CN103599473B - Traditional Chinese medicinal composition for treating dizziness and chest distress - Google Patents
Traditional Chinese medicinal composition for treating dizziness and chest distress Download PDFInfo
- Publication number
- CN103599473B CN103599473B CN201310517944.1A CN201310517944A CN103599473B CN 103599473 B CN103599473 B CN 103599473B CN 201310517944 A CN201310517944 A CN 201310517944A CN 103599473 B CN103599473 B CN 103599473B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- dizziness
- chest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000002173 dizziness Diseases 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 206010008479 Chest Pain Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract description 49
- 229940079593 drug Drugs 0.000 claims abstract description 18
- 240000002943 Elettaria cardamomum Species 0.000 claims abstract description 10
- 235000005300 cardamomo Nutrition 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 11
- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 6
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 244000001632 Acorus gramineus Species 0.000 abstract 1
- 235000013073 Acorus gramineus Nutrition 0.000 abstract 1
- 241001127714 Amomum Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000163122 Curcuma domestica Species 0.000 abstract 1
- 241000804384 Cynomorium songaricum Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 13
- 208000024172 Cardiovascular disease Diseases 0.000 description 12
- 208000026106 cerebrovascular disease Diseases 0.000 description 12
- 238000009835 boiling Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020601 Hyperchlorhydria Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A traditional Chinese medicinal composition for treating dizziness and chest distress relates to the technical field of Chinese herbal medicines. The traditional Chinese medicinal composition comprises the following bulk drugs: by weight, 35-45 parts of rhizoma atractylodis, 35-45 parts of Rhizoma Alismatis, 15-25 parts of red sage root, 25-35 parts of Ligusticum wallichii, 5-15 parts of grass-leaved sweetflag rhizome, 25-35 parts of root of kudzu vine, 10-20 parts of notopterygium root, 10-20 parts of Villous Amomum Fruit, 10-20 parts of bighead atractylodes rhizome, 25-35 parts of Tuber of Dwarf Lilyturf, 5-15 parts of roud cardamon seed, 5-15 parts of cuttlebone, 5-15 parts of Chinese angelica, 10-20 parts of cynomorium songaricum, 25-35 parts of matrimony vine, 5-15 parts of radix bupleuri and 25-35 parts of curcuma tuber. The traditional Chinese medicinal composition provided by the invention has characteristics of easily-obtained materials, simple production, low cost, good practicality and the like, is used for treating phenomena such as dizziness, chest distress and the like caused by heart and cerebral vusculer diseases, and has very good curative effects.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind ofly be used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest.
Background technology
The health of people in the cardiovascular and cerebrovascular disease serious threats such as cerebral thrombosis, cerebral ischemia, coronary heart diseases and angina pectoris, myocardial ischemia, heart failure, arrhythmia, learn according to Epidemiological study, the M & M of cardiovascular and cerebrovascular disease is all in rising trend in recent years, in worldwide, the sickness rate of cardiovascular and cerebrovascular disease is 140-200,/10 ten thousand people, its average mortality is lOO/10 ten thousand people, has leapt to first of various disease at the mortality rate of China's cardiovascular and cerebrovascular disease.In the pathogenic factor of cardiovascular and cerebrovascular disease, atherosclerosis is main cause, and it is the pathogenesis basis of hypertension, coronary heart disease, myocardial infarction, apoplexy cardiovascular and cerebrovascular disease.Suppressing blood coagulation, improve blood fluidity, is one of key areas of cardiovascular medicament research and development.
In the pathogenic process of cardiovascular and cerebrovascular disease; normal meeting is along with phenomenons such as dizzy, uncomfortable in chest, soreness of the waist and knees; at present in the repair process of this kind of disease; Chinese medicine and western medicine is all applied; Chinese medicine is little and occupy the larger market share with its toxic and side effects, but its curative effect not rapidly, effective ingredient is not obvious, medication dose is large.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, and safe and reliable is used for the treatment of dizzy, uncomfortable in chest Chinese medicine composition.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of dizziness, a Chinese medicine composition uncomfortable in chest, the medicament be made up of the crude drug of following weight portion,
Rhizoma Atractylodis 35-45 part, Rhizoma Alismatis 35-45 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Chuanxiong 25-35 part, Rhizoma Acori Graminei 5-15 part, Radix Puerariae 25-35 part, Rhizoma Et Radix Notopterygii 10-20 part, Fructus Amomi 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Ophiopogonis 25-35 part, roud cardamon seed 5-15 part, Endoconcha Sepiae 5-15 part, Radix Angelicae Sinensis 5-15 part, Herba Cynomorii 10-20 part, Fructus Lycii 25-35 part, Radix Bupleuri 5-15 part, Radix Curcumae 25-35 part.
Preferred weight part of each crude drug is:
Rhizoma Atractylodis 40 parts, Rhizoma Alismatis 40 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 30 parts, Rhizoma Acori Graminei 10 parts, Radix Puerariae 30 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Amomi 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 30 parts, roud cardamon seed 10 parts, Endoconcha Sepiae 10 parts, Radix Angelicae Sinensis 10 parts, Herba Cynomorii 15 parts, Fructus Lycii 30 parts, Radix Bupleuri 10 parts, Radix Curcumae 30 parts.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each crude drug is taken by following parts by weight: Rhizoma Atractylodis 40 parts, Rhizoma Alismatis 40 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 30 parts, Rhizoma Acori Graminei 10 parts, Radix Puerariae 30 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Amomi 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 30 parts, roud cardamon seed 10 parts, Endoconcha Sepiae 10 parts, Radix Angelicae Sinensis 10 parts, Herba Cynomorii 15 parts, Fructus Lycii 30 parts, Radix Bupleuri 10 parts, Radix Curcumae 30 parts.
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, can add after preparation commonly uses adjuvant or carrier in decoction, preparations shaping, obtains pill, capsule or tablet.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: decoction, gets a pair and takes herb liquid, each oral 120-150 milliliter, one day twice, and sub-service sooner or later 7 days is a course for the treatment of; Pill or capsule or tablet, once two balls/sheet, twice on the one 7 days is a course for the treatment of.
Pharmacology analysis:
Rhizoma Atractylodis: meridian distribution of property and flavor: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.
Rhizoma Alismatis: be used for the treatment of by deficiency of kidney yin (deficiency of the kidney yin), the kidney high Sheng of fire and cause seminal emission, spermatorrhea, the syndrome such as dizzy, getting it has the effect of rushing down kidney fire.
Radix Salviae Miltiorrhizae: Gui Jing: the popular feeling, Liver Channel.Function: promoting blood circulation to remove obstruction in the collateral, relieving restlessness clears away heart-fire.
Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.
Rhizoma Acori Graminei: function: sensible expectorant, refreshment brain-strengthening, appetizing of drying.Cure mainly: coma epilepsy, forgetful deafness, gastral cavity feeling of fullness is vexed not hungry, a mouthful dysentery of keeping silent.
Radix Puerariae: property feeble QI, taste is micro-bitter.Cure mainly: table disease fever without perspiration, rigidity pain on the head and nape, calentura is thirsty, quenches one's thirst, and macule is not saturating, diarrhea due to hypofunction of the spleen.Better to symptom effects such as improvement headache, dizziness, stiffness of the nape, tinnitus, numb limbs and tense tendons.
Rhizoma Et Radix Notopterygii: function: dispersing wind and cold is wet, pain relieving.Cure mainly: cold, headache, general pain, rheumatic arthralgia.
Fructus Amomi: function: resolving depression of regulating the flow of vital energy, appetite-stimulating indigestion-relieving.Be used for the treatment of cold of insufficiency type and stomachache, strengthen analgesic effect.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Function: invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic; Reduce phlegm, hidroschesis.
Radix Ophiopogonis: nature,taste and action: sweet, micro-hardship, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat.
Roud cardamon seed: regulating the flow of QI to ease the stomach, dry cold-damp, alcoholic intoxication.To treat for stomachache the disease such as abdominal distention, eructation regurgitation.
Endoconcha Sepiae: salty in the mouth, puckery, warm in nature.Return liver, kidney channel.There is the function for the treatment of spontaneous emission and leukorrhagia, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Enrich blood; Invigorate blood circulation.
Herba Cynomorii: beneficial smart shape sun, moisturize laxation, nourishing muscle and tendon.
Fructus Lycii: Gui Jing: return liver; Kidney; Lung meridian.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight; For chronic consumptive disease damage of essence, soreness of waist and knee joint; Vertigo and tinnitus, interior-heat Xiao are thirsty, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Bupleuri: enter liver, gallbladder meridian.Dredge gas, resolving depression, loose fire.
Radix Curcumae: enter the heart, liver lung meridian.To have a respite resolving depression, removing heat from blood removing blood stasis with potent drugs, function of gallbladder promoting.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:
Medicine: the decoction boiled by prescription of the present invention, saves backup in refrigerator, is provided by The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine.
Experimental animal: white mice, body weight is at 30-50g, and male and female Stochastic choice, is provided by Medical University Of Anhui.
Method and result: get white mice 50, be divided into 5 groups, often organize 10, hungry 15 hours, fill with medicine feed thing by every only each 20ml, in 24 hours, fill with medicine feed thing respectively 1,2,3,4,5 times for the 1st, 2,3,4,5 group, observe 5 days, white mice is movable normal, non-toxic reaction, without dead.Wherein white mice dosage is by kg body weight medicine calculation, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat, is provided by Medical University Of Anhui.
Method and result: get rat 50, be divided into 5 groups, often organize 10, wherein the 1st, 2, 3, 4 groups as administration group, often organize and fill with medicine feed thing 15ml respectively, 20ml, 30ml, 40ml, 5th group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, visible by the dosage equal non-toxic reaction of kg body weight calculating relative to clinical 50-200 times, a kind of safe drugs.
3. diagnostic criteria
1) symptom and sign: suffer from cardiovascular and cerebrovascular disease, regular dizziness, uncomfortable in chest, soreness of the waist and knees.
2) in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by random selecting wherein 100 routine patients, the course for the treatment of is the shortest 7 days, and the longest is 6 months.
3) Therapeutic Method
According to drug ratios of the present invention, take raw material (dose), obtain medicinal liquid according to the method for usually boiling medicine, every day potion, sooner or later service once, taking 7 days is a course for the treatment of.
4) efficacy determination: adopt four grade standards;
Recovery from illness clinical improvements rate >=3%, effective clinical improvements rate >=54%, effective clinical improvement rate >=40%, invalid clinical improvements rate >=3%, concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 100 | 3 | 54 | 40 | 3 | 97 |
The invention has the beneficial effects as follows: the present invention draws materials easily, make the features such as simple, with low cost, practicality is good, be used for the treatment of the dizziness occurred in cardiovascular and cerebrovascular disease, the phenomenon such as uncomfortable in chest, there is extraordinary curative effect.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Rhizoma Atractylodis 40 parts, Rhizoma Alismatis 40 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 30 parts, Rhizoma Acori Graminei 19 parts, Radix Puerariae 30 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Amomi 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 30 parts, roud cardamon seed 10 parts, Endoconcha Sepiae 10 parts, Radix Angelicae Sinensis 10 parts, Herba Cynomorii 15 parts, Fructus Lycii 30 parts, Radix Bupleuri 10 parts, Radix Curcumae 30 parts by following parts by weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Instruction: decoction, gets a pair and takes herb liquid, oral 150 milliliters at every turn, one day twice, and sub-service sooner or later 7 days is a course for the treatment of.
Embodiment 2
Each crude drug is taken: Rhizoma Atractylodis 35 parts, Rhizoma Alismatis 35 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 25 parts, Rhizoma Acori Graminei 5 parts, Radix Puerariae 25 parts, Rhizoma Et Radix Notopterygii 10 parts, Fructus Amomi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Ophiopogonis 25 parts, roud cardamon seed 5 parts, Endoconcha Sepiae 5 parts, Radix Angelicae Sinensis 5 parts, Herba Cynomorii 10 parts, Fructus Lycii 25 parts, Radix Bupleuri 5 parts, Radix Curcumae 25 parts by following parts by weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, add after preparation commonly uses adjuvant or carrier in decoction, preparations shaping, obtains pill.Within 1st, take twice, each 2 balls, sub-service sooner or later 7 days is a course for the treatment of.
Embodiment 3
Each crude drug is taken: Rhizoma Atractylodis 45 parts, Rhizoma Alismatis 45 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Chuanxiong 35 parts, Rhizoma Acori Graminei 15 parts, Radix Puerariae 35 parts, Rhizoma Et Radix Notopterygii 20 parts, Fructus Amomi 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Ophiopogonis 35 parts, roud cardamon seed 15 parts, Endoconcha Sepiae 15 parts, Radix Angelicae Sinensis 15 parts, Herba Cynomorii 20 parts, Fructus Lycii 35 parts, Radix Bupleuri 15 parts, Radix Curcumae 35 parts by following parts by weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction; Instruction: decoction, gets a pair and takes herb liquid, oral 120 milliliters at every turn, one day twice, and sub-service sooner or later 7 days is a course for the treatment of.
Model case
Case 1
Permitted certain, man, 59 years old, people from Lixin County, Anhui Province, suffer from cardiovascular and cerebrovascular disease, often feel dizzy, uncomfortable in chest, have Western medicine control always, but all do not have radical cure.After taking 2 courses for the treatment of of decoction of formula preparation of the present invention, the number of times of generation dizzy, uncomfortable in chest obviously reduces, after take again 2 courses for the treatment of continuously after, phenomenon dizzy, uncomfortable in chest there is no generation.
Case 2
Journey so-and-so, man, 42 years old, individual enterprise boss.Suffer from cardiovascular and cerebrovascular disease, through treating rehabilitation substantially.But after leaving hospital, there is dizzy, phenomenon uncomfortable in chest in occasional, is never controlled effectively.Take pill prepared by the present invention afterwards continuously, within 1st, take twice, each 2 balls, sub-service sooner or later, work clothes 2 courses for the treatment of, phenomenon dizzy, uncomfortable in chest does not occur so far.
Case 3
Pan, the phenomenons such as female, 65 years old, suffers from cardiovascular and cerebrovascular disease, and the hands on the left side and lower limb all inconvenient activity, often feel soreness of the waist and knees, dizzy.After taking 2 courses for the treatment of of decoction of formula preparation of the present invention, obviously sensation spirit how, and dizzy number of times significantly reduces.After taken again 4 courses for the treatment of continuously, the phenomenon such as dizziness, soreness of the waist and knees no longer occurs so far, and the limbs of inconvenient activity also can take some things in the past, and life can have been taken care of oneself.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. one kind is used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest, it is characterized in that, the medicament be made up of the crude drug of following weight portion: Rhizoma Atractylodis 35-45 part, Rhizoma Alismatis 35-45 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Chuanxiong 25-35 part, Rhizoma Acori Graminei 5-15 part, Radix Puerariae 25-35 part, Rhizoma Et Radix Notopterygii 10-20 part, Fructus Amomi 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Ophiopogonis 25-35 part, roud cardamon seed 5-15 part, Endoconcha Sepiae 5-15 part, Radix Angelicae Sinensis 5-15 part, Herba Cynomorii 10-20 part, Fructus Lycii 25-35 part, Radix Bupleuri 5-15 part, Radix Curcumae 25-35 part.
2. be according to claim 1ly a kind ofly used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest, it is characterized in that, the medicament be made up of the crude drug of following weight portion: Rhizoma Atractylodis 40 parts, Rhizoma Alismatis 40 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 30 parts, Rhizoma Acori Graminei 10 parts, Radix Puerariae 30 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Amomi 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Ophiopogonis 30 parts, roud cardamon seed 10 parts, Endoconcha Sepiae 10 parts, Radix Angelicae Sinensis 10 parts, Herba Cynomorii 15 parts, Fructus Lycii 30 parts, Radix Bupleuri 10 parts, Radix Curcumae 30 parts.
3. be according to claim 1 and 2ly a kind ofly used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest, it is characterized in that: described medicament is the preparation that any one is suitable for clinically.
4. be according to claim 3ly a kind ofly used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest, it is characterized in that: described preparation is oral formulations.
5. be according to claim 4ly a kind ofly used for the treatment of dizziness, Chinese medicine composition uncomfortable in chest, it is characterized in that: described oral formulations is decoction or capsule or pill or tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310517944.1A CN103599473B (en) | 2013-10-28 | 2013-10-28 | Traditional Chinese medicinal composition for treating dizziness and chest distress |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310517944.1A CN103599473B (en) | 2013-10-28 | 2013-10-28 | Traditional Chinese medicinal composition for treating dizziness and chest distress |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103599473A CN103599473A (en) | 2014-02-26 |
| CN103599473B true CN103599473B (en) | 2015-07-08 |
Family
ID=50117779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310517944.1A Active CN103599473B (en) | 2013-10-28 | 2013-10-28 | Traditional Chinese medicinal composition for treating dizziness and chest distress |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599473B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611063A (en) * | 2013-10-31 | 2014-03-05 | 陈维娜 | Traditional Chinese medicine formula for treating cardio-cerebro vascular diseases |
| CN106266909A (en) * | 2016-08-22 | 2017-01-04 | 安徽兆龙生物科技有限公司 | Utilize buccal tablet of bio-extract treatment cardiovascular and cerebrovascular disease and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100512852C (en) * | 2007-04-19 | 2009-07-15 | 宋建华 | Composite Chinese medicine took orally for treating coronary heart disease |
| CN102335380A (en) * | 2010-07-20 | 2012-02-01 | 戴海清 | Drug for treating cardiovascular and cerebrovascular diseases, and preparation method thereof |
-
2013
- 2013-10-28 CN CN201310517944.1A patent/CN103599473B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103599473A (en) | 2014-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102688420A (en) | Traditional Chinese medicine decoction for treating psoriasis | |
| CN103784890B (en) | A kind of Chinese medicine composition for the treatment of osteopathia | |
| CN103585478B (en) | Chinese medicinal composition for treating hypertension | |
| CN104940810A (en) | Traditional Chinese medicine composition for treating angina | |
| CN102526592B (en) | Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases and immune dysfunction | |
| CN103599474B (en) | A kind of Chinese medicine composition being used for the treatment of poor sleeping quality | |
| CN103599473B (en) | Traditional Chinese medicinal composition for treating dizziness and chest distress | |
| CN103599430B (en) | A kind of Chinese medicine composition being used for the treatment of cardiac asthma | |
| CN103585596B (en) | Traditional Chinese medicine composition for treating migraine | |
| CN103110911B (en) | Traditional Chinese medicine composition for treating coronary heart disease | |
| CN103463397B (en) | Traditional Chinese medicine composition for treating deficiency of kidney-yin | |
| CN102727773B (en) | Traditional Chinese medicinal capsule for treating blood mucoviscidosis | |
| CN104173830A (en) | Medicament for reconciling interior syndromes and relieving exterior syndromes for high fever of cold in winter and preparation method thereof | |
| CN103599279B (en) | Traditional Chinese medicinal preparation for treating diabetes | |
| CN104173933A (en) | Traditional Chinese medicine composition for treating depressive disorder | |
| CN104248677A (en) | Traditional Chinese medicinal preparation for treating erythema multiforme | |
| CN103816469A (en) | Chinese medicinal composition for treating deficiency of spleen and kidneys | |
| CN103599397B (en) | A kind of Chinese medicine composition being used for the treatment of chronic renal insufficiency | |
| CN103599278B (en) | Traditional Chinese medicine for treating diabetes | |
| CN102366591B (en) | Chinese herbal medicinal wine for treating rheumatoid and rheumatoid arthritis and its preparation method | |
| CN101095922A (en) | Chinese traditional medicine composition for treating diabetes peripheral neuritis | |
| CN103599456B (en) | A kind of Chinese medicine composition being used for the treatment of cerebral thrombosis | |
| CN104758888A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN105434846A (en) | Traditional Chinese medicine for treating headaches with syndromes of qi collapse and spleen deficiency | |
| CN104027486A (en) | Traditional Chinese medicine composition for treating coronary heart disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190918 Address after: 511450 Guangzhou Panyu District, Guangdong Province, Shiji Town Jinshan Village Huachuang Animation Industry Park B22 Patentee after: Guangzhou Jindian Jingfang Pharmaceutical Co., Ltd. Address before: 236500 Anhui city of Fuyang Province Jieshou City Gu Lou Xing Zheng Cun town No. 178 Patentee before: Li Kong Lin |
|
| TR01 | Transfer of patent right |