CN107616501A - A kind of composition with clearing lung-heat function and preparation method thereof - Google Patents
A kind of composition with clearing lung-heat function and preparation method thereof Download PDFInfo
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- CN107616501A CN107616501A CN201610557863.8A CN201610557863A CN107616501A CN 107616501 A CN107616501 A CN 107616501A CN 201610557863 A CN201610557863 A CN 201610557863A CN 107616501 A CN107616501 A CN 107616501A
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Abstract
The invention discloses a kind of composition with clearing lung-heat function and preparation method thereof.Said composition is prepared according to a certain weight ratio by radix glycyrrhizae, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, has the effect of lung-heat clearing and detoxification, moistening lung and production of body fluid.It can be made into any common dosage forms, preferably oral formulations.
Description
Technical field
The present invention relates to a kind of composition with clearing lung-heat function and preparation method thereof, belong to the technical field of food.
Background technology
As environmental pollution, air quality deteriorate, gradually increasing occurs in thick weather phenomenon, and harm increasingly aggravates.Haze
The harm of weather is just gradually recognized and paid attention to.Haze weather to body produce infringement mainly due in air be less than 10
The particulate matter of micron enters lung by breathing, in pulmonary deposition.Particulate matter carries the nuisances such as pollutant, virus and bacterium
Matter, cause lung damage to be reduced with function, the diseases such as chronic bronchitis, pulmonary emphysema, bronchial astehma can be caused.Meanwhile
Particulate matter is also used as anaphylactogen, causes body that allergic reaction occurs, and reduces body immunity.People arrange except properly protecting
, should also be by appropriate diet modification, so as to substantially reduce infringement of the haze to human body outside applying.
The content of the invention
It is an object of the present invention to provide a kind of composition with clearing lung-heat function, said composition has lung-heat clearing and detoxification, moistening lung
Promote the production of body fluid, clearing resolving sputum the effect of, can effectively reduce lung inflammation and cough caused by haze etc..
Another object of the present invention there is provided the preparation method of said composition.
The present invention is achieved by the following technical solutions：
The present invention is made of the raw material of following weight parts：
Radix glycyrrhizae 1-10 parts, balloonflower root 1-10 parts, radix polygonati officinalis 1-10 parts, rhizoma imperatae 2-12 parts, Momordica grosvenori 1-10 parts.
Preferably：
Radix glycyrrhizae 2-5 parts, balloonflower root 2-5 parts, radix polygonati officinalis 4-8 parts, rhizoma imperatae 8-15 parts, Momordica grosvenori 2-5 parts.
More preferably：
2 parts of radix glycyrrhizae, 3 parts of balloonflower root, 4 parts of radix polygonati officinalis, 6 parts of rhizoma imperatae, 3 parts of Momordica grosvenori.
Momordica grosvenori can also be replaced with emblic in the present invention.
The mechanism of action of each component is as follows in the present invention：
Radix glycyrrhizae：It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.With invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, reconcile it is all
The effect of medicine, for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus,
Alleviate drug toxicity, strong.Radix glycyrrhizae contains a variety of chemical compositions, and main component has glycyrrhizin, glycyrrhizic acid, enoxolone, sweet
Careless glucoside etc., substantial amounts of research show that glycyrrhizin and Flavonoid substances are most important physiological activators in radix glycyrrhizae, wherein,
Licoflavone, extract of licorice root and enoxolone have an obvious antitussive effect, and phlegm-dispelling functions are also more significant；Also anti-inflammatory, anti-mistake
Quick effect, throat and tunica mucosa tracheae of inflammation etc. can be protected.
Balloonflower root：It is bitter, pungent, put down.Return lung passes through.With facilitaing lung, relieving sore-throat, eliminating the phlegm is uncomfortable in chest for coughing with a lot of sputum the effect of apocenosis
Not smooth, pharyngalgia, sound is mute, lung carbuncle pyemesis, and sore purulence is not into bursting.Experiment shows that balloonflower root has eliminating the phlegm and antitussive effect, anesthetized dog mouth
Balloonflower root decoction 1g/kg is taken, the secretory volume of respiratory mucus can be dramatically increased.In addition, throat is glued when saponin is oral contained by balloonflower root
Film and gastric mucosa cause stimulation to a certain degree, cause respiratory mucosa hypersecretion reflectingly, dilute sputum, promote its row
Go out.Balloonflower root also has the effect of anti-inflammatory, and its water extract can strengthen macrophage phagocytic function, strengthens the sterilization of neutrocyte
Power, improve the activity of lysozyme.
Radix polygonati officinalis：It is sweet, it is slightly cold.Attach to the lung and stomach meridians.With nourishing yin to moisten dryness, the effect of promoting the production of body fluid to quench thirst, hinder for lung stomach-Yin, it is scorching
Cough, dry throat and mouth, Heat Diabetes etc..《The small pandect of domestic. applications herbal cuisine》Record, radix polygonati officinalis to hypertension, chloasma, angina pectoris,
Anaemia deficiency of both qi and yin, weak after being ill, mild heart failure, diabetes are thirsty, urine stranguria with turbid discharge, the elderly's chronic cough are not cured ... has very
Good effect.《Dictionary of medicinal plant》Modern clinic is recorded to emphasize its " nourishing Yin and moistening lung, promoting the production of body fluid to quench thirst, the work(of nourishing the stomach " using radix polygonati officinalis.
Rhizoma imperatae：It is sweet, tremble with fear.Return lung, stomach, bladder warp.The effect of with cooling blood and hemostasis, reducing fever and causing diuresis, spitted blood for blood-head,
Bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, jaundice, oedema, puckery pain of heat gonorrhea, acute nephritis edema etc..Rhizoma imperatae can be clearly in the heat evil of lung, gold
Gas is respectful clearly, and cough is from only；Rhizoma imperatae is sweet cold without injuring one's stomach, and Li Shui is without impairment of yin, and suitable for heat symptom-complex body fluid deficiency person, rhizoma imperatae can be clear
In the heat evil of lung, golden gas is respectful clearly, and cough is from only.
Momordica grosvenori：It is sweet cool in nature, return lung, large intestine channel, the effect of moistening the lung and relieve the cough, promote the production of body fluid to quench thirst, suitable for lung heat or lung
Cough caused by dryness is coughed, pertussis and hot summer weather fluid deficiency and thirsty etc., the effect of in addition with relaxing bowel.Momordica grosvenori is what the Ministry of Public Health announced in the first batch
Medicine-food two-purpose rare traditional Chinese medicine, modern medicine prove that Momordica grosvenori has significant curative effect to diseases such as bronchitis, hypertension, still
Play a part of prevention and treatment of coronary heart disease, vascular sclerosis, obesity.Nutritive value is high, have clearing away summerheat, preventing phlegm from forming and stopping coughing, cool blood relax bone,
Clearing lung-heat ease constipation and promote the production of body fluid to quench thirst and other effects；Can treating acute and chronic tracheitis, sphagitis, bronchial astehma, pertussis, stomach energy, constipation,
The diseases such as acute tonsillitis, diabetic also preferably take.
Emblic：It is sweet, sour, puckery, cool.Return lung warp, stomach.There is clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid,
For blood-head blood stasis, indigestion, abdominal distension, cough, laryngalgia, dry etc..Result of study shows that emblic has anti-inflammatory, antioxygen
Change, anti-aging, liver protection etc. act on.Emblic can significantly inhibit rat agar pedal swelling and dimethylbenzene induced mice ear edge swells
It is swollen, significantly inhibit capillary permeability enhancing and leukocytoplania caused by histamine, show emblic have significant anti-inflammatory and
Anti- transudation.By determining phyllanthus emblica L.juice powder to experimental hypercholesterolemicrabbits rabbit blood fat, MDA level, artery congee
Sample patch is formed and the influence of endothelin-1 expression, it was demonstrated that emblic has stronger lipoid peroxidization resistant, can improve machine
Body oxidation resistance, have the function that to protect function of vascular endothelium.Clinical research shows that emblic makes erythrocyte sod vigor obvious
Increase, before taking（P<0.01）, climbing 100%, Lpo contents decline in blood plasma, rate of descent 73%, show that emblic can
Can have the function that to delay, antagonism senescence process.In addition, emblic also has the effect detoxified, to copper, nickel, calcium, zinc, caesium, ferrous iron
There is antagonism Deng heavy metal, the toxic metals such as internal copper, nickel can be excluded.
From prescription of the present invention, radix glycyrrhizae is clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, is aided with the radix polygonati officinalis of nourishing yin to moisten dryness
And the rhizoma imperatae of clearing lung-heat heat, Momordica grosvenori moisten the lung and relieve the cough, promoted the production of body fluid to quench thirst, and hinder Tianjin for lung heat or xeropulmonary cough, pertussis and hot summer weather
It is thirsty etc., the work(of prescription clearing and antitussive of the present invention can be strengthened, help and shared with balloonflower root clearing lung and eliminating the phlegm relieving sore-throat, all medicines, had well
It is clearing heat and detoxicating, the effect of moistening lung and production of body fluid, relieving sore-throat resolving sputum.
In order that the effect of present composition can perform to maximization, honeysuckle, mountain can also be added in the composition
One or more in honeysuckle flower, Chinese olive, orange peel.
The present composition can use the conventional method of Chinese medicine preparation to be prepared into any conventional preparation, including oral system
Agent, external preparation, injection.Such as these bulk drugs can be smashed well mixed；Can be by the original of the parts by weight
Material medicine adds the ethanol of water or various concentrations to extract respectively, and extract solution is concentrated and dried to obtain crude extract, or uses process for purification, for example,
Water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation enter
Row is refining to obtain extract.
When using said medicine, it can both use and cleaned respectively using the medicine equivalent to the weight proportion as raw material,
Dry, crush, being mixed to get the particle for meeting formulation requirements granularity or powder is directly taken.It can also use with equivalent to described
The medicine of weight proportion relation is that raw material adds pharmaceutic adjuvant after proper treatment, is made into various preparations as needed.
During being prepared into preparation by above-mentioned raw materials medicine, above-mentioned raw materials medicine can be handled with the following method：Respectively plus water or
The ethanol extraction of various concentrations, extract solution are concentrated and dried to obtain crude extract；Or further use water extraction and alcohol precipitation method, water back dissolution method, have
Solvent extraction, flocculent precipitation, column chromatography, carbon dioxide supercritical extraction method, one kind of steam distillation or several
Kind is used in combination after progress suitably refines and obtains extract；The adoptable specific behaviour when being extracted to above-mentioned effective medicinal ingredient
Make and/or application method, both can be the drug ingedient using described each proportional quantities as raw material, extract respectively its effectively it is medicinal into
The mode remixed after point, by the way of can also being extracted jointly again after being mixed by each medicine material of described proportional quantities.Adopt
With required preferable or optimal Extracting temperature when different extraction means, equipment and extraction, solvent load, extraction time, carry
The actual conditionses such as number are taken, then can be screened and find by experiment according to actual conditions.
In order that each raw material in said composition preferably plays drug effect, the preferred pair present composition is using following extraction
Method, but cannot be used for limiting the scope of the invention.
The preparation method of the present composition is as follows：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 4-20 times to measure 20-95% ethanol and extract 1-4 times,
Each 1-3 hours, extract solution merge, and filtering, decompression filtrate recycling ethanol is dried under reduced pressure to without alcohol taste, is ground into fine powder, produce
The active component of the present composition.
The preparation method is preferably：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 6-12 times to measure 50-95% ethanol and extract 1-4 times,
Each 1-3 hours, extract solution merge, and filtering, decompression filtrate recycling ethanol is dried under reduced pressure to without alcohol taste, is ground into fine powder, produce
The active component of the present composition.
Or the preparation method of the present composition can also be：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 4-20 times to measure water and extract 1-4 times, each 1-3
Hour, extract solution merges, and filtering, filtrate decompression is concentrated into thick paste, is dried under reduced pressure, is ground into fine powder, produces the present composition
Active component.
The preparation method is preferably：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 6-12 times to measure water and extract 1-4 times, each 1-3
Hour, extract solution merges, and filtering, filtrate decompression is concentrated into thick paste, is dried under reduced pressure, is ground into fine powder, produces the present composition
Active component.
The active component of the obtained present composition can directly be used as medicine take or add it is acceptable auxiliary in pharmacy
Required preparation is produced in conventional fashion into material.Conventional tablet can such as be made（Dispersible tablet, effervescent tablet, oral disnitegration tablet, contain
Piece, chewable tablets, effervescent tablet）, capsule（Hard shell capsules, soft capsule）, granule, pill（Pill）, the solid pharmaceutical preparation such as powder
The oral drugs of form, the oral medicine of the liquid forms such as syrup, oral liquid, packed medicinal tea, bag tea agent can also be made
Thing.Therefore, in the pharmaceutical composition in addition to active ingredient, pharmaceutically acceptable auxiliary material can also be contained.
Auxiliary material described here, can be different according to different preparations, such as solid in tablet, capsule, granule
Conventional diluent, disintegrant, excipient, adhesive, lubricant, surfactant, filler etc. in body preparation；Syrup,
The surfactant commonly used in the liquid forms such as oral liquid, diluent, preservative, stabilizer, flavouring, thickener, help
Flow agent etc..
Its conventional auxiliary material such as starch, lactose, dextrin, Icing Sugar, microcrystalline cellulose, mannitol, xylitol, polyethylene glycol, sulphur
Sour calcium, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, polyvinylpyrrolidone, heavy magnesium carbonate, carboxymethyl cellulose
It is sodium, HPMC, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose, PVP K30, white
Clay, pregelatinized starch, magnesium stearate, talcum powder, superfine silica gel powder, stevioside glycosides, glycine betaine, aspartame, glycyrrhizin, sugar
Smart sodium, citric acid, tartaric acid, rock sugar, honey, milk flavour, silica etc..
The present invention relates to a kind of composition for clearing lung-heat, be it is serious for modern society's haze, environmental pollution it is serious and
The kind specially researched and developed, there is the effect of lung-heat clearing and detoxification, moistening lung and production of body fluid, clearing resolving sputum, be a kind of pure natural have no toxic side effect
Nutriment, be different from by chemical composition make like product.
Embodiment
Embodiment 1
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 8 times of amount water to extract 3 times, 2 hours every time,
Extract solution merges, and filtering, is concentrated under reduced pressure into thick paste, adds suitable amount of sucrose, aspartame, dextrin, mixes, pelletize, dries, whole
Grain, is produced.
Embodiment 2
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 10 times of amount water to extract 2 times, 2 hours every time,
Extract solution merges, and filtering, is concentrated under reduced pressure into thick paste, adds appropriate lactose, mannitol, mixes, dry, pulverize, produce.
Embodiment 3
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 10 times of amount water to extract 3 times, 1 hour every time,
Extract solution merges, and filtering, is concentrated under reduced pressure into thick paste, adds appropriate maltodextrin, Sucralose, mixes, dry, pulverize, produce.
Embodiment 4
Radix glycyrrhizae 20g, balloonflower root 50g, radix polygonati officinalis 20g, rhizoma imperatae 80g, Momordica grosvenori 20g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 4 times of amount water to extract 3 times, 1 hour every time,
Extract solution merges, and filtering, is concentrated under reduced pressure into thick paste, adds sodium carboxymethyl starch, superfine silica gel powder, microcrystalline cellulose, the poly- dimension of crosslinking
Appropriate ketone, mixing, pelletize, dry, add magnesium stearate, mix, tabletting, be coated or be not coated, produce tablet.
Embodiment 5
Radix glycyrrhizae 50g, balloonflower root 20g, radix polygonati officinalis 60g, rhizoma imperatae 40g, Momordica grosvenori 50g
The radix glycyrrhizae of the weight proportion, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 12 times of amount water to extract 2 times, 1 is small every time
When, extract solution filtering, thick paste is concentrated under reduced pressure into, dry, pulverize into fine powder, adds appropriate amount of auxiliary materials, is mixed, is pelletized, is dried, fills glue
Capsule, produce capsule.
Embodiment 6
Radix glycyrrhizae 10g, balloonflower root 100g, radix polygonati officinalis 10g, rhizoma imperatae 120g, Momordica grosvenori 10g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 20 times of amount water to extract 1 time, extracts 3 hours,
Extract solution filters, and is concentrated under reduced pressure into thick paste, is dried under reduced pressure, and is ground into fine powder, adds right amount of auxiliary materials, mixes, pill is made.
Embodiment 7
Radix glycyrrhizae 100g, balloonflower root 10g, radix polygonati officinalis 100g, rhizoma imperatae 20g, Momordica grosvenori 100g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 6 times of amount water to extract 3 times, 1 hour every time,
Extract solution filters, and appropriate concentration, adds appropriate supensoid agent, flavor enhancement, preservative, mixes, add water constant volume, filter, packing, i.e.,
Obtain oral liquid.
Embodiment 8
Radix glycyrrhizae 30g, balloonflower root 20g, radix polygonati officinalis 70g, rhizoma imperatae 80g, Momordica grosvenori 40g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 12 times of amount water to extract 2 times, 1 hour every time,
Extract solution filters, and is concentrated under reduced pressure into thick paste, is dried under reduced pressure, be ground into fine powder, powder is made.
Embodiment 9
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 10 times of 70% ethanol of amount to extract 2 times, every time 2
Hour, extract solution filtering, ethanol is recovered under reduced pressure to without alcohol taste, continues to be concentrated into thick paste, adds appropriate amount of auxiliary materials, mix, dry, powder
It is broken, produce.
Embodiment 10
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 60g, rhizoma imperatae 90g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, coarse powder is ground into, is conventionally made
Packed medicinal tea or bag tea agent.
Embodiment 11
Radix glycyrrhizae 15g, balloonflower root 35g, radix polygonati officinalis 55g, rhizoma imperatae 95g, Momordica grosvenori 25g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 4 times of 90% ethanol of amount to extract 3 times, every time 1
Hour, extract solution merges, filtering, and ethanol is recovered under reduced pressure to without alcohol taste, continues to be concentrated into thick paste, adds suitable amount of sucrose, A Sipa
It is smooth, dextrin, mix, pelletize, dry, whole grain, produce.
Embodiment 12
Radix glycyrrhizae 25g, balloonflower root 25g, radix polygonati officinalis 90g, rhizoma imperatae 85g, Momordica grosvenori 35g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 6 times of 80% ethanol of amount to extract 2 times, every time 2
Hour, extract solution merges, filtering, and ethanol is recovered under reduced pressure to without alcohol taste, continues to be concentrated into thick paste, is dried under reduced pressure, crush, add suitable
Dextrin, starch, sucrose, Sucralose are measured, mixes, produces.
Embodiment 13
Radix glycyrrhizae 30g, balloonflower root 20g, radix polygonati officinalis 70g, rhizoma imperatae 80g, Momordica grosvenori 20g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 20 times of 20% ethanol of amount to extract 1 time, extraction 3
Hour, extract solution merges, filtering, and ethanol is recovered under reduced pressure extremely without alcohol taste, is dried under reduced pressure, crushes, adds appropriate lactose, mannitol,
Mix, pelletize, dry, whole grain, produce.
Embodiment 14
Radix glycyrrhizae 10g, balloonflower root 40g, radix polygonati officinalis 80g, rhizoma imperatae 100g, Momordica grosvenori 40g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 10 times of 60% ethanol of amount to extract 3 times, every time 1
Hour, extract solution filtering, ethanol is recovered under reduced pressure to without alcohol taste, is dried under reduced pressure, crushes, add appropriate amount of auxiliary materials, mix, produce.
Embodiment 15
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, Momordica grosvenori 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 8 times of 80% ethanol of amount to extract 2 times, every time 2
Hour, extract solution filtering, ethanol is recovered under reduced pressure to without alcohol taste, is dried under reduced pressure, crushes, add appropriate sodium carboxymethyl starch, micro mist
Silica gel, microcrystalline cellulose, PVPP, mixing, pelletize, dry, add magnesium stearate, mix, tabletting, be coated or do not wrap
Clothing, produce tablet.
Embodiment 16
Radix glycyrrhizae 35g, balloonflower root 35g, radix polygonati officinalis 60g, rhizoma imperatae 120g, Momordica grosvenori 35g
The radix glycyrrhizae of the weight proportion, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 15 times of 60% ethanol of amount to extract 2 times, often
Secondary 2 hours, extract solution filtering, ethanol is recovered under reduced pressure extremely without alcohol taste, is dried under reduced pressure, crushes, adds appropriate amount of auxiliary materials, mixes, granulation,
Dry, it is encapsulated, produce capsule.
Embodiment 17
Radix glycyrrhizae 50g, balloonflower root 50g, radix polygonati officinalis 90g, rhizoma imperatae 100g, Momordica grosvenori 50g
The radix glycyrrhizae of the weight proportion, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori are weighed, adds 12 times of 50% ethanol of amount to extract 2 times, often
Secondary 1 hour, extract solution filtering, ethanol is recovered under reduced pressure extremely without alcohol taste, is dried under reduced pressure, crushes, adds appropriate amount of auxiliary materials, mixes, granulation,
Dry, it is encapsulated, produce capsule.
Embodiment 18
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, emblic 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, emblic are weighed, adds 8 times of amount water to extract 3 times, 2 hours every time,
Extract solution merges, and filtering, is concentrated under reduced pressure into thick paste, adds suitable amount of sucrose, aspartame, dextrin, mixes, pelletize, dries, whole
Grain, is produced.
Embodiment 19
Radix glycyrrhizae 20g, balloonflower root 30g, radix polygonati officinalis 40g, rhizoma imperatae 60g, emblic 30g
The radix glycyrrhizaes of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, emblic are weighed, adds 10 times of 70% ethanol of amount to extract 2 times, every time 2
Hour, extract solution filtering, ethanol is recovered under reduced pressure to without alcohol taste, continues to be concentrated into thick paste, adds appropriate amount of auxiliary materials, mix, dry, powder
It is broken, produce.
The beneficial effect of composition of the present invention is expanded on further by tests below：
First, to the influence of rat lung inflammation caused by smog
1st, materials and methods
1.1 material：Mouse age is the male SD rat 18 of 2 months or so, body weight（200±20）G, it is randomly divided into 3 groups, every group 6
Only.Haze environment is simulated with smoke from cigarette.
1.2 method：
（1）A groups：Smog exposure group, allow rat to be exposed in smoke from cigarette, light 3 cigarettes simultaneously every time, last about 20min
Afterwards, 3 cigarettes are refired, altogether 9 cigarettes of spontaneous firing.The 2nd smoking is repeated after 6h, method is the same as the 1st time.（2）B groups：This hair
Bright intervention group, the sample gavage prepared before the daily smog exposure of rat with the embodiment of the present invention 1, smog process for exposing is the same as A groups.
（3）C groups：Healthy control group, rat refuse any processing, with being raised under A, B group rat the same terms.Rat opens chest point after 6 weeks
From right principal bronchus and ligature, with cold sterile saline 9ml point 3 alveolar wasses, the rate of recovery is up to 80%.Carry out cell count
And classify.ELISA surveys BAL fluid（BALF）IL-8 contents in supernatant.
1.3 statistical method：Compare between group with variance analysis and q inspections.
2nd, result
Cell count and classification in 2.1 3 groups of BALF of Rats, are shown in Table 1.
Cell count and classification in 1 three groups of BALF of Rats of table（×105/ml）
| Group | Belong to number（Only） | TCS | Neutrophil leucocyte | Monocytes/Macrophages | Lymphocyte |
| C groups | 6 | 8.90±0.67 | 0.16±0.05 | 7.51±0.49 | 1.12±0.16 |
| A groups | 6 | 10.70±0.51* | 0.31±0.02* | 9.36±0.62* | 1.23±0.11 |
| B groups | 6 | 10.80±0.88* | 0.24±0.06# | 9.27±0.75* | 1.18±0.17 |
Note：Compared with C groups, * P ＜ 0.01, #P ＜ 0.05；Compared with A groups, # P ＜ 0.05
IL-8 content in 2.2 3 groups of BALF of Rats supernatants
A group IL-8 contents（0.68±0.15）Ng/ml ］ apparently higher than C groups（0.30±0.12）Ng/ml ］, B group IL-8 contents
（0.45±0.09）Ng/ml ］ substantially reduced compared with A groups（P ＜ 0.01）.
2.3 conclusion
This result of the test shows, in inventive samples intervention group BALF of Rats in neutrophil leucocyte number and supernatant under IL-8 content
Drop, it is shown that inventive samples can suppress passive smoking rat（I.e. simulation is in the rat in haze environment）Air flue and lung are scorching
Disease.
2-19 of the embodiment of the present invention has carried out experiment similar above, as a result identical with the above results.
2nd, to the influence of concentrated ammonia liquor induced mice cough
1st, materials and methods
1.1 material：Healthy Kunming mouse 30, male and female half and half, 18-22g is taken, is randomly divided into 3 groups, every group 10.
1.2 method：
A groups：Model control group, give deionized water；
B groups：Positive controls, give codeine；
C groups：Intervention group of the present invention：Give the sample of the embodiment of the present invention 1.
Each group mouse stomach gives relative medicine, and A groups give aliquots of deionized water, is administered once per 8h, successive administration 10
It is secondary.The 1h after last dose, mouse is put in glass bell jar, toward the interior spray concentrated ammonia liquor of bell jar（25%-28%）30s（Simulate haze ring
Border）, then proceed to put mouse in bell jar and taken out after 20s, observation self-spray starts to the cough latent period of mouse in 2min（The
Cough length）And cough number, not cough person's incubation period is in terms of 2min.
2nd, result
The influence result that inventive samples are coughed to concentrated ammonia liquor induced mice, is shown in Table 2.
The influence that the inventive samples of table 2 are coughed to concentrated ammonia liquor induced mice
| Group | Mouse number（Only） | Incubation period（s） | Cough number |
| A groups | 10 | 15.82±10.25 | 42.57±11.38 |
| B groups | 10 | 13.44±9.81 | 10.70±9.73* |
| C groups | 10 | 17.59±10.47 | 12.68±10.59* |
Note：Compared with A groups, * P ＜ 0.05
3rd, conclusion
Result of the test shows, compared with A groups, B groups, C groups can significantly reduce concentrated ammonia liquor induced mice（I.e. simulation is in haze ring
Mouse in border）Cough number（P ＜ 0.05）, it is shown that inventive samples have obvious antitussive effect.
2-19 of the embodiment of the present invention has carried out experiment similar above, as a result identical with the above results.
In summary, the present composition can substantially reduce lung, respiratory inflammation and the cough caused by haze, therefore,
It can prompt the present composition that there is the effect of lung-heat clearing and detoxification, moistening lung and production of body fluid, clearing resolving sputum, the work(of haze can be resisted as human body
Can food.
Claims (10)
1. a kind of composition with clearing lung-heat function, it is characterised in that by weight, the bulk drug that said composition is made is：
Radix glycyrrhizae 1-10 parts, balloonflower root 1-10 parts, radix polygonati officinalis 1-10 parts, rhizoma imperatae 2-12 parts, Momordica grosvenori 1-10 parts.
2. composition according to claim 1, it is characterised in that by weight, the bulk drug that said composition is made is：
Radix glycyrrhizae 2-5 parts, balloonflower root 2-5 parts, radix polygonati officinalis 4-8 parts, rhizoma imperatae 8-15 parts, Momordica grosvenori 2-5 parts.
3. the preparation method of the composition of claim 1 or 2, it is characterised in that it is prepared：
The bulk drug of the parts by weight is directly ground to coarse powder；Or add the extraction of the ethanol of water or various concentrations, extract solution concentration
Dry crude extract；Or further using water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, steam distillation
Method carries out being refining to obtain extract；Above-mentioned medicinal material coarse powder or crude extract or extract are the active component of the composition.
4. the preparation method of composition according to claim 3, it is characterised in that it is prepared：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 4-20 times to measure 20-90% ethanol and extract 1-4 times,
Each 1-3 hours, extract solution merge, and filtering, decompression filtrate recycling ethanol is dried under reduced pressure to without alcohol taste, is ground into fine powder, produce
The active component of the composition.
5. the preparation method of composition according to claim 3, it is characterised in that it is prepared：
By the radix glycyrrhizae of the parts by weight, balloonflower root, radix polygonati officinalis, rhizoma imperatae, Momordica grosvenori, add 4-20 times to measure water and extract 1-4 times, each 1-3
Hour, extract solution merges, and filtering, filtrate decompression is concentrated into thick paste, is dried under reduced pressure, is ground into fine powder, produces the composition
Active component.
6. according to the preparation method of the composition of claim 4 or 5, it is characterised in that the active component of obtained composition
Adding or be not added with auxiliary material, routinely the preparation received in pharmacy is made in technique.
7. the preparation method of composition according to claim 6, it is characterised in that described preparation is oral formulations.
8. the preparation method of composition according to claim 7, it is characterised in that described oral formulations refer to tablet,
Granula, capsule, pill, powder, oral liquid, packed medicinal tea, bag tea agent.
9. composition according to claim 1 or 2, it is characterised in that Momordica grosvenori is replaced with emblic.
10. claim 1 or 2 or 9 composition is used to prepare with lung-heat clearing and detoxification, moistening lung and production of body fluid, clearing resolving sputum function
Application in food.
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| CN109432310A (en) * | 2018-10-16 | 2019-03-08 | 兰州奇正生态健康品有限公司 | A kind of composition and the preparation method and application thereof of anti-fog haze |
| CN109498787A (en) * | 2018-12-24 | 2019-03-22 | 右江民族医学院 | A kind of Chinese medicine composition for oral administration and sticking combination for treating laryngeal cough |
| CN110463876A (en) * | 2019-08-14 | 2019-11-19 | 李飞 | A kind of composite plant beverage |
| CN110638944A (en) * | 2019-02-15 | 2020-01-03 | 广西本草坊保健品有限公司 | Chinese herbal medicine composition for conditioning children cough with lung heat and preparation method thereof |
| CN111514235A (en) * | 2019-12-12 | 2020-08-11 | 上海市浦东新区周浦医院 | Traditional Chinese medicine composition and throat-moistening candy with effects of clearing heat from throat and benefiting throat |
| CN112022957A (en) * | 2020-09-18 | 2020-12-04 | 欧赫曼国际母婴用品(深圳)有限公司 | Traditional Chinese medicine lung moistening, toxin expelling and lung clearing tea |
| CN112451621A (en) * | 2020-10-29 | 2021-03-09 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for treating or preventing novel coronavirus pneumonia and application thereof |
| CN112913953A (en) * | 2021-03-17 | 2021-06-08 | 国健药业(深圳)集团有限公司 | Phlegm-reducing and heat-clearing health tea for middle-aged and old people and preparation method thereof |
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| CN109432310A (en) * | 2018-10-16 | 2019-03-08 | 兰州奇正生态健康品有限公司 | A kind of composition and the preparation method and application thereof of anti-fog haze |
| CN109498787A (en) * | 2018-12-24 | 2019-03-22 | 右江民族医学院 | A kind of Chinese medicine composition for oral administration and sticking combination for treating laryngeal cough |
| CN110638944A (en) * | 2019-02-15 | 2020-01-03 | 广西本草坊保健品有限公司 | Chinese herbal medicine composition for conditioning children cough with lung heat and preparation method thereof |
| CN110463876A (en) * | 2019-08-14 | 2019-11-19 | 李飞 | A kind of composite plant beverage |
| CN111514235A (en) * | 2019-12-12 | 2020-08-11 | 上海市浦东新区周浦医院 | Traditional Chinese medicine composition and throat-moistening candy with effects of clearing heat from throat and benefiting throat |
| CN112022957A (en) * | 2020-09-18 | 2020-12-04 | 欧赫曼国际母婴用品(深圳)有限公司 | Traditional Chinese medicine lung moistening, toxin expelling and lung clearing tea |
| CN112451621A (en) * | 2020-10-29 | 2021-03-09 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for treating or preventing novel coronavirus pneumonia and application thereof |
| CN112913953A (en) * | 2021-03-17 | 2021-06-08 | 国健药业(深圳)集团有限公司 | Phlegm-reducing and heat-clearing health tea for middle-aged and old people and preparation method thereof |
| CN115245543A (en) * | 2021-12-14 | 2022-10-28 | 李龙 | Granules for relieving sore throat, nourishing lung and clearing heat and preparation method thereof |
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