CN102430048B - Chinese medicinal composition for treating cough and preparation method thereof - Google Patents
Chinese medicinal composition for treating cough and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of Chinese medicines, in particular to a Chinese medicinal composition for treating cough and a preparation method thereof. The Chinese medicinal composition is prepared from fifteen Chinese medicinal materials such as red tangerine peel, tuckahoe, snake gourd peel, fresh rehmannia root, tangerine peel, platycodon root, dwarf lilyturf tuber, tatarian aster root,bitter apricot seed, prepared pinellia tuber, gypsum, stir-fried perilla fruit, liquoric root, common coltsfoot flower and peppermint oil in a certain weight part ratio. The modern pharmacological research and clinical tests prove that the Chinese medicinal composition has the effects of relieving cough and asthma and moistening lung for removing phlegm, can be prepared into a sucrose-free preparation with the dosage of 4g each time, quickly relieves symptoms such as itchy and sore throat, cough and asthma, is convenient to use, has an obvious effect of treating cough, does not have any toxicor side effect, is comfortable and safe, does not contain brown sugar, is suitable for patients who suffer from diabetes and do not like to eat sugar, is a good medicine for treating cough, can be widely applied to the clinical treatment of cough, and has a wide market prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of cough and preparation method thereof specifically.
Background technology
Cough is one of modal disease in the daily life, is that the mucosa of throat or trachea is air-breathing rapidly when being upset, and exhales consumingly immediately, and the phenomenon of vocal cord vibration is the guarding reflex action that human body is removed respiratory tract endocrine or foreign body.Cough is the cardinal symptom of respiratory system disease, as diseases such as foreign body, pneumonia, pulmonary tuberculosis in respiratory tract infection, acute pharyngolaryngitis, bronchitis, chronic bronchitis, bronchiectasis, the bronchus.The traditional Chinese medical science thinks that cough is because of the diseases caused by exogenous pathogenic factor six climate exopathogens, and the internal organs internal injury influences the sound card that expectorant is arranged due to the lung.Because exopathogen is violated lung, or the internal organs internal injury, involve due to the lung.Point out in " plain inquiring about disease machine gas should save one's life collection " " to cough the no expectorant of meaning and sound, lung qi wound and also unclear; It is noiseless and expectorant arranged coughing, spleen wet moving and be expectorant also.Cough meaning has expectorant and sound, and it is wet that lid moves in spleen in lung qi due to wound, cough and for coughing also ".
The tradition traditional Chinese medical science is divided into exogenous cough and endogenous cough with cough, though exogenous cough's treatment easily is inappropriate if repeated multiple times is suffered from or recuperated under medical treatment after being ill, then can transfer the endogenous cough to.With the passing of time the endogenous cough does not heal, and then can cause lung, spleen, deficiency of the kidney void, and differentiation becomes lung and rises, and this disease is touching, and prolonged difficulty more.
The chemicals that has antitussive action at present contains the anesthesia composition mostly, life-time service tolerates easily, curative effect reduces, even causes serious problems such as drug dependence, and the effective percentage of the numerous Chinese patent medicine of selling in the market is all not high, mostly only can the respite throat itch pain, cough symptom, or reach and reduce phlegm or the purpose of eliminating the phlegm, to some cough patients of outbreak for a long time or repeatedly, effect is not clearly, the healing cycle is relatively long, seldom can thoroughly cure.
Summary of the invention
In view of this, the object of the invention provides Chinese medicine composition of a kind of evident in efficacy, treatment that toxic and side effects is minimum cough and preparation method thereof.
For realizing purpose of the present invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition for the treatment of cough, made by following weight portion raw material:
The present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment cough, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical the accent, emergency is taken in concurrently, and screening has that lung qi dispersing cough-relieving, cold expelling are reduced phlegm, the crude drug of lung benefiting the kidney invigorating, according to the theory of Chinese medical science prescription, be prepared from according to certain weight portion proportioning.Chinese medicine composition of the present invention is selected dried tangerine peel, Poria, Pericarpium Trichosanthis, Radix Rehmanniae, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Ophiopogonis, Radix Asteris, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparatum, Gypsum Fibrosum, Fructus Perillae (parched), Radix Glycyrrhizae, Flos Farfarae and Herba Menthae wet goods ten Chinese medicine of the five flavours materials for use.
Wherein, tangerine, the another name rue skin, rue red, dry outer peel for rutaceae Huazhou Fructus Citri tangerinae (Citrus grandis Osbeck var.tomentosa Hort.) or Fructus Citri tangerinae (Citrus reticulata Blanco) and variety thereof, gather behind the time of the year when autumn changes into winter fruit maturation, cut down outer peel with cutter, dry or dry in the shade.Tangerine warm in nature, acrid in the mouth, hardship have cold expelling, dampness, regulate the flow of vital energy, the effect of spleen invigorating, greasy, the alleviating distention in middle-JIAO of helping digestion, sober up, disappear, the expectorant of solution Eriocheir sinensis poison, be used for the cough due to wind and cold, the itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and the vomiting and nausea painful abdominal mass is vexed, expectorant stagnates, vomits diseases such as singultus, long-term stomachache in the heart.
Poria is commonly called as Poria, Song Ling, Poria, and for colonizing in the fungi plant on the pinaster root, shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Ancients claim that Poria is " refreshing medicine " at 4 o'clock, because its effect is very extensive, are regardless of the four seasons, with it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can both be brought into play its unique effects.Poria is flat, sweet in the mouth, light, be used as medicine have promoting diuresis to eliminate damp pathogen, the effect of invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, insufficiency of the spleen lack of appetite, have loose bowels, diseases such as seminal emission, stranguria with turbid discharge, palpitation and restlessness, insomnia forgetfulness.Modern medicine study finds that Poria can also the enhancing human body immunity function, and pachyman has tangible antitumor and protects the liver dirty effect.
Pericarpium Trichosanthis, another name melon shell, Fructus Trichosanthis shell are the peel of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms etc., and concocting method is to get ripe Fructus Trichosanthis really to produce, being cut into 2-4 lobe to Pedicellus Melo by knife locates, seed and flesh are taken out together, choose clean impurity, wash, pull out, vexed slightly, shredding keeps flat to dry or sling with rope and dries namely.Pericarpium Trichosanthis is cold in nature, and sweet in the mouth has the effect of moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving, cures mainly phlegm-heat cough, pharyngalgia, chest pain, haematemesis, epistaxis, quenches one's thirst, the disease of constipation, carbuncle pyogenic infections from tumour or sore.
Radix Rehmanniae, another name wild country Huang, wine pot flower, mountain cigarette root are the fresh or dried root of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa Libosch.).Excavate autumn, except removing LU, fibrous root and silt, and using fresh herb; Or Radix Rehmanniae slowly cured to about eighty per cant do.The former practises title " Radix Rehmanniae ", and the latter practises title " Radix Rehmanniae ".The used Radix Rehmanniae of the present invention is Radix Rehmanniae, and sweet in the mouth, hardship are cold in nature, and the effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis is arranged.Be used for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, send out diseases such as speckle dermexanthesis, haematemesis, epistaxis, laryngopharynx swelling and pain.
Pericarpium Citri Reticulatae, another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis are the mature peel of rutaceae orange and variety thereof, during 10-12 month fruit maturation, take fruit, strip peel, dry in the shade or aeration-drying.Though Pericarpium Citri Reticulatae, is processed difference because of the two and is divided into Pericarpium Citri Reticulatae with tangerine with deriving from rutaceae orange and variety thereof with tangerine.Pluck when Fructus Citri tangerinae is ripe, strip peel, drying in the shade is called Pericarpium Citri Reticulatae; Fructus Citri tangerinae is plucked when ripe, strips peel, remove Pericarpium Citri tangerinae inner white part after, dry and be called dried tangerine peel.Pericarpium Citri Reticulatae goes whitely to stay red person for tangerine.Pericarpium Citri Reticulatae is warm in nature, and acrid in the mouth, hardship in having regulating qi-flowing for strengthening spleen, transferring, dampness, clears phlegm, cure mainly diseases such as dirty contrary, the difficulty in urination and defecation of full vexed, the abdominal distention of the wet resistance of stagnation of QI in spleen and stomach, chest and diaphragm, anorexia, vomiting, lung qi retardance, cough with copious phlegm.
Radix Platycodonis is the dried roots of campanulaceae Platycodon grandiflouorum, bitter in the mouth, suffering, slightly warm in nature.The effect that have lung qi dispersing, expelling phlegm for arresting cough, sore-throat relieving, evacuation of pus, sharp the five internal organs, fills blood, mends five kinds of over strain, fosters the spirit of nobility cures mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Have another name called dwarf lilyturf, book band grass, Radix Ophiopogonis Radix Ophiopogonis, is the Liliaceae Ophiopogon plant dried root of Radix Ophiopogonis.Cold nature, sweet in the mouth, little hardship are returned, and have YIN nourishing and the production of body fluid promoting, and the effect that lung moistening clears away heart-fire is used for dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, diseases such as dryness of the intestine constipation.Clinical have the heart and do not remove the branch of the heart, and Radix Ophiopogonis of the present invention is for going heart Radix Ophiopogonis.
Radix Asteris, latin name Tatarian Aster Root has another name called blue or green aster, is the dry root and rhizome of feverfew Radix Asteris.Radix Asteris bitter in the mouth, sweet, warm in nature, the effect of nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm is arranged, be used for that abundant expectoration is breathed with cough, diseases such as new chronic cough is coughed, chronic cough hemoptysis.
Semen Armeniacae Amarum, Fructus Pruni in another name Semen Armeniacae Amarum, Semen Armeniacae Amarum, light Semen Armeniacae Amarum, the light, the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni), Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.), prunus mandshuricaKoehne or Fructus Pruni.Semen Armeniacae Amarum bitter in the mouth, suffering, slightly warm in nature has the effect of lung qi dispersing cough-relieving, lowering the adverse-rising QI to subdue asthma, loosening bowel to relieve constipation, parasite killing detoxifcation, cures mainly that cough and asthma, fullness in the chest abundant expectoration, sore throat pharyngalgia, blood deficiency Tianjin are withered, dryness of the intestine constipation, insect poison skin infection.
Rhizoma Pinelliae Preparatum, latin name Rhizoma Pinelliae is for the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.) soaks the process of preparing Chinese medicine processed goods that the back drying forms with the Radix Glycyrrhizae lime liquor.Warm in nature, the acrid in the mouth of Rhizoma Pinelliae Preparatum, energy drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI are used for diseases such as abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, nausea and vomiting.
Gypsum Fibrosum, another name microlith, thin Gypsum Fibrosum, soft gypsum, white tiger, Gypsum Fibrosum are long bulk or the fibrous crystal aggregate of irregular shape, roguing stone and earth, porphyrize is given birth to being used as medicine.Gypsum Fibrosum is cold in nature, acrid in the mouth, sweet, expelling pathogenic factors from muscles for clearing heat is arranged, and relieving restlessness is quenched the thirst, the effect of heat-clearing and toxic substances removing, cures mainly that the calentura high fever does not move back, vexed coma, delirium are gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue.Gypsum Fibrosum is forged deposited promoting tissue regeneration and ulcer healing, the external treatment ulcer sores, burst do not close up, the burning hot wound of soup.
Fructus Perillae, another name Fructus Perillae, FRUCTUS PERILLAE, wild flax, ferrum Fructus Perillae are the dry mature fruit of labiate Folium Perillae, and the effect of sending down the abnormal ascending QI expectorant, relieving cough and asthma, intestine moistening is arranged.Clinical usefulness has Fructus Perillae, Fructus Perillae (parched) not.Fructus Perillae is removed impurity for getting crude drug, and cleaning, drying namely.Fructus Perillae (parched) is fried to detonans is arranged according to the method for frying for getting clean Fructus Perillae, takes out to cool namely.The present invention selects for use Fructus Perillae (parched) to be used as medicine, and acrid in the mouth is warm in nature.Fructus Perillae is fried the hot property mitigation of loosing in back, and the effect of warming the lung sending down the abnormal ascending QI is preferable, is used for the asthma and cough that multiple reason causes, and fry and back gas perfume (or spice), matter crisp, be easy to pulverize and improve fried effect.
Radix Glycyrrhizae, another name Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae are dicotyledon pulse family Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch.), the root and rhizome of Glycyrrhiza inflata Bat. (G.inflata Bat.) or Glycyrrhiza glabra L. (G.glabra L.), be a kind of tonification Chinese herbal medicine, detoxifcation is arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.
Flos Farfarae, latin name Flos Farfarae has another name called Flos Farfarae, is the alabastrum of dicotyledon medicine feverfew coltsfoot.The Flos Farfarae acrid in the mouth, warm in nature, have nourishing the lung to keep the adverse QI downward, an effect of the antitussive that reduces phlegm, cure mainly diseases such as cough with dyspnea is panted, sore throat.
Oleum menthae, the volatile oil that obtains for fresh stem and the Ye Jing vapor distillation of labiate Herba Menthae, be colourless or flaxen supernatant liquid, special residual refrigerant fragrance is arranged, the Oleum menthae acrid in the mouth, cool in nature, have the effect of dispelling wind, heat clearing away, cure mainly affection due to external wind and heat, headache conjunctival congestion, pharyngalgia, have a toothache, disease such as skin wind heat.
As preferred described Chinese medicine composition, made by following weight portion raw material:
The present invention also provides the clinical preparation of described Chinese medicine composition.It is the required various pharmaceutically adjuvants of routine that those skilled in the art can add the preparation different dosage form with Chinese medicine composition of the present invention according to requirement of different patients, as disintegrating agent, lubricant, emulsifying agent, binding agent etc., with conventional method of Chinese medicinal, make common dosage forms through the direct or indirect adding acceptable auxiliary pharmaceutically of routine processing.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is granule, tablet, pill and powder, easily takes, and curative effect is obvious.
Preferably, each preparation unit of clinical preparation of Chinese medicine composition of the present invention is 3～5g, more preferably 4g.
The present invention also provides the preparation method of described Chinese medicine composition.
A kind of preparation method for the treatment of the Chinese medicine composition of cough, get 150g～200 weight portion dried tangerine peels, 100～120 weight portion Poria, 80～100 weight portion Pericarpium Trichosanthiss, 120～150 weight portion Radix Rehmanniae, 60～80 weight portion Pericarpium Citri Reticulataes, 50～90 weight portion Radix Platycodoniss, 80～100 weight portion Radix Ophiopogonis, 120～150 weight portion Radix Asteriss, 100～120 weight portion Semen Armeniacae Amarums, 40～60 weight portion Rhizoma Pinelliae Preparatum, 55～75 weight portion Gypsum Fibrosum, 80～100 weight portion Fructus Perillae (parched), 40～60 weight portion Radix Glycyrrhizaes and 50～80 weight portion Flos Farfaraees, be ground into coarse powder and decoct with water filtration, static 6～8 hours of filtrate, get supernatant, be concentrated into relative density and be 1.10～1.20 extractum, drying sprays into the alcoholic solution that contains 2～5 weight portion Oleum menthae, namely.
As preferably, preparation method of the present invention, described decocting with water filters to decocting with water twice, and each 2 hours, add the water of 12 times of weight for the first time, add the water of 10 times of weight for the second time, gradation filtration, merging filtrate.
The present invention also provides the Chinese medicine composition of above-mentioned preparation method preparation.
The invention provides a kind of granule of cough for the treatment of for getting 150g～200 weight portion dried tangerine peels, 100～120 weight portion Poria, 80～100 weight portion Pericarpium Trichosanthiss, 120～150 weight portion Radix Rehmanniae, 60～80 weight portion Pericarpium Citri Reticulataes, 50～90 weight portion Radix Platycodoniss, 80～100 weight portion Radix Ophiopogonis, 120～150 weight portion Radix Asteriss, 100～120 weight portion Semen Armeniacae Amarums, 40～60 weight portion Rhizoma Pinelliae Preparatum, 55～75 weight portion Gypsum Fibrosum, 80～100 weight portion Fructus Perillae (parched), 40～60 weight portion Radix Glycyrrhizaes and 50～80 weight portion Flos Farfaraees, be ground into coarse powder and decoct with water filtration, static 6～8 hours of filtrate, get supernatant, after being concentrated into relative density and being 1.10～1.20 extract dries, add 600～700 weight portion soluble starches and 5～15 weight portion steviosin mixings, make granule, dry, spray into the alcoholic solution that contains 2～5 weight portion Oleum menthae, mixing, namely.
The present invention in 928 example cough patients, after 15 days, cures 887 examples with traditional Chinese medicine composition for treating of the present invention through clinical observation on the therapeutic effect, and cure rate accounts for 95.6%, 33 examples that take a turn for the better, and total effective rate is 99.1%, invalid 8 examples, inefficiency accounts for 0.9%.
The invention provides a kind of Chinese medicine composition for the treatment of cough of determined curative effect, modern pharmacology research and clinical trial show, Chinese medicine composition of the present invention has the effect of relieving cough and asthma, moistening the lung and resolving phlegm, can alleviate the itch symptom of pain, cough, asthma of throat rapidly, the treatment cough is easy to use, evident in efficacy, have no side effect, comfortable safety, not containing simultaneously brown sugar, be fit to diabetics and do not like the sugar edible for patients, is the good medicine for the treatment of cough, the clinical treatment that can be widely used in coughing has vast market prospect.
The specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition for the treatment of cough and preparation method thereof.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Product of the present invention and method are described by preferred embodiment, the related personnel obviously can be in not breaking away from content of the present invention, spirit and scope to product as herein described with method is changed or suitably change and combination, realize and use the technology of the present invention.
In order further to understand the present invention, the present invention is described in detail below in conjunction with embodiment.
Embodiment 1: the Chinese medicine composition for the treatment of cough of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Preparation method is that dried tangerine peel, Poria, Pericarpium Trichosanthis, Radix Rehmanniae, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Ophiopogonis, Radix Asteris, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparatum, Gypsum Fibrosum, Fructus Perillae (parched), Radix Glycyrrhizae, Flos Farfarae and the Oleum menthae of getting described weight is ground into coarse powder and decocts with water twice, each 2 hours, the water that adds for the first time 12 times of weight, the water that adds for the second time 10 times of weight, gradation filters, merging filtrate, static 6～8 hours, get supernatant, be concentrated into relative density and be 1.10～1.20 extractum, drying sprays into the alcoholic solution of the Oleum menthae that contains described weight portion, namely.
Embodiment 2: the Chinese medicine composition for the treatment of cough of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Preparation method is that dried tangerine peel, Poria, Pericarpium Trichosanthis, Radix Rehmanniae, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Ophiopogonis, Radix Asteris, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparatum, Gypsum Fibrosum, Fructus Perillae (parched), Radix Glycyrrhizae, Flos Farfarae and the Oleum menthae of getting described weight is ground into the decocting that coarse powder adds 12 times of weight and boiled 2 hours, filter, static 6～8 hours of filtrate, get supernatant, be concentrated into relative density and be 1.10～1.20 extractum, drying sprays into the alcoholic solution of the Oleum menthae that contains described weight portion, namely.
Embodiment 3: the Chinese medicine composition for the treatment of cough of the present invention
Described Chinese medicine composition is to be made by following bulk drugs:
Preparation method is that dried tangerine peel, Poria, Pericarpium Trichosanthis, Radix Rehmanniae, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Ophiopogonis, Radix Asteris, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparatum, Gypsum Fibrosum, Fructus Perillae (parched), Radix Glycyrrhizae, Flos Farfarae and the Oleum menthae of getting described weight is ground into coarse powder and decocts with water twice, each 2 hours, the water that adds for the first time 12 times of weight, the water that adds for the second time 10 times of weight, gradation filters, merging filtrate, static 6～8 hours, get supernatant, be concentrated into relative density and be 1.10～1.20 extractum, drying sprays into the alcoholic solution of the Oleum menthae that contains described weight portion, namely.
Embodiment 4: the observation of curative effect of Chinese medicine composition of the present invention
Observe the curative effect of using traditional Chinese medicine composition for treating cough of the present invention.
Adopt the Chinese medicine composition of the embodiment of the invention 3 described preparations to treat 928 example cough patients altogether wherein, male's 426 examples, women's 502 examples; The patient of age minimum 2 years old, maximum patient 76 years old.Three times on the one, each 4g took 15 days continuously, stopped other western medicines in treatment during the treatment.
Observation of curative effect: the present invention has obtained curative effect preferably clinically, in 928 example cough patients, with traditional Chinese medicine composition for treating of the present invention after 15 days, cure 887 examples, cure rate accounts for 95.6%, and 33 examples take a turn for the better, total effective rate is 99.1%, invalid 8 examples, and inefficiency accounts for 0.9%.The Chinese medicine composition group of embodiment 1 and embodiment 2 preparations is similar to the Chinese medicine composition group clinical efficacy of embodiment 3 preparations, no difference of science of statistics.
Embodiment 5: the granule for the treatment of cough of the present invention
Prescription is formed (by 1000 bags of calculating)
Preparation method is the dried tangerine peel of getting described weight; Poria; Pericarpium Trichosanthis; Radix Rehmanniae; Pericarpium Citri Reticulatae; Radix Platycodonis; Radix Ophiopogonis; Radix Asteris; Semen Armeniacae Amarum; Rhizoma Pinelliae Preparatum; Gypsum Fibrosum; Fructus Perillae (parched); Radix Glycyrrhizae; Flos Farfarae and Oleum menthae are ground into coarse powder and decoct with water twice; each 2 hours; the water that adds for the first time 12 times of weight; the water that adds for the second time 10 times of weight; gradation filters; merging filtrate static 6～8 hours, is got supernatant; be concentrated into relative density and be 1.10～1.20 extractum; get extractum 310g, drying adds 675g soluble starch and 15g steviosin mixing; 85% ethanol soaks into; add then in the efficient wet granulator, stir rapidly; high-speed cutting 2min makes granule; 50 ± 5 ℃ of drying 15～20min of inlet temperature; spray into the alcoholic solution of Oleum menthae, mixing, namely.Each preparation unit is that every bag of specification is 4g.
Embodiment 6: the granule for the treatment of cough of the present invention
Prescription is formed (by 1000 bags of calculating)
Preparation method is the dried tangerine peel of getting described weight; Poria; Pericarpium Trichosanthis; Radix Rehmanniae; Pericarpium Citri Reticulatae; Radix Platycodonis; Radix Ophiopogonis; Radix Asteris; Semen Armeniacae Amarum; Rhizoma Pinelliae Preparatum; Gypsum Fibrosum; Fructus Perillae (parched); Radix Glycyrrhizae; Flos Farfarae and Oleum menthae are ground into coarse powder and decoct with water twice; each 2 hours; the water that adds for the first time 12 times of weight; the water that adds for the second time 10 times of weight; gradation filters; merging filtrate static 6～8 hours, is got supernatant; be concentrated into relative density and be 1.10～1.20 extractum; get extractum 365g, drying adds 625g soluble starch and 10g steviosin mixing; 85% ethanol soaks into; add then in the efficient wet granulator, stir rapidly; high-speed cutting 2min makes granule; 50 ± 5 ℃ of drying 15～20min of inlet temperature; spray into the alcoholic solution of Oleum menthae, mixing, namely.Each preparation unit is that every bag of specification is 4g.
Further provide two examples more detailed concrete case below:
Case 1, woman, 29 years old, postinfectious cough two wheat harvesting periods were coughed thick sputum, successively adopted Western medicine and Chinese patent drugs for treatment cough symptom to lose all the time and alleviated.
Take the Chinese medicine composition of the embodiment of the invention 3 preparations, serve on 7 days, cough alleviates, and the thin sputum amount is few.Continued to take 7 days, ill symptoms disappears.
Case 2, man, 65 years old, whenever the cough of winter-spring season abundant expectoration, becoming severe at night, lasting for years is taken multiple Chinese medicine and western medicine and be there is no effect.
Take the granule 15 days of the treatment cough of the embodiment of the invention 5 preparation, cough alleviates, and can put down crouches sleeps peacefully, the clothes 7 days of continuing, patient's recovery from illness.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (9)
1. Chinese medicine composition for the treatment of cough, made by following weight portion raw material:
2. Chinese medicine composition according to claim 1 is characterized in that, is made by following weight portion raw material:
3. comprise the clinical preparation of claim 1 or 2 described Chinese medicine compositions, it is characterized in that, by the Chinese medicine composition of described treatment cough and pharmaceutically conventional adjuvant make up and make.
4. according to the described clinical preparation of claim 3, it is characterized in that it is granule, tablet, pill or powder.
5. according to the described clinical preparation of claim 3, it is characterized in that each preparation unit is 3～5g.
6. the preparation method of the Chinese medicine composition of a treatment cough, it is characterized in that, get 150g～200 weight portion dried tangerine peels, 100～120 weight portion Poria, 80～100 weight portion Pericarpium Trichosanthiss, 120～150 weight portion Radix Rehmanniae, 60～80 weight portion Pericarpium Citri Reticulataes, 50～90 weight portion Radix Platycodoniss, 80～100 weight portion Radix Ophiopogonis, 120～150 weight portion Radix Asteriss, 100～120 weight portion Semen Armeniacae Amarums, 40～60 weight portion Rhizoma Pinelliae Preparatum, 55～75 weight portion Gypsum Fibrosum, 80～100 weight portion Fructus Perillae (parched), 40～60 weight portion Radix Glycyrrhizaes and 50～80 weight portion Flos Farfaraees, be ground into coarse powder and decoct with water filtration, static 6～8 hours of filtrate, get supernatant, be concentrated into relative density and be 1.10～1.20 extractum, drying sprays into the alcoholic solution that contains 2～5 weight portion Oleum menthae, namely.
7. according to the described preparation method of claim 6, it is characterized in that described decocting with water filters to decocting with water twice, each 2 hours, add the water of 12 times of weight for the first time, add the water of 10 times of weight for the second time, gradation filtration, merging filtrate.
8. the Chinese medicine composition of the described preparation method of claim 6～7 preparation.
9. treat the granule of coughing for one kind, it is characterized in that, get 150g～200 weight portion dried tangerine peels, 100～120 weight portion Poria, 80～100 weight portion Pericarpium Trichosanthiss, 120～150 weight portion Radix Rehmanniae, 60～80 weight portion Pericarpium Citri Reticulataes, 50～90 weight portion Radix Platycodoniss, 80～100 weight portion Radix Ophiopogonis, 120～150 weight portion Radix Asteriss, 100～120 weight portion Semen Armeniacae Amarums, 40～60 weight portion Rhizoma Pinelliae Preparatum, 55～75 weight portion Gypsum Fibrosum, 80～100 weight portion Fructus Perillae (parched), 40～60 weight portion Radix Glycyrrhizaes and 50～80 weight portion Flos Farfaraees, be ground into coarse powder and decoct with water filtration, static 6～8 hours of filtrate, get supernatant, after being concentrated into relative density and being 1.10～1.20 extract dries, add 600～700 weight portion soluble starches and 5～15 weight portion steviosin mixings, make granule, dry, spray into the alcoholic solution that contains 2～5 weight portion Oleum menthae, mixing, namely.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105232936A (en) * | 2015-10-25 | 2016-01-13 | 四川双鑫生物科技有限公司 | Decoction medicine capable of treating cold, cough and phlegm and preparation method thereof |
| CN105232935A (en) * | 2015-10-24 | 2016-01-13 | 四川双鑫生物科技有限公司 | Pill medicine treating cold, cough, excessive phlegm and chronic bronchitis and preparation method |
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| CN1698870A (en) * | 2005-05-20 | 2005-11-23 | 太极集团重庆中药二厂 | Method for preparing epicarp citri pills concentrates |
| CN101011527A (en) * | 2007-02-01 | 2007-08-08 | 四川美大康药业股份有限公司 | Improved preparation of Juhong pill, its preparation method and quality inspection method |
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| CN105232935A (en) * | 2015-10-24 | 2016-01-13 | 四川双鑫生物科技有限公司 | Pill medicine treating cold, cough, excessive phlegm and chronic bronchitis and preparation method |
| CN105232936A (en) * | 2015-10-25 | 2016-01-13 | 四川双鑫生物科技有限公司 | Decoction medicine capable of treating cold, cough and phlegm and preparation method thereof |
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