CN102631584B - Traditional Chinese medicine composition for treating idiopathic thrombocytopenic purpura - Google Patents
Traditional Chinese medicine composition for treating idiopathic thrombocytopenic purpura Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating idiopathic thrombocytopenic purpura. The composition is prepared from the following raw material drugs in parts by weight: 6 to 12 parts of prepared rehmannia rhizome, 10 to 20 parts of raw rehmannia rhizome, 10 to 20 parts of figwort root, 9 to 15 parts of scutellaria baicalensis, 9 to 15 parts of cape jasmine, 9 to 15 parts of vietnamese sophora root, 10 to 15 parts of Chinese wolfberry root-bark, 30 to 60 parts of lalang grass rhizome, 10 to 20 parts of buffalo horn, 6 to 12 parts of rhizoma alismatis, 10 to 15 parts of cortex lycii radicis, 6 to 12 parts of Chinese angelica, 6 to 15 parts of peony bark, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of dwarf lilyturf tuber, and 6 to 9 parts of liquorice. The Chinese medicinal composition has selected raw materials, reasonable compatibility, complementary functions and good synergy, can treat both principle and secondary aspect of a disease to idiopathic thrombocytopenic purpura, has relapse prevention after healing, stable curative effect, 95 percent of general effective rate, safe taking, low treatment cost, as well as small pain, drug resistance prevention and low toxic or side effect to a patient, and is easily accepted by patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of idiopathic thrombocytopenic purpura.
Background technology
Idiopathic thrombocytopenic purpura (being called for short ITP); it is the clinical syndrome that platelet destruction is increased because of immunologic mechanism; claim again idiopathic thrombocytopenic purpura (being called for short AITP); it is comparatively common hemorrhage; its characteristics are the periphery thrombocytopenia; platelet life span shortens, and bone marrow megakaryocyte is normal or increase the platelet turnover rate acceleration.According to clinical manifestation, age of onset, thrombocytopenic persistent period and therapeutic effect, be divided into acute and chronic type.Acute is more common in the child, is often self limiting, and chronic type is apt to occur in young women.
Most patients with chronic idiopathic thrombocytopenlc purpuras do not have prodrome or the cause of disease, and women's sickness rate is higher than the male, and insidious onset, symptom are changeable, and some case is except finding thrombocytopenia, and without obviously clinical symptoms and sign, the majority of cases clinical manifestation is skin petechia and ecchymosis.Acute ITP is hemorrhage more common in the child, and age of onset, with more between 2～5 years old, is grown up rare, and asexuality difference is usually more in the morbidity of winter-spring season viral infection peak period.
Through retrieval, the patent that the patent No. is 200910075890.1 discloses a kind of medicine for the treatment of anaphylactoid purpura, crude drug is the components such as Radix Cirsii Japonici, Herba Cirsii, Periostracum Cicadae, fresh rehmannia charcoal, charred Radix Scutellariae, charred Radix Sanguisorbae, Rhizoma Imperatae, Cortex Moutan, Radix Achyranthis Bidentatae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Rubra, Radix Glycyrrhizae, this medical instrument has clearing away heat and cooling blood, removing stasis to stop bleeding and anti-allergic effects, can treat anaphylactoid purpura, but the curative effect for idiopathic thrombocytopenic purpura is not satisfactory, therefore, need a kind of curative effect ideal of research and development can treat the medicine of idiopathic thrombocytopenic purpura.
Summary of the invention
The technical problem to be solved in the present invention: a kind of instant effect is provided, spends Chinese medicine composition low, the treatment idiopathic thrombocytopenic purpura.
Technical scheme of the present invention:
A kind of Chinese medicine composition for the treatment of idiopathic thrombocytopenic purpura, this Chinese medicine composition is made by the crude drug of following weight portion, Radix Rehmanniae Preparata 6-12 part, Radix Rehmanniae 10-20 part, Radix Scrophulariae 10-20 part, Radix Scutellariae 9-15 part, Fructus Gardeniae 9-15 part, Radix Sophorae Tonkinensis 9-15 part, Cortex Lycii 10-15 part, Rhizoma Imperatae 30-60 part, Cornu Bubali 10-20 part, Rhizoma Alismatis 6-12 part, Radix Rubiae 10-15 part, Radix Angelicae Sinensis 6-12 part, Cortex Moutan 6-15 part, Fructus Forsythiae 10-15 part, Radix Ophiopogonis 10-15 part, Radix Glycyrrhizae 6-9 part.
The crude drug of described Chinese medicine composition is preferably: Radix Rehmanniae Preparata 6-8 part, Radix Rehmanniae 10-15 part, Radix Scrophulariae 10-15 part, Radix Scutellariae 9-12 part, Fructus Gardeniae 9-12 part, Radix Sophorae Tonkinensis 9-12 part, Cortex Lycii 10-15 part, Rhizoma Imperatae 30-40 part, Cornu Bubali 10-15 part, Rhizoma Alismatis 6-8 part, Radix Rubiae 10-12 part, Radix Angelicae Sinensis 6-8 part, Cortex Moutan 6-10 part, Fructus Forsythiae 10-12 part, Radix Ophiopogonis 10-12 part, Radix Glycyrrhizae 6-9 part.
The crude drug of described Chinese medicine composition is preferably: Radix Rehmanniae Preparata 10-12 part, Radix Rehmanniae 15-20 part, Radix Scrophulariae 12-16 part, Radix Scutellariae 10-12 part, Fructus Gardeniae 10-12 part, Radix Sophorae Tonkinensis 10-12 part, Cortex Lycii 10-12 part, Rhizoma Imperatae 40-50 part, Cornu Bubali 15-20 part, Rhizoma Alismatis 8-10 part, Radix Rubiae 12-15 part, Radix Angelicae Sinensis 8-12 part, Cortex Moutan 8-15 part, Fructus Forsythiae 12-15 part, Radix Ophiopogonis 10-12 part, Radix Glycyrrhizae 6-9 part.
Decoction, watered pill or the capsule of described Chinese medicine composition for making according to a conventional method.
Instructions of taking: make decoction, get crude drug, with 1: the weight ratio of 5-8 adds water, decocts, and potion on the one, bfore meals.Within 30 days, be a course for the treatment of, take effect general 1-2 the course for the treatment of, and cure 4-6 the course for the treatment of.
While making watered pill or capsule, every watered pill or capsule be containing effective composition 3 grams, every day 2 times, each 1-2 grain.
Pharmacology analysis of the present invention:
The present invention be take motherland's Traditional Chinese Medicine theory as basis, and inventor Wei is taken to hemopathic research as celebrating from nineteen sixties, through the clinical observation of more than 40 years, has formed and take " clearing away heat and cooling blood is invigorated blood circulation " as the hemopathic unique solution of main treatment.In the disease of clinical treatment idiopathic thrombocytopenic purpura, find that the cause of disease of most patient belongs to due to the interior-heat on Chinese medicine, due in pathogenic heat enters, invade the internal organs meridians of body, with the passing of time heat-transformation, through Exploration and conclusion, found out the medicine of " clearing away heat and cooling blood is invigorated blood circulation ".This is the Radix Rehmanniae, Cortex Moutan, Rhizoma Imperatae, Cornu Bubali cooling blood for hemostasis for medicine; With Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Rhizoma Alismatis nourishing YIN and clearing away heat; With Radix Scutellariae, Fructus Gardeniae, Fructus Forsythiae, Radix Sophorae Tonkinensis, Cortex Lycii, Radix Glycyrrhizae heat clearing away; With Radix Rubiae, Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling.Each medicine of integrated application, the effect complementation, but clearing away heat and cooling blood invigorate blood circulation, disease is spontaneous recovery.
The pharmacological action of each crude drug:
Radix Rehmanniae Preparata: i.e. Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, return liver, kidney channel; Effect: Radix Rehmanniae Preparata sweet in the mouth tepor matter profit, the YIN nourishing of both having enriched blood, vital essence replenishing and marrow benifiting again, for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, the disease such as also can be used for hectic fever hectic fever due to YIN-deficiency, night sweat that deficiency of kidney yin causes, pass out semen and quench one's thirst.
The Radix Rehmanniae: i.e. Radix Rehmanniae, cool in nature, sweet in the mouth, enter the heart, liver, kidney channel; Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promote the production of body fluid, and has the clearing away heat and cooling blood effect: for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat, quench one's thirst, haematemesis, epistaxis, send out the disease such as speckle dermexanthesis.
Radix Scrophulariae: property is sweet, bitter, cold, is included into lung, stomach, kidney channel; There is the effects such as clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, eliminating fire and detoxication and hard masses softening and resolving.
Radix Scutellariae: bitter in the mouth, cold in nature, return lung, gallbladder, spleen, large intestine, small intestine meridian; There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis and the effect such as antiabortive; Clinical practice shows that the Radix Scutellariae antibacterial effect is not worse than Rhizoma Coptidis, and does not develop immunity to drugs.
Fructus Gardeniae: cold in nature, bitter in the mouth; Enter the heart, liver, lung, stomach, tri-jiao channel; There is the effects such as pathogenic fire purging relieving restlessness, removing pathogenic heat from blood and toxic substance from the body, eliminating damp-heat.
Radix Sophorae Tonkinensis: cold in nature, bitter in the mouth, poisonous, attach to the lung and stomach meridians; Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; For diseases such as laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, jaundice due to damp-heat, cough due to lung-heat and carbuncle sore tumefacting virus.
Cortex Lycii: sweet in the mouth, cold in nature, return lung, kidney channel; For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat; There is removing heat from blood, heat clearing away, remove the effects such as rash, lung heat clearing pathogenic fire reducing and resisting pathogenic microbes.
Rhizoma Imperatae; Another name Rhizoma Imperatae, blue root, sweet in the mouth, cold, return lung, stomach, urinary bladder channel; Cure mainly removing heat from blood, hemostasis, heat clearing away, removing toxic substances, diuresis; The diseases such as the sound of vomiting and cough of vomitting for haematemesis, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, gastric heat; Rhizoma Imperatae energy lung heat clearing gastric heat, therefore be applicable to above-mentioned all diseases.
Cornu Bubali: nature and flavor, bitter salty, cold; Heat clearing away, removing heat from blood, removing toxic substances, for calentura headache, high fever coma, macule, tell the diseases such as nosebleed, infantile convulsion and sore throat pharyngeal swelling.
Rhizoma Alismatis: cold in nature, sweet in the mouth, light, enter kidney, bladder two warps; Cure mainly (1) promoting diuresis to eliminate damp pathogen: this product slightly sweet flavor and cold in nature, the cold diarrhea of heat type water that can win, it is light that to ooze diuretic wet; (2) expel the heat-evil: Rhizoma Alismatis is cold in nature, cold can heat clearing away, enter kidney channel, can rush down kidney channel fire mutually, can be used for seminal emission, tinnitus, the disease such as dizzy.
Radix Rubiae: cold in nature, bitter in the mouth, return liver, the heart, kidney, spleen, stomach, pericardium channel; Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling; Cure mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore and the disease such as hemorrhoid are swollen.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering, return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For diseases such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down and ulcer sores.
Cortex Moutan: acrid in the mouth, hardship, cool in nature; Enter the heart, liver, kidney three warps; Cure mainly (1) clearing away heat and cooling blood, Cortex Moutan acrid in the mouth, hardship, cool in nature, be the good medicine of clearing away heat and cooling blood, is usually used in all diseases of heat in blood, is used for the treatment of heat and enters the diseases such as nutrient blood, infantile convulsion, headache due to pathogenic wind-heat, heat in blood are hemorrhage, osteopyrexia and fever; (2) dissipating blood stasis and reducing the stagnation, Cortex Moutan acrid in the mouth, hardship, cool in nature, Xin Nenghang can fall apart, circulation of qi promoting promoting the circulation of blood, but hardship dampness, expel the heat-evil, dredging collateral, but its cool heat clearing away, therefore be used for the treatment of the disease caused because of blood stasis, the stagnation of QI, be used for the treatment of the diseases such as carbuncle, traumatic injury, blood stasis amenorrhea, lumps in the chest and abdomen, wind heat numbness.
Fructus Forsythiae: hardship, be slightly cold, return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma send out the diseases such as speckle and pyretic stranguria urine retention.
Radix Ophiopogonis: sweet, micro-hardship, be slightly cold, GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease cough, thirsty, the vexed insomnia of Tianjin wound, interior-heat quench one's thirst, the diseases such as dryness of the intestine constipation and pharyngeal diphtheria.
Radix Glycyrrhizae: sweet in the mouth, flat, GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, the toxicity of energy cushion and strong.
Positive beneficial effect of the present invention:
(1) the present invention, according to traditional Chinese medical science traditional theory, in conjunction with inventor's long-term clinical practice, has formed and take " clearing away heat and cooling blood is invigorated blood circulation " as main unique therapeutic scheme.This YAOJING is selected raw material, and compatibility is reasonable, and the effect complementation can produce synergism preferably.Clinical practice shows, but this medicine the idiopathic thrombocytopenic purpura treating both the principal and secondary aspects of a disease is not rebounded after healing, efficacy consolidation, total effective rate can reach 95%.
(2) the present invention is pure tcm product, safety, and medical expense is low, instant effect, take effect general 1-2 the course for the treatment of, and the patient suffering is little, drug resistance not, and toxic and side effects is little, easily by the patient, is accepted, and has avoided the toxic and side effects of heavy dose of use Western medicine.
(3) Chinese medicine composition of the present invention reacts well in the patient, firmly gets patient's favorable comment.
The case statistics:
The inventor accepts idiopathic thrombocytopenic purpura on the books 162 examples for medical treatment altogether from 1994-2011, male 54 examples, and female's 108 examples, the male: female ratio is 1: 2, patient age is between 2-48 year, 23.5 years old mean age, course of disease 6-18 month, average course of disease 14 months.
In 162 routine patients, cure altogether 112 examples, account for 69%; Progressive 42 examples, account for 26%; Invalid 4 examples account for 2.5%; Automatically 4 examples of leaving hospital account for 2.5%, and total effective rate is 95%.
The criterion of therapeutical effect of above case is that standard is as follows according to the discussion canonical statistics of the 5th Chinese Medical Association whole nation Thrombosis and hemostasis art meeting:
(1) cure: platelet count recovers normal, without bleeding, continues more than 3 months, and maintaining more than 2 years is to cure without the recidivist;
(2) progressive: platelet count rises to some extent, and bleeding makes moderate progress, and continues 2 weeks above persons;
(3) invalid: platelet count and bleeding are not improved or deterioration person.
Model case:
Case 1, Zhao, female, 22 years old, people from Jieshou City, Anhui Province.Find that the blood purpura appears in two lower limb in November, 2008, do not take notice of at that time, occur while then brushing teeth that gingiva bleeds incessantly, and hyper-menorrhea, menostaxis.With going to the People's Hospital, Anhui Province medical, the conventional prompting platelet of having a blood test is on the low side, and bone marrow prompting megakaryocytic maturation, be the obstruction type thrombocytopenic purpura.Successively repeatedly arrive again various big hospital inside the province and go to a doctor, all be diagnosed as " idiopathic thrombocytopenic purpura ", through doctor trained in Western medicine, Chinese traditional treatment, have no improvement.Be illustrated in my institute's treatment of 6 monthly incomes in 2009, hemogram while being admitted to hospital: hemoglobin 110g/L, leukocyte 7.3 * 10 by friend
9/ L, platelet 18 * 10
9/ L.Giving Chinese medicine after being admitted to hospital is main treatment.Adopt the prescription of embodiment mono-, be Radix Rehmanniae Preparata 12g, Radix Rehmanniae 20g, Radix Scrophulariae 20g, Radix Scutellariae 15g, Fructus Gardeniae 15g, Radix Sophorae Tonkinensis 15g, Cortex Lycii 15g, Rhizoma Imperatae 60g, Cornu Bubali 20g, Rhizoma Alismatis 12g, Radix Rubiae 15g, Radix Angelicae Sinensis 12g, Cortex Moutan 15g, Fructus Forsythiae 15g, Radix Ophiopogonis 15g, Radix Glycyrrhizae 6g.
Get crude drug, with 1: the weight ratio of 5-8 adds water, decocts, and makes heat clearing and blood cooling decoction, takes 1 pair of every day.By this side, take medicine 20 days, two lower limb purpuras partly disappear; After continuing to take medicine 6 months, two lower limb purpuras disappear fully, check routine blood test prompting: hemoglobin 130g/L, leukocyte 6.8 * 10
9/ L, platelet 118 * 10
9/ L, routine blood test is fully normal.Continue to strengthen treatment 4 months, cure, follow up a case by regular visits to repeatedly, not recurrence.
Case 2, Qiu, female, 5 years old, people from Shangcai County, Henan Province.In July, 2009, the patient skin mucosa petechia occurred without obvious inducement, and sx↑ after a week, go to Zhumadian hospital, is diagnosed as " idiopathic thrombocytopenic purpura ".Successively go to the various big hospitals such as Tianjin, Beijing medical, have no improvement.Introduce into my institute's treatment in November, 2010 through the ward mate, the conventional prompting of having a blood test while being admitted to hospital: hemoglobin 110g/L, leukocyte 5.6 * 10
9/ L, platelet 27 * 10
9/ L.Giving Chinese medicine is main treatment, and side uses heat clearing and blood cooling decoction, makes decoction with the prescription of embodiment bis-, 1 pair of every day.After taking medicine 30 days, two lower limb purpuras disappear fully, continual cure 5 months, check, routine blood test prompting: hemoglobin 120g/L, leukocyte 5.6 * 10
9/ L, platelet 146 * 10
9/ L, routine blood test is fully normal.Continue to strengthen treatment 3 months, thoroughly cure, follow up a case by regular visits to repeatedly, not recurrence.
Case 3, the time, man, 4 years old, the Shangqiu City people of Henan Province.The two lower limb purpuras of in May, 2007 patient's low grade fever companion, do not pay attention to the processing of bringing down a fever in local clinic at that time.Then sx↑, go to the Shangqiu City the People's Hospital to check, routine blood test prompting: hemoglobin 110g/L, leukocyte 4.5 * 10
9/ L, platelet 20 * 10
9/ L.Rear patient repeatedly goes to national various big hospital medical, all is diagnosed as " idiopathic thrombocytopenic purpura ", through doctor trained in Western medicine, Chinese traditional treatment, has no improvement.In August, 2008, the patient introduced into my institute's treatment through friend, the rear routine blood test prompting of being admitted to hospital: hemoglobin 120g/L, leukocyte 5.0 * 10
9/ L, platelet 20 * 10
9/ L.Give treatment by Chinese herbs, with the prescription of embodiment tri-, make heat clearing and blood cooling decoction, 1 pair of every day.Take patient's upper and lower extremities purpura transference cure after 20 days; Continue to take traditional Chinese medicine 5 months, routine blood test prompting after check: hemoglobin 120g/L, leukocyte 5.0 * 10
9/ L, platelet 130 * 10
9/ L.Routine blood test is fully normal, continues to strengthen treatment 6 months, thoroughly cures, and follows up a case by regular visits to repeatedly, has no recurrence.
Case 4, the week certain, man, 21 years old, people from Kaifeng, Henan Province.Find that without obvious inducement hemorrhage purpura appears in two lower limb in August, 2009, do not pay attention at that time, then increase petechia, goes to the attached institute of Henan Province's medical college one medical, routine blood test prompting platelet is on the low side, bone marrow prompting megakaryocytic maturation obstruction type thrombocytopenic purpura.Repeatedly arrive again a plurality of Big urban hospitals medical, all be diagnosed as " idiopathic thrombocytopenic purpura ", through doctor trained in Western medicine, Chinese traditional treatment, have no improvement.Be illustrated in my institute's treatment of 7 monthly incomes in 2005, hemogram while being admitted to hospital: hemoglobin 115g/L, leukocyte 6.5 * 10 by friend
9/ L, platelet 22 * 10
9/ L.Giving Chinese medicine after being admitted to hospital is main treatment, with the prescription of embodiment tetra-, makes heat clearing and blood cooling decoction, 1 pair of every day.Check routine blood test after taking medicine 50 days, the platelet bottom out, continue to take medicine 8 months, routine blood test prompting: hemoglobin 135g/L, leukocyte 6.5 * 10
9/ L, platelet 146 * 10
9/ L, routine blood test is fully normal.Continue to strengthen treatment 5 months, thoroughly cure, follow up a case by regular visits to repeatedly, have no recurrence.
The specific embodiment
Embodiment mono-: the Chinese medicine composition for the treatment of idiopathic thrombocytopenic purpura, and the crude drug prescription:
Radix Rehmanniae Preparata 12g, Radix Rehmanniae 20g, Radix Scrophulariae 20g, Radix Scutellariae 15g, Fructus Gardeniae 15g, Radix Sophorae Tonkinensis 15g, Cortex Lycii 15g, Rhizoma Imperatae 60g, Cornu Bubali 20g, Rhizoma Alismatis 12g, Radix Rubiae 15g, Radix Angelicae Sinensis 12g, Cortex Moutan 15g, Fructus Forsythiae 15g, Radix Ophiopogonis 15g, Radix Glycyrrhizae 6g.
Method for making: get crude drug, with 1: the weight ratio of 5-8 adds water, decocts, and is brewed into decoction.
Embodiment bis-: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 6g, Radix Rehmanniae 10g, Radix Scrophulariae 10g, Radix Scutellariae 10g, Fructus Gardeniae 10g, Radix Sophorae Tonkinensis 10g, Cortex Lycii 10g, Rhizoma Imperatae 30g, Cornu Bubali 10g, Rhizoma Alismatis 6g, Radix Rubiae 10g, Radix Angelicae Sinensis 6g, Cortex Moutan 9g, Fructus Forsythiae 10g, Radix Ophiopogonis 10g, Radix Glycyrrhizae 6g.
Embodiment tri-: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 8g, Radix Rehmanniae 10g, Radix Scrophulariae 12g, Radix Scutellariae 9g, Fructus Gardeniae 9g, Radix Sophorae Tonkinensis 9g, Cortex Lycii 10g, Rhizoma Imperatae 35g, Cornu Bubali 10g, Rhizoma Alismatis 8g, Radix Rubiae 10g, Radix Angelicae Sinensis 8g, Cortex Moutan 7g, Fructus Forsythiae 11g, Radix Ophiopogonis 10g, Radix Glycyrrhizae 7g.
Embodiment tetra-: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 8g, Radix Rehmanniae 20g, Radix Scrophulariae 20g, Radix Scutellariae 15g, Fructus Gardeniae 12g, Radix Sophorae Tonkinensis 15g, Cortex Lycii 15g, Rhizoma Imperatae 50g, Cornu Bubali 20g, Rhizoma Alismatis 10g, Radix Rubiae 15g, Radix Angelicae Sinensis 8g, Cortex Moutan 10g, Fructus Forsythiae 15g, Radix Ophiopogonis 15g, Radix Glycyrrhizae 8g.
Embodiment five: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 10g, Radix Rehmanniae 15g, Radix Scrophulariae 15g, Radix Scutellariae 12g, Fructus Gardeniae 14g, Radix Sophorae Tonkinensis 12g, Cortex Lycii 12g, Rhizoma Imperatae 40g, Cornu Bubali 20g, Rhizoma Alismatis 10g, Radix Rubiae 15g, Radix Angelicae Sinensis 8g, Cortex Moutan 10g, Fructus Forsythiae 12g, Radix Ophiopogonis 12g, Radix Glycyrrhizae 8g.Make according to a conventional method the watered pill, every watered pill is containing effective composition 3 grams.
Embodiment six: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 7g, Radix Rehmanniae 15g, Radix Scrophulariae 15g, Radix Scutellariae 12g, Fructus Gardeniae 9g, Radix Sophorae Tonkinensis 10g, Cortex Lycii 10g, Rhizoma Imperatae 40g, Cornu Bubali 15g, Rhizoma Alismatis 8g, Radix Rubiae 12g, Radix Angelicae Sinensis 8g, Cortex Moutan 10g, Fructus Forsythiae 12g, Radix Ophiopogonis 12g, Radix Glycyrrhizae 9g.Make according to a conventional method the watered pill, every watered pill is containing effective composition 3 grams.
Embodiment seven: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 6g, Radix Rehmanniae 12g, Radix Scrophulariae 12g, Radix Scutellariae 10g, Fructus Gardeniae 12g, Radix Sophorae Tonkinensis 12g, Cortex Lycii 15g, Rhizoma Imperatae 35g, Cornu Bubali 10g, Rhizoma Alismatis 6g, Radix Rubiae 10g, Radix Angelicae Sinensis 6g, Cortex Moutan 8g, Fructus Forsythiae 10g, Radix Ophiopogonis 10g, Radix Glycyrrhizae 6g.Make according to a conventional method capsule, every capsules is containing effective composition 3 grams.
Embodiment eight: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 11g, Radix Rehmanniae 18g, Radix Scrophulariae 14g, Radix Scutellariae 11g, Fructus Gardeniae 11g, Radix Sophorae Tonkinensis 12g, Cortex Lycii 12g, Rhizoma Imperatae 45g, Cornu Bubali 18g, Rhizoma Alismatis 10g, Radix Rubiae 15g, Radix Angelicae Sinensis 8g, Cortex Moutan 10g, Fructus Forsythiae 14g, Radix Ophiopogonis 12g, Radix Glycyrrhizae 8g.Make according to a conventional method capsule, every capsules is containing effective composition 3 grams.
Embodiment nine: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 10g, Radix Rehmanniae 20g, Radix Scrophulariae 12g, Radix Scutellariae 10g, Fructus Gardeniae 12g, Radix Sophorae Tonkinensis 12g, Cortex Lycii 12g, Rhizoma Imperatae 50g, Cornu Bubali 15g, Rhizoma Alismatis 10g, Radix Rubiae 15g, Radix Angelicae Sinensis 8g, Cortex Moutan 15g, Fructus Forsythiae 15g, Radix Ophiopogonis 10g, Radix Glycyrrhizae 9g.
Embodiment ten: basic identical with embodiment mono-, difference is:
The crude drug prescription: Radix Rehmanniae Preparata 12g, Radix Rehmanniae 17g, Radix Scrophulariae 18g, Radix Scutellariae 14g, Fructus Gardeniae 13g, Radix Sophorae Tonkinensis 10g, Cortex Lycii 10g, Rhizoma Imperatae 40g, Cornu Bubali 20g, Rhizoma Alismatis 10g, Radix Rubiae 12g, Radix Angelicae Sinensis 8g, Cortex Moutan 8g, Fructus Forsythiae 15g, Radix Ophiopogonis 12g, Radix Glycyrrhizae 6g.
Claims (4)
1. a Chinese medicine composition for the treatment of idiopathic thrombocytopenic purpura, it is characterized in that: this Chinese medicine composition is made by the crude drug of following weight portion, Radix Rehmanniae Preparata 6-12 part, Radix Rehmanniae 10-20 part, Radix Scrophulariae 10-20 part, Radix Scutellariae 9-15 part, Fructus Gardeniae 9-15 part, Radix Sophorae Tonkinensis 9-15 part, Cortex Lycii 10-15 part, Rhizoma Imperatae 30-60 part, Cornu Bubali 10-20 part, Rhizoma Alismatis 6-12 part, Radix Rubiae 10-15 part, Radix Angelicae Sinensis 6-12 part, Cortex Moutan 6-15 part, Fructus Forsythiae 10-15 part, Radix Ophiopogonis 10-15 part, Radix Glycyrrhizae 6-9 part.
2. Chinese medicine composition according to claim 1, it is characterized in that: the crude drug of described Chinese medicine composition is preferably: Radix Rehmanniae Preparata 6-8 part, Radix Rehmanniae 10-15 part, Radix Scrophulariae 10-15 part, Radix Scutellariae 9-12 part, Fructus Gardeniae 9-12 part, Radix Sophorae Tonkinensis 9-12 part, Cortex Lycii 10-15 part, Rhizoma Imperatae 30-40 part, Cornu Bubali 10-15 part, Rhizoma Alismatis 6-8 part, Radix Rubiae 10-12 part, Radix Angelicae Sinensis 6-8 part, Cortex Moutan 6-10 part, Fructus Forsythiae 10-12 part, Radix Ophiopogonis 10-12 part, Radix Glycyrrhizae 6-9 part.
3. Chinese medicine composition according to claim 1, it is characterized in that: the crude drug of described Chinese medicine composition is preferably: Radix Rehmanniae Preparata 10-12 part, Radix Rehmanniae 15-20 part, Radix Scrophulariae 12-16 part, Radix Scutellariae 10-12 part, Fructus Gardeniae 10-12 part, Radix Sophorae Tonkinensis 10-12 part, Cortex Lycii 10-12 part, Rhizoma Imperatae 40-50 part, Cornu Bubali 15-20 part, Rhizoma Alismatis 8-10 part, Radix Rubiae 12-15 part, Radix Angelicae Sinensis 8-12 part, Cortex Moutan 8-15 part, Fructus Forsythiae 12-15 part, Radix Ophiopogonis 10-12 part, Radix Glycyrrhizae 6-9 part.
4. according to the described Chinese medicine composition of claim 1-3 any one, it is characterized in that: decoction, watered pill or the capsule of described Chinese medicine composition for making according to a conventional method.
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| 古学奎等.分期辨治难治性原发性血小板减少性紫癜57例疗效观察.《新中医》.2010,第42卷(第9期),68-69. |
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