CN104758478A

CN104758478A - Chinese medicine composite used for treating insomnia

Info

Publication number: CN104758478A
Application number: CN201510216070.5A
Authority: CN
Inventors: 臧孝国
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-30
Filing date: 2015-04-30
Publication date: 2015-07-08

Abstract

The invention provides a Chinese medicine composite used for treating insomnia. The Chinese medicine composite is prepared from radix astragali, radix codonopsis and polygala tenuifolia and can be used for treating the insomnia.

Description

A kind of Chinese medicine composition being used for the treatment of insomnia

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of insomnia and its preparation method and application.

Background technology

Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS, for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia often brings painful and psychological burden greatly to patient, can damage other every aspects of health again because of abuse insomnia drug.For this reason, the needs that the medicine developing more Cure for insomnias safely and effectively meets clinical treatment are bursting to.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation for the treatment of insomnia.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of Chinese medicine composition being used for the treatment of insomnia, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: the Herba Gentianae tsinglingensis 12 parts, 18 parts, numb sheep rattan, the Radix Astragali 10 parts, Semen Ziziphi Spinosae 10 parts, Caulis Polygoni Multiflori 15 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 10 parts, Semen Platycladi 10 parts, 10 parts, Poria, 3 parts, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae 10 parts, Cortex Albiziae 15 parts, Herba Agrimoniae 30 parts, Radix Polygalae 6 parts.

The described Chinese medicine composition being used for the treatment of insomnia, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described Chinese medicine composition being used for the treatment of insomnia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described Chinese medicine composition being used for the treatment of insomnia is preparing the application in medicament for treating insomnia.

The Herba Gentianae tsinglingensis is the herb of Gentianaceae agueweed Herba Gentianae tsinglingensis Gentiana apiata N.E.Brown.Summer gathers, and dries.Regulating menstruation and activating blood, clearing away heat to improve acuity of vision, diuresis.For menoxenia, dysmenorrhea, dizzy, insomnia, dysuria, stranguria, metrorrhagia, leucorrhea, dysentery, stomachache.Fiber crops sheep rattan is Vitaceae fiber crops sheep rattan Vitis piasezkii Maxim., goes out juice be used as medicine with young stemflow.Heat-clearing and toxic substances removing, dispelling, collateral-activating, pain relieving, hemostasis.For rheumatic arthritis, vomiting, diarrhoea, Peptic Ulcers; Traumatic injury is controlled in external, swells and ache, sore swollen toxin, traumatic hemorrhage, burn and scald.All the other medical materials are pharmacopeia kind.

Beneficial effect: Cure for insomnia successful of the present invention.The present invention actively can prevent and treat generation and the development of insomnia effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Herba Gentianae tsinglingensis 12g, fiber crops sheep rattan 18g, Radix Astragali 10g, Semen Ziziphi Spinosae 10g, Caulis Polygoni Multiflori 15g, Radix Angelicae Sinensis 10g, Radix Codonopsis 10g, Semen Platycladi 10g, Poria 10g, Radix Glycyrrhizae 3g, Rhizoma Atractylodis Macrocephalae 10g, Cortex Albiziae 15g, Herba Agrimoniae 30g, Radix Polygalae 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Herba Gentianae tsinglingensis 12g, fiber crops sheep rattan 18g, Radix Astragali 10g, Semen Ziziphi Spinosae 10g, Caulis Polygoni Multiflori 15g, Radix Angelicae Sinensis 10g, Radix Codonopsis 10g, Semen Platycladi 10g, Poria 10g, Radix Glycyrrhizae 3g, Rhizoma Atractylodis Macrocephalae 10g, Cortex Albiziae 15g, Herba Agrimoniae 30g, Radix Polygalae 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: get Herba Gentianae tsinglingensis 12g, fiber crops sheep rattan 18g, Radix Astragali 10g, Semen Ziziphi Spinosae 10g, Caulis Polygoni Multiflori 15g, Radix Angelicae Sinensis 10g, Radix Codonopsis 10g, Semen Platycladi 10g, Poria 10g, Radix Glycyrrhizae 3g, Rhizoma Atractylodis Macrocephalae 10g, Cortex Albiziae 15g, Herba Agrimoniae 30g, Radix Polygalae 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.

4, traditional Chinese medicine composition for treating insomnia clinical research of the present invention

4.1 general data: this Chinese medicine composition is applied to clinical observation insomnia case 40 example, wherein man 20 example, female 20 example, 23 ~ 53 years old age.The shortest person of the course of disease 1 month, most elder reaches 2 years, average 1.2 years.

4.2 diagnostic criterias: (1) is slight: accidental, little to Quality of Life; (2) moderate: occur every night, moderate influence quality of life, accompanies certain symptom (irritability, anxiety, tired etc.); (3) severe: occur every night, has a strong impact on quality of life, and clinical symptoms is had outstanding performance.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: (1) clinical recovery: sleep is normal, more than the 6 hours length of one's sleep, simultaneous phenomenon disappears; (2) effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improved; (3) invalid: before sleeping as taking medicine, or extend the length of one's sleep less than 2 hours, symptom is without improvement.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	20	5	10	5	75
Blank group	20	1	2	17	15

Visible, the medicine that the present invention obtains can safe and effective Cure for insomnia.

4.6 Chens, female, 28 years old, the length of one's sleep, every night less than 2 hours, cannot fall asleep after waking up midnight again, and companion's anxiety, continues a wheat harvesting period.Take 2 courses for the treatment of of Chinese medicinal composition granules of the present invention, be increased to 5 hours the length of one's sleep; Continue to strengthen 2 courses for the treatment of, ensure sleep more than 5 hours every day, with other transference cures.

Claims

1. one kind is used for the treatment of the Chinese medicine composition of insomnia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: the Herba Gentianae tsinglingensis 12 parts, 18 parts, numb sheep rattan, the Radix Astragali 10 parts, Semen Ziziphi Spinosae 10 parts, Caulis Polygoni Multiflori 15 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 10 parts, Semen Platycladi 10 parts, 10 parts, Poria, 3 parts, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae 10 parts, Cortex Albiziae 15 parts, Herba Agrimoniae 30 parts, Radix Polygalae 6 parts.

2. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the Chinese medicine composition of insomnia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of Chinese medicine composition in medicament for treating insomnia of insomnia according to claim 1.