CN104138441A - Traditional Chinese medicine formula for treating infantile cough and asthma and preparation thereof - Google Patents
Traditional Chinese medicine formula for treating infantile cough and asthma and preparation thereof Download PDFInfo
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- CN104138441A CN104138441A CN201410422074.4A CN201410422074A CN104138441A CN 104138441 A CN104138441 A CN 104138441A CN 201410422074 A CN201410422074 A CN 201410422074A CN 104138441 A CN104138441 A CN 104138441A
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Abstract
The invention relates to a traditional Chinese medicine formula for treating infantile cough and asthma and a preparation thereof. The traditional Chinese medicine formula is composed of the following raw materials: vegetable sponge, folia perillae acutae, exocarpium, coleus forskohlii, platycodon grandiflorum, dry persimmon cream, nandin and licorice roots. A preparation method of the preparation comprises the following steps: preparing the above eight raw materials; adding 70% ethanol with an amount being 10 times that of the coleus forskohlii, carrying out reflux extraction three times, 1.5 hours each time, mixing extracts prepared in the three times, filtrating and keeping filter liquor for later use; and adding water with an amount being 10 times that of the rest of seven raw materials except the dry persimmon cream into the rest of seven raw materials except the dry persimmon cream, decocting three times, 1 hour each time, carrying out pressure-reduced concentration until clear cream with a relative density of 1.10-1.22 at a temperature of 60 DEG C is obtained; adding alcohol so that the ethanol content reaches 60%, standing for 24 hours, taking liquid supernatant, mixing the liquid supernatant with the alcohol extract of coleus forskohlii; recovering ethanol, and carrying out pressure-reduced concentration so as to obtain a thick cream; adding the dry persimmon cream and an appropriate amount of auxiliaries and flavoring agents into the thick cream, preparing into granules, drying until the weight of the obtained object is 1000g, thus obtaining the target product. The preparation disclosed by the invention has the effects of ventilating the lung, relieving exterior syndrome, dispelling cold, regulating qi, reducing phlegm and relieving a cough, and has the advantages that both manifestation and root causes of diseases are treated, the quality is controllable, and the curative effect is exact.
Description
Technical field
The present invention relates to a kind of Chinese prescription and preparation for the treatment of infantile cough, asthma, be used for the treatment of children's cough due to wind and cold disease, disease is seen: cough is done frequently, coughs thin and whitish sputum, rhinorrhea with clear discharge, and aversion to cold is lossless, head-body-pain, tongue fur is light white, floating and tense pulse, fingerprint color is light.
Background technology
Infantile cough asthma is common in child, and children's is due to " internal organs are tender and lovely ", and " shape gas does not fill " this physiological characteristics is poor to the resistance of disease, according to statistics, respiratory system disease is children disease first.Long-time cough, asthma can cause immunization programs for children power to decline, long-term taking antibiotic, very threat to life.Therefore actively prevent and treat growth and development, the nutrient health of primary disease to child in close relations.Infantile cough asthma is common clinical, frequently-occurring disease, particularly after children's's Common Cold, often leaves over cough symptom, and the prolonged difficulty of the course of disease more, treat rather thornyly, and has a strong impact on children's's normal growth growth.Modern medicine study thinks, cough is a kind of guarding reflex action of human body.Pathologic secretions in respiratory tract and enter the foreign body in respiratory tract from the external world, can borrow the action of coughre flex and excrete.Doctor trained in Western medicine mainly adopts antibiotic and cough suppressing medicine to carry out symptomatic treatment to the treatment of this disease at present, but because the extensive use of a large amount of broad ectrum antibiotic makes that bacterial drug resistance constantly strengthens, less etc. the reason of anti-inflammation drugs kind, the treatment drawback of chemicals manifests gradually.And Chinese Traditional Medicine has accumulated rich experience to the understanding of primary disease, adopt multi-medicament composition of prescription, treating both the principal and secondary aspects of a disease, toxic and side effects is little, has safety, good effect, the feature such as easy to use, aspect treatment infantile cough asthma, has certain advantage.But always Chinese medicine mostly is decoction or powder, take inconvenience, children's's compliance is very poor, even affect the treatment, we develop Chinese medicine, natural drug new drug six classes-infantile cough stops granule on the basis through proved recipe, and prescription is formed by clinical experience sideization sanction, in side, eight taste medical materials have been imperial medical material, do not contain the medicine of the incompatibilitys such as drug toxicity and eighteen incompatible medicaments, nineteen medicaments of mutual restraint.We taking decoction oral as clinical practice more than 30 years, have that performance curative effect is fast, determined curative effect through pediatric hospital doctor, and children's is easy to accept the feature of being convenient to take, and the preliminary test of we's process pharmacodynamics, respond well.Its reasonable recipe, has treating both the principal and secondary aspects of a disease, easy to use, quality controllable, and drug effect is definite, and safe and reliable advantage can meet the demand of extensive patients.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese prescription and preparation for the treatment of infantile cough, asthma, and this medicine has effect of diffusing lung, relieving exterior syndrome cold expelling, activating QI to eliminate phlegm relieving cough and asthma.
Medicine of the present invention is made up of the raw material of Chinese medicine of following weight proportioning:
Chalina 100 ~ 300g Folium Perillae 100 ~ 300g Exocarpium Citri Grandis 100 ~ 300g
The dry Mannosum Kaki 50 ~ 200g of Flos Colei esquirolii 100 ~ 300g Radix Platycodonis 100 ~ 300g
Fructus Nandinae Domesticae 50 ~ 200g Radix Glycyrrhizae 50 ~ 150g
The preferred weight proportioning of the each raw material of the present invention is:
Chalina 150 ~ 300g Folium Perillae 150 ~ 300g Exocarpium Citri Grandis 150 ~ 300g
The dry Mannosum Kaki 100 ~ 200g of Flos Colei esquirolii 150 ~ 300g Radix Platycodonis 150 ~ 300g
Fructus Nandinae Domesticae 75 ~ 150g Radix Glycyrrhizae 75 ~ 150g
The optimum weight proportioning of the each raw material of the present invention is:
Chalina 200g Folium Perillae 200g Exocarpium Citri Grandis 200g
The dry Mannosum Kaki 150g of Flos Colei esquirolii 200g Radix Platycodonis 200g
Fructus Nandinae Domesticae 100g Radix Glycyrrhizae 150g
Preparation method of the present invention is: above eight tastes, and get Flos Colei esquirolii and add ten times of amount reflux, extract, of 70% ethanol three times, each 1.5 hours, merge three times extracting solution, filter, filtrate is for subsequent use; All the other seven tastes add the decocting of ten times of amounts to boil three times except dry Mannosum Kaki, each 1 hour, the clear paste of relative density 1.10-1.22 while being evaporated to 60 DEG C, added ethanol and makes to reach 60% containing alcohol amount, leave standstill 24 hours, get supernatant, merge with Flos Colei esquirolii alcohol extract, reclaim ethanol concentrating under reduced pressure and become thick paste, add dry Mannosum Kaki and adjuvant, the appropriate granulation of flavoring agent, dry, make 1000g, to obtain final product.
Medicine of the present invention can add one or more pharmaceutic adjuvants as required, pharmaceutic adjuvant can be diluent, binding agent, correctives, excipient, as sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin.
The present invention can make any clinical pharmaceutical preparation that is applicable to according to existing process of Chinese medicine preparation, comprises solid preparation (hard capsule, granule, tablet, dispersible tablet, soft capsule, drop pill, pill), liquid preparation (syrup, soft extract, oral liquid, mixture) etc.The preferred dosage form of the present invention is granule.
The present invention is formed by eight taste Chinese prescriptions, and chalina sweet in the mouth is flat, enters lung, stomach, Liver Channel, has relieving cough and resolving phlegm effect, is to be monarch drug; Folium Perillae has the merit of the cold expelling of inducing sweat, and principal drug assistance lung qi dispersing relieving cough and asthma is ministerial drug; Exocarpium Citri Grandis regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm, principal drug assistance eliminating phlegm and stopping cough, is ministerial drug; Flos Colei esquirolii hardship, pungent, warm.Returning liver, lung meridian, have the effect of depressed lung-energy dispersing, eliminating phlegm and stopping cough, is ministerial drug altogether; Radix Platycodonis hardship, pungent, flat, return lung meridian, lung qi dispersing, sore-throat relieving, the effect of eliminating the phlegm, is adjuvant drug; Fructus Nandinae Domesticae, bitter, cold, to dispel the wind, preventing phlegm from forming and stopping coughing, is adjuvant drug; Dry Fructus Kaki sweet in the mouth, puckery, cold in nature, has heat clearing away to go effect dry, moistening the lung and resolving phlegm, is adjuvant drug altogether; Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription, for making medicine.Full side plays effect of diffusing lung, relieving exterior syndrome cold expelling, activating QI to eliminate phlegm cough-relieving altogether.For the infantile cough due to affection of exogenous wind-cold.Disease is seen: cough is done frequently, coughs thin and whitish sputum, rhinorrhea with clear discharge, and aversion to cold is lossless, head-body-pain, tongue fur is light white, floating and tense pulse, fingerprint color is light.
An important feature of the present invention is pure Chinese medicinal preparation, and determined curative effect, toxic and side effects are little, and the effect of existing diffusing lung, relieving exterior syndrome cold expelling has again the merit of taking stopgap measures of activating QI to eliminate phlegm cough-relieving concurrently.Meanwhile, after granulation agent, facilitated carrying and taking of patient, and quality controllable, safety good.
Using method of the present invention is: oral, and three times on the one, once a bag; During medication, avoid greasy, maror.
The present invention derives from hospital clinical through proved recipe, and with 2000-2014 clinical observation infant 85 examples, clinical report is summarized as follows:
In 85 routine infants, age 0-3 year, the course of disease is many at 3-5 days, and symptom is: cough is done frequently, coughs thin and whitish sputum, rhinorrhea with clear discharge, and aversion to cold is lossless, head-body-pain, tongue fur is light white, floating and tense pulse, fingerprint color is light.Use Granules in Treating of the present invention, every day three times, each one bag 3 days is a course for the treatment of.Therapeutic outcome is formulated with reference to " Chinese medicine Clinical Researches of New Drugs guideline ": cure: the symptom such as cough or headache aversion to cold does not appear in infant; Effective: the symptoms such as cough and watery nasal discharge obviously alleviate; Invalid: symptom is not improved.Result: in 85 routine infants, cure 68 examples (80.0%), effective 13 examples (15.3%), invalid 4 examples (4.7%), total effective rate 95.3%.
Model case: Ma: female, 3 years old, cough was frequent, and watery nasal discharge is swallowed micro-redly, and floating and tense pulse, uses medicine of the present invention, and every day three times, after 1 course for the treatment of, symptom obviously alleviates, and cough alleviates, and continual cure, after 2 days, is fully recovered.
Hu: female, 11 months, cough many days, time heavy when light, expectoration recently, expectorant color is rare white, watery nasal discharge, fingerprint color is light, uses medicine of the present invention, every day three times, after 1 course for the treatment of, symptom takes a turn for the better, and occasionally has nasal mucus, continues to take 1 course for the treatment of, fully recovers.
The pharmacodynamic study result that the present invention treats infantile cough is summarized as follows:
Get 50 of mices, male and female half and half, body weight 20 ± 2g, is divided into 5 groups at random according to weight data, matched group, heavy dose of group, middle dosage group, small dose group, positive drug group.Except matched group, other each group gavages respectively medicine and the positive drug of large, medium and small dosage, every day 1 time, totally 1 week.60min mice after giving last medicine is placed in the bell jar of 500 ml, with 400-500 mmHg constant voltage, ammonia (28%) is evenly sprayed in bell jar, spraying 5s, record cough number of times in mouse cough incubation period and 2min, applied statistics software, carries out one factor analysis of variance, result and matched group comparison, each administration group all has significant difference, illustrates that the present invention treats infantile cough determined curative effect.
Pharmacodynamics test shows reasonable recipe of the present invention, has obvious antitussive action, can reach the object for the treatment of cough.
Detailed description of the invention
Realize and further illustrating of the present invention by following detailed description of the invention, but should not be understood to any limitation of the invention.
Press column weight amount and take raw material:
Chalina 200g Folium Perillae 200g Exocarpium Citri Grandis 200g
The dry Mannosum Kaki 150g of Flos Colei esquirolii 200g Radix Platycodonis 200g
Fructus Nandinae Domesticae 100g Radix Glycyrrhizae 150g
Preparation method of the present invention is: above eight tastes, and get Flos Colei esquirolii and add ten times of amount reflux, extract, of 70% ethanol three times, each 1.5 hours, merge three times extracting solution, filter, filtrate is for subsequent use; All the other seven tastes add the decocting of ten times of amounts to boil three times except dry Mannosum Kaki, each 1 hour, the clear paste of relative density 1.10-1.22 while being evaporated to 60 DEG C, added ethanol and makes to reach 60% containing alcohol amount, leave standstill 24 hours, get supernatant, merge with Flos Colei esquirolii alcohol extract, reclaim ethanol concentrating under reduced pressure and become thick paste, add dry Mannosum Kaki and adjuvant, the appropriate granulation of flavoring agent, dry, make 1000g, to obtain final product.
Claims (5)
1. treat Chinese prescription and the preparation of infantile cough, asthma, it is characterized in that it is to be made up of the raw material of Chinese medicine of following weight proportion:
Chalina 200g Folium Perillae 200g Exocarpium Citri Grandis 200g
The dry Mannosum Kaki 150g of Flos Colei esquirolii 200g Radix Platycodonis 200g
Fructus Nandinae Domesticae 100g Radix Glycyrrhizae 150g.
2. Chinese prescription and the preparation for the treatment of infantile cough according to claim 1, asthma, is characterized in that preparation method is: above eight tastes, and get Flos Colei esquirolii and add ten times of amount reflux, extract, of 70% ethanol three times, each 1.5 hours, merge three times extracting solution, filter, filtrate is for subsequent use; All the other seven tastes add the decocting of ten times of amounts to boil three times except dry Mannosum Kaki, each 1 hour, the clear paste of relative density 1.10-1.22 while being evaporated to 60 DEG C, added ethanol and makes to reach 60% containing alcohol amount, leave standstill 24 hours, get supernatant, merge with Flos Colei esquirolii alcohol extract, reclaim ethanol concentrating under reduced pressure and become thick paste, add dry Mannosum Kaki and adjuvant, the appropriate granulation of flavoring agent, dry, make 1000g, to obtain final product.
3. a kind of Chinese prescription and preparation for the treatment of infantile cough, asthma according to claim 2, wherein appropriate amount of auxiliary materials is diluent, binding agent, correctives, excipient.
4. a kind of Chinese prescription and preparation for the treatment of infantile cough, asthma according to claim 2, wherein adjuvant is one or more in sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin.
5. a kind of Chinese prescription and preparation for the treatment of infantile cough, asthma according to claim 2, wherein preparation is the one in capsule, granule, tablet, soft extract, mixture, syrup, pill.
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| CN104138441B CN104138441B (en) | 2016-07-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873603A (en) * | 2015-06-09 | 2015-09-02 | 武汉药谷科技开发有限公司 | Traditional Chinese medicine composition for treating children cough and preparation method thereof |
| CN105998498A (en) * | 2016-07-15 | 2016-10-12 | 秦文雄 | Traditional Chinese preparation for treating asthma and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850193A (en) * | 2005-04-22 | 2006-10-25 | 安徽科创中药天然药物研究所有限责任公司 | Method for preparing capsule of Exocarpium citri Tangerinae seu Grandis and loquat, and its quality control technology |
| KR20130055059A (en) * | 2011-11-18 | 2013-05-28 | 재단법인충북테크노파크 | A pharmaceutical for treating or preventing asthma |
-
2014
- 2014-08-26 CN CN201410422074.4A patent/CN104138441B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850193A (en) * | 2005-04-22 | 2006-10-25 | 安徽科创中药天然药物研究所有限责任公司 | Method for preparing capsule of Exocarpium citri Tangerinae seu Grandis and loquat, and its quality control technology |
| KR20130055059A (en) * | 2011-11-18 | 2013-05-28 | 재단법인충북테크노파크 | A pharmaceutical for treating or preventing asthma |
Non-Patent Citations (4)
| Title |
|---|
| 刘一丹等: "复方鞘蕊苏颗粒止咳、平喘和祛痰药效学研究", 《昆明医学院学报》 * |
| 吴静等: "《民间祖传秘方大全》", 31 May 2012, 北京科学技术出版社 * |
| 王玉生等: "《南方药用植物》", 30 April 2011, 南方日报出版社 * |
| 陈冲: "《中药提取物-鉴别与质量标准参考》", 31 March 2013, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873603A (en) * | 2015-06-09 | 2015-09-02 | 武汉药谷科技开发有限公司 | Traditional Chinese medicine composition for treating children cough and preparation method thereof |
| CN104873603B (en) * | 2015-06-09 | 2018-11-30 | 天士力医药集团股份有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating children cough |
| CN105998498A (en) * | 2016-07-15 | 2016-10-12 | 秦文雄 | Traditional Chinese preparation for treating asthma and preparation method thereof |
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| CN104138441B (en) | 2016-07-06 |
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Effective date of registration: 20180306 Address after: 430079 Wuhan East Lake New Technology Development Zone, East Lake New Technology Development Zone, No. 388, No. 388, Wuhan Optics Valley international bio pharmaceutical enterprise accelerator one phase Patentee after: In the Wuhan science and technology development limited company check dam Address before: 430079 building A2-2, pharmaceutical industry park, 858 hi tech Avenue, East Lake Development Zone, Hubei, Wuhan, China Patentee before: Yaogu Sci-Tech Development Co., Ltd., Wuhan |
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Effective date of registration: 20220408 Address after: 300410 2 East Road Puji River, Beichen District, Tianjin (Tsun Li modern Chinese medicine city) Patentee after: TASLY PHARMACEUTICAL GROUP Co.,Ltd. Address before: 430079 Wuhan Optical Valley International Biomedical enterprise accelerator phase I, No. 388, Gaoxin Second Road, Donghu New Technology Development Zone, Wuhan, Hubei Province Patentee before: WUHAN JUNGUFANG TECHNOLOGY DEVELOPMENT CO.,LTD. |