CN104940793A - Chinese material medicine preparation for treating dengue fever and preparation method thereof - Google Patents
Chinese material medicine preparation for treating dengue fever and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a Chinese material medicine preparation for treating dengue fever and a preparation method thereof. The Chinese material medicine preparation is prepared by bezoar, honeysuckle, coptis chinensis, folium isatidis, lalang grass rhizome, semen coicis, fructus amomi, the roots of Chinese thorowax, radix scrophulariae and liquorice. The Chinese material medicine preparation is reasonable in formula and easy to prepare, has remarkable treating effects of clearing away heat and toxic materials, invigorating spleen to eliminate dampness and eliminating phlegm and fever and is an effective medicine especially for eliminating dampness, fever and repression and treating dengue.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind ofly treat Chinese medicine preparation of Dengue calentura and preparation method thereof.
Background technology
Dengue fever is caused by dengue virus, through the acute infectious disease that mosquito matchmaker propagates.Primary disease can be fallen ill in tropical and subtropical region throughout the year, is Seasonal Incidence in China, mainly concentrates on 3-11 month, and wherein 7-9 month is the high-incidence season, multiple on the south coastal areas of southern China area, the Changjiang river, is that popularity or fulminant are popular.Along with global warming, urban population excessively increases, and city size expands rapidly and worsens with environmental health, and dengue fever occurs expanding pandemic trend.Dengue fever is clinical in projection heating, and whole-body muscle, bone, arthralgia are extremely tired, erythra, lymphadenectasis and leukopenia are feature, and some patients can with the symptom of digestive tract such as nausea,vomiting,diarrhea, stomachache, the life and health of serious threat patient.
The name of disease of dengue fever is there is no in motherland's medical science, but according to its Epidemiology and clinical characters, at present, medical circles generally believe that primary disease can belong to " pestilence " category of " epidemic febrile disease caused by summerheat and dryness " or " epidemic disease caused by damp-heat pathogen " in science of epidemic febrile disease of Chinese medicine, and its basic pathogenesis is invade in epidemic disease poison, diseases caused by exogenous pathogenic factor are damp and hot, epidemic disease caused by damp-heat pathogen poison is staggered, and heat steams wet dynamic or excessive noxious heat, the absurd row of forcing blood, noxious dampness knot, gas Tianjin two is hindered, and causes visceral dysfunction, occurs comparatively complicated deteriorated case.
To modern medicine, as a kind of arbovirus sexually transmitted disease, dengue fever mainly takes Supporting Therapy to the ill, and doctor trained in Western medicine there is no vaccine and specific treatment medicine safely and effectively and comes out.Therefore, the preventing and controlling of dengue fever are also faced with huge challenge.Chinese medicine is with a long history, defines perfect theoretical system, have accumulated abundant clinical experience in control acute infectious disease.Based on this kind of situation; play the advantage of Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; invention, the Chinese medicine preparation finding treatment dengue fever determined curative effect; improve the overall Level of first-aid treatment of dengue fever; the life security of protection broad masses of the people; be of great immediate significance, Developing TCM cause is also had great importance.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of Chinese medicine preparation for the treatment of dengue fever and preparation method thereof.
An object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of dengue fever.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of dengue fever.
The present invention treats the Chinese medicine preparation of dengue fever; its active ingredient is made up of the crude drug of following weight proportion: Calculus Bovis 13-17 part; Flos Lonicerae 10-12 part, Rhizoma Coptidis 2-4 part, Folium Isatidis 6-8 part; Rhizoma Imperatae 8-12 part; Semen Coicis 10-12 part, Fructus Amomi 3-5 part, Radix Bupleuri 4-6 part; Radix Scrophulariae 7-9 part, Radix Glycyrrhizae 5-8 part.
Optimal technical scheme of the present invention is that Chinese medicine preparation of the present invention is obtained by the crude drug of following weight proportion: Calculus Bovis 15 parts, Flos Lonicerae 11 parts, Rhizoma Coptidis 3 parts, Folium Isatidis 7 parts; Rhizoma Imperatae 10 parts, Semen Coicis 11 parts, Fructus Amomi 4 parts; Radix Bupleuri 5 parts, Radix Scrophulariae 8 parts, 6 parts, Radix Glycyrrhizae.
The Chinese medicine preparation that the present invention treats dengue fever can also contain pharmaceutically acceptable carrier, is prepared into conventional formulation, as tablet, capsule, pill or granule, is preferably granule.
The Chinese medicine preparation preparation method step that the present invention treats dengue fever is as follows: take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 6-8 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3-4 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Be prepared into pharmaceutically acceptable preparation according to a conventional method again.
The present invention relatively and prior art, has following clear superiority:
First, Chinese medicine preparation prescription of the present invention mainly develops according to the pathogenic characteristic of dengue fever, Calculus Bovis in side, Flos Lonicerae, Rhizoma Coptidis, heat-clearing and toxic substances removing, heat radiation of eliminating the phlegm; Folium Isatidis, Rhizoma Imperatae, Radix Scrophulariae, heat-clearing and toxic substances removing, cooling blood for hemostasis; Semen Coicis, Fructus Amomi, spleen invigorating eliminating dampness by diuresis, removing dampness is whetted the appetite; Radix Bupleuri, induces sweat and brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Radix Glycyrrhizae, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, and heat-clearing and toxic substances removing is played, invigorating the spleen for eliminating dampness altogether by full side, the special effect of heat radiation of eliminating the phlegm, to dengue fever particularly the damp and hot card dengue fever that checks have extremely strong specific aim curative effect, and onset is rapid, treating both the principal and secondary aspects of a disease.
Secondly, Chinese medicine preparation of the present invention adopts sophisticated equipment and technique preparation, and dosage form is advanced, and taking convenience, patient tolerability is strong.
3rd, after 1 course for the treatment of of clinical observation, total effective rate comparison therapy group 93.02%, matched group 67.4%, two groups of total effective rates compare, and treatment group has more significantly clinical efficacy, has and studies and the value applied further.
Further, in Chinese medicine preparation of the present invention, the function of each crude drug cures mainly:
Calculus Bovis, bitter in the mouth; Sweet; Cool in nature.GUIXIN, Liver Channel.Clear away heart-fire cool liver; Eliminate phlegm for resuscitation; Heat-clearing and toxic substances removing.Main calentura coma; Apoplexy key closes; Infantile convulsion is twitched; Acute infantile convulsion; Swelling throat is rotten; Aphtha of the mouth and tongue; Carbuncle furunculosis.
Flos Lonicerae, sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Rhizoma Coptidis, property is bitter, cold.Enter the heart, liver, stomach, large intestine channel.Pathogenic fire purging, dampness, removing toxic substances, parasite killing.Row pyretic toxicity when controlling, typhoid fever, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, and lung knot is pressed, and tells, is defeated in battle, hematochezia, quench one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.
Folium Isatidis, bitter, cold.Enter liver, the heart, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Rhizoma Imperatae, sweet, cold.Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Semen Coicis is sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Fructus Amomi, acrid in the mouth; Warm in nature.Return spleen, stomach, kidney channel.Removing dampness is whetted the appetite; It is antiabortive that promoting the circulation of QI to alleviate the stagnation in middle-JIAO is warming spleen and stopping diarrha.Main retention of damp leading to blockage of QI; Distension and fullness in the abdomen; Anorexia; Nausea and vomiting; Stomachache is had loose bowels pregnancy reactions; Frequent fetal movement
Radix Bupleuri, bitter in the mouth; Pungent; Cold nature.Return liver; Gallbladder meridian.Induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Main fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis.
Radix Scrophulariae, sweet, bitter, salty, be slightly cold.Return lung, stomach, kidney channel.Removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tablet
The each crude drug of the present invention is taken: Calculus Bovis 15 parts, Flos Lonicerae 11 parts, Rhizoma Coptidis 3 parts, Folium Isatidis 7 parts, Rhizoma Imperatae 10 parts, Semen Coicis 11 parts, Fructus Amomi 4 parts, Radix Bupleuri 5 parts, Radix Scrophulariae 8 parts, 6 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 7 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Add the magnesium stearate of 1%, mix to obtain slow release layer granule, tabletting, Hardness Control is at 5.7kg/mm
2, namely coating obtains Tablets.
When using Chinese medicine preparation of the present invention to treat dengue fever, take prepared tablet, every sheet is containing crude drug amount 0.15g, and each 3-4 sheet, every day 3 times, takes after meal half an hour.
Embodiment 2 capsule
The each crude drug of the present invention is taken: Calculus Bovis 15 parts, Flos Lonicerae 11 parts, Rhizoma Coptidis 3 parts, Folium Isatidis 7 parts, Rhizoma Imperatae 10 parts, Semen Coicis 11 parts, Fructus Amomi 4 parts, Radix Bupleuri 5 parts, Radix Scrophulariae 8 parts, 6 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 7 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Make wetting agent with 50% ethanol, be uniformly mixed agent and become soft material, 30 mesh sieves are granulated; Drying, granulate, mix homogeneously incapsulates and obtains capsule of the present invention.
When using Chinese medicine preparation of the present invention to treat dengue fever, take prepared capsule, every contains crude drug amount 0.15g, and every day 3 times, each 3-4 grain, takes after meal half an hour.
Embodiment 3 granule
The each crude drug of the present invention is taken: Calculus Bovis 15 parts, Flos Lonicerae 11 parts, Rhizoma Coptidis 3 parts, Folium Isatidis 7 parts, Rhizoma Imperatae 10 parts, Semen Coicis 11 parts, Fructus Amomi 4 parts, Radix Bupleuri 5 parts, Radix Scrophulariae 8 parts, 6 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 7 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Add the adjuvant soft materials such as appropriate mannitol, make wet granular and cross 40 mesh sieves, dry, granulate, sieves again, and granule of the present invention is packed and obtained in pack.
When using Chinese medicine preparation of the present invention to treat dengue fever, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4 granule
The each crude drug of the present invention is taken: Calculus Bovis 13 parts, Flos Lonicerae 10 parts, Rhizoma Coptidis 2 parts, Folium Isatidis 6 parts, Rhizoma Imperatae 8 parts, Semen Coicis 10 parts, Fructus Amomi 3 parts, Radix Bupleuri 4 parts, Radix Scrophulariae 7 parts, 5 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 6 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Add the adjuvant soft materials such as appropriate mannitol, make wet granular and cross 40 mesh sieves, dry, granulate, sieves again, and granule of the present invention is packed and obtained in pack.
When using Chinese medicine preparation of the present invention to treat dengue fever, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 5 granule
The each crude drug of the present invention is taken: Calculus Bovis 17 parts, Flos Lonicerae 12 parts, Rhizoma Coptidis 4 parts, Folium Isatidis 8 parts, Rhizoma Imperatae 12 parts, Semen Coicis 12 parts, Fructus Amomi 5 parts, Radix Bupleuri 6 parts, Radix Scrophulariae 9 parts, 8 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight portion and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Add the adjuvant soft materials such as appropriate mannitol, make wet granular and cross 40 mesh sieves, dry, granulate, sieves again, and granule of the present invention is packed and obtained in pack.
When using Chinese medicine preparation of the present invention to treat dengue fever, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
The clinical observation of embodiment 6 Chinese medicine preparation treatment of the present invention dengue fever
1, clinical data:
Select hospital outpatient and ward to be diagnosed as damp and hot checking and demonstrate,prove dengue fever 86 example.Wherein man 47 example, female 39 example; The oldest 71 years old, minimum 19 years old, 35 years old mean age; Disease time is the shortest 2 days, the longest 7 days.Be divided into treatment group and each 43 examples of matched group at random.Western medicine diagnose standard is with reference to the Diagnosis of Infectious Diseases standard (trying) of " People's Republic of China's law on the prevention and control of infectious diseases " regulation management that August nineteen ninety, Ministry of Public Health was formulated.Allly meet Western medicine diagnose standard, Chinese medical discrimination is damp and hotly check card, and withdraws at viewing duration and to treat relevant other Chinese and western drugses (especially not using antipyretic analgesic) with primary disease and be and include the object of observation in.All patients are all with onset of generating heat, and wherein companioned with headache person 52 example, muscle, the joint person of aching 23 example, companion erythra person 12 example, flushing conjunctival congestion person 18 is routine.Lab testing: leukocyte < 4.0 × 10
9/ L72 example, the lowest is 1.1 × 10
9/ L; Platelet < 100 × 10
9/ L76 example, the lowest is 60 × 10
9/ L.
Damp and hot check card disease see: damp and hot all weights, heating, indistinctive fever, not aversion to cold, limbs are heavy miserable, indigestion and loss of appetite, chest distress, singultus or vomiting, oliguria with reddish urine, red tongue, and thick, yellow and greasy fur is turbid, soft and rapid pulse.
2, exclusion standard:
(1) allergic constitution or to drug allergy persons such as Chinese medicines;
(2) trimester of pregnancy or women breast-feeding their children;
(3) psychotic;
(4) merge intentionally, brain, liver, the serious protopathy person such as kidney and hemopoietic system.
3, reject, the case that comes off standard:
(1) find after entering group to include the object person that do not meet inclusive criteria in;
(2) include object in after entering group and interrupt this research approach process person;
(3) duration of test generation severely adverse event or change of illness state can not continual cure persons.
4, Therapeutic Method:
Matched group: give vitamin C 2.0g and add ringer's solution 500ml iv drip from staying sight, every day 1 time.
Treatment group: add granule prepared by the embodiment of the present invention 3 on matched group basis, containing crude drug amount 0.5g, every day 2 times, each 1 bag, takes for every bag after meal half an hour.
5, efficacy determination:
Effective: clinical symptoms and the whole or most of disappearance of sign, platelet, leukocyte recover normally or obviously to improve.
Effective: clinical symptoms and sign are alleviated, platelet, leukocyte recover slower.
Invalid: clinical symptoms and sign are all without improving.
Total effective rate=obvious effective rate+effective percentage.
6, therapeutic effect:
86 routine patients all complete clinical observation, without coming off, exiting case.
Treat and carry out observation and comparison to the therapeutic effect of two groups of patients after 4 days, the routine patient for the treatment of group 43,29 examples are effective, 11 examples effectively, 3 examples are invalid, total effective rate 93.02%, the routine patient of matched group 43,10 examples are effective, effectively, 14 examples are invalid, total effective rate 67.4% for 19 examples, effective number of cases and total effective rate, treatment group is obviously better than matched group.
Two groups of fever times compare and see the following form:
| Number of cases | The course of disease (d) | Fever time (d) | |
| Treatment group | 43 | 4.63±1.65 | 2.07±1.26 |
| Matched group | 43 | 4.87±1.89 | 3.34±2.15 |
Above-mentioned clinical effectiveness shows, using Chinese medicine preparation of the present invention to treat, dengue fever is particularly damp and hot checks card Dengue calentura, can effectively alleviate patients symptomatic's sign, shorten the course of disease, determined curative effect, obvious effective rate is high, be a kind of ideal medicament for the treatment of Dengue calentura, be worth studying and applying further.
Claims (7)
1. treat the Chinese medicine preparation of dengue fever for one kind; it is characterized in that, it is obtained by the crude drug of following weight portion: Calculus Bovis 13-17 part, Flos Lonicerae 10-12 part; Rhizoma Coptidis 2-4 part; Folium Isatidis 6-8 part, Rhizoma Imperatae 8-12 part, Semen Coicis 10-12 part; Fructus Amomi 3-5 part; Radix Bupleuri 4-6 part, Radix Scrophulariae 7-9 part, Radix Glycyrrhizae 5-8 part.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Calculus Bovis 15 parts, Flos Lonicerae 11 parts; Rhizoma Coptidis 3 parts, Folium Isatidis 7 parts, Rhizoma Imperatae 10 parts, Semen Coicis 11 parts; Fructus Amomi 4 parts, Radix Bupleuri 5 parts, Radix Scrophulariae 8 parts, 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation as described in claim 1 or 2, is characterized in that, described Chinese medicine preparation is tablet, capsule, pill or granule.
4. the Chinese medicine preparation as described in claim 3, it is characterized in that, described Chinese medicine preparation is preferably granule.
5. the Chinese medicine preparation as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine preparation comprises following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 6-8 times amount, soak 2h, decoct 3h, filter; Medicinal residues add water 3-4 times amount, decoct 2h, filter; Merge twice decoction liquor, again filter; When filtrate is concentrated into 75 DEG C, relative density is the extractum of 1.11 ~ 1.21, dry, pulverize into fine powder, crosses 150 mesh sieves; Be prepared into pharmaceutically acceptable preparation according to a conventional method again.
6. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in the medicine of preparation treatment dengue fever.
7. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in the damp and hot medicine checking card dengue fever of preparation treatment.
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| CN105920380A (en) * | 2016-04-13 | 2016-09-07 | 林家希 | Repair traditional Chinese medicine used for treating blood cell infected by flaviviridae |
| CN105902619A (en) * | 2016-06-08 | 2016-08-31 | 广州中医药大学 | Traditional Chinese medicine composition for treating I-type dengue virus infection and preparation method thereof |
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| CN105943981A (en) * | 2016-06-15 | 2016-09-21 | 林二洪 | Traditional Chinese medicine composition for treating dengue |
| CN110201068A (en) * | 2018-02-28 | 2019-09-06 | 广州王老吉药业股份有限公司 | The application of a kind of gram of sense relieving sore-throat composition or preparation in preparation prevention and treatment dengue fever medicine |
| CN110201068B (en) * | 2018-02-28 | 2022-01-28 | 广州王老吉药业股份有限公司 | Application of Kegan Liyan composition or preparation in preparation of medicine for preventing and treating dengue fever |
| CN110279823A (en) * | 2019-06-28 | 2019-09-27 | 广州市第八人民医院 | A kind of Chinese medicine composition and preparation method thereof for treating dengue fever |
| CN110279823B (en) * | 2019-06-28 | 2021-08-06 | 广州市第八人民医院 | Traditional Chinese medicine composition for treating dengue fever and preparation method thereof |
| JP2021046366A (en) * | 2019-09-18 | 2021-03-25 | 救心製薬株式会社 | Pharmaceutical uses of toad venom and oriental bezoar |
| JP7376871B2 (en) | 2019-09-18 | 2023-11-09 | 救心製薬株式会社 | Medical uses of Senso and Goou |
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