9g, Rhizoma Atractylodis 9g, Cortex Lycii 9g, Flos Papaveris rhoeadis pollen 14g, Semen Armeniacae Amarum 14g, Rhizoma Dioscoreae 14g, Rhizoma Atractylodis Macrocephalae 11g, Radix Aconiti Lateralis Preparata 9g, Rhizoma Coptidis 9g.Above-mentioned each taste material medicine is ground to form mix homogeneously after smalls, then adds common carrier, preparations shaping, make pill, 3-5g/ ball, a ball, every day 2 ball, sub-service sooner or later 7 days is a course for the treatment of.
Embodiment 3
Each crude drug is taken: Rhizoma Pinelliae 10g by following parts by weight, Fructus Aurantii 10g, Radix Saposhnikoviae 10g, Radix Platycodonis 10g, Fructus Schisandrae Chinensis 11g, Herba Artemisiae Annuae 10g, Radix Bupleuri 11g, Radix Astragali 16g, Radix Scutellariae 10g, Rhizoma Phragmitis 16g, coltsfoot 21g, Radix Asteris 21g, Pericarpium Citri Reticulatae 21g, Poria 11g, Cortex Phellodendri 11g, fry Rhizoma Alismatis 16g, Radix Paeoniae Alba 16g, Cortex Magnoliae Officinalis 16g, Radix Et Rhizoma Rhei 11g, Rhizoma Zingiberis 11g, Ramulus Cinnamomi 11g, Radix Angelicae Dahuricae 10g, Radix Angelicae Sinensis 10g, Fructus Amomi Rotundus 11g, Rhizoma Et Radix Notopterygii 11g, Rhizoma Atractylodis 11g, Cortex Lycii 11g, Flos Papaveris rhoeadis pollen 16g, Semen Armeniacae Amarum 16g, Rhizoma Dioscoreae 16g, Rhizoma Atractylodis Macrocephalae 13g, Radix Aconiti Lateralis Preparata 11g, Rhizoma Coptidis 11g, Semen Fagopyri Esculenti 9g, Pericarpium Citri junoris 9g, Fructus Crataegi 10g, Fructus Cnidii 10g.Above-mentioned each taste material medicine is ground to form mix homogeneously after smalls, then adds common carrier, preparations shaping, make pill, 3-5g/ ball, a ball, every day 2 ball, sub-service sooner or later 7 days is a course for the treatment of.
Model case:
Case 1
So-and-so, male together, 71 years old, peasant, people from Jieshou City, Anhui Province.Suffer from tracheitis and be accompanied with asthma, through regular incidence, all do not effect a radical cure although take medicine always.After take pill prepared by the present invention, be almost recovered after 6 courses for the treatment of, after take again 3 courses for the treatment of continuously and consolidated, follow up a case by regular visits to and do not recur so far.
Case 2
Zeng, man, 58 years old, civil servant, people from Lixin County, Anhui Province, smoked too much at ordinary times, and the length of smoking is longer, suffers from chronic pharyngitis, transferred the concurrent asthma of tracheitis to afterwards, and sought medical advice always and do not take a turn for the better by cough.After take pill prepared by the present invention, after 3 courses for the treatment of, symptoms of asthma disappears substantially, after take again 4 courses for the treatment of continuously and consolidated, follow up a case by regular visits to and do not recur so far.
Case 3
Summer, 11 years old, student, people from Mingguang City, Anhui Province, heritability is panted, cannot concentrate on during morbidity attending class, seek medical advice has no resolution always, after toss about in bed here, give pill of the present invention and eat, eaten 4 courses for the treatment of, feel effective, after take again 6 courses for the treatment of, thoroughly cure, follow up a case by regular visits to and do not recur so far.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.