CN108434326A - A kind of pummelo pee tablets and preparation method thereof - Google Patents

A kind of pummelo pee tablets and preparation method thereof Download PDF

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Publication number
CN108434326A
CN108434326A CN201810610737.3A CN201810610737A CN108434326A CN 108434326 A CN108434326 A CN 108434326A CN 201810610737 A CN201810610737 A CN 201810610737A CN 108434326 A CN108434326 A CN 108434326A
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China
Prior art keywords
parts
pummelo pee
pee tablets
pummelo
gypsum
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CN201810610737.3A
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Chinese (zh)
Inventor
张盈盈
姚廷富
尹中秋
陈远强
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Guangxi Yulan Pharmaceutical Co Ltd
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Guangxi Yulan Pharmaceutical Co Ltd
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Priority to CN201810610737.3A priority Critical patent/CN108434326A/en
Publication of CN108434326A publication Critical patent/CN108434326A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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Abstract

The invention discloses a kind of pummelo pee tablets and preparation method thereof, belong to Chinese medicine and its preparation field.The pummelo pee tablets for being intended to provide a kind of relieving cough and asthma, clearing heat and eliminating phlegm, supporting lung moistening lung.The pummelo pee tablets, including be made of following parts by weight of component：12 parts of 30 58 parts of Exocarpium Citri Grandis, 30 39 parts of dried orange peel, 32 38 parts of rhizoma pinellinae praeparata, 20 35 parts of Poria cocos, 15 25 parts of tussilago, 10 20 parts of Radix Glycyrrhizae, 20 37 parts of PERICARPIUM TRICHOSANTHIS, 20 33 parts of aster, 40 45 parts of Radix Ophiopogonis, 20 29 parts of rhizoma anemarrhenae, 30 40 parts of campanulaceae, 40 50 parts of glutinous rehmannia, 40 50 parts of gypsum, 40 50 parts of semen armeniacae amarae, 12 parts of matrimony vine, 12 parts of jujube and longan.

Description

A kind of pummelo pee tablets and preparation method thereof
Technical field
The invention belongs to Chinese medicine and its preparation field, especially a kind of pummelo pee tablets and preparation method thereof.
Background technology
Cough is a kind of common sudden symptom of respiratory tract, and cough is by trachea-bronchial epithelial cell mucous membrane or pleura by inflammation, different Object, physically or chemically sexual stimulus causes, and Closure states of glottis, respiratory muscle are shunk before this when cough, and intrapulmonic pressure increases, then glottis It opens, pulmonary air is spouting.Usually along with sound.Coughing, there is the protectiveness for removing respiratory tract foreign body and secretion to make With.Cough is because very much, it is necessary to find out, can effect a radical cure in time.If cough do not stop, by it is acute switch to it is chronic, usually give patient The pain of bigger, such as uncomfortable in chest, pharynx is brought to itch, breathe.Many people think that cough does not have to treatment, shoulder once shouldering over.In fact, If cannot timely and effectively be treated in the starting that cough occurs, it is easy to so that cough is frequently broken out, cause to have sore throat, sound Hoarse, pectoralgia of sound etc..
Currently there are various cough suppressing medicines, but most drugs are conventional tablet, capsule etc. Solid pharmaceutical preparation, and its curative effect is more general.Dispersible tablet is a kind of novel pharmaceutical formulation developed in recent years, and dispersible tablet is meant Evenly dispersed tablet can be disintegrated rapidly in water.Relative to conventional tablet, capsule etc., dispersible tablet have it is convenient to take, collapse Solution is rapid, absorbs the features such as fast and bioavilability is high.It is simple, convenient to take with preparing, and can reduce the bad anti-of drug It answers, improve the advantages that drug bioavailability.
Invention content
The pummelo pee tablets that first of the present invention is designed to provide a kind of relieving cough and asthma, clearing heat and eliminating phlegm, supports lung moistening lung.
Second object of the present invention is to provide the preparation method of above-mentioned pummelo pee tablets.
In order to realize above-mentioned first technical purpose, the first technical solution provided by the invention is such：A kind ofization tangerine Red, including be made of following parts by weight of component：30-58 parts of Exocarpium Citri Grandis, 30-39 parts of dried orange peel, 32-38 parts of rhizoma pinellinae praeparata, Poria cocos 20- 35 parts, 15-25 parts of tussilago, 10-20 parts of Radix Glycyrrhizae, 20-37 parts of PERICARPIUM TRICHOSANTHIS, 20-33 parts of aster, Radix Ophiopogonis 40-45 part, rhizoma anemarrhenae 20- 29 parts, 30-40 parts of campanulaceae, 40-50 parts of glutinous rehmannia, 40-50 parts of gypsum, 40-50 parts of semen armeniacae amarae, 1-2 parts of matrimony vine, 1-2 parts of jujube and 1-2 parts of longan.
Wherein, including by following parts by weight of component it is made：30-48 parts of Exocarpium Citri Grandis, 30-35 parts of dried orange peel, rhizoma pinellinae praeparata 32-36 Part, 20-30 parts of Poria cocos, 15-20 parts of tussilago, 10-18 parts of Radix Glycyrrhizae, 20-33 parts of PERICARPIUM TRICHOSANTHIS, 20-30 parts of aster, Radix Ophiopogonis 40-43 It is part, 20-25 parts of rhizoma anemarrhenae, 30-36 parts of campanulaceae, 40-45 parts of glutinous rehmannia, 40-45 parts of gypsum, 40-45 parts of semen armeniacae amarae, 1-2 parts of matrimony vine, red 1-2 parts of 1-2 parts of jujube and longan.
Wherein, including by following parts by weight of component it is made：38 parts of Exocarpium Citri Grandis, 33 parts of dried orange peel, 34 parts of rhizoma pinellinae praeparata, Poria cocos 28 Part, 18 parts of tussilago, 15 parts of Radix Glycyrrhizae, 27 parts of PERICARPIUM TRICHOSANTHIS, 25 parts of aster, 41 parts of Radix Ophiopogonis, 23 parts of rhizoma anemarrhenae, 33 parts of campanulaceae, glutinous rehmannia 44 1 part of part, 42 parts of gypsum, 43 parts of semen armeniacae amarae, 2 parts of matrimony vine, 1 part of jujube and longan.
Wherein, further include following parts by weight of component：27 portions of filler, 6 parts of additional disintegrant, is rectified interior plus 14 parts of disintegrant 3 parts of 6 parts of taste agent, 5 parts of adhesive, 4 parts of lubricant and glidant.
Wherein, the filler be soluble starch, it is mannitol, microcrystalline cellulose, sucrose, sodium chloride, calcium sulfate, low Replace one or more of hydroxypropylcellulose, carboxyrnethyl starch sodium, croscarmellose sodium.
Wherein, the corrigent is one or more of aspartame, citric acid, orange flavor.
Wherein, the adhesive is povidone k30, one kind in hydroxypropyl methylcellulose or two kinds.
Wherein, the lubricant is one or both of magnesium stearate, lauryl sodium sulfate.
Wherein, the glidant is one or both of silica, talcum powder.
In order to realize the second technical purpose of the present invention, the second technical solution of the invention is such：A kind of institute as above The preparation method for stating pummelo pee tablets, includes the following steps：
Step 1：Each raw material is weighed by mass fraction proportioning, cleans and cleans, it is spare；
Step 2：Gypsum is ground into coarse powder, add water to cook it is secondary, 1 hour every time, be separated by solid-liquid separation, obtain filtrate, the dregs of a decoction, By Exocarpium Citri Grandis, dried orange peel, tussilago, semen armeniacae amarae steam distillation, distillate 250ml, the filtration of distiller inner liquid medicine, filtrate are collected Add ethyl alcohol that alcohol content is made to reach 60%, stir evenly, stand 24 hours, filtration obtains filtrate, the dregs of a decoction, by rhizoma pinellinae praeparata, Poria cocos, Radix Glycyrrhizae, melon Beach wormwood skin, aster, Radix Ophiopogonis, rhizoma anemarrhenae, campanulaceae, glutinous rehmannia, matrimony vine, jujube and longan are ground into coarse powder and are mixed with two kinds of obtained dregs of a decoction Even, using percolation, diacolation after impregnating 24 hours collects the liquid 2700ml that filters, merges with the two kinds of filtrates obtained before, depressurize back Ethyl alcohol is received to no alcohol taste, is merged with gypsum decocting liquid, concentrates, makes it under 50 DEG C of temperature condition, relative density 1.06, decompression It is dry, obtain extract；
Step 3：Extract is ground into fine powder, addition filler, interior plus disintegrant are uniformly mixed, adhesive are added, adopts It is pelletized with fluidized bed granulation technology, obtains whole grain, high temperature drying, using ultraviolet disinfection, by whole grain, additional disintegrant, flavoring Agent, lubricant, glidant are uniformly mixed, and tabletting obtains a kind of pummelo pee tablets.
The present invention has the following advantages compared with conventional method：
In drug：
Exocarpium Citri Grandis, phlegm-eliminiating and qi-regulating, removing heat from the lung to relieve cough, reinforcing spleen to promote digestion is stagnant for phlegm in the heart, cough and asthma, eating accumulation, vomiting The diseases such as hiccup；
Dried orange peel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, is used for abdominal fullness and distention, and deficiency of food is vomited and diarrhoea, coughing with a lot of sputum；
Rhizoma pinellinae praeparata, it is eliminating dampness and eliminating phlegm, it is used for abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache；
Poria cocos, eliminating dampness and diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative cure mainly：Difficult urination, oedema turgor, phlegm and retained fluid cough is inverse, vomiting, Spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness, gonorrhoea of passing out semen；
Tussilago, moistening lung to lower qi, resolving sputum are only coughed, and control that cough is inverse to pant, larynx numbness；
Radix Glycyrrhizae, clearing heat and detoxicating, expelling phlegm and arresting coughing；
PERICARPIUM TRICHOSANTHIS, moistening lung for removing phlegm, the sharp wide chest of gas control phlegm-heat cough, pharyngalgia, and pectoralgia is spitted blood, and bleeding from five sense organs or subcutaneous tissue is quenched one's thirst, constipation, carbuncle Pyogenic infections from tumour or sore；
Cough due to wind-cold evil's asthma, consumptive disease cough vomiting of pus and blood, larynx numbness, difficult urination are controlled in aster, warm lung, lower gas, dissolving phlegm, cough-relieving；
Radix Ophiopogonis, nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire are used for dryness of the lung dry cough, and cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, interior heat disappears Yearningly, vexed insomnia, dry constipation of intestines；
Rhizoma anemarrhenae, nourishing yin and lessening fire, moisturize laxation, sharp stool and urine, cures mainly：Warm heat disease, hyperpyrexia polydipsia, cough and asthma, cough caused by dryness, just Secret, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst；
Campanulaceae, facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis are used for coughing with a lot of sputum, chest distress, pharyngalgia, hoarse voice, lung carbuncle pyemesis；
Glutinous rehmannia, enriching yin and nourishing kidney, blood-nourishing enrich blood, cool blood, gypsum, clearing heat-fire, and relieving restlessness is quenched the thirst；
Semen armeniacae amarae, sending down abnormally ascending, are relievingd asthma at cough-relieving, are relaxed bowel, and are used for cough and asthma, fullness sensation in chest abundant expectoration, deficiency of blood Tianjin is withered, and intestinal dryness is just It is secret；
Perilla seed, sending down abnormally ascending dissolving phlegm, relieving cough and asthma, ease constipation.
Beneficial effects of the present invention：A kind of pummelo pee tablets of the present invention, have effects that clearing lung-heat, cough-relieving, resolving sputum, dissolve Property, favorable dispersibility, dissolution rate is high, and bioavilability is good, and distribution in vivo is rapid, and stable quality is in good taste, convenient to take, can Swallow, chew, containing suck or it is water-dispersible after take, be more suitable for old man and swallow difficult patient, compared with oral solution, there is medicine Object stability is good, packs, and the advantages that facilitating is stored in transport, and preparation method is simple and practicable, is suitable for industrial production.
Specific implementation mode
With reference to embodiment, the claim of the present invention is described in further detail, but do not constituted pair Any restrictions of the present invention, any limited number of time modification made within the scope of the present invention, still in the present invention Claims in.
Embodiment 1
30 parts of Exocarpium Citri Grandis, 39 parts of dried orange peel, 32 parts of rhizoma pinellinae praeparata, 35 parts of Poria cocos, 15 parts of tussilago, 20 parts of Radix Glycyrrhizae, PERICARPIUM TRICHOSANTHIS 20 Part, 33 parts of aster, 40 parts of Radix Ophiopogonis, 29 parts of rhizoma anemarrhenae, 30 parts of campanulaceae, 50 parts of glutinous rehmannia, 40 parts of gypsum, 50 parts of semen armeniacae amarae, 1 part of matrimony vine, 2 parts of jujube, 2 parts of longan, 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 3 parts of 4 parts of lubricant and glidant.
Embodiment 2
58 parts of Exocarpium Citri Grandis, 30 parts of dried orange peel, 38 parts of rhizoma pinellinae praeparata, 20 parts of Poria cocos, 25 parts of tussilago, 10 parts of Radix Glycyrrhizae, PERICARPIUM TRICHOSANTHIS 37 Part, 20 parts of aster, 45 parts of Radix Ophiopogonis, 20 parts of rhizoma anemarrhenae, 40 parts of campanulaceae, 40 parts of glutinous rehmannia, 50 parts of gypsum, 40 parts of semen armeniacae amarae, 2 parts of matrimony vine, 1 part of jujube, 2 parts of longan, 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 3 parts of 4 parts of lubricant and glidant.
Embodiment 3
30 parts of Exocarpium Citri Grandis, 35 parts of dried orange peel, 32 parts of rhizoma pinellinae praeparata, 30 parts of Poria cocos, 15 parts of tussilago, 18 parts of Radix Glycyrrhizae, PERICARPIUM TRICHOSANTHIS 20 Part, 30 parts of aster, 40 parts of Radix Ophiopogonis, 25 parts of rhizoma anemarrhenae, 30 parts of campanulaceae, 45 parts of glutinous rehmannia, 40 parts of gypsum, 45 parts of semen armeniacae amarae, 1 part of matrimony vine, 2 parts of jujube, 1 part of longan, 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 3 parts of 4 parts of lubricant and glidant.
Embodiment 4
48 parts of Exocarpium Citri Grandis, 30 parts of dried orange peel, 36 parts of rhizoma pinellinae praeparata, 20 parts of Poria cocos, 20 parts of tussilago, 10 parts of Radix Glycyrrhizae, PERICARPIUM TRICHOSANTHIS 33 Part, 20 parts of aster, 43 parts of Radix Ophiopogonis, 20 parts of rhizoma anemarrhenae, 36 parts of campanulaceae, 40 parts of glutinous rehmannia, 45 parts of gypsum, 40 parts of semen armeniacae amarae, 2 parts of matrimony vine, 1 part of jujube, 2 parts of longan, 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 3 parts of 4 parts of lubricant and glidant.
Embodiment 5
38 parts of Exocarpium Citri Grandis, 33 parts of dried orange peel, 34 parts of rhizoma pinellinae praeparata, 28 parts of Poria cocos, 18 parts of tussilago, 15 parts of Radix Glycyrrhizae, PERICARPIUM TRICHOSANTHIS 27 Part, 25 parts of aster, 41 parts of Radix Ophiopogonis, 23 parts of rhizoma anemarrhenae, 33 parts of campanulaceae, 44 parts of glutinous rehmannia, 42 parts of gypsum, 43 parts of semen armeniacae amarae, 2 parts of matrimony vine, 1 part of jujube, 1 part of longan, 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 3 parts of 4 parts of lubricant and glidant.
The preparation method of the pummelo pee tablets of embodiment 1-5, includes the following steps：
Step 1：Each raw material is weighed by mass fraction proportioning, cleans and cleans, it is spare；
Step 2：Gypsum is ground into coarse powder, add water to cook it is secondary, 1 hour every time, be separated by solid-liquid separation, obtain filtrate, the dregs of a decoction, By Exocarpium Citri Grandis, dried orange peel, tussilago, semen armeniacae amarae steam distillation, distillate 250ml, the filtration of distiller inner liquid medicine, filtrate are collected Add ethyl alcohol that alcohol content is made to reach 60%, stir evenly, stand 24 hours, filtration obtains filtrate, the dregs of a decoction, by rhizoma pinellinae praeparata, Poria cocos, Radix Glycyrrhizae, melon Beach wormwood skin, aster, Radix Ophiopogonis, rhizoma anemarrhenae, campanulaceae, glutinous rehmannia, matrimony vine, jujube and longan are ground into coarse powder and are mixed with two kinds of obtained dregs of a decoction Even, using percolation, diacolation after impregnating 24 hours collects the liquid 2700ml that filters, merges with the two kinds of filtrates obtained before, depressurize back Ethyl alcohol is received to no alcohol taste, is merged with gypsum decocting liquid, concentrates, makes it under 50 DEG C of temperature condition, relative density 1.06, decompression It is dry, obtain extract；
Step 3：Extract is ground into fine powder, addition filler, interior plus disintegrant are uniformly mixed, adhesive are added, adopts It is pelletized with fluidized bed granulation technology, obtains whole grain, high temperature drying, using ultraviolet disinfection, by whole grain, additional disintegrant, flavoring Agent, lubricant, glidant are uniformly mixed, and tabletting obtains a kind of pummelo pee tablets.
Above-described is only presently preferred embodiments of the present invention, all timess done within the scope of the spirit and principles in the present invention What modifications, equivalent substitutions and improvements etc., should be included within the scope of the present invention.

Claims (10)

1. a kind of pummelo pee tablets, which is characterized in that including being made of following parts by weight of component：30-58 parts of Exocarpium Citri Grandis, dried orange peel 30- 39 parts, 32-38 parts of rhizoma pinellinae praeparata, 20-35 parts of Poria cocos, 15-25 parts of tussilago, 10-20 parts of Radix Glycyrrhizae, 20-37 parts of PERICARPIUM TRICHOSANTHIS, aster 20-33 parts, Radix Ophiopogonis 40-45 part, 20-29 parts of rhizoma anemarrhenae, 30-40 parts of campanulaceae, 40-50 parts of glutinous rehmannia, 40-50 parts of gypsum, semen armeniacae amarae 40- 1-2 parts of 50 parts, 1-2 parts of matrimony vine, 1-2 parts of jujube and longan.
2. a kind of pummelo pee tablets according to claim 1, which is characterized in that including being made of following parts by weight of component：Change 30-48 parts of Exocarpium Citri Rubrum, 30-35 parts of dried orange peel, 32-36 parts of rhizoma pinellinae praeparata, 20-30 parts of Poria cocos, 15-20 parts of tussilago, 10-18 parts of Radix Glycyrrhizae, 20-33 parts of PERICARPIUM TRICHOSANTHIS, 20-30 parts of aster, Radix Ophiopogonis 40-43 part, 20-25 parts of rhizoma anemarrhenae, 30-36 parts of campanulaceae, 40-45 parts of glutinous rehmannia, stone 1-2 parts of 40-45 parts of cream, 40-45 parts of semen armeniacae amarae, 1-2 parts of matrimony vine, 1-2 parts of jujube and longan.
3. a kind of pummelo pee tablets according to claim 1, which is characterized in that including being made of following parts by weight of component：Change 38 parts of Exocarpium Citri Rubrum, 33 parts of dried orange peel, 34 parts of rhizoma pinellinae praeparata, 28 parts of Poria cocos, 18 parts of tussilago, 15 parts of Radix Glycyrrhizae, 27 parts of PERICARPIUM TRICHOSANTHIS, aster 25 Part, 41 parts of Radix Ophiopogonis, 23 parts of rhizoma anemarrhenae, 33 parts of campanulaceae, 44 parts of glutinous rehmannia, 42 parts of gypsum, 43 parts of semen armeniacae amarae, 2 parts of matrimony vine, 1 part of jujube and 1 part of longan.
4. according to a kind of any pummelo pee tablets of claim 1-3, which is characterized in that further include following parts by weight of component： 27 parts of filler, interior plus 14 parts of disintegrant, 6 parts of additional disintegrant, 6 parts of corrigent, 5 parts of adhesive, 4 parts of lubricant and glidant 3 parts.
5. a kind of pummelo pee tablets according to claim 4, which is characterized in that the filler is soluble starch, sweet Reveal alcohol, microcrystalline cellulose, sucrose, sodium chloride, calcium sulfate, low-substituted hydroxypropyl cellulose, carboxyrnethyl starch sodium, cross-linked carboxymethyl fiber One or more of plain sodium.
6. a kind of pummelo pee tablets according to claim 4, which is characterized in that the corrigent is aspartame, citron One or more of acid, orange flavor.
7. a kind of pummelo pee tablets according to claim 4, which is characterized in that the adhesive is povidone k30, hydroxypropyl One kind in methylcellulose or two kinds.
8. a kind of pummelo pee tablets according to claim 4, which is characterized in that the lubricant is magnesium stearate, 12 One or both of sodium alkyl sulfate.
9. a kind of pummelo pee tablets according to claim 4, which is characterized in that the glidant is silica, talcum One or both of powder.
10. a kind of preparation method of pummelo pee tablets as described in claim 1-9, which is characterized in that include the following steps：
Step 1：Each raw material is weighed by mass fraction proportioning, cleans and cleans, it is spare；
Step 2：Gypsum is ground into coarse powder, add water to cook it is secondary, 1 hour every time, be separated by solid-liquid separation, obtain filtrate, the dregs of a decoction, will change Exocarpium Citri Rubrum, dried orange peel, tussilago, semen armeniacae amarae steam distillation, collect distillate 250ml, the filtration of distiller inner liquid medicine, and filtrate adds second Alcohol makes alcohol content reach 60%, stirs evenly, and stands 24 hours, and filtration obtains filtrate, the dregs of a decoction, by rhizoma pinellinae praeparata, Poria cocos, Radix Glycyrrhizae, Snakegourd Fruit Skin, aster, Radix Ophiopogonis, rhizoma anemarrhenae, campanulaceae, glutinous rehmannia, matrimony vine, jujube and longan are ground into coarse powder and are mixed with two kinds of obtained dregs of a decoction Even, using percolation, diacolation after impregnating 24 hours collects the liquid 2700ml that filters, merges with the two kinds of filtrates obtained before, depressurize back Ethyl alcohol is received to no alcohol taste, is merged with gypsum decocting liquid, concentrates, makes it under 50 DEG C of temperature condition, relative density 1.06, decompression It is dry, obtain extract；
Step 3：Extract is ground into fine powder, filler is added, interior plus disintegrant is uniformly mixed, addition adhesive, using stream Change the granulation of bed granulation technique, obtains whole grain, high temperature drying, using ultraviolet disinfection, by whole grain, additional disintegrant, corrigent, profit Lubrication prescription, glidant are uniformly mixed, and tabletting obtains a kind of pummelo pee tablets.
CN201810610737.3A 2018-06-14 2018-06-14 A kind of pummelo pee tablets and preparation method thereof Withdrawn CN108434326A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102430048A (en) * 2011-12-28 2012-05-02 成都拜特尔药业有限公司 Chinese medicinal composition for treating cough and preparation method thereof
CN104383250A (en) * 2014-11-26 2015-03-04 黑龙江省智诚医药科技有限公司 Pummelo peel dispersible tablets with function of relieving cough and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102430048A (en) * 2011-12-28 2012-05-02 成都拜特尔药业有限公司 Chinese medicinal composition for treating cough and preparation method thereof
CN104383250A (en) * 2014-11-26 2015-03-04 黑龙江省智诚医药科技有限公司 Pummelo peel dispersible tablets with function of relieving cough and preparation method thereof

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