CN103191282B - Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN103191282B CN103191282B CN201310152281.8A CN201310152281A CN103191282B CN 103191282 B CN103191282 B CN 103191282B CN 201310152281 A CN201310152281 A CN 201310152281A CN 103191282 B CN103191282 B CN 103191282B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- fever
- children
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a traditional Chinese medicinal composition for treating fever in children. The composition is characterized by being prepared from the following raw materials in parts by weight: 6 to 12 parts of yam rhizome, 4 to 8 parts of Chinese violet, 6 to 12 parts of chingma abutilon seed, 3 to 7 parts of gyp, 6 to 12 parts of schizonepeta, 6 to 12 parts of cyrtomium rhizome, 6 to 12 parts of fructus forsythiae, 6 to 12 parts of kudzuvine root, 6 to 12 parts of baical skullcap root, 6 to 12 parts of radix scrophulariae, 6 to 12 parts of raw rehmannia root, and 6 to 12 parts of divaricate saposhnikovia root. By adopting a corresponding preparation method, oral solution, tablets, capsules or granules can be prepared. The traditional Chinese medicinal composition has the functions of dispelling wind and clearing heat, nourishing yin and removing toxicity, and can be used for treating fever in children.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method and application that are used for the treatment of fever of children.
Background technology
The children's of growth and development stage, their nervous system is often grown imperfect, is easy to the impact of the factors such as climate, environment, improper feeding, disease, medicine and lacks of proper care, Here it is why children's in the easy basic reason of heating in summer.Fever, in body, first " protecting wall " fever is a kind of symptom, is a kind of normal immunoreation in body, the effect of helpful sterilization and lifting resistance.During fever, the various immunologic functions in body are all " activated ", and metabolism speeds, antibody is synthetic increases and phagocyte activity.High heat energy causes dehydration, convulsions, cytoclasis, if use chemical drugs, has larger toxic and side effects, lacks very much at present a kind of fever of children Chinese medicine preparation for the treatment of safely and effectively.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition and preparation method and application that are used for the treatment of fever of children.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine composition that is used for the treatment of fever of children, it prepares: Rhizoma Dioscoreae Septemlobae 6-12 part, Herba Violae 4-8 part, Semen Abutili 6-12 part, Gypsum Fibrosum 3-7 part, Herba Schizonepetae 6-12 part, Rhizoma Osmundae 6-12 part, Fructus Forsythiae 6-12 part, Radix Puerariae 6-12 part, Radix Scutellariae 6-12 part, Radix Scrophulariae 6-12 part, Radix Rehmanniae 6-12 part, Radix Saposhnikoviae 6-12 part by the raw material of following parts by weight.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, it prepares 9 parts of: Rhizoma Dioscoreae Septemlobae, 6 parts of Herba Violaes, 9 parts of Semen Abutilis, 5 parts, Gypsum Fibrosum, 9 parts of Herba Schizonepetae, 9 parts of Rhizoma Osmundae, 9 parts of Fructus Forsythiaes, 9 parts of Radix Puerariaes, 9 parts of Radix Scutellariaes, 9 parts of Radix Scrophulariaes, 9 parts, the Radix Rehmanniae, 9 parts of Radix Saposhnikoviaes by the raw material of following parts by weight.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, described raw material adds adjuvant and makes oral liquid, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, it comprises the steps: Qu Rhizoma Dioscoreae Septemlobae, Herba Violae, Semen Abutili, Gypsum Fibrosum, Herba Schizonepetae, Rhizoma Osmundae, Fructus Forsythiae, Radix Puerariae, Radix Scutellariae, Radix Scrophulariae, the Radix Rehmanniae, Radix Saposhnikoviae medical material merges, decoct with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, in step, spraying drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The application of the above-mentioned Chinese medicine composition that is used for the treatment of fever of children in the medicine of preparation treatment fever of children.
In Chinese medicine of the present invention, Semen Abutili is the mature seed of Malvaceae annual herb plant Semen Abutili, and all the other are pharmacopeia kind.
Beneficial effect:
1, from theory of Chinese medical science, children's is " pure-yang constituent ", and life is flourishing, blastoprolepsis, but internal organs are tender and lovely, and shape gas does not fill, call it " the young sun of young the moon ", Chang Hannuan can not self-regulated, and breast food is not known from joint, once maintenance is inappropriate,, easily by six climate exopathogens, invaded, interior is easily injury due to diet, and ill rear variation is rapid, " easily cold easily heat, easily empty easily real ".In the children's exogenous course of disease, the every easily heat-transformation of its cold syndrome, thermoae Yi Shengfeng again, clinical common children's's heat syndrome and infantile convulsion, control wrong treatment once lose, and misses an opportunity because of a delay, and very easily decline of YANG QI is de-, and occurs the card of YIN-cold YANG-depletion.Therefore, often at the beginning of morbidity, suddenly throw the product of wind and heat dispersing, the spirit clearly of good fortune children's visceral-qi, the rehabilitation that easily becomes, controls if distinguish rationally, writes out a prescription precise and appropriate, " with pulling out with answering ".We's children's's physiological and pathological feature that hits, knows infantile fever caused by exogenous pathogens, and mainly with wind heat, for suffering from, in very easily passing, wind symptom very, therefore should suddenly throw the product of wind and heat dispersing and the product of heat-clearing and toxic substances removing.Even if affection of exogenous wind-cold, in knowing that soon heat-transformation of cold-evil passes, also should early throw the product of wind and heat dispersing and heat-clearing and toxic substances removing.In side, take Herba Schizonepetae, Radix Saposhnikoviae, Fructus Forsythiae, Radix Puerariae four medicines is monarch, has the meaning of Antiphlogistic Powder of Schizonepetae and Ledebouriellae, Lonicerae and Forsythiae Powder, GEGEN TANG, is intended to wind and heat dispersing.Minister expels the heat-evil with Radix Scutellariae, Gypsum Fibrosum lung heat clearing, Semen Abutili, Herba Violae heat-clearing and toxic substances removing, and especially the epidemic febrile disease serious symptom of diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison more needs heavy prescription to treat.Assistant is with Radix Scrophulariae, the Radix Rehmanniae, and merit is at clearing away heat and nourishing YIN, relieving restlessness removing toxic substances, and both anti-consumption of YIN caused by febrile disease, probably heat is disturbed the mind again, more help Rhizoma Dioscoreae Septemlobae dampness removing and go turbidly, wind expelling stagnation removing, controls ailment said due to cold or exposure folder wet, and children's's sweating is sticky, and indistinctive fever person is especially suitable.Rhizoma Osmundae heat-clearing and toxic substances removing, cooling blood for hemostasis, nature and flavor are arduous to be slightly cold, and enters lung meridian, be the meaning of guiding action also.Make a general survey of full side, play altogether the merit of wind and heat dispersing, the effect of Yin and detoxification of holding concurrently, is used for the treatment of fever of children.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, have no side effect, and low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
1,, in conjunction with the specific embodiment, the present invention is further described as follows:
2, according to the form below, listed weight proportion takes raw material required for the present invention, unit: g
| ? | Rhizoma Dioscoreae Septemlobae | Herba Violae | Semen Abutili | Gypsum Fibrosum | Herba Schizonepetae | Rhizoma Osmundae | Fructus Forsythiae | Radix Puerariae | Radix Scutellariae | Radix Scrophulariae | The Radix Rehmanniae | Radix Saposhnikoviae |
| 1 | 6 | 8 | 6 | 7 | 6 | 12 | 6 | 12 | 6 | 12 | 6 | 12 |
| 2 | 9 | 6 | 9 | 5 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 |
| 3 | 12 | 4 | 12 | 3 | 12 | 6 | 12 | 6 | 12 | 6 | 12 | 6 |
3. Preparation Example
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: Qu Rhizoma Dioscoreae Septemlobae 6g, Herba Violae 8g, Semen Abutili 6g, Gypsum Fibrosum 7g, Herba Schizonepetae 6g, Rhizoma Osmundae 12g, Fructus Forsythiae 6g, Radix Puerariae 12g, Radix Scutellariae 6g, Radix Scrophulariae 12g, Radix Rehmanniae 6g, Radix Saposhnikoviae 12g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 85 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), adding appropriate amount of starch, dry granulation, crosses 60 mesh sieves, packs No. 1 capsule into and gets final product to obtain capsule.
Embodiment 2: Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 1h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.20, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, and reclaim ethanol, obtain concentrated solution, filter, add water and sucrose is mixed with oral liquid.
Embodiment 3: Qu Rhizoma Dioscoreae Septemlobae 12g, Herba Violae 4g, Semen Abutili 12g, Gypsum Fibrosum 3g, Herba Schizonepetae 12g, Rhizoma Osmundae 6g, Fructus Forsythiae 12g, Radix Puerariae 6g, Radix Scutellariae 12g, Radix Scrophulariae 6g, Radix Rehmanniae 12g, Radix Saposhnikoviae 6g medical material merges, decoct with water twice, adding for the first time water is 12 times of amounts of medical material weight, decoct 2h, adding for the second time water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.20, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 120 ℃, leaving air temp is 90 ℃, temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add appropriate dextrin, mix homogeneously, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, crosses 30 mesh sieves and granulates, in 70～80 ℃ dry, with 60 mesh sieve granulate, tabletting, sugar coating, obtains tablet.
Embodiment 4: Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 65 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 110 ℃, leaving air temp is 80 ℃, temperature of charge is 70 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add appropriate lactose, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 70-80 ℃ is dry, and 60 order granulate, obtain granule.
4. the impact of granule of the present invention on fever of children
4.1 animals: animal SD rat, male, body weight 220～250g, purchased from Nanjing Medical University's animal center, production licence number SCXK (Soviet Union) 2002-0031.
4.2 medicines and reagent: press above-described embodiment 4 preparation granule of the present invention, be Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 65 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 110 ℃, leaving air temp is 80 ℃, temperature of charge is 70 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add appropriate lactose, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, crossing 14 mesh sieves granulates, 70-80 ℃ dry, 60 order granulate, obtain granule 100g, be distributed into 10g granule/bag, in every bag of granule, contain crude drug 10g, lot number 20120511, clinical people's consumption per day is each 1 bag, every day 3 times, be that clinical people's consumption per day is 30g crude drug, therefore determine that every 200g rat consumption is 30x0.018=0.54g crude drug, with a kilogram calculating, dosage is 2.7g crude drug/kg, this is low dosage, dosage 5.4g crude drug/kg is middle dosage, dosage 10.8g crude drug/kg is high dose.Reagent: purification LPS (Escherichca coliendotoxin055:B5, L2880, Sigma Co.) is diluted in physiological saline solution, is made into the solution of 20 μ g/ml, and-20 ℃ save backup.
4.3 processs of the test: rat take temperature every day (anus temperature) 2 times, continuous 2 days, the meansigma methods of getting twice body temperature was designated as basal body temperature.Single body temperature surpasses 38 ℃ or 2 poor animals rejectings that surpass 0.5 ℃ of body temperature.50 of rats that meet experiment condition are divided into 5 groups at random: Normal group, model group, senior middle school of the present invention low dose group, 10 every group.Before experiment, water is can't help in 6h fasting.Model group and administration group rat be lumbar injection LPS (20 μ g/kg or 80 μ g/kg) respectively, brings out animal heating; Normal group injecting normal saline.Administration in the time of modeling, normal group and model group give same volume distilled water.After injection LPS, every 0.5h, survey 1 body temperature, monitor continuously 8h, t test and judge group difference, the results are shown in Table 1.
The impact (n=10) of table 1 granules of rats heating of the present invention
With model group comparison, * * P < 0.01 * P < 0.05
Result: the large, medium and small dosage group of granule of the present invention has stronger intensification inhibitory action to LPS fever model rat, and presents certain dose dependent.
5 clinical research datas are summed up
5.1 physical data: be divided at random treatment group 123 example and matched group 61 examples by medical order.Treatment group man 63 examples, female's 60 examples; Body temperature 38-40 ℃, 1 years old to 12 years old age, average 5.16 ± 1.39 years old; Matched group man 32 examples, female's 29 examples; Body temperature 38-40 ℃, 1 years old to 12 years old age, average 4.93 ± 1.67 years old.The general clinical data indices of test group and matched group has comparability, two groups of characteristic of diseases not, age, body weight, body temperature, symptom score difference not statistically significant (P > 0.05).5.2 diagnostic criterias: all fever of children meet traditional Chinese medical science infantile common cold diagnostic criteria person, clinical manifestation is heating, nasal obstruction, watery nasal discharge, or companion cough, feel sick, the cold symptoms such as vomiting.
5.3 Therapeutic Method: it is oral that (1) matched group is got children-welfare tablet (dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing, for cold, fever, are contained the diseases such as fever and headache in phlegm-fire), one time 2,3 times on the one.(2) treatment group is taken above-described embodiment 4 preparation granule of the present invention, each 1 bag, every day 3 times.
5.4 criterions of therapeutical effect: draft with reference to the < < of pharmaceutical control and administration department of Ministry of Health of the People's Republic of China new drug (Chinese medicine) treatment infantile fever caused by exogenous pathogens (acute upper respiratory tract infection) guideline of clinical investigations > >.Take and bring down a fever as leading indicator.Recovery from illness: in medication 24～48h, temperature recovery normal level, and do not go up again, disease disappears; Effective: in medication 24～48h, temperature recovery normal level, main disease is most of to disappear; Effective: in medication 24～48h, temperature recovery normal level, main disease partly disappears; Invalid: not meet above standard person.
The comparison of 5.5 liang of group curative effects
Between group, relatively, application SPSS18.0 statistical software processes, χ 2=10.233, and P < 0.05, shows that treatment group is better than matched group.
Result: granule therapy infantile fever caused by exogenous pathogens total effective rate of the present invention reaches 97.6%.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of fever of children, is characterized in that, it is prepared by the raw material of following parts by weight: Rhizoma Dioscoreae Septemlobae 6-12 part, Herba Violae 4-8 part, Semen Abutili 6-12 part, Gypsum Fibrosum 3-7 part, Herba Schizonepetae 6-12 part, Rhizoma Osmundae 6-12 part, Fructus Forsythiae 6-12 part, Radix Puerariae 6-12 part, Radix Scutellariae 6-12 part, Radix Scrophulariae 6-12 part, Radix Rehmanniae 6-12 part, Radix Saposhnikoviae 6-12 part, preparation method comprises the steps: Qu Rhizoma Dioscoreae Septemlobae, Herba Violae, Semen Abutili, Gypsum Fibrosum, Herba Schizonepetae, Rhizoma Osmundae, Fructus Forsythiae, Radix Puerariae, Radix Scutellariae, Radix Scrophulariae, the Radix Rehmanniae, Radix Saposhnikoviae medical material merges, and decocts with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adds ethanol and makes to reach 75-85% containing the percent by volume of alcohol amount, stirs, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaims ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
2. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1, it is characterized in that, it prepares 9 parts of: Rhizoma Dioscoreae Septemlobae, 6 parts of Herba Violaes, 9 parts of Semen Abutilis, 5 parts, Gypsum Fibrosum, 9 parts of Herba Schizonepetae, 9 parts of Rhizoma Osmundae, 9 parts of Fructus Forsythiaes, 9 parts of Radix Puerariaes, 9 parts of Radix Scutellariaes, 9 parts of Radix Scrophulariaes, 9 parts, the Radix Rehmanniae, 9 parts of Radix Saposhnikoviaes by the raw material of following parts by weight.
3. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1, it is characterized in that, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
4. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1, is characterized in that, in preparation method step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
5. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1, it is characterized in that, in preparation method step, spraying drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
6. the application of the Chinese medicine composition that is used for the treatment of fever of children described in claim 1 or 2 in the medicine of preparation treatment fever of children.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310152281.8A CN103191282B (en) | 2013-04-28 | 2013-04-28 | Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310152281.8A CN103191282B (en) | 2013-04-28 | 2013-04-28 | Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103191282A CN103191282A (en) | 2013-07-10 |
| CN103191282B true CN103191282B (en) | 2014-11-05 |
Family
ID=48714216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310152281.8A Expired - Fee Related CN103191282B (en) | 2013-04-28 | 2013-04-28 | Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103191282B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069269A (en) * | 2014-07-07 | 2014-10-01 | 海城市中医院 | Preparation for cooling blood, relieving internal heat and abating fever, and method of using preparation |
| CN105434810A (en) * | 2015-12-29 | 2016-03-30 | 刘树芹 | Granules for treating infantile fever and respiratory tract infection and application thereof |
| CN108938571A (en) * | 2018-09-04 | 2018-12-07 | 江苏省中医药研究院 | A method of it eliminating Chinese medical extract dry granulation and sticks roller phenomenon |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
| CN102018907A (en) * | 2011-01-22 | 2011-04-20 | 陈鹏 | Medicine for treating fever in children and preparation method thereof |
-
2013
- 2013-04-28 CN CN201310152281.8A patent/CN103191282B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
| CN102018907A (en) * | 2011-01-22 | 2011-04-20 | 陈鹏 | Medicine for treating fever in children and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103191282A (en) | 2013-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101049424B (en) | Medication for treating infection in respiratory system | |
| CN102048895B (en) | Pure traditional Chinese medicine preparation for treating dilated cardiomyopathy | |
| CN101559099B (en) | Traditional Chinese medicine composition for curing wind cold and preparation method thereof | |
| CN106806853B (en) | Traditional Chinese medicine composition for relieving physical fatigue and/or improving anoxia endurance, preparation method and application thereof | |
| CN114470114B (en) | Application of Mailuoshutong preparation in preparation of medicine for treating constipation | |
| CN103191282B (en) | Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof | |
| CN101322761A (en) | Medicament for treating tracheitis and bronchitic and preparation thereof | |
| CN102961584B (en) | Traditional Chinese medicine composition capable of relieving fatigue, as well as preparation method and application thereof | |
| CN116139237B (en) | A Chinese medicinal composition for preventing and treating respiratory tract infection caused by coronavirus, and its application | |
| CN102293894B (en) | Traditional Chinese medicine composition for treating dysmenorrhea, and preparation method and application thereof | |
| CN103263654B (en) | Medicine for treating lobar pneumonia and preparation method thereof | |
| CN1330359C (en) | Chinese medicine preparation for treating AIDS and process thereof | |
| CN102836203B (en) | Traditional Chinese medicine composition for treating wind-heat type common cold as well as preparation method and application thereof | |
| CN102988921B (en) | Chinese medicinal composition for treating diarrhea as well as preparation method and application thereof | |
| CN102451401A (en) | Recipe of vitamin C lonicera and forsythia | |
| CN102727627B (en) | Traditional Chinese medicine composition for treating heart failure and preparation method and application thereof | |
| CN105250552A (en) | Pharmaceutical preparation used for treating acute gastroenteritis | |
| CN101468056B (en) | Chinese medicine preparation for treating enteritis, diarrhea, and red-white dysentery | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN103040939A (en) | Traditional Chinese medicine composition for treating cold, as well as preparation method and application thereof | |
| CN106620266A (en) | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine | |
| CN105056057A (en) | Pharmaceutical preparation for treating bronchial asthma | |
| CN104784567B (en) | A kind of pharmaceutical composition for the treatment of urinary system infection | |
| CN105079717A (en) | Pharmaceutical preparation for treating depression | |
| CN104888050A (en) | Drug for treating constipation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141105 Termination date: 20190428 |