CN101264208A - Medicinal composition for treating stomach and intestine dysfunction and preparation thereof - Google Patents
Medicinal composition for treating stomach and intestine dysfunction and preparation thereof Download PDFInfo
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- CN101264208A CN101264208A CNA2008101058324A CN200810105832A CN101264208A CN 101264208 A CN101264208 A CN 101264208A CN A2008101058324 A CNA2008101058324 A CN A2008101058324A CN 200810105832 A CN200810105832 A CN 200810105832A CN 101264208 A CN101264208 A CN 101264208A
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Abstract
The invention discloses a medicine composition for curing gastrointestinal dysfunction and the preparation method. The invention comprises the active pharmaceutical ingredients with the following weight proportion: Largehead Atractylodes Rhizome 10 to 60 weight shares, (rhizoma fagopyricymosi wild buckwheat rhizome 10 to 50 weight shares, astragalus 10 to 50 weight shares, prepared rhizome of rehmanniae 10 to 50 weight shares, angelica sinensis 10 to 40 weight shares, Chinese yam 10 to 40 weight shares, lanceolata 10 to 40 weight shares, poria cocos 10 to 30 weight shares, tangerine peel 10 to 30 weight shares and baked radix glycyrrhizae 5 to 20 weight shares. The medicine composition has the functions of spleen strengthening, stomach regulating, spleen invigorating and qi replenishing, and is used for curing anorexia, wiredness, tiredness and anorexia caused by gastrointestinal dysfunction.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction and preparation method thereof, belong to the novel technique field.
Background technology
Gastrointestinal dysfunction disease claims functional gastrointestinal power disease again, it is one group of gastrointestinal syndrome, often show as clinically gastrointestinal portion pain, appetite poor, return symptoms such as acid, abdominal distention, constipation, diarrhoea, but clinical examination does not have organic disease, its pathogenesis it be not immediately clear, also is difficult to clinically cure.
Gastrointestinal dysfunction belongs to the Chinese medicine syndrome of deficiency of spleen qi, be meant the syndrome due to deficiency of spleen-QI and stomach-QI, the fortuneization functional disorder, how because of eating and drinking without temperance, overstrain, excessive thinking, or the not enough institute of natural endowment causes, be found in the stomach painful abdominal mass, have loose bowels, multiple disease such as edema, chronic gastritis, gastroptosis, chronic non-specific ulcerative colitis, disease is seen diseases such as spiritlessness and sparing of words, fatigue and asthenia, indigestion and loss of appetite loose stool.At present, the clinical medicine that is used for the treatment of digestive tract disease is a lot, but because of the pathogenesis of gastrointestinal dysfunction indeterminate, therefore, clinical treatment is many based on the exterior syndrome treatment, as the application of medicines such as pain relieving, antidiarrheal, but though the clinical card shape of respite, very easily recurrence, more the back effect is undesirable.
China's Chinese medicine has the prospect for the treatment of preferably aspect the treatment gastrointestinal dysfunction, but is still waiting further raising for the further discussion of gastrointestinal dysfunction theory of Chinese medical science and the exploitation of this type of medicine.
Summary of the invention
One of the object of the invention is to provide a kind of pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction, this product has the effect of invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, is used for the treatment of inappetence that gastrointestinal dysfunction causes, fatigue and asthenia, spiritlessness and sparing of words, indigestion and loss of appetite loose stool etc.
Two of the object of the invention is to provide this preparation of drug combination method.
Spleen plays crucial effect to the digestion and the absorption of food, deficiency-weakness of spleen-QI then spleen loses fortuneization, fortuneization functional disorder then each visceral peritoneum of body is lost it and is supported and the dysfunction that causes each internal organs, in the course of time, can cause that the body negative and positive of qi and blood is unbalance and causes the generation of multiple disease.The present invention is on the gastrointestinal dysfunction of tcm clinical practice treatment for many years experiential basis, in conjunction with Chinese medical theory and modern pharmacology, clinical research achievement, selected pure Chinese medicine with effect of invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, form through the science compatibility, through clinical verification, the present invention has better therapeutic effect to the gastrointestinal dysfunction due to the deficiency-weakness of spleen-QI.
The present invention adopts modern preparation technique, by extract, concentrate, preparation process such as drying is processed into clinical acceptable tablet, capsule, granule, syrup, the arbitrary dosage form of chewable tablet.
The pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction provided by the invention is to be made by following raw materials by weight proportions:
The Rhizoma Atractylodis Macrocephalae 10~60 weight portion Rhizoma Fagopyri Dibotryiss 10~50 weight portions
The Radix Astragali 10~50 weight portion Radix Rehmanniaes Preparata 10~50 weight portions
Radix Angelicae Sinensis 10~40 weight portion Rhizoma Dioscoreaes 10~40 weight portions
Radix Codonopsis 10~40 weight portion Poria 10~30 weight portions
Pericarpium Citri Reticulatae 10~30 weight portion Radix Glycyrrhizae Preparatas 5~20 weight portions
Further, the pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction provided by the invention, can adopt following raw materials by weight proportions to make especially:
The Rhizoma Atractylodis Macrocephalae 30 weight portion Rhizoma Fagopyri Dibotryiss 40 weight portions
The Radix Astragali 30 weight portion Radix Rehmanniaes Preparata 30 weight portions
Radix Angelicae Sinensis 20 weight portion Rhizoma Dioscoreaes 20 weight portions
Radix Codonopsis 20 weight portion Poria 20 weight portions
Pericarpium Citri Reticulatae 20 weight portion Radix Glycyrrhizae Preparatas 10 weight portions
The preparation of drug combination method that is used for the treatment of gastrointestinal dysfunction provided by the invention is as follows:
(1) the depletion Semen Fagopyri Esculenti is ground into coarse powder, with 6~10 times of amount 30%~95% alcohol reflux 2~4 times, and each 1~4 hour, extract pure liquid and filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10~1.30 (55 ℃~70 ℃), and is standby;
(2) get the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Poria, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata, be ground into coarse powder, decoct 2~3 times with 8~12 times of water gagings, each 1~3 hour, decocting liquid filters, merging filtrate is evaporated to relative density and is the clear paste of 1.10~1.30 (55 ℃~70 ℃), and is standby;
(3) get above-mentioned clear paste, merge, add the conventional formulation adjuvant, molding, packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Rhizoma Atractylodis Macrocephalae 180g Rhizoma Fagopyri Dibotryis 240g Radix Astragali 180g
Radix Rehmanniae Preparata 180g Radix Angelicae Sinensis 120g Rhizoma Dioscoreae 120g
Radix Codonopsis 120g Poria 120g Pericarpium Citri Reticulatae 120g
Radix Glycyrrhizae Preparata 60g
Make 1000 altogether
Preparation method:
(1) depletion Semen Fagopyri Esculenti, be ground into coarse powder, with 10 times of amount 50% alcohol reflux 3 hours, extract pure liquid and filter, medicinal residues add 10 times of amount 50% alcohol reflux 2 hours, extracting pure liquid filters, medicinal residues add 10 times of amount 50% alcohol reflux 2 hours again, extract pure liquid and filter, and filtrate merges, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.30 (55 ℃), and is standby;
(2) get the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Poria, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters, and medicinal residues add 10 times of water gagings and decocted 1.5 hours, decocting liquid filters, medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters, merging filtrate, be evaporated to relative density and be the clear paste of 1.30 (60 ℃), standby;
(3) get above-mentioned clear paste, merge, drying is ground into fine powder, crosses 80 mesh sieves, gets extract powder, and is standby;
(4) get extract powder, add 0.6% magnesium stearate, mix homogeneously, encapsulated, packing, check, promptly.
Embodiment 2
Prescription is formed:
Rhizoma Atractylodis Macrocephalae 60g Rhizoma Fagopyri Dibotryis 80g Radix Astragali 60g
Radix Rehmanniae Preparata 60g Radix Angelicae Sinensis 40g Rhizoma Dioscoreae 40g
Radix Codonopsis 40g Poria 40g Pericarpium Citri Reticulatae 40g
Radix Glycyrrhizae Preparata 20g sucrose 930g
Make 1000g altogether
Preparation method:
(1) depletion Semen Fagopyri Esculenti, be ground into coarse powder, with 10 times of amount 50% alcohol reflux 3 hours, extract pure liquid and filter, medicinal residues add 10 times of amount 50% alcohol reflux 2 hours, extracting pure liquid filters, medicinal residues add 10 times of amount 50% alcohol reflux 2 hours again, extract pure liquid and filter, and filtrate merges, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.30 (55 ℃), and is standby;
(2) get the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Poria, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters, and medicinal residues add 10 times of water gagings and decocted 1.5 hours, decocting liquid filters, medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters, merging filtrate, be evaporated to relative density and be the clear paste of 1.10 (60 ℃), standby;
(3) get above-mentioned clear paste, merge, mix homogeneously adds sucrose, makes granule, drying, and granulate gets granule;
(4) get granule, packing, packing, check, promptly.
Claims (3)
1, the pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction is characterized in that this pharmaceutical composition is to be made by following raw materials by weight proportions:
The Rhizoma Atractylodis Macrocephalae 10~60 weight portion Rhizoma Fagopyri Dibotryiss 10~50 weight portions
The Radix Astragali 10~50 weight portion Radix Rehmanniaes Preparata 10~50 weight portions
Radix Angelicae Sinensis 10~40 weight portion Rhizoma Dioscoreaes 10~40 weight portions
Radix Codonopsis 10~40 weight portion Poria 10~30 weight portions
Pericarpium Citri Reticulatae 10~30 weight portion Radix Glycyrrhizae Preparatas 5~20 weight portions
2, the pharmaceutical composition that is used for the treatment of gastrointestinal dysfunction as claimed in claim 1 is characterized in that this pharmaceutical composition can adopt following raw materials by weight proportions to make especially:
The Rhizoma Atractylodis Macrocephalae 30 weight portion Rhizoma Fagopyri Dibotryiss 40 weight portions
The Radix Astragali 30 weight portion Radix Rehmanniaes Preparata 30 weight portions
Radix Angelicae Sinensis 20 weight portion Rhizoma Dioscoreaes 20 weight portions
Radix Codonopsis 20 weight portion Poria 20 weight portions
Pericarpium Citri Reticulatae 20 weight portion Radix Glycyrrhizae Preparatas 10 weight portions
3, preparation of drug combination method as claimed in claim 1 or 2 is as follows:
(1) the depletion Semen Fagopyri Esculenti is ground into coarse powder, with 6~10 times of amount 30%~95% alcohol reflux 2~4 times, and each 1~4 hour, extract pure liquid and filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10~1.30 (55 ℃~70 ℃), and is standby;
(2) get the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Poria, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata, be ground into coarse powder, decoct 2~3 times with 8~12 times of water gagings, each 1~3 hour, decocting liquid filters, merging filtrate is evaporated to relative density and is the clear paste of 1.10~1.30 (55 ℃~70 ℃), and is standby;
(3) get above-mentioned clear paste, merge, add the conventional formulation adjuvant, molding, packing, check, promptly.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNA2008101058324A CN101264208A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating stomach and intestine dysfunction and preparation thereof |
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Application Number | Priority Date | Filing Date | Title |
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CNA2008101058324A CN101264208A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating stomach and intestine dysfunction and preparation thereof |
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CN101264208A true CN101264208A (en) | 2008-09-17 |
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CNA2008101058324A Pending CN101264208A (en) | 2008-05-04 | 2008-05-04 | Medicinal composition for treating stomach and intestine dysfunction and preparation thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105521441A (en) * | 2014-09-28 | 2016-04-27 | 韦栩原 | Intestinal function disorder treating drug |
CN107223974A (en) * | 2017-08-06 | 2017-10-03 | 周海云 | Health products that a kind of coordinating intestines and stomach is wriggled and preparation method thereof |
-
2008
- 2008-05-04 CN CNA2008101058324A patent/CN101264208A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105521441A (en) * | 2014-09-28 | 2016-04-27 | 韦栩原 | Intestinal function disorder treating drug |
CN107223974A (en) * | 2017-08-06 | 2017-10-03 | 周海云 | Health products that a kind of coordinating intestines and stomach is wriggled and preparation method thereof |
CN107223974B (en) * | 2017-08-06 | 2020-11-20 | 嘉兴市迅程信息技术有限公司 | Health product for regulating gastrointestinal peristalsis and preparation method thereof |
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Open date: 20080917 |