CN104888080A - Traditional Chinese medicine composition for treating insomnia - Google Patents
Traditional Chinese medicine composition for treating insomnia Download PDFInfo
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- CN104888080A CN104888080A CN201510314297.3A CN201510314297A CN104888080A CN 104888080 A CN104888080 A CN 104888080A CN 201510314297 A CN201510314297 A CN 201510314297A CN 104888080 A CN104888080 A CN 104888080A
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Abstract
The invention provides a traditional Chinese medicine composition for treating insomnia. The traditional Chinese medicine composition is prepared from the following raw materials: 12 parts of sedum lineare, 18 parts of asystasiella neesiana, 15 parts of angelica sinensis, 20 parts of astragalus membranaceus, 10 parts of poria cocos, 10 parts of caulis polygoni multiflori, 10 parts of polygala tenuifolia, 30 parts of magnet, 10 parts of dragon's bone, 10 parts of semen zizyphi spinosae, 10 parts of cortex albiziae, 6 parts of coptis chinensis, 10 parts of colla corii asini, 10 parts of fructus alpiniae oxyphyllae, 10 parts of combined spicebush root, 10 parts of lophatherum gracile and 5 parts of liquorice. The traditional Chinese medicine composition can be used for treating insomnia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of insomnia and its preparation method and application.
Background technology
Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS, for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia often brings painful and psychological burden greatly to patient, can damage other every aspects of health again because of abuse insomnia drug.For this reason, the needs that the medicine developing more Cure for insomnias safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation for the treatment of insomnia.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of insomnia, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Mus tooth half 12 parts, Rhizoma seu herba Asystasiellae Chinensis 18 parts, Radix Angelicae Sinensis 15 parts, the Radix Astragali 20 parts, 10 parts, Poria, Poria cum Radix Pini 10 parts, Caulis Polygoni Multiflori 10 parts, Radix Polygalae 10 parts, Magnetitum 30 parts, Os Draconis 10 parts, Semen Ziziphi Spinosae 10 parts, Cortex Albiziae 10 parts, Rhizoma Coptidis 6 parts, 10 parts, Colla Corii Asini, Fructus Alpiniae Oxyphyllae 10 parts, the Radix Linderae 10 parts, Herba Lophatheri 10 parts, 5 parts, Radix Glycyrrhizae.
The described Chinese medicine composition being used for the treatment of insomnia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of insomnia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described Chinese medicine composition being used for the treatment of insomnia is preparing the application in medicament for treating insomnia.
Mus tooth half is the herb of Crassulaceae sengreen Herba Stellariae Alsines Sedum lineare Thunb..The four seasons can adopt, and clean, using fresh herb or dry.Heat-clearing and toxic substances removing, detumescence hemostasis.For pharyngolaryngitis, hepatitis, cancer of pancreas; Burn and scald is controlled in external, traumatic hemorrhage, herpes zoster, sore swollen toxin, venom.
Rhizoma seu herba Asystasiellae Chinensis, Classification system: Asystasiella neesiana (Wall.) Lindau, for Acanthaceae Rhizoma seu herba Asystasiellae Chinensis belongs to herbaceous plant.White, rich mucus, blade papery, Hua Dansheng or to life; Corolla lilac red.Medicinal source is rhizome or the herb of Rhizoma seu herba Asystasiellae Chinensis.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, diuresis.For pulmonary tuberculosis, laryngopharynx swelling and pain, diabetes, ascites; Traumatic hemorrhage is controlled in external, sprains, furuncle and phyma.The present invention adopts all herbal medicine.All the other medical materials are pharmacopeia kind.
Beneficial effect: Mus tooth of the present invention half, Rhizoma seu herba Asystasiellae Chinensis, Radix Angelicae Sinensis, Radix Astragali heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, QI invigorating is monarch drug, Poria, Poria cum Radix Pini, Caulis Polygoni Multiflori, Radix Polygalae, Magnetitum, Os Draconis, Semen Ziziphi Spinosae, Cortex Albiziae, Rhizoma Coptidis, Colla Corii Asini, Fructus Alpiniae Oxyphyllae, Radix Linderae tranquillizing and allaying excitement are ministerial drug, Herba Lophatheri, Radix Glycyrrhizae are adjuvant, mutual compatibility, Cure for insomnia successful.The present invention actively can prevent and treat generation and the development of insomnia effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Mus tooth half 12g, Rhizoma seu herba Asystasiellae Chinensis 18g, Radix Angelicae Sinensis 15g, Radix Astragali 20g, Poria 10g, Poria cum Radix Pini 10g, Caulis Polygoni Multiflori 10g, Radix Polygalae 10g, Magnetitum 30g, Os Draconis 10g, Semen Ziziphi Spinosae 10g, Cortex Albiziae 10g, Rhizoma Coptidis 6g, Colla Corii Asini 10g, Fructus Alpiniae Oxyphyllae 10g, Radix Linderae 10g, Herba Lophatheri 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Mus tooth half 12g, Rhizoma seu herba Asystasiellae Chinensis 18g, Radix Angelicae Sinensis 15g, Radix Astragali 20g, Poria 10g, Poria cum Radix Pini 10g, Caulis Polygoni Multiflori 10g, Radix Polygalae 10g, Magnetitum 30g, Os Draconis 10g, Semen Ziziphi Spinosae 10g, Cortex Albiziae 10g, Rhizoma Coptidis 6g, Colla Corii Asini 10g, Fructus Alpiniae Oxyphyllae 10g, Radix Linderae 10g, Herba Lophatheri 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Mus tooth half 12g, Rhizoma seu herba Asystasiellae Chinensis 18g, Radix Angelicae Sinensis 15g, Radix Astragali 20g, Poria 10g, Poria cum Radix Pini 10g, Caulis Polygoni Multiflori 10g, Radix Polygalae 10g, Magnetitum 30g, Os Draconis 10g, Semen Ziziphi Spinosae 10g, Cortex Albiziae 10g, Rhizoma Coptidis 6g, Colla Corii Asini 10g, Fructus Alpiniae Oxyphyllae 10g, Radix Linderae 10g, Herba Lophatheri 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating insomnia clinical research of the present invention
4.1 general data: this Chinese medicine composition is applied to clinical observation insomnia case 50 example, wherein man 30 example, female 20 example, 26 ~ 50 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years, average 1.5 years.
4.2 diagnostic criterias: (1) is slight: accidental, little to Quality of Life; (2) moderate: occur every night, moderate influence quality of life, accompanies certain symptom (irritability, anxiety, tired etc.); (3) severe: occur every night, has a strong impact on quality of life, and clinical symptoms is had outstanding performance.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) clinical recovery: sleep is normal, more than the 6 hours length of one's sleep, simultaneous phenomenon disappears; (2) effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improved; (3) invalid: before sleeping as taking medicine, or extend the length of one's sleep less than 2 hours, symptom is without improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
Treatment group | 25 | 8 | 10 | 7 | 72 |
Blank group | 25 | 1 | 1 | 23 | 8 |
Visible, the medicine that the present invention obtains can safe and effective Cure for insomnia.
4.6 Wang, female, 28 years old, the length of one's sleep, every night less than 3 hours, cannot fall asleep after waking up frequent midnight again, and companion's anxiety, continues 5 wheat harvesting periods.Take 3 courses for the treatment of of Chinese medicinal composition granules of the present invention, be increased to 6 hours the length of one's sleep; Continue to strengthen 2 courses for the treatment of, ensure sleep more than 6 hours every day, with other transference cures.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of insomnia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Mus tooth half 12 parts, Rhizoma seu herba Asystasiellae Chinensis 18 parts, Radix Angelicae Sinensis 15 parts, the Radix Astragali 20 parts, 10 parts, Poria, Poria cum Radix Pini 10 parts, Caulis Polygoni Multiflori 10 parts, Radix Polygalae 10 parts, Magnetitum 30 parts, Os Draconis 10 parts, Semen Ziziphi Spinosae 10 parts, Cortex Albiziae 10 parts, Rhizoma Coptidis 6 parts, 10 parts, Colla Corii Asini, Fructus Alpiniae Oxyphyllae 10 parts, the Radix Linderae 10 parts, Herba Lophatheri 10 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in medicament for treating insomnia of insomnia according to claim 1.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107050364A (en) * | 2017-05-02 | 2017-08-18 | 李军 | It is a kind of to treat medicine of insomnia and preparation method thereof and application method |
Citations (2)
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CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
CN103405716A (en) * | 2013-08-08 | 2013-11-27 | 谢春红 | Herbal decoction for treating insomnia |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
CN103405716A (en) * | 2013-08-08 | 2013-11-27 | 谢春红 | Herbal decoction for treating insomnia |
Non-Patent Citations (1)
Title |
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王婷婷: "张波论治失眠的思想探析", 《中医药临床杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107050364A (en) * | 2017-05-02 | 2017-08-18 | 李军 | It is a kind of to treat medicine of insomnia and preparation method thereof and application method |
CN107050364B (en) * | 2017-05-02 | 2020-09-04 | 李军 | Medicine for treating insomnia and preparation method and using method thereof |
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