CN104189368A - Traditional Chinese medicinal composition for treating spleen and stomach diseases and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating spleen and stomach diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating spleen and stomach diseases. The traditional Chinese medicinal composition is prepared from the following raw materials: bighead atractylodes rhizome, prepared rehmannia root, pericarpium citri reticulatae, ligusticum wallichii, hawthorn, yam, semen plantaginis, liquorice, poria cocos, angelica, mulberries, divaricate saposhnikovia root, lotus seeds, cassia twig, earthworm, Chinese dodder seeds and honeysuckle. In clinic, the traditional Chinese medicinal composition disclosed by the invention is mainly used for treating spleen and stomach diseases, and is significant in clinical curative effect, low in reoccurrence, free of toxic and side effect, and high in safety and comfort.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly, the present invention relates to a kind ofly for curing mainly the Chinese medicine composition of the spleen-stomach disease, the invention still further relates to the preparation method of described Chinese medicine composition.
Background technology
Tcm syndrome differentiation and typing is mainly divided into hepatic qi attacking stomach type, spleen-stomach deficiency-cold and type of deficiency of stomach yin etc. by gastropathy, and wherein spleen-stomach deficiency-cold is divided into again simple deficiency and coldness and two hypotypes of the middle empty stagnation of QI.The spleen-stomach disease is clinically very common digestive tract illness, and wherein spleen-stomach deficiency-cold person is in the majority, the showing as of Deficiency and coldness of spleen and stomach: stomach dull pain, like warm pain relieved by pressing, and pain of empty stomach is very, must eat alleviation of pain, general vomiting watery fluid, poor appetite, spiritlessness and weakness, very extremity are not warm, and large loose stool is thin, pale tongue with white fur, and slow pulse is slow or weak.The Chinese patent medicine that is used for the treatment of at present gastropathy is a lot, as Xiangshayangwei capsule, JIANWEI WAN, KUAIWEI PIAN, SANJIU WEITAI electuary, little Rhizoma Pinelliae Mixture and middle reason spleen ball etc., but stagnant, the disperse blood stasis and dredge collateral of being mostly to disappear for regulating the flow of vital energy, clearing away phlegm expel the heat-evil, dispelling cold and activating YANG, the less spleen-stomach deficiency-cold that is used for the treatment of.XIANGSHA LIUJU WAN is comprised of the Radix Aucklandiae, Fructus Amomi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria Cocos, Radix Glycyrrhizae Preparata etc., the function with replenishing QI to invigorate the spleen stomach function regulating, be applicable to treat the diseases such as the insufficiency of the spleen stagnation of QI, dyspepsia, eructation and poor appetite, distension and fullness in the abdomen, gastral cavilty painful abdominal mass pain, this medicine be take circulation of qi promoting as main, the medicine that is aided with air making-up and spleen enlivening, these medicine flavour of a drug are more, and complex manufacturing is relatively difficult to the overall quality control of medicine.
In doctor trained in Western medicine, gastropathy is divided into acute gastritis, chronic superficial gastritis, chronic atrophic gastritis, gastroduodenal ulcer, gastric cancer etc. conventionally, develop rapidly due to gastroscope technology, binding of pathological is learned biopsy, very easy to the diagnosis of chronic superficial gastritis, however in treatment, still lack reliable means.At present western medicine primary disease be take symptomatic treatment as main, and gastric acid wretched insufficiency person can oral dilute hydrochloric acid, to increase gastric acidity: dyspepsia person can take Pepsin Mixture, polyzyme tablets etc.; Glutted, nauseating, vomiter can answer amine, motilium or cisapride, not husky Billy with stomach; With bile reflux, can destroy gastric mucosal barrier because of long-term bile reflux, cause chronic superficial gastritis, and then develop into chronic atrophic gastritis, can apply medicine for stomach dynamic in the case, prevent bile reflux, thereby reach the object of protection gastric mucosa, motilium or cisapride can resist bile reflux, and promote emptying and emesis; Have a stomachache obvious person with mountain peak eggplant sheet, 654-2 relieving spasm to stop pain; With infected with Helicobacter pylori, also will add antibiotic effects a radical cure with degerming.Sucralfate, Marzulene are gastric mucosa protectants, can reduce the stimulation of external factor to gastric mucosa, are conducive to the recovery of gastric mucosal lesion, various chronic gastritis all available it.Chronic atrophic gastritis adds vitacoenzyme, can improve body immunity, strengthens the activity of detoxication enzyme in human body, anticancer growth and prevent the abnormal metabolism of cell.But more than can only temporarily control the state of an illness, control table disease, can not obtain the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.And long-term taking Western medicine can have side effects and cause yin-Yang imbalance, produce dependency, also may there is dyshormonia, body immunity is declined, and health anti-virus ability is low, and resistance against diseases is poor, make Relapse rate difficulty more finally tend to worsen, lead to complications simultaneously.
Spleen-stomach deficiency-cold the spleen-stomach disease is modal a kind of pattern of syndrome in the numerous types of tcm clinical practice digestive system disease, crowd's sickness rate is high, doctor trained in Western medicine adopts the symptomatic treatments such as acid inhibitor, gastrointestinal prokinetic agent more to the digestive system disease of this kind of pattern of syndrome at present, to this type of gastrointestinal disease without effective treatment means, though exist the similar medicine that is used for the treatment of the spleen-stomach disease all to there is the therapeutical effect to taste on market, but the valuable feature determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science will be according to the concrete state of an illness, differential diagnosis of diseases and distinguish disease being used in conjunction with each other, to formulate the therapeutic scheme of a very personalized proper state of an illness.
Several Deficiency and coldness of spleen and stomach medicine of the prior art has reached certain drug effect in treatment, but pharmacodynamic stability is poor, relatively difficult to the overall quality control of medicine, existing Western medicine side effect is larger, can not treating both the principal and the secondary aspects of a disease at the same time, therefore, be necessary to study a kind of medicine source abundant, clinical efficacy is good, has no side effect, and preparation method is simply treated the medicine of the spleen-stomach disease.
The present invention is directed to that the flavour of a drug that the Chinese medicine of existing treatment spleen-stomach deficiency-cold the spleen-stomach disease exists are more, complex manufacturing, drug quality are controlled difficulty and Western medicine is difficult to the easily series of problems such as imbalance for the treatment of both the principal and the secondary aspects of a disease at the same time, physical function, proposed that a kind of prescription is rigorous, clinical efficacy significantly, reduce Chinese medicine composition of the treatment the spleen-stomach disease that recurs, has no side effect and uses thereof.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of the spleen-stomach disease, it is characterized in that being prepared from by following raw material components: the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Fructus Crataegi, Rhizoma Dioscoreae, Semen Plantaginis, Radix Glycyrrhizae, Poria, Radix Angelicae Sinensis, Fructus Mori, Radix Saposhnikoviae, Semen Nelumbinis, Ramulus Cinnamomi, Pheretima, Semen Cuscutae, Flos Lonicerae.
Wherein, Rhizoma Atractylodis Macrocephalae 10-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Fructus Crataegi 10-20 weight portion, Rhizoma Dioscoreae 10-25 weight portion, Semen Plantaginis 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Poria 20-30 weight portion, Radix Angelicae Sinensis 20-30 weight portion, Fructus Mori 10-25 weight portion, Radix Saposhnikoviae 10-15 weight portion, Semen Nelumbinis 10-20 weight portion, Ramulus Cinnamomi 10-15 weight portion, Pheretima 10-20 weight portion, Semen Cuscutae 10-20 weight portion, Flos Lonicerae 20-30 weight portion.
Preferably, Rhizoma Atractylodis Macrocephalae 20-30 weight portion, Radix Rehmanniae Preparata 16-20 weight portion, Pericarpium Citri Reticulatae 25-30 weight portion, Rhizoma Chuanxiong 18-25 weight portion, Fructus Crataegi 15-20 weight portion, Rhizoma Dioscoreae 19-25 weight portion, Semen Plantaginis 15-20 weight portion, Radix Glycyrrhizae 14-20 weight portion, Poria 25-30 weight portion, Radix Angelicae Sinensis 24-30 weight portion, Fructus Mori 17-25 weight portion, Radix Saposhnikoviae 13-15 weight portion, Semen Nelumbinis 16-20 weight portion, Ramulus Cinnamomi 12-15 weight portion, Pheretima 14-20 weight portion, Semen Cuscutae 16-20 weight portion, Flos Lonicerae 24-30 weight portion.
Further preferably, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Rehmanniae Preparata 16 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Rhizoma Chuanxiong 18 weight portions, Fructus Crataegi 15 weight portions, Rhizoma Dioscoreae 19 weight portions, Semen Plantaginis 15 weight portions, Radix Glycyrrhizae 14 weight portions, Poria 25 weight portions, Radix Angelicae Sinensis 24 weight portions, Fructus Mori 17 weight portions, Radix Saposhnikoviae 13 weight portions, Semen Nelumbinis 16 weight portions, Ramulus Cinnamomi 12 weight portions, Pheretima 14 weight portions, Semen Cuscutae 16 weight portions, Flos Lonicerae 24 weight portions.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of the spleen-stomach disease, and preparation process is:
Each raw material components is mixed in proportion, and adds 50-80% alcohol reflux secondary, adds for the first time ethanol 5-8 and doubly measures, and backflow 1-3 hour, adds for the second time ethanol 5-8 and doubly measure, and backflow 1-3 hour merges extracted twice liquid, filters; Filtrate recycling ethanol, concentrating under reduced pressure, control vacuum for-0.06Mpa～-0.08MPa, temperature be 60 ℃～80 ℃, the clear paste that when being concentrated into temperature and being 50 ℃～80 ℃, relative density is 1.10～1.39, dry, pulverize into fine powder, add appropriate amount of PEG 6000 to mix, even through colloidal grinding, make soft capsule.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition of preparation treatment the spleen-stomach disease.
Beneficial effect of the present invention:
Technical problem to be solved by this invention is, a kind of Chinese medicine composition for the treatment of the spleen-stomach disease is provided, described Chinese medicine composition is mainly used in the treatment of the spleen-stomach disease clinically, and clinical efficacy is remarkable, minimizing is recurred, had no side effect, and has safety and the comfort of height.
The specific embodiment
The invention provides a kind of Chinese medicine composition for the treatment of the spleen-stomach disease, it is characterized in that being prepared from by following raw material components: the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Fructus Crataegi, Rhizoma Dioscoreae, Semen Plantaginis, Radix Glycyrrhizae, Poria, Radix Angelicae Sinensis, Fructus Mori, Radix Saposhnikoviae, Semen Nelumbinis, Ramulus Cinnamomi, Pheretima, Semen Cuscutae, Flos Lonicerae.
Wherein, Rhizoma Atractylodis Macrocephalae 10-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Fructus Crataegi 10-20 weight portion, Rhizoma Dioscoreae 10-25 weight portion, Semen Plantaginis 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Poria 20-30 weight portion, Radix Angelicae Sinensis 20-30 weight portion, Fructus Mori 10-25 weight portion, Radix Saposhnikoviae 10-15 weight portion, Semen Nelumbinis 10-20 weight portion, Ramulus Cinnamomi 10-15 weight portion, Pheretima 10-20 weight portion, Semen Cuscutae 10-20 weight portion, Flos Lonicerae 20-30 weight portion.
Preferably, Rhizoma Atractylodis Macrocephalae 20-30 weight portion, Radix Rehmanniae Preparata 16-20 weight portion, Pericarpium Citri Reticulatae 25-30 weight portion, Rhizoma Chuanxiong 18-25 weight portion, Fructus Crataegi 15-20 weight portion, Rhizoma Dioscoreae 19-25 weight portion, Semen Plantaginis 15-20 weight portion, Radix Glycyrrhizae 14-20 weight portion, Poria 25-30 weight portion, Radix Angelicae Sinensis 24-30 weight portion, Fructus Mori 17-25 weight portion, Radix Saposhnikoviae 13-15 weight portion, Semen Nelumbinis 16-20 weight portion, Ramulus Cinnamomi 12-15 weight portion, Pheretima 14-20 weight portion, Semen Cuscutae 16-20 weight portion, Flos Lonicerae 24-30 weight portion.
Further preferably, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Rehmanniae Preparata 16 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Rhizoma Chuanxiong 18 weight portions, Fructus Crataegi 15 weight portions, Rhizoma Dioscoreae 19 weight portions, Semen Plantaginis 15 weight portions, Radix Glycyrrhizae 14 weight portions, Poria 25 weight portions, Radix Angelicae Sinensis 24 weight portions, Fructus Mori 17 weight portions, Radix Saposhnikoviae 13 weight portions, Semen Nelumbinis 16 weight portions, Ramulus Cinnamomi 12 weight portions, Pheretima 14 weight portions, Semen Cuscutae 16 weight portions, Flos Lonicerae 24 weight portions.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of the spleen-stomach disease, and preparation process is:
Each raw material components is mixed in proportion, and adds 50-80% alcohol reflux secondary, adds for the first time ethanol 5-8 and doubly measures, and backflow 1-3 hour, adds for the second time ethanol 5-8 and doubly measure, and backflow 1-3 hour merges extracted twice liquid, filters; Filtrate recycling ethanol, concentrating under reduced pressure, control vacuum for-0.06Mpa～-0.08MPa, temperature be 60 ℃～80 ℃, the clear paste that when being concentrated into temperature and being 50 ℃～80 ℃, relative density is 1.10～1.39, dry, pulverize into fine powder, add appropriate amount of PEG 6000 to mix, even through colloidal grinding, make soft capsule.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition of preparation treatment the spleen-stomach disease.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, the advantage such as provide a kind of pointed strong, good effect, the cycle is short, price is low, have no side effect, can make again patient take like a shot, can treat preferably the pure Chinese medicinal preparation of the spleen-stomach disease.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
embodiment 1:
Get Rhizoma Atractylodis Macrocephalae 10g, Radix Rehmanniae Preparata 10g, Pericarpium Citri Reticulatae 20g, Rhizoma Chuanxiong 10g, Fructus Crataegi 10g, Rhizoma Dioscoreae 10g, Semen Plantaginis 10g, Radix Glycyrrhizae 10g, Poria 20g, Radix Angelicae Sinensis 20g, Fructus Mori 10g, Radix Saposhnikoviae 10g, Semen Nelumbinis 10g, Ramulus Cinnamomi 10g, Pheretima 10g, Semen Cuscutae 10g, Flos Lonicerae 20g, after chopping, add 50% alcohol reflux secondary, add for the first time 5 times of amounts of ethanol, reflux 1 hour, add for the second time 5 times of amounts of ethanol, reflux 1 hour, merge extracted twice liquid, filter; Filtrate recycling ethanol, concentrating under reduced pressure, controls vacuum for-0.06Mpa, temperature are 60 ℃, and the clear paste that when being concentrated into temperature and being 50 ℃, relative density is 1.10, dry, pulverize into fine powder, adds appropriate amount of PEG 6000 to mix, even through colloidal grinding, makes soft capsule.
embodiment 2:
Get Rhizoma Atractylodis Macrocephalae 30g, Radix Rehmanniae Preparata 20g, Pericarpium Citri Reticulatae 30g, Rhizoma Chuanxiong 25g, Fructus Crataegi 20g, Rhizoma Dioscoreae 25g, Semen Plantaginis 20g, Radix Glycyrrhizae 20g, Poria 30g, Radix Angelicae Sinensis 30g, Fructus Mori 25g, Radix Saposhnikoviae 15g, Semen Nelumbinis 20g, Ramulus Cinnamomi 15g, Pheretima 20g, Semen Cuscutae 20g, Flos Lonicerae 30g, after chopping, add 80% alcohol reflux secondary, add for the first time 8 times of amounts of ethanol, reflux 3 hours, add for the second time 8 times of amounts of ethanol, reflux 3 hours, merge extracted twice liquid, filter; Filtrate recycling ethanol, concentrating under reduced pressure, controls vacuum for-0.08MPa, temperature are 80 ℃, and the clear paste that when being concentrated into temperature and being 80 ℃, relative density is 1.39, dry, pulverize into fine powder, adds appropriate amount of PEG 6000 to mix, even through colloidal grinding, makes soft capsule.
embodiment 3:
Get Rhizoma Atractylodis Macrocephalae 20g, Radix Rehmanniae Preparata 16g, Pericarpium Citri Reticulatae 25g, Rhizoma Chuanxiong 18g, Fructus Crataegi 15g, Rhizoma Dioscoreae 19g, Semen Plantaginis 15g, Radix Glycyrrhizae 14g, Poria 25g, Radix Angelicae Sinensis 24g, Fructus Mori 17g, Radix Saposhnikoviae 13g, Semen Nelumbinis 16g, Ramulus Cinnamomi 12g, Pheretima 14g, Semen Cuscutae 16g, Flos Lonicerae 24g, after chopping, add 70% alcohol reflux secondary, add for the first time 7 times of amounts of ethanol, reflux 2 hours, add for the second time 7 times of amounts of ethanol, reflux 2 hours, merge extracted twice liquid, filter; Filtrate recycling ethanol, concentrating under reduced pressure, controls vacuum for-0.07MPa, temperature are 70 ℃, and the clear paste that when being concentrated into temperature and being 65 ℃, relative density is 1.25, dry, pulverize into fine powder, adds appropriate amount of PEG 6000 to mix, even through colloidal grinding, makes soft capsule.
embodiment 4:
In clinical experiment, selected 200 examples are diagnosed as the patient of the spleen-stomach disease, and between age 21-45 year, the mean age is 30.4 years old, and the course of disease is the shortest is half a year, and the longest is 5 years, average out to 2.31 years.Random packet, test group 100 examples, matched group 100 examples.
Therapeutic Method: Chinese medicinal capsule prepared by the oral embodiment of the present invention 1-3 of test group, every day 3 times, each 1-3 grain, 2 weeks is 1 course for the treatment of.The oral JIANWEI WAN of matched group, every day 3 times, each 1-2 grain, 2 weeks is 1 course for the treatment of.
Diagnostic criteria: with reference to clinical criteria, and with symptom be divided into gently, in, severe.
Therapeutic outcome:
Test group: after 2 courses for the treatment of, cure 86 examples, cure rate accounts for 86%, 11 examples that take a turn for the better, obvious effective rate accounts for 11%, and total effective rate is 97%, invalid 3 examples, inefficiency accounts for 3%.
Matched group: treat after 2 courses for the treatment of, cure 54 examples, cure rate accounts for 54%, 12 examples that take a turn for the better, obvious effective rate accounts for 12%, and total effective rate is 66%, invalid 34 examples, inefficiency accounts for 34%.
Curative effect comparison: test group total effective rate and cure rate, apparently higher than matched group, are learned and processed by statistics, and difference all has very significant (P < 0.01).In addition, visible in clinical observation, Chinese medicine composition of the present invention is not found toxic and side effects in using.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. treat a Chinese medicine composition for the spleen-stomach disease, it is characterized in that being prepared from by following raw material components: the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Fructus Crataegi, Rhizoma Dioscoreae, Semen Plantaginis, Radix Glycyrrhizae, Poria, Radix Angelicae Sinensis, Fructus Mori, Radix Saposhnikoviae, Semen Nelumbinis, Ramulus Cinnamomi, Pheretima, Semen Cuscutae, Flos Lonicerae.
2. according to the Chinese medicine composition of claim 1, wherein, Rhizoma Atractylodis Macrocephalae 10-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Rhizoma Chuanxiong 10-25 weight portion, Fructus Crataegi 10-20 weight portion, Rhizoma Dioscoreae 10-25 weight portion, Semen Plantaginis 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Poria 20-30 weight portion, Radix Angelicae Sinensis 20-30 weight portion, Fructus Mori 10-25 weight portion, Radix Saposhnikoviae 10-15 weight portion, Semen Nelumbinis 10-20 weight portion, Ramulus Cinnamomi 10-15 weight portion, Pheretima 10-20 weight portion, Semen Cuscutae 10-20 weight portion, Flos Lonicerae 20-30 weight portion.
3. according to the Chinese medicine composition of claim 2, wherein, Rhizoma Atractylodis Macrocephalae 20-30 weight portion, Radix Rehmanniae Preparata 16-20 weight portion, Pericarpium Citri Reticulatae 25-30 weight portion, Rhizoma Chuanxiong 18-25 weight portion, Fructus Crataegi 15-20 weight portion, Rhizoma Dioscoreae 19-25 weight portion, Semen Plantaginis 15-20 weight portion, Radix Glycyrrhizae 14-20 weight portion, Poria 25-30 weight portion, Radix Angelicae Sinensis 24-30 weight portion, Fructus Mori 17-25 weight portion, Radix Saposhnikoviae 13-15 weight portion, Semen Nelumbinis 16-20 weight portion, Ramulus Cinnamomi 12-15 weight portion, Pheretima 14-20 weight portion, Semen Cuscutae 16-20 weight portion, Flos Lonicerae 24-30 weight portion.
4. according to the Chinese medicine composition of claim 1-3, wherein, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Rehmanniae Preparata 16 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Rhizoma Chuanxiong 18 weight portions, Fructus Crataegi 15 weight portions, Rhizoma Dioscoreae 19 weight portions, Semen Plantaginis 15 weight portions, Radix Glycyrrhizae 14 weight portions, Poria 25 weight portions, Radix Angelicae Sinensis 24 weight portions, Fructus Mori 17 weight portions, Radix Saposhnikoviae 13 weight portions, Semen Nelumbinis 16 weight portions, Ramulus Cinnamomi 12 weight portions, Pheretima 14 weight portions, Semen Cuscutae 16 weight portions, Flos Lonicerae 24 weight portions.
5. the preparation method of the Chinese medicine composition of any one in claim 1-4, is characterized in that, preparation process is:
Each raw material components is mixed in proportion, and adds 50-80% alcohol reflux secondary, adds for the first time ethanol 5-8 and doubly measures, and backflow 1-3 hour, adds for the second time ethanol 5-8 and doubly measure, and backflow 1-3 hour merges extracted twice liquid, filters; Filtrate recycling ethanol, concentrating under reduced pressure, control vacuum for-0.06Mpa～-0.08MPa, temperature be 60 ℃～80 ℃, the clear paste that when being concentrated into temperature and being 50 ℃～80 ℃, relative density is 1.10～1.39, dry, pulverize into fine powder, add appropriate amount of PEG 6000 to mix, even through colloidal grinding, make soft capsule.
6. the application of the raw material components of any one in the Chinese medicine composition of preparation treatment the spleen-stomach disease in claim 1-4.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784651A (en) * | 2015-05-16 | 2015-07-22 | 张晗 | Method for preparing pharmaceutical preparation for treating gastric ulcer |
| CN105287735A (en) * | 2015-11-11 | 2016-02-03 | 北京市祖国红医疗科技中心（有限合伙） | Pharmaceutical composition used for moderating physique, and preparation method and application thereof |
| CN108969736A (en) * | 2017-06-02 | 2018-12-11 | 徐定清 | A kind of medicine pill of tonifying speen and tonifying kidney |
-
2014
- 2014-09-05 CN CN201410450895.9A patent/CN104189368A/en active Pending
Non-Patent Citations (1)
| Title |
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| 李小双等: "建中四君汤治疗虚寒型腹痛72例", 《中国民间疗法》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784651A (en) * | 2015-05-16 | 2015-07-22 | 张晗 | Method for preparing pharmaceutical preparation for treating gastric ulcer |
| CN104784651B (en) * | 2015-05-16 | 2018-01-19 | 张晗 | A kind of method for preparing the pharmaceutical preparation for treating gastric ulcer |
| CN105287735A (en) * | 2015-11-11 | 2016-02-03 | 北京市祖国红医疗科技中心（有限合伙） | Pharmaceutical composition used for moderating physique, and preparation method and application thereof |
| CN108969736A (en) * | 2017-06-02 | 2018-12-11 | 徐定清 | A kind of medicine pill of tonifying speen and tonifying kidney |
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Application publication date: 20141210 |