CN104367941A - Preparation method of traditional Chinese medicinal preparation for treating singapore hemorrhagic fever - Google Patents
Preparation method of traditional Chinese medicinal preparation for treating singapore hemorrhagic fever Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicinal preparation for treating Singapore hemorrhagic fever. The traditional Chinese medicinal preparation for treating the Singapore hemorrhagic fever is prepared from the following medicinal raw materials: aristolochia tubiflora, cortex phellodendri, muskroot-like semiaquilegia root, wild goose fat, polygonum multiflorum, changium smyrnioides, chrysanthemum, long-shaped rice, curcuma aromatica, liquorice, costusroot, radix bupleuri, scutellaria baicalensis, calculus bovis, sweet wormwood herb, angelica root, fructus forsythiae, divaricate saposhnikovia root, kudzu vine root, clove, golden larch bark, rhizoma anemarrhenae, gurgeon stopper and snake slough. A dosage form of the traditional Chinese medicinal preparation for treating the Singapore hemorrhagic fever is an aqueous solution. The preparation method of the traditional Chinese medicinal preparation for treating the Singapore hemorrhagic fever comprises the following steps: firstly mixing the medicinal raw materials in ratio, putting the mixed medicinal raw materials into a marmite, adding water for soaking, boiling with a strong fire, and then boiling for 20 minutes with a soft fire; filtering medicinal liquid for later use, adding water and continuously heating until the medicinal liquid is boiled, boiling for 15 minutes with a soft fire, filtering while hot and abandoning residue; mixing concentrated medicinal liquids, cooling to room temperature, and packaging under sterile condition, wherein the packaged medicine is namely the aqueous solution finished product. Compared with the prior art, the traditional Chinese medicinal preparation for treating the Singapore hemorrhagic fever has the effects of clearing away heat and toxic materials, regulating qi and blood, replenishing blood and tonifying qi, eliminating dampness and stopping pain as well as removing lesions and is strong in pertinence.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of preparation method for the treatment of the Chinese medicine preparation of dengue fever.
Background technology
Dengue fever (dengue fever) is that dengue virus causes, her mosquito-borne a kind of acute infectious disease.Clinical symptoms is that onset is hurried, high heat, whole-body muscle, bone marrow and arthralgia, and extremely tired, part is suffered from can erythra, bleeding tendency and lymphadenectasis.
Primary disease found in 1779 in Cairo, EGY, Indonesia Jakarta and U.S. Philadelphia, and according to symptom called after joint heat and fracture fever.1869 by London Society of Internal Medicine of imperial family called after dengue fever.In 20th century, dengue fever occurred all over the world to be repeatedly very popular, the millions of meter of case.In Southeast Asia always in endemic conditions.China is popular in Guangdong in 1978, and isolates the IVth type dengue virus.After this, in 1979,1980,1985 little isolate in the groove I, II, III type virus.
The source of infection: patient and inapparent infection person are major source of infection, does not find healthy carrier.Patient is little of the course of disease the 6th day at premorbid 6 ~ 8, has obvious viremia, can make to bite yellow-fever mosquito and be contaminted.Epidemic period, light-duty patient populations is 10 times of typical patient, and inapparent infection person is crowd's 1/3, it may be the important source of infection, although some domestic animal has the serological evidence infecting dengue virus in the monkey in jungle mountain area and city, as the source of infection, not yet can determine.
Communication media: yellow-fever mosquito, known 12 kinds of yellow-fever mosquitos can propagate primary disease, but most importantly Aedes aegypti and aedes w-alba.Guangdong, Guangxi mostly are Aedes albopictus and propagate, and the Lezhou Peninsula, ALONG GUANGXI COAST, Hainan Province and south east asia are based on Aedes aegypti.As long as yellow-fever mosquito and infectious liquid comes into contact are once, can obtain infection, namely have infectiousness after virus copies 8--14 days in mosquito body, infective stage elder can reach 174.There is communicable yellow-fever mosquito when biting human body, by virus disseminating to people.Because detecting dengue virus granule in the ovary of catching yellow-fever mosquito, infer that yellow-fever mosquito may be the reservoir of virus.
Susceptible population: at the general susceptible of new epidemic area.1980 in Guangdong in the groove, minimal ages 3 months, maximum 86 years old, but the highest with between twenty and fifty sickness rate.In endemic area, the resident of more than 20 years old, 100% neutralizing antibody that can detect anti-dengue virus in serum, thus sends out patient and mostly is child.
The treatment of prior art is generally based on hormone, as oral prednisone, oral cimetidine etc., because patient mostly is child, use the sequela brought of hormone unimaginable, and relapse rate is also higher, all can causes larger harmful effect to the economy of patient, health, psychology, based on this, now provide a kind of preparation method for the treatment of the Chinese medicine preparation of dengue fever, the method is started with from the aspect such as QI and blood, removing toxic substances, heat clearing away, rash of dispelling, pain relieving, antipruritic, mediation, realizes the treating both the principal and secondary aspects of a disease to dengue fever.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of practical, the preparation method of the Chinese medicine preparation of the treatment dengue fever that therapeutic effect is desirable.
In order to realize foregoing invention object, the invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of dengue fever, comprise the raw medicinal material of following ratio of weight and number: Radix aristolochiae tubiflorae 20-40 part, Cortex Phellodendri 20-35 part, Radix Semiaquilegiae 15-30 part, Adeps Anser albifrons 5-15 part, Radix Polygoni Multiflori 10-28 part, Radix Changii 10-25 part, Flos Chrysanthemi 15-25 part, Semen Oryzae 25-45 part, Radix Curcumae 10-22 part, Radix Glycyrrhizae 15-40 part, Radix Aucklandiae 10-20 part, Radix Bupleuri 5-18 part, Radix Scutellariae 5-20 part, Calculus Bovis 1-15 part, Herba Artemisiae Annuae 20-33 part, Radix Angelicae Dahuricae 10-28 part, Fructus Forsythiae 15-40 part, Radix Saposhnikoviae 10-18 part, Radix Puerariae 5-35 part, Flos Caryophylli 20-30 part, Cortex Pseudolaricis 15-30 part, Rhizoma Anemarrhenae 6-18 part, Radix Syzygii Buxifolii 1-8 part, Periostracum Serpentis 1-20 part,
The dosage form of described Chinese medicine is water preparation, and its preparation method comprises the following steps:
Step one, first by said medicine in inserting in marmite after the mixing of described ratio, add 2-5 times of water of said medicine weight, soak 40-50 minute;
Step 2, to boil with very hot oven, then change slow fire and boil 20 minutes;
For subsequent use after step 3, medical filtration, medicinal residues add 3-4 times of water to be continued to be heated to boil, and changes and simmers in water 15 minutes, filtered while hot waste;
Step 4, merge twice concentrated medicament, be cooled to sterile packaged after room temperature, the medicine after encapsulation is finished product water preparation.
Further, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 25-35 part, Cortex Phellodendri 22-30 part, Radix Semiaquilegiae 20-26 part, Adeps Anser albifrons 6-12 part, Radix Polygoni Multiflori 15-25 part, Radix Changii 15-22 part, Flos Chrysanthemi 18-22 part, Semen Oryzae 30-40 part, Radix Curcumae 12-20 part, Radix Glycyrrhizae 20-35 part, Radix Aucklandiae 12-18 part, Radix Bupleuri 8-15 part, Radix Scutellariae 10-15 part, Calculus Bovis 2-12 part, Herba Artemisiae Annuae 25-30 part, Radix Angelicae Dahuricae 15-25 part, Fructus Forsythiae 20-35 part, Radix Saposhnikoviae 12-16 part, Radix Puerariae 10-25 part, Flos Caryophylli 22-28 part, Cortex Pseudolaricis 18-28 part, Rhizoma Anemarrhenae 10-16 part, Radix Syzygii Buxifolii 2-6 part, Periostracum Serpentis 2-10 part.
As preferably, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 28 parts, Cortex Phellodendri 25 parts, Radix Semiaquilegiae 22 parts, Adeps Anser albifrons 8 parts, Radix Polygoni Multiflori 18 parts, Radix Changii 18 parts, Flos Chrysanthemi 20 parts, Semen Oryzae 35 parts, Radix Curcumae 15 parts, 25 parts, Radix Glycyrrhizae, the Radix Aucklandiae 15 parts, Radix Bupleuri 10 parts, Radix Scutellariae 12 parts, Calculus Bovis 5 parts, Herba Artemisiae Annuae 26 parts, the Radix Angelicae Dahuricae 18 parts, Fructus Forsythiae 25 parts, Radix Saposhnikoviae 14 parts, Radix Puerariae 15 parts, Flos Caryophylli 25 parts, Cortex Pseudolaricis 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Syzygii Buxifolii 4 parts, Periostracum Serpentis 4 parts.
As preferably, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 30 parts, Cortex Phellodendri 28 parts, Radix Semiaquilegiae 25 parts, Adeps Anser albifrons 10 parts, Radix Polygoni Multiflori 22 parts, Radix Changii 20 parts, Flos Chrysanthemi 21 parts, Semen Oryzae 38 parts, Radix Curcumae 18 parts, 30 parts, Radix Glycyrrhizae, the Radix Aucklandiae 16 parts, Radix Bupleuri 12 parts, Radix Scutellariae 14 parts, Calculus Bovis 3 parts, Herba Artemisiae Annuae 28 parts, the Radix Angelicae Dahuricae 20 parts, Fructus Forsythiae 22 parts, Radix Saposhnikoviae 15 parts, Radix Puerariae 20 parts, Flos Caryophylli 26 parts, Cortex Pseudolaricis 25 parts, the Rhizoma Anemarrhenae 15 parts, Radix Syzygii Buxifolii 5 parts, Periostracum Serpentis 5 parts.
As preferably, in described step one, add 3 times of water of drug weight, soak 45 minutes.
The dosage form of described Chinese medicine also can be made into granule, and its concrete preparation process is:
Step one: described raw medicinal material is mixed in described ratio, cross 60 mesh sieves after grinding to form granule, be placed in and decoct marmite, add three times of water soakings of mixture weight, soak time is 20 minutes;
Step 2: be heated to boil, changes slow fire and boils 15 minutes, then isolate decoction liquor;
Step 3: after the water adding isolated medicinal residues weight three times repeats to boil, change slow fire and boil 15 minutes, then isolate decoction liquor;
Step 4: collect twice decoction liquor, centrifugalize, when being evaporated to 60 ~ 70 DEG C under vacuum 0.08 ~ 0.12Mpa, relative density is the mastic of 1.20 ~ 1.25, spraying dry, the inlet temperature 120 ~ 130 DEG C of spray dryer, leaving air temp 75 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 5: the beta-schardinger dextrin-adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.4 times in the dried cream powder obtained, makes granule, dry in 85 DEG C of environment, obtains granule.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Radix aristolochiae tubiflorae: nature and flavor are bitter; Pungent; Cold.Return Liver Channel.Heat-clearing and toxic substances removing; Promoting the circulation of QI to relieve pain, main venom; Skin infection furuncle and phyma; Have a stomach-ache pain; Enteritis and dysentery; Diarrhoea; Fengshi Guanjie pain; Dysmenorrhea; Traumatic injury.
Cortex Phellodendri: nature and flavor are bitter, cold.Enter kidney, urinary bladder channel.Heat clearing away, dampness, pathogenic fire purging, removing toxic substances, cure mainly hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
Radix Semiaquilegiae: nature and flavor sweetness and bitterness, cold.Enter spleen, small intestinal, bladder three warp.Heat clearing away, removing toxic substances, detumescence, eliminating stagnation, diuresis, cures mainly carbuncle, scrofula, furuncle, stranguria with turbid discharge, leukorrhagia, cough due to deficiency of the lung, hernia, epilepsy, infantile convulsion, hemorrhoid, traumatic injury, venom.
Adeps Anser albifrons: be the fat of Anatidae animal white volume wild goose, nature and flavor are sweet is flat.GUIXIN; Liver; Stomach warp.Promoting blood circulation by removing wind, heat-clearing and toxic substances removing, cures mainly apoplexy hemiplegia, contracture of the limbs; Ambition stagnation of pathogenic heat, painful abdominal mass plug vomiting; Carbuncle sore, loss of hairs are not long.
Radix Polygoni Multiflori: nature and flavor are bitter; Sweet; Puckery; Slightly warm in nature.Return liver; Kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances, cures mainly blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid.
Radix Changii: sweet, the micro-hardship of nature and flavor, is slightly cold.Return lung, spleen, Liver Channel.Moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver, removing toxic substances, is mainly used to cough due to lung-heat, and vomiting regurgitation, lack of appetite xerostomia, conjunctival congestion is dizzy, furunculosis skin infection.
Flos Chrysanthemi: nature and flavor sweetness and bitterness is cool.Be included into lung, Liver Channel.Dispelling wind, heat clearing away, improving eyesight, removing toxic substances, cures mainly headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.
Semen Oryzae: nature and flavor are sweet; Temperature.Return spleen; Stomach; Heart channel.Warming middle-JIAO QI invigorating; Invigorating the spleen to arrest diarrhea, cures mainly Deficiency and coldness of spleen and stomach and has loose bowels.
Radix Curcumae: nature and flavor are pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, is mainly used to amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, and epilepsy is gone mad, jaundice dark coloured urine.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian.With middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.
The Radix Aucklandiae: nature and flavor are worked hard, temperature.Be included into lung, liver, spleen channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.
Radix Bupleuri: nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating, is mainly used to cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Scutellariae: nature and flavor are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, be mainly used to hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Calculus Bovis: nature and flavor are sweet is cool.GUIXIN, Liver Channel.Clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, and removing toxic substances, is mainly used to calentura coma, middle wind-phlegm fan, and infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Herba Artemisiae Annuae: nature and flavor bitter, acrid, cold.Return liver, gallbladder meridian.Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria, is mainly used to pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
The Radix Angelicae Dahuricae: nature and flavor are pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis, is mainly used to headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, and toothache, leucorrhea, skin infection swells and ache.
Fructus Forsythiae: nature and flavor are bitter, cool.Be included into the heart, liver, gallbladder meridian.Heat clearing away, removing toxic substances, eliminating stagnation, detumescence, cures mainly warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Radix Saposhnikoviae: nature and flavor acrid, sweet, warm.Return bladder, liver, spleen channel.Inducing diaphoresis to dispel wind, victory is wet, and relieving convulsion, is mainly used to headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Puerariae: nature and flavor are sweet pungent is flat.Be included into spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
Flos Caryophylli: nature and flavor are pungent, temperature.Be included into stomach, spleen, kidney channel.Warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI, cures mainly singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.
Cortex Pseudolaricis: nature and flavor are pungent, temperature; Poisonous.Return lung, spleen channel.Parasite killing, antipruritic.
The Rhizoma Anemarrhenae: nature and flavor are bitter, cold.Be included into lung, stomach, kidney channel.Nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.
Radix Syzygii Buxifolii: nature and flavor are sweet; Micro-hardship; Pungent; Property is put down.Return kidney; Spleen; Liver Channel.Invigorating spleen to remove dampness; Relieving asthma; Dissipating blood stasis for subsidence of swelling.Master breathes with cough; Edema; Stranguria with turbid discharge; Lithangiuria; Dysentery; Hepatitis; Uterine prolapse; Rheumatalgia; Hernia; Orchitis; Hemorrhoid; Carbuncle; Burn due to hot liquid or fire; Treating swelling and pain by traumatic injury.
Periostracum Serpentis: nature and flavor are salty, sweet is flat.Return Liver Channel.Dispel the wind, arresting convulsion, removing toxic substances, nebula removing, is mainly used to infantile convulsion, tic spasm, cataracta, sore throat, and furuncle swells, skin pruritus.
According to above-mentioned property of medicine pharmacology, substantially medicine can be divided into following a few class by function:
For heat-clearing and toxic substances removing: Radix aristolochiae tubiflorae, Cortex Phellodendri, Radix Semiaquilegiae, Adeps Anser albifrons, Radix Polygoni Multiflori, Radix Changii, Flos Chrysanthemi.
For QI invigorating: Semen Oryzae.
For circulation of qi promoting removing heat from blood: Radix Curcumae.
For being in harmonious proportion: Radix Glycyrrhizae, the Radix Aucklandiae.
For the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.: Radix Bupleuri, Radix Scutellariae, Calculus Bovis.
Dispel pain, treatment muscular soreness and skeleton pain: Herba Artemisiae Annuae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Saposhnikoviae.
Treatment outgoing disease: Radix Puerariae, Flos Caryophylli, Cortex Pseudolaricis, the Rhizoma Anemarrhenae, Radix Syzygii Buxifolii, Periostracum Serpentis.
But consider mutual reinforcement between and the mutual-assistance of Chinese medicine, and its attainable function, in known said medicine, except above-mentioned functions divides, often kind of medicine also can be used as other purposes, such as Radix aristolochiae tubiflorae is except can except heat-clearing and toxic substances removing, also can be used for treating skeleton pain; Cortex Phellodendri, except can be used for heat-clearing and toxic substances removing, also can be used for QI invigorating; Adeps Anser albifrons is except except heat-clearing and toxic substances removing, can also can be used for auxiliary treatment outgoing disease; Radix Polygoni Multiflori is except except heat-clearing and toxic substances removing, can also can be used for treatment outgoing disease; Radix Puerariae, except being used for the treatment of outgoing disease, can also moving back high heat, promote the production of body fluid, rash etc., can treat dengue fever and digestive tract disease; Radix Saposhnikoviae, except dispelling in addition to pain, also can be used for treating the headache in outgoing disease; Cortex Pseudolaricis, except can treating outgoing disease, also can be used for dispelling pain; The Radix Angelicae Dahuricae can cold expelling, sensible, pain relieving etc., can treat the symptom of dengue fever headache targetedly; Herba Artemisiae Annuae can antiinflammatory, antiviral, antipyretic, analgesia etc., effectively can improve the symptom of overall pain; Periostracum Serpentis, except the tic can treated in outgoing disease, erythra, also can be used for heat-clearing and toxic substances removing.
The beneficial effect that technical scheme provided by the invention is brought is: Chinese medicine of the present invention has effect of heat-clearing and toxic substances removing, adjustment QI and blood, QI invigorating, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., damp-clearing pain-relieving, the various outgoing disease of complete treatment, releasing focus, remove the basic cause of disease, specific aim is stronger, drug effect is gone directly focus, the cooperation of pulling together of multi-medicament, indispensable, realize the effect for the treatment of both the principal and secondary aspects of a disease, evident in efficacy; Adopt Chinese crude drug, medicine source is abundant, safe and effective, inexpensive, not easily produces drug resistance, makes simple, convenient drug administration, and patient is easy to accept.
Detailed description of the invention
A kind of Chinese medicine preparation for the treatment of dengue fever provided by the invention, its concrete ingredient and preparation process are as described in the following Examples.
Embodiment 1:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 20 parts, Cortex Phellodendri 20 parts, Radix Semiaquilegiae 15 parts, Adeps Anser albifrons 5 parts, Radix Polygoni Multiflori 10 parts, Radix Changii 10 parts, Flos Chrysanthemi 15 parts, Semen Oryzae 25 parts, Radix Curcumae 10 parts, 15 parts, Radix Glycyrrhizae, the Radix Aucklandiae 10 parts, Radix Bupleuri 5 parts, Radix Scutellariae 5 parts, Calculus Bovis 1 part, Herba Artemisiae Annuae 20 parts, the Radix Angelicae Dahuricae 10 parts, Fructus Forsythiae 15 parts, Radix Saposhnikoviae 10 parts, Radix Puerariae 5 parts, Flos Caryophylli 20 parts, Cortex Pseudolaricis 15 parts, the Rhizoma Anemarrhenae 6 parts, Radix Syzygii Buxifolii 1 part, Periostracum Serpentis 1 part.
The dosage form of described Chinese medicine is water preparation, and its preparation method comprises the following steps:
Step one, first by said medicine in inserting in marmite after the mixing of described ratio, add 3 times of water of said medicine weight, soak 45 minutes;
Step 2, to boil with very hot oven, then change slow fire and boil 20 minutes;
For subsequent use after step 3, medical filtration, medicinal residues add 3 times of water to be continued to be heated to boil, and changes and simmers in water 15 minutes, filtered while hot waste;
Step 4, merge twice concentrated medicament, be cooled to sterile packaged after room temperature, the medicine after encapsulation is finished product water preparation.
Embodiment 2:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 40 parts, Cortex Phellodendri 35 parts, Radix Semiaquilegiae 30 parts, Adeps Anser albifrons 15 parts, Radix Polygoni Multiflori 28 parts, Radix Changii 25 parts, Flos Chrysanthemi 25 parts, Semen Oryzae 45 parts, Radix Curcumae 22 parts, 40 parts, Radix Glycyrrhizae, the Radix Aucklandiae 20 parts, Radix Bupleuri 18 parts, Radix Scutellariae 20 parts, Calculus Bovis 15 parts, Herba Artemisiae Annuae 33 parts, the Radix Angelicae Dahuricae 28 parts, Fructus Forsythiae 40 parts, Radix Saposhnikoviae 18 parts, Radix Puerariae 35 parts, Flos Caryophylli 30 parts, Cortex Pseudolaricis 30 parts, the Rhizoma Anemarrhenae 18 parts, Radix Syzygii Buxifolii 8 parts, Periostracum Serpentis 20 parts.
The dosage form of described Chinese medicine is granule, and its concrete preparation process is:
Step one: described raw medicinal material is mixed in described ratio, cross 60 mesh sieves after grinding to form granule, be placed in and decoct marmite, add three times of water soakings of mixture weight, soak time is 20 minutes;
Step 2: be heated to boil, changes slow fire and boils 15 minutes, then isolate decoction liquor;
Step 3: after the water adding isolated medicinal residues weight three times repeats to boil, change slow fire and boil 15 minutes, then isolate decoction liquor;
Step 4: collect twice decoction liquor, centrifugalize, when being evaporated to 60 ~ 70 DEG C under vacuum 0.08 ~ 0.12Mpa, relative density is the mastic of 1.20 ~ 1.25, spraying dry, the inlet temperature 120 ~ 130 DEG C of spray dryer, leaving air temp 75 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 5: the beta-schardinger dextrin-adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.4 times in the dried cream powder obtained, makes granule, dry in 85 DEG C of environment, obtains granule.
Embodiment 3:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 25 parts, Cortex Phellodendri 22 parts, Radix Semiaquilegiae 20 parts, Adeps Anser albifrons 6 parts, Radix Polygoni Multiflori 15 parts, Radix Changii 15 parts, Flos Chrysanthemi 18 parts, Semen Oryzae 30 parts, Radix Curcumae 12 parts, 20 parts, Radix Glycyrrhizae, the Radix Aucklandiae 12 parts, Radix Bupleuri 8 parts, Radix Scutellariae 10 parts, Calculus Bovis 2 parts, Herba Artemisiae Annuae 25 parts, the Radix Angelicae Dahuricae 15 parts, Fructus Forsythiae 20 parts, Radix Saposhnikoviae 12 parts, Radix Puerariae 10 parts, Flos Caryophylli 22 parts, Cortex Pseudolaricis 18 parts, the Rhizoma Anemarrhenae 10 parts, Radix Syzygii Buxifolii 2 parts, Periostracum Serpentis 2 parts.
The dosage form of this Chinese medicine is granule, and its preparation method is with embodiment 1.
Embodiment 4:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 35 parts, Cortex Phellodendri 30 parts, Radix Semiaquilegiae 26 parts, Adeps Anser albifrons 12 parts, Radix Polygoni Multiflori 25 parts, Radix Changii 22 parts, Flos Chrysanthemi 22 parts, Semen Oryzae 40 parts, Radix Curcumae 20 parts, 35 parts, Radix Glycyrrhizae, the Radix Aucklandiae 18 parts, Radix Bupleuri 15 parts, Radix Scutellariae 15 parts, Calculus Bovis 12 parts, Herba Artemisiae Annuae 30 parts, the Radix Angelicae Dahuricae 25 parts, Fructus Forsythiae 35 parts, Radix Saposhnikoviae 16 parts, Radix Puerariae 25 parts, Flos Caryophylli 28 parts, Cortex Pseudolaricis 28 parts, the Rhizoma Anemarrhenae 16 parts, Radix Syzygii Buxifolii 6 parts, Periostracum Serpentis 10 parts.
The dosage form of this Chinese medicine is water preparation, and its preparation method is with embodiment 2.
Embodiment 5:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 28 parts, Cortex Phellodendri 25 parts, Radix Semiaquilegiae 22 parts, Adeps Anser albifrons 8 parts, Radix Polygoni Multiflori 18 parts, Radix Changii 18 parts, Flos Chrysanthemi 20 parts, Semen Oryzae 35 parts, Radix Curcumae 15 parts, 25 parts, Radix Glycyrrhizae, the Radix Aucklandiae 15 parts, Radix Bupleuri 10 parts, Radix Scutellariae 12 parts, Calculus Bovis 5 parts, Herba Artemisiae Annuae 26 parts, the Radix Angelicae Dahuricae 18 parts, Fructus Forsythiae 25 parts, Radix Saposhnikoviae 14 parts, Radix Puerariae 15 parts, Flos Caryophylli 25 parts, Cortex Pseudolaricis 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Syzygii Buxifolii 4 parts, Periostracum Serpentis 4 parts.
The dosage form of this Chinese medicine is granule, and its preparation method is with embodiment 1.
Embodiment 6:
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 30 parts, Cortex Phellodendri 28 parts, Radix Semiaquilegiae 25 parts, Adeps Anser albifrons 10 parts, Radix Polygoni Multiflori 22 parts, Radix Changii 20 parts, Flos Chrysanthemi 21 parts, Semen Oryzae 38 parts, Radix Curcumae 18 parts, 30 parts, Radix Glycyrrhizae, the Radix Aucklandiae 16 parts, Radix Bupleuri 12 parts, Radix Scutellariae 14 parts, Calculus Bovis 3 parts, Herba Artemisiae Annuae 28 parts, the Radix Angelicae Dahuricae 20 parts, Fructus Forsythiae 22 parts, Radix Saposhnikoviae 15 parts, Radix Puerariae 20 parts, Flos Caryophylli 26 parts, Cortex Pseudolaricis 25 parts, the Rhizoma Anemarrhenae 15 parts, Radix Syzygii Buxifolii 5 parts, Periostracum Serpentis 5 parts.
The dosage form of this Chinese medicine is granule, and its preparation method is with embodiment 1.
Said medicine is water preparation when taking, and every day 1 dose, decocting takes at twice, and every 7 days is a course for the treatment of; When using granules medicine of the present invention, after first pressing the encapsulation of 0.6g/ bag, then divide 2 times on the one, take for each 2 bags, every 7 days is a course for the treatment of.
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, 4 week age and 8 week age etc. count, and male and female half and half, body weight 12.26 ~ 23.22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 10 hours before experiment; (concentration is 8.56g crude drug/ml to the water preparation prepared by embodiments of the invention 6, maximum concentration) gavage, gavage volume is 4.52ml/kg(and unit dosage form is 38.69 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 8 hours, Continuous Observation 15 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 15 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.
Mouse oral gavage pill solution of the present invention LD50>38.69 crude drug/kg, every day, maximum dosage-feeding was 48.35 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.95g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 17g) oral administration gavage Chinese medicine of the present invention is 582 times of quantity.
From result, all animals are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable
Long term toxicity test: the water preparation of the embodiment of the present invention 3 is pressed 5.35,22.25 and 38.69g crude drug/kg continuous use 24 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 6 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 24 weeks and drug withdrawal are after 6 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: be proven, in the 78 routine medical records of to provide follow-up care for a patient so far for 2011, less than 20 years old 42 example, 20-40 year 26 examples, more than 40 years old 10 examples, about 20 years old mean age, the ill course of disease between 1-5 week, after taking medicament of the present invention, cure 76 examples completely, basic healing 2 example, invalid 0 example, therapeutic effect is very good.
Model case:
, 38 years old, female, in June, 2012 is ill, onset is anxious, initial shiver with cold endlessly, body temperature raises rapidly thereupon, be up to 40.3 DEG C, in certain hospitalize after five days, body temperature rapid drawdown is to normal, raise again again after 7th day, with headache, severe pain from head to foot, appetite declines simultaneously, weak all over, by discovery leukocyte of taking a blood sample, platelet die-offs, gingival hemorrhage is serious, be diagnosed as dengue fever, use the mode of ethanol cooling during western medical treatment and be equipped with low dose of adrenocortical hormone, to treat after ten days to no effect, after take two courses for the treatment of of Chinese medicine of the present invention after, temperature recovery is normal, leukocyte, platelet recovery is normal, taking another dose recovers substantially with after the course for the treatment of, consolidate and take drug withdrawal after the 5th course for the treatment of of this Chinese medicine, health is fully recovered, follow up a case by regular visits to so far without recurrence.
Lee, 12 years old, man, during morbidity there is erythra in various degree in health, hemoptysis is serious, and with high temperature, liver swells and ALT rising on inspection, and capillary fragility test is positive, headache situation is serious, and platelet counts is 5 × 109/L, is diagnosed as dengue fever, after taking three courses for the treatment of of Chinese medicine of the present invention, high temperature drops to low temperature, and platelet counts rises to 90 × 109/L, headache situation is alleviated, and recovers appetite, after three courses for the treatment of are taken in rear consolidation, all recover normal on inspection, and health is fully recovered, and follow up a case by regular visits to so far without recurrence.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. treat the preparation method of the Chinese medicine preparation of dengue fever for one kind, it is characterized in that, comprise the raw medicinal material of following ratio of weight and number: Radix aristolochiae tubiflorae 20-40 part, Cortex Phellodendri 20-35 part, Radix Semiaquilegiae 15-30 part, Adeps Anser albifrons 5-15 part, Radix Polygoni Multiflori 10-28 part, Radix Changii 10-25 part, Flos Chrysanthemi 15-25 part, Semen Oryzae 25-45 part, Radix Curcumae 10-22 part, Radix Glycyrrhizae 15-40 part, Radix Aucklandiae 10-20 part, Radix Bupleuri 5-18 part, Radix Scutellariae 5-20 part, Calculus Bovis 1-15 part, Herba Artemisiae Annuae 20-33 part, Radix Angelicae Dahuricae 10-28 part, Fructus Forsythiae 15-40 part, Radix Saposhnikoviae 10-18 part, Radix Puerariae 5-35 part, Flos Caryophylli 20-30 part, Cortex Pseudolaricis 15-30 part, Rhizoma Anemarrhenae 6-18 part, Radix Syzygii Buxifolii 1-8 part, Periostracum Serpentis 1-20 part,
The dosage form of described Chinese medicine is water preparation, and its preparation method comprises the following steps:
Step one, first by said medicine in inserting in marmite after the mixing of described ratio, add 2-5 times of water of said medicine weight, soak 40-50 minute;
Step 2, to boil with very hot oven, then change slow fire and boil 20 minutes;
For subsequent use after step 3, medical filtration, medicinal residues add 3-4 times of water to be continued to be heated to boil, and changes and simmers in water 15 minutes, filtered while hot waste;
Step 4, merge twice concentrated medicament, be cooled to sterile packaged after room temperature, the medicine after encapsulation is finished product water preparation.
2. the preparation method of the Chinese medicine preparation for the treatment of dengue fever according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 25-35 part, Cortex Phellodendri 22-30 part, Radix Semiaquilegiae 20-26 part, Adeps Anser albifrons 6-12 part, Radix Polygoni Multiflori 15-25 part, Radix Changii 15-22 part, Flos Chrysanthemi 18-22 part, Semen Oryzae 30-40 part, Radix Curcumae 12-20 part, Radix Glycyrrhizae 20-35 part, Radix Aucklandiae 12-18 part, Radix Bupleuri 8-15 part, Radix Scutellariae 10-15 part, Calculus Bovis 2-12 part, Herba Artemisiae Annuae 25-30 part, Radix Angelicae Dahuricae 15-25 part, Fructus Forsythiae 20-35 part, Radix Saposhnikoviae 12-16 part, Radix Puerariae 10-25 part, Flos Caryophylli 22-28 part, Cortex Pseudolaricis 18-28 part, Rhizoma Anemarrhenae 10-16 part, Radix Syzygii Buxifolii 2-6 part, Periostracum Serpentis 2-10 part.
3. the preparation method of the Chinese medicine preparation for the treatment of dengue fever according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 28 parts, Cortex Phellodendri 25 parts, Radix Semiaquilegiae 22 parts, Adeps Anser albifrons 8 parts, Radix Polygoni Multiflori 18 parts, Radix Changii 18 parts, Flos Chrysanthemi 20 parts, Semen Oryzae 35 parts, Radix Curcumae 15 parts, 25 parts, Radix Glycyrrhizae, the Radix Aucklandiae 15 parts, Radix Bupleuri 10 parts, Radix Scutellariae 12 parts, Calculus Bovis 5 parts, Herba Artemisiae Annuae 26 parts, the Radix Angelicae Dahuricae 18 parts, Fructus Forsythiae 25 parts, Radix Saposhnikoviae 14 parts, Radix Puerariae 15 parts, Flos Caryophylli 25 parts, Cortex Pseudolaricis 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Syzygii Buxifolii 4 parts, Periostracum Serpentis 4 parts.
4. the preparation method of the Chinese medicine preparation for the treatment of dengue fever according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix aristolochiae tubiflorae 30 parts, Cortex Phellodendri 28 parts, Radix Semiaquilegiae 25 parts, Adeps Anser albifrons 10 parts, Radix Polygoni Multiflori 22 parts, Radix Changii 20 parts, Flos Chrysanthemi 21 parts, Semen Oryzae 38 parts, Radix Curcumae 18 parts, 30 parts, Radix Glycyrrhizae, the Radix Aucklandiae 16 parts, Radix Bupleuri 12 parts, Radix Scutellariae 14 parts, Calculus Bovis 3 parts, Herba Artemisiae Annuae 28 parts, the Radix Angelicae Dahuricae 20 parts, Fructus Forsythiae 22 parts, Radix Saposhnikoviae 15 parts, Radix Puerariae 20 parts, Flos Caryophylli 26 parts, Cortex Pseudolaricis 25 parts, the Rhizoma Anemarrhenae 15 parts, Radix Syzygii Buxifolii 5 parts, Periostracum Serpentis 5 parts.
5. the preparation method of the Chinese medicine preparation for the treatment of dengue fever according to claim 1 and 2, is characterized in that, adds 3 times of water of drug weight in described step one, soaks 45 minutes.
Priority Applications (1)
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| CN104771483A (en) * | 2015-05-02 | 2015-07-15 | 淄博齐鼎立专利信息咨询有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing dengue virus infection |
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| CN110279823B (en) * | 2019-06-28 | 2021-08-06 | 广州市第八人民医院 | Traditional Chinese medicine composition for treating dengue fever and preparation method thereof |
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