CN108938785B - Traditional Chinese medicine composition for treating cough variant asthma and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating cough variant asthma and a preparation method thereof. The traditional Chinese medicine composition is prepared from radix sophorae flavescentis, fried ephedra herb, bitter apricot seed, Japanese ardisia herb, earthworm, dried orange peel, inula flower, radix peucedani, fried tatarian aster root and liquorice according to a certain weight ratio. It is prepared into an oral preparation, and the traditional Chinese medicine composition has the function of treating cough variant asthma.

Description

Traditional Chinese medicine composition for treating cough variant asthma and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine composition for treating cough variant asthma and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background

Cough Variant Asthma (CVA), also known as occult asthma or cough-type asthma, is a particular type of asthma. It is characterized by that it has no any wheeze or dyspnea symptom, so that it is often missed to diagnose and mistreated, and the disease condition is prolonged and worsened. At the beginning of the attack of bronchial asthma, about 5% to 6% of bronchial asthma is mainly manifested by persistent cough, which often occurs at night or in the early morning, often as irritant cough, and at this time, it is often misdiagnosed as bronchitis. In recent years, the problem has attracted the attention of many scholars at home and abroad, and the asthma accounts for 24 percent and is in the 2 nd place among the single causes of chronic cough, and 28 percent of asthma patients have cough as the only clinical symptom.

At present, bronchodilators, inhaled glucocorticoids and leukotriene receptor antagonists are used as main treatment medicines in western medicine for treating cough variant asthma, cough symptoms can be controlled in a short time, and the like, but adverse reactions, many complications, high recurrence rate and the like exist in long-term treatment.

The invention applies the Chinese medicine theory, adopts the Chinese medicine prescription to treat cough variant asthma, has unexpected effect, and has small side effect, lasting effect and difficult relapse.

Disclosure of Invention

The invention aims to provide a novel traditional Chinese medicine composition which has the effects of dispelling wind and relieving spasm, relieving cough and calming asthma, and is used for treating cough variant asthma wind evil lingering lung, symptoms of irritative dry cough or choking cough, cough caused by throat itching, chest distress and shortness of breath during cough, exacerbation at night or in the early morning, no phlegm or a small amount of mucus phlegm, dry mouth, nasal obstruction and running nose, aversion to wind and other symptoms, reddish tongue, white fur and floating pulse.

It is another object of the present invention to provide a process for the preparation of the above composition.

The invention is realized by the following technical scheme:

the traditional Chinese medicine composition for treating cough variant asthma provided by the invention is prepared from the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, herba Ephedrae preparata, semen Armeniacae amarum, herba Ardisiae Japonicae, Lumbricus, pericarpium Citri Tangerinae, Inulae flos, radix Peucedani, radix Asteris preparata, and Glycyrrhrizae radix.

The traditional Chinese medicine composition for treating cough variant asthma is prepared from the following raw materials in parts by weight: 1-15 parts of radix sophorae flavescentis, 1-15 parts of roasted ephedra herb, 1-15 parts of bitter almond, 3-20 parts of Japanese ardisia herb, 3-20 parts of earthworm, 1-15 parts of dried orange peel, 1-15 parts of inula flower, 3-20 parts of radix peucedani, 3-20 parts of roasted aster and 1-15 parts of liquorice.

Preferably 2-10 parts of radix sophorae flavescentis, 2-10 parts of fried ephedra, 2-10 parts of bitter almond, 5-15 parts of Japanese ardisia, 5-15 parts of earthworm, 2-10 parts of dried orange peel, 2-10 parts of inula flower, 5-15 parts of radix peucedani, 5-15 parts of fried aster and 2-10 parts of liquorice.

More preferably: 5 parts of radix sophorae flavescentis, 6 parts of roasted ephedra herb, 6 parts of bitter almond, 10 parts of Japanese ardisia herb, 10 parts of earthworm, 6 parts of dried orange peel, 6 parts of inula flower, 10 parts of radix peucedani, 10 parts of roasted aster and 5 parts of liquorice.

The raw material medicaments can be any crude drug or combination of any processed product. The preparation prepared from the raw material medicines in parts by weight is taken in 3 times a day.

The invention is based on the theory of traditional Chinese medicine, adopts the formula of the effective medicines which are matched with each other, and achieves the effects of dispelling wind and relieving spasm, and relieving cough and asthma. Can be used as an effective formulation for cough variant asthma. Wherein,

flavescent sophora root: bitter in taste and cold in nature, it enters lung meridian. Has the functions of clearing away heat, dispersing lung qi, relieving cough and asthma. In Nei Jing, the interior syndrome of the cloud indicates that the lung has bitter flavor and adverse rising of qi, and the lung takes bitter flavor to purge. The sophora flavescens can dispel wind and relieve itching, has the function of clearing wind evil of long-term tiny collaterals, and can relieve itching and asthma when wind goes away. Modern pharmacological research shows that the kuh-seng is a powerful anti-inflammatory drug with hormone-like effect and no hormone-like side effect, and simultaneously has the effects of exciting beta receptors and anticholinergic receptors, expanding bronchus and relieving bronchospasm.

Herba ephedrae: pungent, slightly bitter and warm, entering lung and bladder meridians. The Chinese pharmacopoeia records that the hair has the functions of sweating, dispelling cold, ventilating and smoothing lung, relieving asthma, inducing diuresis and reducing edema. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema; bronchial asthma.

Bitter apricot seeds: bitter and warm in nature, entering lung and large intestine meridians. Has effects of eliminating phlegm, relieving cough, relieving asthma and moistening intestine. It is indicated for cough due to exogenous pathogenic factor, dyspnea, throat impediment, constipation due to intestinal dryness. Not only can disperse and descend to regulate lung qi with ephedra, but also can disperse and descend to relieve asthma, and can coordinate with liquorice which is a decoction of stropanthus, thereby multiplying the efficacy of relieving cough and asthma.

Herba Ardisiae Japonicae: mild in nature, pungent and slightly bitter in flavor. It enters lung and liver meridians. Herba Ardisiae Japonicae has effects of eliminating phlegm, relieving cough, clearing away damp-heat, promoting blood circulation and removing blood stasis. It can be used for treating chronic cough, asthma and excessive phlegm. The formula of Danhe Fisher's Dan-Li Tang' is prepared from Angelica sinensis, and the Dan-Li Tang from Yi Chun-Yi (medical alcohol Reserve) is used for treating cough due to wind-phlegm entering lung. Prescription for convenience of grass and wood: it is indicated for chronic arthralgia due to wind-damp, lung rash and chronic cough. The modern pharmacology suggests that the Japanese ardisia herb has the effect of relieving cough, continuous administration has no tolerance and selectivity on the inhibition of cough centers.

Earthworm: bitter taste and cold nature, and has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination. The herba ephedrae is matched with herba ephedrae to have the functions of relaxing and relieving spasm of bronchial smooth muscle and relaxing capillary bronchus, so that the airway can be unobstructed, the respiratory resistance can be reduced, the ventilation and air exchange functions can be improved, and the mucous membrane can be repaired.

Dried orange peel: bitter, pungent and warm. It enters lung and spleen meridians. On one hand, the medicine has the efficacy of eliminating dampness and phlegm, and on the other hand, the medicine can prevent the stimulation of the medicines to the stomach.

And (3) inula flower rotation: also known as Jinboehuo herb, it is bitter, pungent, salty and slightly warm in flavor, entering lung, spleen, stomach and large intestine meridians. Has effects of lowering qi, eliminating phlegm, promoting diuresis, and relieving vomiting, and can be used for treating phlegm and saliva accumulation in lung, cough, asthma, excessive phlegm, phlegm and fluid accumulation, fullness in chest, belching and vomiting. Pungent flavor can disperse and move, lung qi can be dispersed and spread to the skin and hair, salty flavor can enter the kidney, and qi can be received and move downward to enter the root. "all flowers ascend and all descend" with revolving, covering flower has the functions of clearing lung qi, eliminating phlegm and removing retained fluid, and restoring lung qi and treating lung governing. Inula flower flavone has obvious protection effect on guinea pig bronchospasm asthma caused by histamine and also has resisting effect on guinea pig isolated bronchospasm caused by histamine, as described in Chinese materia medica.

Radix peucedani: dispel wind and clear heat, direct qi downward and resolve phlegm, and combined with Zi Wan for resolving phlegm and relieving cough. The compatibility of the two herbs is the property of the powder, so it is recorded in Yi Chun Yu Yi (medical alcohol Residul records) that it is used for treating lung meridian common cold, dizziness, headache, cough and profuse sputum.

Roasting radix asteris: bitter in taste, entering lung meridian, warm in nature without heat, moist without cold, and has certain curative effect on cough of new and old age.

Licorice root: has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used together with dried orange peel as a guiding drug, and can be combined with ephedra herb and almond to form a stropanthus decoction, so that the cough relieving effect is obvious.

The invention uses the traditional Chinese medicine as the raw material, has no toxic or side effect, good taste and convenient administration, is prepared by repeated verification of clinical tests, and accords with the theory of the traditional Chinese medicine. The traditional Chinese medicine composition takes the lightyellow sophora root and the mix-fried ephedra herb as monarch drugs, and has the effects of dispelling wind, relieving spasm, relieving cough and asthma; bitter apricot seeds, Japanese ardisia herb, earthworm and dried orange peel are used as ministerial drugs to assist the monarch drugs to exert the effects of relieving spasm and asthma; inulae flos, radix Peucedani and radix Asteris preparata are used as adjuvant drugs to relieve cough and resolve phlegm; the liquorice is used as a guiding drug to coordinate the effects of the other drugs in the recipe.

When the medicines are used, the medicines which are equivalent to the weight ratio can be respectively cleaned, dried, crushed and mixed to obtain granules or powder with the granularity meeting the preparation requirement for direct administration. The medicines which are equivalent to the weight proportion relation can be used as raw materials, and after proper treatment, the medicines can be added with pharmaceutic adjuvant and made into various preparations according to the needs. In the process of preparing the preparation from the raw material medicines, the raw material medicines can be processed by adopting the following method: extracting with water or ethanol of different concentrations, respectively, concentrating the extractive solution, and drying to obtain crude extract; or further refining by one or more of alcohol precipitation, water dissolution, organic solvent extraction, flocculation precipitation, and column chromatography to obtain refined extract; the specific operation and/or use method for extracting the effective medicinal components can be a mode of respectively extracting the effective medicinal components of the medicinal components in the proportional amounts as raw materials and then mixing the effective medicinal components, or a mode of mixing the medicinal components in the proportional amounts and then extracting the medicinal components together. Different extraction methods, equipment and ideal or optimal extraction temperature, solvent dosage, extraction time, extraction times and other specific conditions required during extraction are adopted, and the extract can be screened and found through experiments according to actual conditions.

In order to make the raw materials of the drug exert better drug effects, the following preparation method is preferably adopted for the present invention:

the preparation method of the traditional Chinese medicine composition comprises the following steps:

weighing raw materials of radix Sophorae Flavescentis, herba Ephedrae preparata, semen Armeniacae amarum, herba Ardisiae Japonicae, Lumbricus, pericarpium Citri Tangerinae, Inulae flos, radix Peucedani, radix Asteris preparata, and Glycyrrhrizae radix, mixing, extracting with water or 50-95% ethanol, filtering, concentrating into soft extract, drying, and pulverizing into extract powder; adding or not adding auxiliary materials, and preparing into pharmaceutically acceptable preparations by conventional process.

The preparation method of the traditional Chinese medicine composition can also comprise the following steps:

weighing raw material medicines of radix sophorae flavescentis, mix-fried ephedra herb, bitter apricot seed, Japanese ardisia herb, earthworm, dried orange peel, inula flower, radix peucedani, mix-fried tatarian aster root and liquorice, adding 8-12 times of water for extracting for 1-3 times, each time for 0.5-2 hours, combining extracting solutions, filtering, concentrating into thick paste, drying, and crushing into paste powder; adding or not adding auxiliary materials, and preparing into pharmaceutically acceptable preparations by conventional process.

The prepared paste powder extract can be directly used as a medicine for administration or added with pharmaceutically acceptable auxiliary materials to prepare the required preparation by a conventional process. For example, the composition can be prepared into oral medicaments in solid preparation forms such as common tablets (dispersible tablets, effervescent tablets, orally disintegrating tablets, buccal tablets, chewable tablets and effervescent tablets), capsules (hard capsules and soft capsules), granules, pills (dropping pills, honey pills, water-honeyed pills and concentrated pills), powder, bagged tea and the like, and can also be prepared into oral medicaments in liquid preparation forms such as syrup, oral liquid and the like. Therefore, the pharmaceutical composition can also contain pharmaceutically acceptable auxiliary materials besides the extract of the traditional Chinese medicine composition.

The auxiliary materials described herein may be different depending on the formulation, such as diluents, disintegrants, excipients, binders, lubricants, surfactants, fillers, etc. which are commonly used in solid formulations such as tablets, capsules, granules, etc.; surfactants, diluents, preservatives, stabilizers, flavoring agents, thickeners, glidants and the like are commonly used in liquid preparation forms such as syrups, oral liquids and the like.

The common adjuvants include starch, lactose, dextrin, sugar powder, microcrystalline cellulose, mannitol, xylitol, polyethylene glycol, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, modified starch, sorbitol, polyvinylpyrrolidone, heavy magnesium carbonate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, ethyl cellulose, carboxymethyl starch sodium, hydroxypropyl cellulose, polyvidone K30, kaolin, pregelatinized starch, magnesium stearate, pulvis Talci, Gum Acacia, stevioside, betaine, aspartame, glycyrrhizin, saccharin sodium, citric acid, sorbic acid, potassium sorbate, ethylparaben, sucrose, starch syrup, guar gum, stevioside, sodium alginate, maltose, citric acid, malic acid, sucralose, menthol, coffee powder, monoglyceride, magnesium lauryl sulfate, betacyclodextrin, etc.

The preparation method of the granules of the traditional Chinese medicine composition comprises the following steps:

weighing raw material medicines of radix sophorae flavescentis, mix-fried ephedra herb, bitter apricot seed, Japanese ardisia herb, earthworm, dried orange peel, inula flower, radix peucedani, mix-fried tatarian aster root and liquorice, adding 8-12 times of water for extracting for 1-3 times, each time for 0.5-2 hours, combining extracting solutions, filtering, concentrating into thick paste, drying, and crushing into paste powder; adding appropriate amount of adjuvants, granulating, drying, and grading to obtain granule.

From the foregoing, it will be apparent that various other modifications, substitutions and variations can be made in the present invention without departing from the basic technical spirit of the invention, as defined by the common technical knowledge and common practice in the art.

Detailed Description

The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Example 1

Weighing 5g of radix sophorae flavescentis, 6g of roasted ephedra herb, 6g of bitter almond, 10g of Japanese ardisia herb, 10g of earthworm, 6g of dried orange peel, 6g of inula flower, 10g of radix peucedani, 10g of roasted aster and 5g of liquorice, mixing, adding 10 times of water for 2 times, extracting for 1 hour each time, combining extracting solutions, filtering, concentrating into thick paste, drying, crushing into paste powder, adding a proper amount of dextrin, soluble starch and aspartame, granulating, drying and finishing granules to obtain the granules.

Example 2

Weighing 2g of radix sophorae flavescentis, 8g of roasted ephedra herb, 2g of bitter almond, 20g of Japanese ardisia herb, 5g of earthworm, 10g of dried orange peel, 15g of inula flower, 3g of radix peucedani, 5g of roasted aster and 1g of liquorice, mixing, adding 12 times of water for 1 time, extracting for 2 hours, filtering, concentrating into thick paste, drying, crushing into paste powder, adding a proper amount of starch and powdered sugar, granulating, drying, finishing granules, adding magnesium stearate, mixing uniformly, tabletting, and coating or not coating to obtain the tablet.

Example 3

Weighing 15g of radix sophorae flavescentis, 10g of roasted ephedra herb, 1g of bitter almond, 15g of Japanese ardisia herb, 3g of earthworm, 2g of dried orange peel, 10g of inula flower, 20g of radix peucedani, 15g of roasted aster and 10g of liquorice, mixing, adding 11 times of water for 3 times, extracting for 0.5 hour each time, combining extracting solutions, filtering, concentrating into thick paste, drying, crushing into paste powder, adding a proper amount of auxiliary materials, granulating, drying, finishing granules and obtaining the granules.

Example 4

Weighing 10g of radix sophorae flavescentis, 2g of roasted ephedra herb, 15g of bitter almond, 5g of Japanese ardisia herb, 20g of earthworm, 1g of dried orange peel, 2g of inula flower, 15g of radix peucedani, 20g of roasted aster and 2g of liquorice, mixing, adding 8 times of 50% ethanol for extraction for 3 times, 0.5 hour each time, combining extracting solutions, filtering, recovering ethanol until no alcohol smell exists, concentrating to thick paste, drying, crushing to obtain paste powder, adding a proper amount of auxiliary materials, mixing uniformly, and preparing the powder.

Example 5

Weighing 1g of radix sophorae flavescentis, 15g of roasted ephedra herb, 10g of bitter almond, 3g of Japanese ardisia herb, 15g of earthworm, 8g of dried orange peel, 1g of inula flower, 5g of radix peucedani, 3g of roasted aster and 15g of liquorice, mixing, adding 12 times of 95% ethanol for extraction for 1 time for 2 hours, filtering, recovering ethanol until no ethanol smell exists, concentrating into thick paste, drying, crushing into paste powder, adding a proper amount of auxiliary materials, mixing uniformly, and preparing the pill.

Example 6

Weighing 12g of radix sophorae flavescentis, 9g of roasted ephedra herb, 8g of bitter almond, 10g of Japanese ardisia herb, 10g of earthworm, 15g of dried orange peel, 16g of inula flower, 10g of radix peucedani, 7g of roasted aster and 8g of liquorice, mixing, adding 70% ethanol in an amount which is 10 times that of the mixture, extracting for 2 times, 1 hour each time, combining extracting solutions, filtering, recovering ethanol until no alcohol smell exists, concentrating to thick paste, drying, crushing to obtain paste powder, adding a proper amount of dextrin and stevioside, granulating, drying and finishing granules to obtain the granules.

Example 7

Weighing 2g of radix sophorae flavescentis, 10g of roasted ephedra herb, 6g of bitter almond, 12g of Japanese ardisia herb, 15g of earthworm, 15g of dried orange peel, 2g of inula flower, 5g of radix peucedani, 10g of roasted aster and 12g of liquorice, mixing, adding 9 times of water for 2 times, extracting for 1 hour for the first time and 0.5 hour for the second time, combining extracting solutions, filtering, concentrating, adding ethanol until the alcohol concentration reaches 60%, standing for 36 hours, taking supernate, recovering ethanol until no alcohol taste exists, concentrating, adding a proper amount of water, uniformly stirring, refrigerating for 48 hours, filtering, adding a proper amount of suspension, flavoring agent and preservative into the filtrate, uniformly mixing, adding water for constant volume, filtering, and subpackaging to obtain the oral liquid preparation.

Example 8

Weighing 5g of radix sophorae flavescentis, 6g of roasted ephedra herb, 12g of bitter almond, 7g of Japanese ardisia herb, 12g of earthworm, 6g of dried orange peel, 6g of inula flower, 12g of radix peucedani, 12g of roasted aster and 5g of liquorice, mixing, adding 10 times of water for 2 times, extracting for 1 hour each time, combining extracting solutions, filtering, concentrating into thick paste, drying, crushing into paste powder, adding an appropriate amount of auxiliary materials, granulating, drying, finishing granules, and encapsulating to obtain the capsule.

The beneficial effects of the compositions according to the invention are further illustrated by the following test examples:

research on effect of traditional Chinese medicine composition for treating cough variant asthma

Action of relieving cough

20 mice with the weight of 19 +/-1 g are taken and randomly divided into two groups, wherein each group comprises 10 mice, and the male and female groups are respectively a model control group and a treatment group. The granules of example 1 according to the invention were administered to the treatment group in an amount corresponding to the clinically equivalent dose of 60Kg for adults. Each group of mice was administered by gavage 1 time a day with 0.2ml/10g body weight for 3 consecutive days, and the model control group was given distilled water under the same conditions. One hour after the last administration, the mice were placed in a plastic box of 30cm × 20cm × 15cm in order, ammonia was sprayed with an ultrasonic atomizer for 20 seconds, taken out and placed in a cage, the time from the taking out of the mice until the first cough occurred (latency) was recorded, and the number of coughs within 3 minutes was recorded, and the results were statistically processed using an inter-group test.

TABLE 1 antitussive effect of anti-allergic antitussive granules on mice

Group of	Animal number (only)	Incubation period (seconds)	Number of coughs (times)
				Model control group	10	18.91±18.20	13.5±8.03
Treatment group	10	27.70±3.63*	7.6±4.07*

As can be seen from Table 1, the treatment group has a certain effect of prolonging the latent period of mouse cough caused by ammonia water, has a certain effect of reducing the cough frequency of mice caused by ammonia water, and has significant difference (P is less than 0.05) compared with a model control group.

Second, asthma relieving action

30 guinea pigs with body weight of 225 + -25 g were divided into three groups, each group containing 10 male and female halves, and the three groups were blank control group, model control group, and treatment group. The granules of example 1 according to the invention were administered to the treatment group in an amount corresponding to the clinically equivalent dose of 60Kg for adults. Except for the blank control group, each of the other two groups of guinea pigs was intraperitoneally administered with 10% ovalbumin physiological saline 1ml, and the administration was started from the 3 rd day after the sensitization, 1 time daily, 1ml/100g body weight, and continued for 12 days, and the blank control group and the model control group were given distilled water under the same conditions. The weight was weighed once a week, and one hour after the last administration, guinea pigs were sequentially placed in a 30cm × 20cm × 15cm plastic box, sprayed with 5% ovalbumin physiological saline at constant pressure for 30 seconds using an ultrasonic atomizer, observed for 5 minutes after the spraying was stopped, and the time from when the guinea pigs stopped spraying until wheezy convulsions appeared (latency) and the number of animals that suffered a falling shock were recorded, and the results were statistically processed using an inter-group test.

TABLE 2 antitussive effects of anti-allergic antitussive granules on guinea pigs

As can be seen from Table 2, the treatment group has a certain effect of prolonging the latent period of the asthma of the guinea pig caused by the ovalbumin, has a certain effect of reducing the falling shock of the guinea pig caused by the ovalbumin, and has significant difference (P is less than 0.05) compared with a model control group.

Inventive examples 2-8 were similarly tested as described above, with the same results as described above.

Claims (10)

1. A traditional Chinese medicine composition for treating cough variant asthma is characterized by comprising the following raw material medicines in parts by weight: 1-15 parts of radix sophorae flavescentis, 1-15 parts of roasted ephedra herb, 1-15 parts of bitter almond, 3-20 parts of Japanese ardisia herb, 3-20 parts of earthworm, 1-15 parts of dried orange peel, 1-15 parts of inula flower, 3-20 parts of radix peucedani, 3-20 parts of roasted aster and 1-15 parts of liquorice.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 2-10 parts of radix sophorae flavescentis, 2-10 parts of fried ephedra herb, 2-10 parts of bitter almond, 5-15 parts of Japanese ardisia herb, 5-15 parts of earthworm, 2-10 parts of dried orange peel, 2-10 parts of inula flower, 5-15 parts of radix peucedani, 5-15 parts of fried aster and 2-10 parts of liquorice.

3. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising the following raw material medicines in parts by weight: 5 parts of radix sophorae flavescentis, 6 parts of roasted ephedra herb, 6 parts of bitter almond, 10 parts of Japanese ardisia herb, 10 parts of earthworm, 6 parts of dried orange peel, 6 parts of inula flower, 10 parts of radix peucedani, 10 parts of roasted aster and 5 parts of liquorice.

4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized in that the method for preparing the composition comprises the following steps:

directly pulverizing the above raw materials to obtain medicinal powder; or extracting with water or ethanol of different concentrations, concentrating the extractive solution, and drying to obtain crude extract; or further refining by one or more of water extraction and ethanol precipitation, organic solvent extraction, column chromatography, and steam distillation to obtain refined extract; the crude extract or refined extract obtained from the powder of the medicinal materials is the active component of the traditional Chinese medicine composition, and the active component is prepared into any preparation in pharmaceutics according to the conventional process.

5. The method for preparing a Chinese medicinal composition according to claim 4, which is prepared by:

weighing raw materials of radix Sophorae Flavescentis, herba Ephedrae preparata, semen Armeniacae amarum, herba Ardisiae Japonicae, Lumbricus, pericarpium Citri Tangerinae, Inulae flos, radix Peucedani, radix Asteris preparata, and Glycyrrhrizae radix, mixing, extracting with water or 50-95% ethanol, filtering, concentrating into soft extract, drying, and pulverizing into extract powder; adding or not adding auxiliary materials, and preparing into pharmaceutically acceptable preparations by conventional process.

6. The method for preparing a Chinese medicinal composition according to claim 5, which is prepared by:

weighing raw material medicines of radix sophorae flavescentis, mix-fried ephedra herb, bitter apricot seed, Japanese ardisia herb, earthworm, dried orange peel, inula flower, radix peucedani, mix-fried tatarian aster root and liquorice, adding 8-12 times of water for extracting for 1-3 times, each time for 0.5-2 hours, combining extracting solutions, filtering, concentrating into thick paste, drying, and crushing into paste powder; adding or not adding auxiliary materials, and preparing into pharmaceutically acceptable preparations by conventional process.

7. The preparation method of the Chinese medicinal composition according to claim 5 or 6, wherein the preparation is tablets, granules, capsules, pills, powder or oral liquid.

8. The method for preparing a Chinese medicinal composition according to claim 7, wherein the preparation is in the form of granules.

9. The method for preparing a Chinese medicinal composition according to claim 8, wherein the granules are prepared by:

weighing raw material medicines of radix sophorae flavescentis, mix-fried ephedra herb, bitter apricot seed, Japanese ardisia herb, earthworm, dried orange peel, inula flower, radix peucedani, mix-fried tatarian aster root and liquorice, adding 8-12 times of water for extracting for 1-3 times, each time for 0.5-2 hours, combining extracting solutions, filtering, concentrating into thick paste, drying, and crushing into paste powder; adding appropriate amount of adjuvants, granulating, drying, and grading to obtain granule.

10. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for treating cough variant asthma.