CN104784349A - Traditional Chinese medicine composition for treating insomnia - Google Patents
Traditional Chinese medicine composition for treating insomnia Download PDFInfo
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- CN104784349A CN104784349A CN201510218226.3A CN201510218226A CN104784349A CN 104784349 A CN104784349 A CN 104784349A CN 201510218226 A CN201510218226 A CN 201510218226A CN 104784349 A CN104784349 A CN 104784349A
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Abstract
The invention provides a traditional Chinese medicine composition for treating insomnia. The traditional Chinese medicine composition is prepared from the following raw materials: 30 parts of milkvetch root, 15 parts of codonopsis pilosula, 10 parts of angelica sinensis and 15 parts spina date seeds. The traditional Chinese medicine composition can treat the insomnia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of insomnia and its preparation method and application.
Background technology
Insomnia is also known as DIMS, for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., painful and psychological burden is greatly brought to patient, for this reason, the needs that the medicine developing more Cure for insomnias safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation for the treatment of insomnia.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of insomnia, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Angelicae Sinensis 10 parts, Semen Ziziphi Spinosae 15 parts, Fructus Lycii 16 parts, Fructus Leonuri 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Arillus Longan 15 parts, Semen Vaccariae 15 parts, Rhizoma Chuanxiong 12 parts, 6 parts, Radix Glycyrrhizae, Radix Polygoni Multiflori 18 parts, Fructus Liquidambaris 12 parts, Fructus Crataegi 10 parts, Pericarpium Citri Reticulatae 18 parts.
The described Chinese medicine composition being used for the treatment of insomnia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of insomnia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described Chinese medicine composition being used for the treatment of insomnia is preparing the application in medicament for treating insomnia.
Above-mentioned Chinese medicine is pharmacopeia kind.
Beneficial effect: the Radix Astragali of the present invention, Radix Codonopsis QI invigorating strengthening the spleen are monarch drug, Radix Angelicae Sinensis, Semen Ziziphi Spinosae, Fructus Lycii, Fructus Leonuri, Endothelium Corneum Gigeriae Galli, Arillus Longan, Semen Vaccariae, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Fructus Liquidambaris, Fructus Crataegi, Pericarpium Citri Reticulatae blood circulation promoting and blood stasis dispelling, Anshen Bunao is ministerial drug, Radix Glycyrrhizae mediation pig medicine, for adjuvant, full side's compatibility, Anshen Bunao, Cure for insomnia successful.The present invention actively can prevent and treat generation and the development of insomnia effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 10g, Semen Ziziphi Spinosae 15g, Fructus Lycii 16g, Fructus Leonuri 10g, Endothelium Corneum Gigeriae Galli 12g, Arillus Longan 15g, Semen Vaccariae 15g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 6g, Radix Polygoni Multiflori 18g, Fructus Liquidambaris 12g, Fructus Crataegi 10g, Pericarpium Citri Reticulatae 18g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 10g, Semen Ziziphi Spinosae 15g, Fructus Lycii 16g, Fructus Leonuri 10g, Endothelium Corneum Gigeriae Galli 12g, Arillus Longan 15g, Semen Vaccariae 15g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 6g, Radix Polygoni Multiflori 18g, Fructus Liquidambaris 12g, Fructus Crataegi 10g, Pericarpium Citri Reticulatae 18g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 10g, Semen Ziziphi Spinosae 15g, Fructus Lycii 16g, Fructus Leonuri 10g, Endothelium Corneum Gigeriae Galli 12g, Arillus Longan 15g, Semen Vaccariae 15g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 6g, Radix Polygoni Multiflori 18g, Fructus Liquidambaris 12g, Fructus Crataegi 10g, Pericarpium Citri Reticulatae 18g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, traditional Chinese medicine composition for treating insomnia clinical research of the present invention
4.1 general data: this Chinese medicine composition is applied to clinical observation insomnia case 60 example, wherein man 26 example, female 34 example, 19 ~ 63 years old age.In the course of disease 2 week of the shortest person, most elder reaches 2 years, average 1.2 years.
4.2 diagnostic criterias: (1) is slight: accidental, little to Quality of Life; (2) moderate: occur every night, moderate influence quality of life, accompanies certain symptom (irritability, anxiety, tired etc.); (3) severe: occur every night, has a strong impact on quality of life, and clinical symptoms is had outstanding performance.
4.3 usage and dosages: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.
4.4 criterions of therapeutical effect: (1) clinical recovery: sleep is normal, more than the 6 hours length of one's sleep, simultaneous phenomenon disappears; (2) effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improved; (3) invalid: before sleeping as taking medicine, or extend the length of one's sleep less than 2 hours, symptom is without improvement.
4.5 therapeutic effect: in this clinical observation case, take medicine 1-6 the course for the treatment of, clinical recovery 36 example, effective 18 examples, and invalid 6 examples, effective percentage 90%, toxic and side effects does not occur treatments period.
4.6 model cases:
Zhang, man, 58 years old, the length of one's sleep, every night less than 2 hours, cannot fall asleep after waking up again, and companion's anxiety, continues three wheat harvesting periods.Take 2 courses for the treatment of of Chinese medicinal composition granules of the present invention, be increased to 5 hours the length of one's sleep; Continue to strengthen 2 courses for the treatment of, ensure sleep more than 7 hours every day, with other transference cures.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of insomnia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Angelicae Sinensis 10 parts, Semen Ziziphi Spinosae 15 parts, Fructus Lycii 16 parts, Fructus Leonuri 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Arillus Longan 15 parts, Semen Vaccariae 15 parts, Rhizoma Chuanxiong 12 parts, 6 parts, Radix Glycyrrhizae, Radix Polygoni Multiflori 18 parts, Fructus Liquidambaris 12 parts, Fructus Crataegi 10 parts, Pericarpium Citri Reticulatae 18 parts.
2. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in medicament for treating insomnia of insomnia according to claim 1.
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| CN201510218226.3A CN104784349A (en) | 2015-05-02 | 2015-05-02 | Traditional Chinese medicine composition for treating insomnia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105105112A (en) * | 2015-08-17 | 2015-12-02 | 俸莲英 | Healthcare beverage capable of soothing nerves and promoting sleep and making method thereof |
| CN106421616A (en) * | 2016-11-14 | 2017-02-22 | 天津金匮堂生物科技有限公司 | Traditional Chinese medicine formula for treating insomnia caused by physical deficiency |
| CN107050093A (en) * | 2017-05-02 | 2017-08-18 | 长春中医药大学 | A kind of Auricular point seed pressing coordinates Traditional Chinese medicine mealses to improve medicine of insomnia and preparation method thereof |
| CN109527140A (en) * | 2018-12-04 | 2019-03-29 | 广东百安常晟信息科技有限公司 | A kind of alternative tea and preparation method thereof for treating insomnia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496858A (en) * | 2008-01-29 | 2009-08-05 | 上海健鋈医药科技有限公司 | Chinese medicinal composition for treating insomnia and preparation method thereof |
| CN102370832A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating insomnia and preparation method thereof |
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2015
- 2015-05-02 CN CN201510218226.3A patent/CN104784349A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496858A (en) * | 2008-01-29 | 2009-08-05 | 上海健鋈医药科技有限公司 | Chinese medicinal composition for treating insomnia and preparation method thereof |
| CN102370832A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating insomnia and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105105112A (en) * | 2015-08-17 | 2015-12-02 | 俸莲英 | Healthcare beverage capable of soothing nerves and promoting sleep and making method thereof |
| CN106421616A (en) * | 2016-11-14 | 2017-02-22 | 天津金匮堂生物科技有限公司 | Traditional Chinese medicine formula for treating insomnia caused by physical deficiency |
| CN107050093A (en) * | 2017-05-02 | 2017-08-18 | 长春中医药大学 | A kind of Auricular point seed pressing coordinates Traditional Chinese medicine mealses to improve medicine of insomnia and preparation method thereof |
| CN109527140A (en) * | 2018-12-04 | 2019-03-29 | 广东百安常晟信息科技有限公司 | A kind of alternative tea and preparation method thereof for treating insomnia |
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Application publication date: 20150722 |