CN105125823A - Medicine preparation for treating chronic nasosinusitis - Google Patents
Medicine preparation for treating chronic nasosinusitis Download PDFInfo
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- CN105125823A CN105125823A CN201510628219.0A CN201510628219A CN105125823A CN 105125823 A CN105125823 A CN 105125823A CN 201510628219 A CN201510628219 A CN 201510628219A CN 105125823 A CN105125823 A CN 105125823A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of a traditional Chinese medicine preparation, and concretely provides a medicine preparation for treating chronic nasosinusitis. The medicine preparation is prepared from the following ingredients: 30 parts of splended bredia herb, 25 parts of khas aletris herb, 28 parts of twining rhynchosia herb, 15 parts of perilla frutescens, 25 parts of honeysuckle, 28 parts of cynanchum paniculatum, 15 parts of magnolia flowers, 15 parts of chrysanthemum, 20 parts of fructus trichosanthis, 25 parts of cocklebur fruit, 20 parts of radix angelicae, 25 parts of houttuynia cordata, 20 parts of scutellaria baicalensis, 15 parts of coptis chinensis, 15 parts of mint, 15 parts of platycodon grandiflorum, 25 parts of schisandra chinensis, 15 parts of agastache rugosus and 5 parts of liquorice. The medicine preparation can be used for treating the chronic nasosinusitis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic sinusitis and its preparation method and application.
Background technology
Chronic sinusitis is the chronic suppurative inflammation of nasal sinuses.More acute person is common, often gets involved for multiple nasal sinuses simultaneously.Chronic sinusitis affects the quality of life of sufferer, the respiratory tract infection symptom of making patients, and severe patient has the possibility causing cranium eye pulmonary lesions, causes vision to change, and even infects and to increase the weight of and dead.Under medicine, operative treatment, most of patients with chronic sinusitis can be cured, the idiocratic patients such as minority companion allergy, asthma, aspirin intolerance, the normal recurrent exerbation of disease.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic sinusitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic sinusitis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic sinusitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Brediae Amoenae 30 parts, Herba Aletridis Khasianae 25 parts, Herba rhynchosiae volubilis 28 parts, cockscomb Folium Perillae 15 parts, Flos Lonicerae 25 parts, Radix Cynanchi Paniculati 28 parts, Flos Magnoliae 15 parts, Flos Chrysanthemi 15 parts, Fructus Trichosanthis 20 parts, Fructus Xanthii 25 parts, the Radix Angelicae Dahuricae 20 parts, Herba Houttuyniae 25 parts, Radix Scutellariae 20 parts, Rhizoma Coptidis 15 parts, Herba Menthae 15 parts, Radix Platycodonis 15 parts, Fructus Schisandrae Chinensis 25 parts, Herba Pogostemonis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic sinusitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic sinusitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic sinusitis medicine being used for the treatment of chronic sinusitis.
Herba Brediae Amoenae is herb and the root of Melastomateae plants Herba Brediae Amoenae.Expelling wind and removing dampness, promoting blood flow to regulate menstruation.Herba Aletridis Khasianae is Liliaceae Aletris plant Herba Aletridis Khasianae AletrislanuginosaBur.etFranch., with all herbal medicine.Autumn gathers, and cleans and dries.Tonify deficiency arresting sweating, hemostasis.For the empty hyperhidrosis of body, neurasthenia, hemoptysis of pulmonary tuberculosis, night sweat.Herba rhynchosiae volubilis is pulse family Herba rhynchosiae volubilis platymiscium Herba rhynchosiae volubilis RhynchosiavolubilisLour., with root and all herbal medicine.Xia Qiu gathers, and cleans section, dries.Removing food stagnancy eliminating stagnation, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.For infantile malnutrition, toothache, nervous headache, lymphoid tuberculosis, rheumatic arthritis, lumbar muscle strain; Carbuncle furuncle and phyma poison is controlled in external, venom.Cockscomb Folium Perillae, Latin is called Perillafrutescens (L.) Brittonvar.crispa (Thunb.) Decne., Labiatae Perilla plant.Annual herb, the special fragrance of tool.Deliver, cold expelling, regulate the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen etc.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, nose is key clearly, is the door of lung, and it is unimpeded that it is breathed, and the sensitive complete of olfactory sensation relies clear sun to supplement nutrition.Sinusitis belongs to the traditional Chinese medical science " sinusitis with purulent discharge " category, Herba Brediae Amoenae of the present invention, Herba Aletridis Khasianae, Herba rhynchosiae volubilis, cockscomb Folium Perillae, Flos Lonicerae, Radix Cynanchi Paniculati, Flos Magnoliae, Flos Chrysanthemi, Fructus Trichosanthis, Fructus Xanthii, Radix Angelicae Dahuricae heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, tonification lung spleen, logical loose nose key is monarch drug, Herba Houttuyniae, Radix Scutellariae, Rhizoma Coptidis, Herba Menthae, Radix Platycodonis, Fructus Schisandrae Chinensis, the stagnant blood stasis dispelling of Herba Pogostemonis row, wind-dispelling heat-dissipating are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment chronic sinusitis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Brediae Amoenae 30g, Herba Aletridis Khasianae 25g, Herba rhynchosiae volubilis 28g, cockscomb Folium Perillae 15g, Flos Lonicerae 25g, Radix Cynanchi Paniculati 28g, Flos Magnoliae 15g, Flos Chrysanthemi 15g, Fructus Trichosanthis 20g, Fructus Xanthii 25g, Radix Angelicae Dahuricae 20g, Herba Houttuyniae 25g, Radix Scutellariae 20g, Rhizoma Coptidis 15g, Herba Menthae 15g, Radix Platycodonis 15g, Fructus Schisandrae Chinensis 25g, Herba Pogostemonis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Brediae Amoenae 30g, Herba Aletridis Khasianae 25g, Herba rhynchosiae volubilis 28g, cockscomb Folium Perillae 15g, Flos Lonicerae 25g, Radix Cynanchi Paniculati 28g, Flos Magnoliae 15g, Flos Chrysanthemi 15g, Fructus Trichosanthis 20g, Fructus Xanthii 25g, Radix Angelicae Dahuricae 20g, Herba Houttuyniae 25g, Radix Scutellariae 20g, Rhizoma Coptidis 15g, Herba Menthae 15g, Radix Platycodonis 15g, Fructus Schisandrae Chinensis 25g, Herba Pogostemonis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Brediae Amoenae 30g, Herba Aletridis Khasianae 25g, Herba rhynchosiae volubilis 28g, cockscomb Folium Perillae 15g, Flos Lonicerae 25g, Radix Cynanchi Paniculati 28g, Flos Magnoliae 15g, Flos Chrysanthemi 15g, Fructus Trichosanthis 20g, Fructus Xanthii 25g, Radix Angelicae Dahuricae 20g, Herba Houttuyniae 25g, Radix Scutellariae 20g, Rhizoma Coptidis 15g, Herba Menthae 15g, Radix Platycodonis 15g, Fructus Schisandrae Chinensis 25g, Herba Pogostemonis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment chronic sinusitis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic sinusitis case 60 example, 25 ~ 55 years old age.The shortest person of the course of disease 6 months, most elder reaches 3 years.
4.2 diagnostic criterias: draft with reference to " chronic sinusitis " diagnostic criteria in " practical ear larynx rhinology ".(1) symptom: have a stuffy nose, suppurate, hyposmia or disappearance, and how with headache, dizzy, feeling of fullness in the head.(2) sign: have purulent secretion to flow out in nasal meatus, nasal conchae hypertrophy, edema or polypoid change.(3) auxiliary examination: all cases all take the photograph Ke, Fahrenheit X-ray film inspection display meets chronic sinusitis and sexually revises.Get rid of other character pathological changes of nasal sinuses.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: symptom disappears without recurrence completely, without any discomfort symptom; Effective: transference cure, without recurrence within 1 year; Effective: symptom obviously alleviates, or partial symptoms disappears, and needs continual cure; Invalid: symptom does not have any improvement, even there is the trend increased the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 8 | 9 | 11 | 2 | 93.3 |
| Blank group | 30 | 1 | 1 | 2 | 26 | 13.3 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic sinusitis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic sinusitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Brediae Amoenae 30 parts, Herba Aletridis Khasianae 25 parts, Herba rhynchosiae volubilis 28 parts, cockscomb Folium Perillae 15 parts, Flos Lonicerae 25 parts, Radix Cynanchi Paniculati 28 parts, Flos Magnoliae 15 parts, Flos Chrysanthemi 15 parts, Fructus Trichosanthis 20 parts, Fructus Xanthii 25 parts, the Radix Angelicae Dahuricae 20 parts, Herba Houttuyniae 25 parts, Radix Scutellariae 20 parts, Rhizoma Coptidis 15 parts, Herba Menthae 15 parts, Radix Platycodonis 15 parts, Fructus Schisandrae Chinensis 25 parts, Herba Pogostemonis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic sinusitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic sinusitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic sinusitis medicine of chronic sinusitis according to claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943738A (en) * | 2006-10-23 | 2007-04-11 | 杨磊 | A medicine for treatment of chronic nasosinusitis |
| CN101181408A (en) * | 2007-11-30 | 2008-05-21 | 胡玉翠 | Chinese medicine composition for the oral medication of chronic sinusitis |
| CN101926901A (en) * | 2010-09-01 | 2010-12-29 | 吴业刚 | Chinese medicinal oral liquid for treating chronic rhinitis and sinusitis and preparation method thereof |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
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2015
- 2015-09-28 CN CN201510628219.0A patent/CN105125823A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943738A (en) * | 2006-10-23 | 2007-04-11 | 杨磊 | A medicine for treatment of chronic nasosinusitis |
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Application publication date: 20151209 |