CN104906439A

CN104906439A - Medicine for treating chronic respiratory failure

Info

Publication number: CN104906439A
Application number: CN201510381357.3A
Authority: CN
Inventors: 李慧
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-03
Filing date: 2015-07-03
Publication date: 2015-09-16

Abstract

The invention relates to a medicine for treating chronic respiratory failure. The medicine is prepared from raw herbal materials including, by weight, 30 parts of centella, 10 parts of bamboo shavings, 12 parts of semen cuscutae, 25 parts of serissa, 15 parts of silkworm excrement, 15 parts of cocklebur fruits and 30 parts of ching-chieh. Clinical experiments prove that the chronic respiratory failure can be safely and effectively treated.

Description

A kind of medicine being used for the treatment of chronic respiratory failure

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of chronic respiratory failure.

Background technology

Chronic exhale to decline be secondary to chronic respiratory system diseases, as chronic obstructive pulmonary disease, far advanced tuberculosis etc. more; Its Respiratory Function Impairments increases the weight of gradually, though have anoxia and carbon dioxide retention, by the compensatory adaptation of body, is still engaged in personal lifestyle, is called chronic respiratory failure; Once generation respiratory tract infection, or increase physiology of respiration burden, then decompensation because of other reasons, occur the clinical manifestation of severe depletion of oxygen, carbon dioxide retention and respiratory acidosis, be called decompensated chronic respir atory failure.Respiratory failure is the anoxia that causes of the ventilation that caused by various diseases and (or) dysfunction of ventilation or with carbon dioxide retention.Breathe under atmospheric condition on sea level, arterial partial pressure of oxygen (PaO2) higher than 6.66kPa, and produces the clinical syndrome of serial pathophysiological change and metabolism disorder lower than 8kPa and arterial partial pressure of carbon dioxide (PaCO2).Lung governing qi, can breathe, and suck clearing heat in QI system in air, exhalation foul smell, communicates with air, is the hinge of mechanism of qi discrepancy lifting.Lung being a delicate viscus, outer conjunction fur.Exopathogen invasion and attack human body attacking the lung first, impairment of dispersing and descending function of the lung and send out cough with asthma.If obstinate disease can cause deficiency and damage of lung-QI, and involve spleen kidney.The deficiency of the lung can not regulate administers the operation of painstaking effort, then motive heart-yang also virtual loss, eventually to lung, spleen, kidney, all void of the heart and become the pathogenesis basis of primary disease.Climate change, the factors such as diet, feelings will and fatigue, then can bring out for primary disease.

Medical material present Research involved in the present invention is as follows:

Herba Centellae [another name] collapses jorum, Herba Calthae Membranaceae, Gotu Kola, Carnis Arca inflata shell grass, Hydrocotyle vulgaris L., Herba sambuci chinensis.[source] this product is the dry herb of samphire Herba Centellae.Summer, Qiu Erji gather, and removing silt, dries.[nature and flavor] bitter, acrid, cold.[return through] returns liver,spleen,kidney warp.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.[usage and dosage] takes orally: decoct soup, 15 ~ 30g.[attention] deficiency and coldness person is unsuitable.[extracts] " China's book on Chinese herbal medicine ".

Caulis Bambusae In Taenia [another name] [source] this product is the dry intermediate layer of stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.The whole year all can gather and process, and gets fresh stem, and removing crust, spreads to strand by slightly viridant intermediate layer, or chip, tie up bunchy, dry in the shade.The former claims " loose Caulis Bambusae In Taenia ", and the latter claims " neat Caulis Bambusae In Taenia ".[nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.[usage and dosage] takes orally: decoct soup, 4.5 ~ 9g.[attention] gastrofrigid vomiting: and the cold being accompanied by dyspepsia of sense is used as to tell and is avoided.[extracts] " China's book on Chinese herbal medicine ".

Semen Cuscutae [another name] bean parasitism, Cassytha filiformis, yellow silk, Huang Siteng, without ma rattan, golden yellow SIZI.[source] this product is the dry mature seed of convolvulus cuscuta plant.To gather during fruit maturation in autumn plant, dry, lay seed, removing impurity.[nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.[usage and dosage] takes orally: decoct soup, 6 ~ 12g.It is good that [attention] obtains wine.Rhizoma Dioscoreae, Colophonium make ， E Di bacterium for it.How fiery kidney man is, and strong sun not flaccidity person avoids it, and constipation due to dry stool person also avoids it.[extracts] " China's book on Chinese herbal medicine ".

Serissa foetida [another name] Radix Serissae, Caulis et folium pavettae hongkongensis [Jiangsu, Guangdong], Rhizoma Hedychii Coronarii, TianXing wood, roadside chaste tree, Os Gallus domesticus bavin.[source] is used as medicine with Herb for Rubiaceae Serissa foetida platymiscium Serissa foetida.The whole year can adopt.Clean using fresh herb or cutting are dried.[nature and flavor] are light, micro-pungent, cool.[function cures mainly] dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.For flu, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea; Stem ashing eye dripping controls mist.[usage and dosage] takes orally: decoct soup, 20 ~ 50g.[extracts] " China's book on Chinese herbal medicine ".

Silkworm excrement [another name] silkworm dung, Faeces bombycis, silkworm feculae, silkworm faeces.[source] this product is the dry feces of Bombycidae insecticide silkworm.Collect silkworm feces, dry, well sifted impurity and get final product.[nature and flavor] sweet, acrid, warm.[function cures mainly] wind-damp dispelling, pain relieving.For the waist gonalgia, menorrhagia, stomachache, skin rubella.[usage and dosage] takes orally: decoct soup, 9 ~ 16g.[extracts] " China's book on Chinese herbal medicine ".

Fructus Xanthii [another name] Herba Xanthii, stout pale, grey son, Xi ear, Fructus Xanthii, Mao Cangzi, silly head are violent, sheep band is returned.[source] this product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii.Gather during fruit maturation in autumn, dry, except impurity such as destemming, leaves.Herb also can be used as medicine.[nature and flavor] are pungent, bitter, temperature; [return through] returns lung, Liver Channel.[function cures mainly] loose wind dehumidifying, clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.Headache, the arthralgia pain of [attention] blood deficiency avoid clothes.[extracts] " China's book on Chinese herbal medicine ".

Herba Schizonepetae [another name] fragrant Schizonepeta tenuifolia Briq, line shepherd's purse, Herba Schizonepetae, false Soviet Union.[source] this product is the dry aerial parts of labiate Herba Schizonepetae.Summer, season in autumn two, the flowers are in blossom to top, fringe green time tap, removing impurity, dry.[nature and flavor] are pungent, tepor.[return through] returns lung, Liver Channel.[function cures mainly] induces sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.[usage and dosage] takes orally: decoct soup, 4.5 ~ 9g.[attention] exterior deficiency spontaneous perspiration, headache due to yin-deficiency avoid clothes.[extracts] " China's book on Chinese herbal medicine ".

Summary of the invention

The present invention aims to provide a kind of medicine being used for the treatment of chronic respiratory failure, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing chronic respiratory failure.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine being used for the treatment of chronic respiratory failure, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Centellae 30 parts, Caulis Bambusae In Taenia 10 parts, Semen Cuscutae 12 parts, Serissa foetida 25 parts, silkworm excrement 15 parts, Fructus Xanthii 15 parts, Herba Schizonepetae 30 parts.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Outpatient service is collected and chronic respiratory failure 124 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 62 example and matched group 62 example at random, treatment group man 42 example, female 20 example, 57 ~ 80 years old age, 70.32 years old mean age, the course of disease 10 ~ 32 years; Matched group man 46 example, female 16 example, 58 ~ 79 years old age, 70.76 years old mean age, the course of disease 12 ~ 35 years.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.

Diagnostic criteria

Diagnostic criteria according to the meeting of national chronic respiratory failure clinical speciality: (1). there is the cause of disease of respiratory failure, as sick in airway obstructive disease, pulmonary parenchyma infiltration, pulmonary edema, Pulmonary Vascular, thorax and pleural diseases, anesthetics are excessive, neuromuscular disease or sleep apnea syndrome etc.;

(2). there is anoxia or with the clinical manifestation of carbon dioxide retention, as dyspnea, cyanosis, Spirit nerve symptoms of disease etc.Occur during concurrent pulmonary encephalopathy that disturbance of consciousness, bulbar conjunctiva congestion and edema, papilloedema, flapping wing tremble.Severe patient can have digestive tract hemorrhage;

(3). blood gas analysis: in sea-level atmosphere pressure, under quiescent condition, breathe room air arterial partial pressure of oxygen (PaO2) < 8.0kPa(60mmHg), partial pressure of carbon dioxide (PaCO:> 6.6kPa) (50mmHg) (or≤normal).

2, test method

2.1 Therapeutic Method

The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.30 days was 1 course for the treatment of, took 3 courses for the treatment of.

Mg is oral for matched group oral prednisone 10,3 times/day; Mg is oral for azathioprine 100,2 times/day; Give IV 1 acetylcysteines (NAC) effervescent tablet 0.6 g oral.30 days was 1 course for the treatment of, took 3 courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Effective: after treating 15 d, the clinical symptoms such as dyspnea, dry cough, crepitation (Velcro rale), cyanosis and sign significantly take a turn for the better, and blood gas index is clearly better;

Effective: after treating 15 d, the clinical symptoms such as dyspnea, dry cough, crepitation (Velcro rale), cyanosis and sign alleviate, blood gas index takes a turn for the better;

Invalid: after treating 15 d, clinical symptoms and sign, blood gas index all do not improve or worsen.

3.2 therapeutic outcomes are in table 1.

Table 1 liang group comparitive study

Group	n	Effective	Effectively	Invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	62	24	32	6	90.32%	0
Matched group	62	20	22	20	67.74%	0

Visible, the medicine that the present invention obtains can safe and effective treatment chronic respiratory failure, has promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Embodiment 1

Take: Herba Centellae 30 grams, Caulis Bambusae In Taenia 10 grams, Semen Cuscutae 12 grams, Serissa foetida 25 grams, silkworm excrement 15 grams, Fructus Xanthii 15 grams, Herba Schizonepetae 30 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of chronic respiratory failure.Oral, every bu Morning Afternoon Evening is taken for three times.

Embodiment 2

Take: Herba Centellae 30 grams, Caulis Bambusae In Taenia 10 grams, Semen Cuscutae 12 grams, Serissa foetida 25 grams, silkworm excrement 15 grams, Fructus Xanthii 15 grams, Herba Schizonepetae 30 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Embodiment 3

Take: Herba Centellae 30 grams, Caulis Bambusae In Taenia 10 grams, Semen Cuscutae 12 grams, Serissa foetida 25 grams, silkworm excrement 15 grams, Fructus Xanthii 15 grams, Herba Schizonepetae 30 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Claims

1. one kind is used for the treatment of the medicine of chronic respiratory failure, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Centellae 30 parts, Caulis Bambusae In Taenia 10 parts, Semen Cuscutae 12 parts, Serissa foetida 25 parts, silkworm excrement 15 parts, Fructus Xanthii 15 parts, Herba Schizonepetae 30 parts.