CN105056057A - Pharmaceutical preparation for treating bronchial asthma - Google Patents
Pharmaceutical preparation for treating bronchial asthma Download PDFInfo
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- CN105056057A CN105056057A CN201510552777.3A CN201510552777A CN105056057A CN 105056057 A CN105056057 A CN 105056057A CN 201510552777 A CN201510552777 A CN 201510552777A CN 105056057 A CN105056057 A CN 105056057A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutical preparation for treating the bronchial asthma. The pharmaceutical preparation for treating the bronchial asthma is prepared by 25 parts of pachysandra, 28 parts of costus speciosus, 30 parts of moellendorf's spidemoss herb, 18 parts of phyllodium longipes, 25 parts of inula flower, 15 parts of snakegourd fruits, 20 parts of dark plum, 20 parts of blackberry lily, 25 parts of pinellia ternata, 25 parts of white atractylodes rhizome, 20 parts of cinnamon, 15 parts of almonds, 18 parts of white mulberry root barks, 15 parts of dayflower and 5 parts of licorice. The pharmaceutical preparation can treat the bronchial asthma.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of bronchial asthma and its preparation method and application.
Background technology
Bronchial asthma is the chronic airway inflammation disease participated in by various kinds of cell and cellular component, this chronic inflammatory disease is relevant to airway hyperreactivity, the reversible airflow limitation that usual appearance is extensive and changeable, cause the symptoms such as the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough, how in night and (or) outbreak in early morning, aggravation, most of patients can spontaneous remission or alleviate through treatment.For this reason, be bursting to and develop the needs that more medicines for the treatment of bronchial asthma safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of bronchial asthma disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of bronchial asthma, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: careless 25 parts green for a long time, Costus speciosus 28 parts, Herba Selaginellae Moellendorfii 30 parts, row money set 18 parts, Flos Inulae 25 parts, Fructus Trichosanthis 15 parts, Fructus Mume 20 parts, Rhizoma Belamcandae 20 parts, the Rhizoma Pinelliae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Cortex Cinnamomi 20 parts, 15 parts, Semen Armeniacae Amarum, Cortex Mori 18 parts, Herba Commelinae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of bronchial asthma, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of bronchial asthma, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment bronchial asthma medicine being used for the treatment of bronchial asthma.
Grass green for a long time is Buxaceae powder stamen Buxus plant top stamen Herba Pachysandrae Stylosae PachysandraterminalisSieb.etZucc., with all herbal medicine.The whole year can adopt, and cleans cutting, dries.Dispelling wind stopping cough, relaxing muscles and tendons and activating QI and blood in the collateral, adjusting meridian and stopping leukorrhea.For chronic tracheitis, rheumatic arthritis, spasm of the calf, leucorrhea, amenorrhea, psychosis dysphoria.
Costus speciosus, Latin is called Costusspeciosus (Koen.) Smith, is Zingiberaceae Costus L herbaceos perennial, and like and grow under warm, moist environment, original producton location is Tropical Asia.Inducing diuresis to remove edema, detoxifying and relieving itching.For pertussis, oedema due to nephritis, urinary tract infection, cirrhotic ascites, dysuria; Urticaria is controlled in external, furuncle toxic swelling, otitis media.The present invention is with all herbal medicine.
Herba Selaginellae Moellendorfii is Selaginaceae Rock lily plant Herba Selaginellae Involventis SelaginellamoellendorfiiHieron., with all herbal medicine.The four seasons can adopt, and clean, dry.Clearing away heat-damp and promoting diuresis, hemostasis.For acute icterohepatitis, anasarca, hemoptysis of pulmonary tuberculosis, spits blood, bleeding hemorrhoids; Traumatic hemorrhage is controlled in external, burn and scald.
Row Qian Shuwei pulse family beggar-ticks rows of plants money tree Desmodiumpulchellum (L.) Benth., is used as medicine with root and leaf.Xia Qiu gathers, and summer shreds, and dries or using fresh herb.Clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.For cold, fever, malaria, hepatitis, cirrhotic ascites, schistosomicide hepatosplenomegaly, rheumatalgia, traumatic injury.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks the lung being the dominator of QI, the kidney being the root of QI.When asthmatic attacks, lung road can not main gas, and suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI, then QI rising in reverse order is in upper, and sends out in dyspnea with rapid respiration.The spleen is the source of growth and development, spleen deficiency generating phlegm, stagnation of phlegm air flue, therefore see and breath with cough, and breathes hard.Therefore, asthma is the disease of kidney, lung, spleen, three void.The present invention's grass green for a long time, Costus speciosus, Herba Selaginellae Moellendorfii, row Qian Shu, Flos Inulae, Fructus Trichosanthis, Fructus Mume, Rhizoma Belamcandae, Rhizoma Pinelliae strengthening spleen, tonifying kidney, relieving cough and relieving asthma, regulate the flow of vital energy and eliminate the phlegm as monarch drug, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Semen Armeniacae Amarum, Cortex Mori, Herba Commelinae dispersing lung-QI and dissipating phlegm, antiasthmatic-antitussive are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, dispersing lung-QI and dissipating phlegm, antiasthmatic-antitussive, treatment bronchial asthma successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get careless 25g green for a long time, Costus speciosus 28g, Herba Selaginellae Moellendorfii 30g, row's money tree 18g, Flos Inulae 25g, Fructus Trichosanthis 15g, Fructus Mume 20g, Rhizoma Belamcandae 20g, Rhizoma Pinelliae 25g, Rhizoma Atractylodis Macrocephalae 25g, Cortex Cinnamomi 20g, Semen Armeniacae Amarum 15g, Cortex Mori 18g, Herba Commelinae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get careless 25g green for a long time, Costus speciosus 28g, Herba Selaginellae Moellendorfii 30g, row's money tree 18g, Flos Inulae 25g, Fructus Trichosanthis 15g, Fructus Mume 20g, Rhizoma Belamcandae 20g, Rhizoma Pinelliae 25g, Rhizoma Atractylodis Macrocephalae 25g, Cortex Cinnamomi 20g, Semen Armeniacae Amarum 15g, Cortex Mori 18g, Herba Commelinae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get careless 25g green for a long time, Costus speciosus 28g, Herba Selaginellae Moellendorfii 30g, row's money tree 18g, Flos Inulae 25g, Fructus Trichosanthis 15g, Fructus Mume 20g, Rhizoma Belamcandae 20g, Rhizoma Pinelliae 25g, Rhizoma Atractylodis Macrocephalae 25g, Cortex Cinnamomi 20g, Semen Armeniacae Amarum 15g, Cortex Mori 18g, Herba Commelinae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment bronchial asthma of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation bronchial asthma case 60 example, wherein man 30 example, female 30 example, 17 ~ 56 years old age.The shortest person of the course of disease 4 months, most elder reaches 4 years.
4.2 diagnostic criterias: 1. recurrent exerbation pant, out of breath, uncomfortable in chest or cough, how with to contact allergen, cold air, physics, chemical irritation, viral upper respiratory tract infection, motion etc. relevant.2. during outbreak at two lung audible and be dispersed in or diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation.3. above-mentioned symptom can be alleviated or spontaneous remission through treatment.4. panting except caused by other diseases, out of breath, uncomfortable in chest or cough.5. atypical symptoms person's (as without obviously panting or sign) should at least possess with the next item down test positive: (1) brinchial provocation test or the exercise test positive; (2) the Bronchodilation Test positive (FEV1 increases by more than 15%, and FEV1 absolute value increases >200ml); (3) in PEF day, aberration rate or day and night fluctuation rate >=20% meet above 1-4 bar or 4,5 persons, can be diagnosed as bronchial asthma.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 8 | 19 | 3 | 90 |
| Blank group | 30 | 1 | 3 | 26 | 13.3 |
Visible, the medicine that the present invention obtains can safe and effective treatment bronchial asthma, and have no side effect.
4.6 Lee, female, 35 years old, suffers from bronchial asthma 2 years, show as recurrent exerbation pant, out of breath, uncomfortable in chest, lab testing confirmation is for bronchial asthma.Give the Chinese medicine that granule embodiment of the present invention provides, after 2 courses for the treatment of, clinical symptoms all disappears, and test chamber inspection is normal.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of bronchial asthma, it is characterized in that, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: careless 25 parts green for a long time, Costus speciosus 28 parts, Herba Selaginellae Moellendorfii 30 parts, row money set 18 parts, Flos Inulae 25 parts, Fructus Trichosanthis 15 parts, Fructus Mume 20 parts, Rhizoma Belamcandae 20 parts, the Rhizoma Pinelliae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Cortex Cinnamomi 20 parts, 15 parts, Semen Armeniacae Amarum, Cortex Mori 18 parts, Herba Commelinae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of bronchial asthma as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of bronchial asthma as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment bronchial asthma medicine of bronchial asthma according to claim 1.
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| CN201510552777.3A CN105056057A (en) | 2015-09-01 | 2015-09-01 | Pharmaceutical preparation for treating bronchial asthma |
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| CN201510552777.3A CN105056057A (en) | 2015-09-01 | 2015-09-01 | Pharmaceutical preparation for treating bronchial asthma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317787A (en) * | 2020-03-25 | 2020-06-23 | 漳州片仔癀药业股份有限公司 | Application of traditional Chinese medicine composition and preparation thereof in preparation of medicine for treating bronchial asthma |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094306A (en) * | 1993-11-16 | 1994-11-02 | 张斌尚 | The Chinese patent medicine of treatment bronchitis, bronchial asthma |
| CN1196953A (en) * | 1998-05-05 | 1998-10-28 | 王立泉 | Chinese patent drug for treating chronic bronchitis and asthma |
| CN101983675A (en) * | 2010-11-08 | 2011-03-09 | 西安谦坤商务咨询管理有限公司 | Traditional Chinese medicine composition for treating asthma and preparation method thereof |
| CN103211938A (en) * | 2013-03-28 | 2013-07-24 | 宁波市镇海嘉慧知识产权服务有限公司 | Traditional Chinese medicine composite for treating asthma |
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2015
- 2015-09-01 CN CN201510552777.3A patent/CN105056057A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094306A (en) * | 1993-11-16 | 1994-11-02 | 张斌尚 | The Chinese patent medicine of treatment bronchitis, bronchial asthma |
| CN1196953A (en) * | 1998-05-05 | 1998-10-28 | 王立泉 | Chinese patent drug for treating chronic bronchitis and asthma |
| CN101983675A (en) * | 2010-11-08 | 2011-03-09 | 西安谦坤商务咨询管理有限公司 | Traditional Chinese medicine composition for treating asthma and preparation method thereof |
| CN103211938A (en) * | 2013-03-28 | 2013-07-24 | 宁波市镇海嘉慧知识产权服务有限公司 | Traditional Chinese medicine composite for treating asthma |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317787A (en) * | 2020-03-25 | 2020-06-23 | 漳州片仔癀药业股份有限公司 | Application of traditional Chinese medicine composition and preparation thereof in preparation of medicine for treating bronchial asthma |
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Application publication date: 20151118 |