CN103191282A - Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal composition for treating fever in children. The composition is characterized by being prepared from the following raw materials in parts by weight: 6 to 12 parts of yam rhizome, 4 to 8 parts of Chinese violet, 6 to 12 parts of chingma abutilon seed, 3 to 7 parts of gyp, 6 to 12 parts of schizonepeta, 6 to 12 parts of cyrtomium rhizome, 6 to 12 parts of fructus forsythiae, 6 to 12 parts of kudzuvine root, 6 to 12 parts of baical skullcap root, 6 to 12 parts of radix scrophulariae, 6 to 12 parts of raw rehmannia root, and 6 to 12 parts of divaricate saposhnikovia root. By adopting a corresponding preparation method, oral solution, tablets, capsules or granules can be prepared. The traditional Chinese medicinal composition has the functions of dispelling wind and clearing heat, nourishing yin and removing toxicity, and can be used for treating fever in children.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method and application that are used for the treatment of fever of children.
Background technology
The children's of growth and development stage, their nervous system is often grown imperfect, is easy to be subjected to the influence of factors such as weather, environment, improper feeding, disease, medicine and lacks of proper care, Here it is why children's in the basic reason of heating easily in summer.First road " protecting wall " fever is a kind of symptom in the fever, body, is a kind of normal immunoreation in the body, the effect of helpful sterilization and lifting resistance.During fever, the various immunologic functions in the body all are " activated ", and metabolism speeds, antibody is synthetic increases and the phagocyte activity.High heat energy causes dehydration, convulsions, cytoclasis, if use chemical drugs, has bigger toxic and side effects, lacks very much a kind of fever of children Chinese medicine preparation for the treatment of safely and effectively at present.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition and preparation method and application that are used for the treatment of fever of children.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition that is used for the treatment of fever of children, it obtains: Rhizoma Dioscoreae Septemlobae 6-12 part, Herba Violae 4-8 part, Semen Abutili 6-12 part, Gypsum Fibrosum 3-7 part, Herba Schizonepetae 6-12 part, Rhizoma Osmundae 6-12 part, Fructus Forsythiae 6-12 part, Radix Puerariae 6-12 part, Radix Scutellariae 6-12 part, Radix Scrophulariae 6-12 part, Radix Rehmanniae 6-12 part, Radix Saposhnikoviae 6-12 part by the feedstock production of following parts by weight.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, it obtains 9 parts of: Rhizoma Dioscoreae Septemlobae, 6 parts of Herba Violaes, 9 parts of Semen Abutilis, 5 parts in Gypsum Fibrosum, 9 parts of Herba Schizonepetae, 9 parts of Rhizoma Osmundae, 9 parts of Fructus Forsythiaes, 9 parts of Radix Puerariaes, 9 parts of Radix Scutellariaes, 9 parts of Radix Scrophulariaes, 9 parts in the Radix Rehmanniae, 9 parts of Radix Saposhnikoviaes by the feedstock production of following parts by weight.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, described raw material add adjuvant and make oral liquid, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of fever of children, described adjuvant are one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, it comprises the steps: the Qu Rhizoma Dioscoreae Septemlobae, Herba Violae, Semen Abutili, Gypsum Fibrosum, Herba Schizonepetae, Rhizoma Osmundae, Fructus Forsythiae, Radix Puerariae, Radix Scutellariae, Radix Scrophulariae, the Radix Rehmanniae, the Radix Saposhnikoviae medical material merges, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and recovery ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fever of children, in the step, the spray drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The above-mentioned application of Chinese medicine composition in the medicine of preparation treatment fever of children that is used for the treatment of fever of children.
Semen Abutili is the mature seed of Malvaceae annual herb plant Semen Abutili in the Chinese medicine of the present invention, and all the other are the pharmacopeia kind.
Beneficial effect:
1, from theory of Chinese medical science, children's is " pure-yang constituent ", and life is flourishing, blastoprolepsis, but internal organs are tender and lovely, and shape gas does not fill, call it " the young sun of young the moon ", Chang Hannuan can not self-regulated, and the breast food is not known from joint, in case maintenance is inappropriate, easily invaded by six climate exopathogens then, interior is injury due to diet easily, and ill back changes rapidly, " easily cold easily heat is easily empty easily real ".In the children's exogenous course of disease, the every easily heat-transformation of its cold syndrome, thermoae Yi Shengfeng again, clinical see children's's heat syndrome and infantile convulsion are controlled wrong treatment in case lose more, miss an opportunity because of a delay, and very easily decline of YANG QI takes off, and the card of YIN-cold YANG-depletion occurs.Therefore, the normal anxious product of throwing wind and heat dispersing at the beginning of morbidity, the spirit clearly of good fortune children's visceral-qi, the rehabilitation that easily becomes, if distinguish and control rationally, it is precise and appropriate write out a prescription, then " with pulling out with answering ".We's children's's physiological and pathological feature that hits is known infantile fever caused by exogenous pathogens, is trouble with the wind heat how, and in very easily passing, so wind symptom very then is the suitable anxious product of wind and heat dispersing and the product of heat-clearing and toxic substances removing thrown.Even affection of exogenous wind-cold in knowing that cold-evil's heat-transformation soon passes, also should early be thrown the product of wind and heat dispersing and heat-clearing and toxic substances removing.Be monarch with Herba Schizonepetae, Radix Saposhnikoviae, Fructus Forsythiae, Radix Puerariae four medicines in the side, the meaning of Antiphlogistic Powder of Schizonepetae and Ledebouriellae, Lonicerae and Forsythiae Powder, GEGEN TANG is arranged, be intended to wind and heat dispersing.Minister expels the heat-evil with Radix Scutellariae, Gypsum Fibrosum lung heat clearing, Semen Abutili, Herba Violae heat-clearing and toxic substances removing, and especially the epidemic febrile disease serious symptom of diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison more needs heavy prescription to execute to control.Assistant is with Radix Scrophulariae, the Radix Rehmanniae, and merit is at clearing away heat and nourishing YIN, the relieving restlessness detoxifcation, both anti-calentura impairment of YINs, probably heat is disturbed the mind again, more help the Rhizoma Dioscoreae Septemlobae dampness removing go turbid, the eliminating impediment that dispels the wind, it is wet to control the ailment said due to cold or exposure folder, children's's sweating is sticky, the indistinctive fever person is suitable especially.The Rhizoma Osmundae heat-clearing and toxic substances removing, cooling blood for hemostasis, nature and flavor are arduous to be slightly cold, and goes into lung meridian, be the meaning of guiding action also.Make a general survey of full side, be total to the merit of long memorial wind heat clearing away, the effect of Yin and detoxification of holding concurrently is used for the treatment of fever of children.
2, the present invention writes out a prescription reasonable in designly, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with the specific embodiment, the present invention is further described as follows:
2, listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: g
| ? | Rhizoma Dioscoreae Septemlobae | Herba Violae | Semen Abutili | Gypsum Fibrosum | Herba Schizonepetae | Rhizoma Osmundae | Fructus Forsythiae | Radix Puerariae | Radix Scutellariae | Radix Scrophulariae | The Radix Rehmanniae | Radix Saposhnikoviae |
| 1 | 6 | 8 | 6 | 7 | 6 | 12 | 6 | 12 | 6 | 12 | 6 | 12 |
| 2 | 9 | 6 | 9 | 5 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 |
| 3 | 12 | 4 | 12 | 3 | 12 | 6 | 12 | 6 | 12 | 6 | 12 | 6 |
3. preparation embodiment
More than proportioning raw materials is example in the table, may further comprise the steps:
Embodiment 1: Qu Rhizoma Dioscoreae Septemlobae 6g, Herba Violae 8g, Semen Abutili 6g, Gypsum Fibrosum 7g, Herba Schizonepetae 6g, Rhizoma Osmundae 12g, Fructus Forsythiae 6g, Radix Puerariae 12g, Radix Scutellariae 6g, Radix Scrophulariae 12g, Radix Rehmanniae 6g, Radix Saposhnikoviae 12g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and recovery ethanol, get concentrated solution, (condition is that inlet temperature is 100 ℃ with the concentrated solution spray drying, leaving air temp is 85 ℃, temperature of charge is 80 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), add appropriate amount of starch, dry granulation is crossed 60 mesh sieves, No. 1 capsule of packing into get final product capsule.
Embodiment 2: Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, add for the first time 8 times of amounts that water is medical material weight, decoct 1h, add for the second time 6 times of amounts that water is medical material weight, decoct 1h, collecting decoction, 0.07MPa, relative density is 1.20 when being evaporated to 65 ℃ under 60-70 ℃, add 95% (v/v) ethanol and make the alcohol amount of containing reach 80% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.30 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and reclaimed ethanol, got concentrated solution, filtration adds water and sucrose is mixed with oral liquid.
Embodiment 3: Qu Rhizoma Dioscoreae Septemlobae 12g, Herba Violae 4g, Semen Abutili 12g, Gypsum Fibrosum 3g, Herba Schizonepetae 12g, Rhizoma Osmundae 6g, Fructus Forsythiae 12g, Radix Puerariae 6g, Radix Scutellariae 12g, Radix Scrophulariae 6g, Radix Rehmanniae 12g, Radix Saposhnikoviae 6g medical material merges, decoct with water twice, add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add for the second time 10 times of amounts that water is medical material weight, decoct 2h, collecting decoction, 0.07MPa, relative density is 1.20 extractum when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 85% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.30 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and recovery ethanol, get concentrated solution, (condition is that inlet temperature is 120 ℃ with the concentrated solution spray drying, leaving air temp is 90 ℃, temperature of charge is 90 ℃, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.), adding an amount of dextrin, mix homogeneously with the moistening of an amount of 80% (v/v) ethanol, soft material processed, is crossed 30 mesh sieves and is granulated, and in 70～80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating gets tablet.
Embodiment 4: Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 65 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 80% (v/v), stir, left standstill 24 hours, decompression filtrate recycling ethanol also concentrates, filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and recovery ethanol, get concentrated solution, (condition is that inlet temperature is 110 ℃ with the concentrated solution spray drying, leaving air temp is 80 ℃, temperature of charge is 70 ℃, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add an amount of lactose, with the moistening of an amount of 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 70-80 ℃ of drying, 60 order granulate get granule.
4. granule of the present invention is to the influence of fever of children
4.1 animal: animal SD rat, male, body weight 220～250g, available from Nanjing Medical University's animal center, production licence number SCXK (Soviet Union) 2002-0031.
4.2 medicine and reagent: press above-described embodiment 4 preparations granule of the present invention, be Qu Rhizoma Dioscoreae Septemlobae 9g, Herba Violae 6g, Semen Abutili 9g, Gypsum Fibrosum 5g, Herba Schizonepetae 9g, Rhizoma Osmundae 9g, Fructus Forsythiae 9g, Radix Puerariae 9g, Radix Scutellariae 9g, Radix Scrophulariae 9g, Radix Rehmanniae 9g, Radix Saposhnikoviae 9g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 65 ℃, adds 95% (v/v) ethanol and makes the alcohol amount of containing reach 80% (v/v), stirs, left standstill 24 hours, decompression filtrate recycling ethanol also concentrates, and filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and reclaimed ethanol, get concentrated solution, (condition is that inlet temperature is 110 ℃, and leaving air temp is 80 ℃, and temperature of charge is 70 ℃ with the concentrated solution spray drying, atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add an amount of lactose, with the moistening of an amount of 80% (v/v) ethanol, soft material processed, crossing 14 mesh sieves granulates, 70-80 ℃ of drying, 60 order granulate get granule 100g, be distributed into 10g granule/bag, contain crude drug 10g in every bag of granule, lot number 20120511, clinical people's consumption per day are each 1 bag, every day 3 times, be that clinical people's consumption per day is the 30g crude drug, determine that therefore every 200g rat consumption is the 30x0.018=0.54g crude drug, calculate with kilogram, dosage is 2.7g crude drug/kg, this is low dosage, and dosage 5.4g crude drug/kg is middle dosage, and dosage 10.8g crude drug/kg is high dose.Reagent: purification LPS (Escherichca coliendotoxin055:B5, L2880, Sigma Co.) is diluted in physiological saline solution, is made into the solution of 20 μ g/ml, and-20 ℃ of preservations are standby.
4.3 process of the test: rat take temperature every day (anus temperature) 2 times, continuous 2 days, the meansigma methods of getting twice body temperature was designated as basal body temperature.Single body temperature surpasses 38 ℃ or 2 the animals rejectings of body temperature differences above 0.5 ℃.50 of the rats that will meet experiment condition are divided into 5 groups at random: normal control group, model group, senior middle school of the present invention low dose group, 10 every group.Water is can't help in the 6h fasting before the experiment.Model group and administration group rat be lumbar injection LPS (20 μ g/kg or 80 μ g/kg) respectively, brings out the animal heating; The normal group injecting normal saline.Administration in the time of modeling, normal group and model group give with the volume distilled water.Survey 1 body temperature every 0.5h behind the injection LPS, continuous monitoring 8h, group difference is judged in the t check, the results are shown in Table 1.
Table 1 granule of the present invention is to the influence (n=10) of rat fever
Compare * * P＜0.01 * P＜0.05 with model group
The result: the large, medium and small dosage group of granule of the present invention has stronger intensification inhibitory action to LPS fever model rat, and presents certain dose dependent.
5 clinical research datas are summed up
5.1 physical data: be divided into treatment group 123 example and matched group 61 examples at random by the prescription on individual diagnosis order.Male 63 examples are organized in treatment, women 60 examples; Body temperature 38-40 ℃, 1 years old to 12 years old age, average 5.16 ± 1.39 years old; Matched group man 32 examples, women 29 examples; Body temperature 38-40 ℃, 1 years old to 12 years old age, average 4.93 ± 1.67 years old.The every index of the general clinical data of test group and matched group has comparability, two groups of characteristic of diseases not, age, body weight, body temperature, symptom score difference not statistically significant (P＞0.05).5.2 diagnostic criteria: all fever of children meet traditional Chinese medical science infantile common cold diagnostic criteria person, and clinical manifestation is heating, nasal obstruction, watery nasal discharge, or companion cough, feel sick, cold symptoms such as vomiting.
5.3 Therapeutic Method: it is oral that (1) matched group is got children-welfare tablet (dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing are used for cold, fever, contain diseases such as fever and headache in the phlegm-fire), one time 2,3 times on the one.(2) treatment group is taken above-described embodiment 4 preparations granule of the present invention, each 1 bag, every day 3 times.
5.4 criterion of therapeutical effect: draft with reference to pharmaceutical control and administration department of Ministry of Health of the People's Republic of China " new drug (Chinese medicine) treatment infantile fever caused by exogenous pathogens (acute upper respiratory tract infection) clinical research guideline ".Be leading indicator to bring down a fever.Recovery from illness: in medication 24～48h, the temperature recovery normal level, and do not go up again, disease disappears; Produce effects: in medication 24～48h, the temperature recovery normal level, main disease is most of to disappear; Effectively: in medication 24～48h, the temperature recovery normal level, main disease partly disappears; Invalid: as not meet above standard person.
5.5 two groups of curative effects relatively
Relatively, use the SPSS18.0 statistical software and handle between group, χ 2=10.233, P＜0.05 shows that the treatment group is better than matched group.
The result: granule therapy infantile fever caused by exogenous pathogens total effective rate of the present invention reaches 97.6%.
Claims (8)
1. Chinese medicine composition that is used for the treatment of fever of children, it is characterized in that it obtains: Rhizoma Dioscoreae Septemlobae 6-12 part, Herba Violae 4-8 part, Semen Abutili 6-12 part, Gypsum Fibrosum 3-7 part, Herba Schizonepetae 6-12 part, Rhizoma Osmundae 6-12 part, Fructus Forsythiae 6-12 part, Radix Puerariae 6-12 part, Radix Scutellariae 6-12 part, Radix Scrophulariae 6-12 part, Radix Rehmanniae 6-12 part, Radix Saposhnikoviae 6-12 part by the feedstock production of following parts by weight.
2. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1, it is characterized in that it obtains 9 parts of: Rhizoma Dioscoreae Septemlobae, 6 parts of Herba Violaes, 9 parts of Semen Abutilis, 5 parts in Gypsum Fibrosum, 9 parts of Herba Schizonepetae, 9 parts of Rhizoma Osmundae, 9 parts of Fructus Forsythiaes, 9 parts of Radix Puerariaes, 9 parts of Radix Scutellariaes, 9 parts of Radix Scrophulariaes, 9 parts in the Radix Rehmanniae, 9 parts of Radix Saposhnikoviaes by the feedstock production of following parts by weight.
3. the Chinese medicine composition that is used for the treatment of fever of children according to claim 1 and 2 is characterized in that, described raw material adds adjuvant and makes oral liquid, tablet, capsule or granule after extracting.
4. the Chinese medicine composition that is used for the treatment of fever of children according to claim 3, it is characterized in that described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
5. claim 1 or the 2 described preparation methoies that are used for the treatment of the Chinese medicine composition of fever of children, it is characterized in that, it comprises the steps: the Qu Rhizoma Dioscoreae Septemlobae, Herba Violae, Semen Abutili, Gypsum Fibrosum, Herba Schizonepetae, Rhizoma Osmundae, Fructus Forsythiae, Radix Puerariae, Radix Scutellariae, Radix Scrophulariae, the Radix Rehmanniae, the Radix Saposhnikoviae medical material merges, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and reclaimed ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
6. the preparation method that is used for the treatment of the Chinese medicine composition of fever of children according to claim 5 is characterized in that, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
7. the preparation method that is used for the treatment of the Chinese medicine composition of fever of children according to claim 5, it is characterized in that, in the step, the spray drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
8. claim 1 or the 2 described application of Chinese medicine composition in the medicine of preparation treatment fever of children that are used for the treatment of fever of children.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069269A (en) * | 2014-07-07 | 2014-10-01 | 海城市中医院 | Preparation for cooling blood, relieving internal heat and abating fever, and method of using preparation |
| CN105434810A (en) * | 2015-12-29 | 2016-03-30 | 刘树芹 | Granules for treating infantile fever and respiratory tract infection and application thereof |
| CN108938571A (en) * | 2018-09-04 | 2018-12-07 | 江苏省中医药研究院 | A method of it eliminating Chinese medical extract dry granulation and sticks roller phenomenon |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
| CN102018907A (en) * | 2011-01-22 | 2011-04-20 | 陈鹏 | Medicine for treating fever in children and preparation method thereof |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
| CN102018907A (en) * | 2011-01-22 | 2011-04-20 | 陈鹏 | Medicine for treating fever in children and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069269A (en) * | 2014-07-07 | 2014-10-01 | 海城市中医院 | Preparation for cooling blood, relieving internal heat and abating fever, and method of using preparation |
| CN105434810A (en) * | 2015-12-29 | 2016-03-30 | 刘树芹 | Granules for treating infantile fever and respiratory tract infection and application thereof |
| CN108938571A (en) * | 2018-09-04 | 2018-12-07 | 江苏省中医药研究院 | A method of it eliminating Chinese medical extract dry granulation and sticks roller phenomenon |
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