CN105012587A - Medicinal preparation for treating epilepsy - Google Patents
Medicinal preparation for treating epilepsy Download PDFInfo
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- CN105012587A CN105012587A CN201510504819.6A CN201510504819A CN105012587A CN 105012587 A CN105012587 A CN 105012587A CN 201510504819 A CN201510504819 A CN 201510504819A CN 105012587 A CN105012587 A CN 105012587A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a medicinal preparation for treating epilepsy. The medicinal preparation for treating the epilepsy is prepared by, 28 parts of Chinese redbud barks, 25 parts of ardisia lindleyana, 20 parts of desmodium heterocarpon, 25 parts of peltateleaf begonia herbs, 18 parts of agilawood, 20 parts of bryozoatum, 18 parts of poria cocos, 20 parts of keels, 15 parts of oysters, 18 parts of uncaria, 20 parts of white atractylodes rhizomes, 10 parts of acorus tatarinowii, 15 parts of white paeony roots and 5 parts of liquorice. The medicinal preparation can treat the epilepsy.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of epilepsy and its preparation method and application.
Background technology
Epilepsy is commonly called as " sheep is insane crazy " or " epilepsy ", epilepsy belongs to the traditional Chinese medical science " carbuncle card " category, just has relevant record in the Huangdi's Internal Classics before in two thousand 2 hundred.Epilepsy is the chronic brain diseases of the abnormal brain function imbalance caused by high-frequency discharge of brain local neuron that many reasons causes, during its outbreak, there is sudden loss of consciousness, complete tetanus spasm in patient, normal companion screams, face is livid purple, urinary incontinence, tongue bite, spit out white foams or blood foam, platycoria etc.Current treatment epilepsy takes Western medicine more, and its principle is generally and directly suppresses brain neuron paradoxical discharge, epilepsy syndromes is controlled, such as, takes the calm class medicine such as phenobarbital, phenytoin Sodium.But this kind of medicine has certain toxic action, can increase hepatic metabolism burden, and need life-time service, due to health toleration, using dosage needs constantly to increase, and medicine can only play control action to epilepsy, can not reach real therapeutic effect.For this reason, be bursting to and develop the needs that more medicines for the treatment of epilepsy safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of epileptic condition.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of epilepsy, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Cortex cercis chinensis 28 parts, Radix Ardisiae punctatae 25 parts, Herba pycnosporae lutescentis 20 parts, Herba Begoniae Cavalerei 25 parts, Lignum Aquilariae Resinatum 18 parts, Pumex 20 parts, 18 parts, Poria, Os Draconis 20 parts, Concha Ostreae 15 parts, Ramulus Uncariae Cum Uncis 18 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Acori Graminei 10 parts, the Radix Paeoniae Alba 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of epilepsy, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of epilepsy, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment AED being used for the treatment of epilepsy.
Cortex cercis chinensis is the dry bark of leguminous plant cercis, Classification system Cercis chinensis Bunge, energy promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, removing toxic substances.For menoxenia, dysmenorrhea, amenorrhea is suffered from abdominal pain, rheumatic arthritis, traumatic injury, laryngopharynx swelling and pain; Swelling and pain of hemorrhoid is controlled in external, worm venom.
Radix Ardisiae punctatae is root or the Herb of Myrsinacea plant Radix Ardisiae punctatae.Promoting blood flow to regulate menstruation, timid wind dehumidifying.Control amenorrhea, dysmenorrhea, rheumatic arthralgia, traumatic injury.The present invention is used as medicine with Herb.
Herba pycnosporae lutescentis is the herb of the close sub-bean of leguminous plant.Latin is called Desmodium heterophyllum (Willd.) DC., is used as medicine with Herb.Relieving stranguria by diuresis, dissipating blood stasis for subsidence of swelling.Cure mainly urinary system calculus, traumatic injury congestive edema, traumatic hemorrhage.
Herba Begoniae Cavalerei is herb and the rhizome of Begoniaceae plant begonia cavalerei levl.Regulate the flow of vital energy and blood; Regulating menstruation skin moistening.Main traumatic injury; Menoxenia; Fertile skin is not flourish.All the other medical materials are pharmacopeia kind.
Beneficial effect: what the traditional Chinese medical science thought epilepsy is by wind, fire, expectorant, the stasis of blood is trouble, the heart, liver,spleen,kidney, visceral-qi is caused to be lacked of proper care, the hepatic and renal YIN deficiency, the deficiency of YIN then yang hyperactivity, yang hyperactivity then the extremely raw wind of liver-wind stirring up internally, high and intenseness of heat, intenseness of heat fire-transformation, fire, wind-fire help for suffering from, another insufficiency of the spleen mistake fortune, clear QI failing to ascend, foul smell decline, and knot, mental confusion due to phlegm, the unsuccessful stasis of blood of painstaking effort, the stasis of blood then blockage of main and collateral channels, stagnation of phlegm blood stasis disturb key clearly in sputum, cause epilepsy eventually.Cortex cercis chinensis of the present invention, Radix Ardisiae punctatae, Herba pycnosporae lutescentis, Herba Begoniae Cavalerei, Lignum Aquilariae Resinatum blood circulation promoting and blood stasis dispelling, eliminate the phlegm and have one's ideas straightened out for monarch drug, Pumex, Poria, Os Draconis, Concha Ostreae, Ramulus Uncariae Cum Uncis tranquillizing and allaying excitement are ministerial drug, the Rhizoma Atractylodis Macrocephalae, Rhizoma Acori Graminei, the Radix Paeoniae Alba, Radix Glycyrrhizae are for being adjuvant, the mutual compatibility of full side, determine that epilepsy relieves dizziness, high fever, infantile convulsions, epilepsy, etc., suppressing the hyperactive liver pathogenic fire purging, treatment epilepsy successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Cortex cercis chinensis 28g, Radix Ardisiae punctatae 25g, Herba pycnosporae lutescentis 20g, Herba Begoniae Cavalerei 25g, Lignum Aquilariae Resinatum 18g, Pumex 20g, Poria 18g, Os Draconis 20g, Concha Ostreae 15g, Ramulus Uncariae Cum Uncis 18g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Acori Graminei 10g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Cortex cercis chinensis 28g, Radix Ardisiae punctatae 25g, Herba pycnosporae lutescentis 20g, Herba Begoniae Cavalerei 25g, Lignum Aquilariae Resinatum 18g, Pumex 20g, Poria 18g, Os Draconis 20g, Concha Ostreae 15g, Ramulus Uncariae Cum Uncis 18g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Acori Graminei 10g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Cortex cercis chinensis 28g, Radix Ardisiae punctatae 25g, Herba pycnosporae lutescentis 20g, Herba Begoniae Cavalerei 25g, Lignum Aquilariae Resinatum 18g, Pumex 20g, Poria 18g, Os Draconis 20g, Concha Ostreae 15g, Ramulus Uncariae Cum Uncis 18g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Acori Graminei 10g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment epilepsy of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation epilepsy cases 40 example, wherein man 20 example, female 20 example, 16 ~ 58 years old age.The shortest person of the course of disease 4 months, most elder reaches 5 years.
4.2 diagnostic criterias: with reference to criteria for classification (Intemational League Against Epilepsy (ILAE) .Commission on Classification andTerminology of the International League Against Epilepsy Proposal for revised classificationof epilepsies and epileptic syndromes [J] Epilepsia1989 of international epilepsy alliance in 1989 about epilepsy and epilepsy syndromes, 30 (4): 389-399) and " practical craniocerebral injury " (Liu Mingfeng, practical craniocerebral injury [M] Beijing: People's Medical Officer Press 1992428-431) and " neurosurgery " (Wang Zhongcheng, neurosurgery [M [Wuhan: Hubei science tech publishing house 1998365-367) work out: 1. EEG (electrocardiogram) examination has epilepsy ripple, 2. ictal disturbance of consciousness, faint, twitch, vegetative nerve function is abnormal, 3. without the past encephalitis, cerebral traumas etc. may lead epileptogaenic posteriority illness, and 4. CT or MRI brain scanning display brain is abnormal.Person is got rid of following situations: take other antiepileptics patient before 1. going to a doctor; 2. previously undergone surgery patient person; 3. hepatorenal disease, or other degenerative disease patient; 4. gestation or mammalian patient; 5. epilepsy family history patient.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: effective: after medication, epilepsy is controlled substantially, or seizure frequency comparatively treat before reduce and be greater than 75%, electroencephalogram and outbreak symptom are improved obviously.Effective: after medication, seizure trequency reduces 51%-75% before comparatively treating, electroencephalogram and outbreak symptom have improvement in various degree.Invalid: after medication, seizure trequency reduces less than 50% before comparatively treating, and electroencephalogram is unchanged, outbreak symptom is also not improved.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Effective | Effectively | Invalid | Total effective rate (%) |
Treatment group | 20 | 5 | 11 | 4 | 80 |
Blank group | 20 | 1 | 2 | 17 | 15 |
Visible, the medicine that the present invention obtains can safe and effective treatment epilepsy, and has no side effect.
4.6 Zhangs, female, 27 years old, suffers from epilepsy, faints suddenly during outbreak, tic of the limbs, spit out white foams.Within 5-7 minute, revive, absentminded after reviving, head has an intense pain.January about 3 times time serious.Take the Chinese medicine that granule embodiment of the present invention provides, during 3 courses for the treatment of, symptom alleviates, and attack times reduces.With taking again 6 courses for the treatment of, transference cure.Follow up a case by regular visits to one year over without outbreak.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of epilepsy, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Cortex cercis chinensis 28 parts, Radix Ardisiae punctatae 25 parts, Herba pycnosporae lutescentis 20 parts, Herba Begoniae Cavalerei 25 parts, Lignum Aquilariae Resinatum 18 parts, Pumex 20 parts, 18 parts, Poria, Os Draconis 20 parts, Concha Ostreae 15 parts, Ramulus Uncariae Cum Uncis 18 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Acori Graminei 10 parts, the Radix Paeoniae Alba 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of epilepsy as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of epilepsy as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment AED of epilepsy according to claim 1.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105687969A (en) * | 2016-03-03 | 2016-06-22 | 冯字 | Pharmaceutical preparation for treating epilepsy |
CN112813084A (en) * | 2021-02-26 | 2021-05-18 | 云南农业大学 | Carbon glycosyltransferase DhCGT1 gene in pseudo-ginseng plant and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104306597A (en) * | 2014-11-10 | 2015-01-28 | 胡健 | Traditional Chinese medicine for treating epilepsy |
CN104758591A (en) * | 2015-04-08 | 2015-07-08 | 吴德红 | Traditional Chinese medicinal composition for treating epilepsy, transient tic disorder and hyperactivity |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104306597A (en) * | 2014-11-10 | 2015-01-28 | 胡健 | Traditional Chinese medicine for treating epilepsy |
CN104758591A (en) * | 2015-04-08 | 2015-07-08 | 吴德红 | Traditional Chinese medicinal composition for treating epilepsy, transient tic disorder and hyperactivity |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105687969A (en) * | 2016-03-03 | 2016-06-22 | 冯字 | Pharmaceutical preparation for treating epilepsy |
CN112813084A (en) * | 2021-02-26 | 2021-05-18 | 云南农业大学 | Carbon glycosyltransferase DhCGT1 gene in pseudo-ginseng plant and application thereof |
CN112813084B (en) * | 2021-02-26 | 2022-07-19 | 云南农业大学 | Carbon glycosyltransferase DhCGT1 gene in pseudo-anethod plants and application thereof |
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