CN1970032A - Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold - Google Patents
Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal preparation which is prepared from Chinese medicinal herbs including honeysuckle flower, kudzu vine root, capsule of weeping forsythia, arctium fruit, mentha, isatic root, anemarrhena rhizome, cimicifuga rhizome, cicada shell.
Description
Technical field:
The present invention relates to a kind of YINQIAO Chinese medicine preparation that relieves internal heat, particularly use Flos Lonicerae, Radix Puerariae, Fructus Forsythiae, Fructus Arctii, Herba Menthae, Radix Isatidis, the Rhizoma Anemarrhenae, Rhizoma Cimicifugae, the Chinese medicine preparation that Chinese medicines such as Periostracum Cicadae are made.
Background technology:
Prescription of the present invention system sums up in recent years on the empirical basis of tcm clinical, to the cause of disease, pathogenesis and the method for treatment of catching a cold and the progress of clinical application, carries out the clinical experience side of prescription in conjunction with Chinese medicine in recent years by the principles of formulating prescriptions of present science of TCM formulas.The present invention's prescription is made up of Flos Lonicerae, Radix Puerariae, Fructus Arctii, Periostracum Cicadae, Fructus Forsythiae, Radix Isatidis etc., and the main effect in full side is: dispelling wind and heat pathogens, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, pathogenic fire purging sore-throat relieving.Be used for anemopyretic common cold and influenza.It is clinical in showing as: heating, headache, systemic pain, cough, expectoration, xerostomia and thirsty, diseases such as red swelling and pain of throat.
The present invention has overcome the defective of prior art, and a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect are provided.
Summary of the invention:
The invention provides a kind of YINQIAO Chinese medicine preparation that relieves internal heat, its function cures mainly and is relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing.Be used for anemopyretic common cold and influenza, disease is seen heating, headache, systemic pain, and nasal obstruction, watery nasal discharge, cough, expectoration, throat is itched, xerostomia and thirsty, red swelling and pain of throat, red tongue, diseases such as rapid pulse.
Chinese medicine preparation of the present invention, its prescription is composed as follows:
Flos Lonicerae 100-400g Radix Puerariae 75-300g Fructus Forsythiae 100-400g Fructus Arctii 60-240g
Herba Menthae 60-240g Radix Isatidis 60-240g Rhizoma Anemarrhenae 75-300g Rhizoma Cimicifugae 50-200g
Periostracum Cicadae 30-120g
Most preferred prescription is composed as follows:
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
In more than forming, weight is calculated with crude drug, more than form to can be made into 1000 doses of pharmaceutical preparatioies, and described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000 grams, oral liquid 1000ml etc.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the Chinese medicine preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, every bottle of oral liquid, every bag of granule etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.Tablet most preferably.
Chinese medicine preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation preferred manufacturing procedure of the present invention is as follows:
Fructus Forsythiae, Herba Menthae two flavors, steam distillation extracts volatile oil, and gained volatile oil gets clathrate with beta-cyclodextrin inclusion compound, and extracting solution filters, and is standby; Carry oil back medicinal residues extracting in water, filter, filtrate and vapor distillation extracting solution merge, and be standby;
All the other seven flavors decoct with water, and extracting solution concentrates, and put coldly, add ethanol, leave standstill, and filter, and reclaim ethanol, drying, dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
Concrete grammar is:
In the prescription nine flavor medicine, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, and steam distillation extracts volatile oil, and 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
As preparation for tablet, can adopt above active component, add starch, sucrose, magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, the bag film-coat, packing, promptly.
Extraction process of the present invention obtains through screening, in order to reduce oral dose, improves clinical efficacy, and we divide into groups medical material according to the physicochemical property of each medical material effective ingredient, and every group is carried out Study on extraction process respectively.
(1) the effective ingredient type of seven flavor medicine material such as Radix Puerariae is many, and the polarity scope is big, but most of known effective ingredient is water solublity, as the flavones ingredient in the monarch drug Radix Puerariae; Known content reaches 6.6% antimicrobial component chlorogenic acid, isochlorogenic acid in the monarch drug Flos Lonicerae; Steroidal saponin in the ministerial drug Rhizoma Anemarrhenae, organic acid, alkaloids and flavones ingredient; The decocting liquid tool antiinflammatory action of adjuvant drug Fructus Arctii, the decocting liquid tool bacteriostasis of Radix Isatidis, the triterpenes in the Rhizoma Cimicifugae, phenolic acids, alkaloids and flavones ingredient, the amino acids composition in the Periostracum Cicadae; In sum, more than the most water soluble of main effective ingredient of each flavour of a drug, therefore can adopt water is that solvent extracts.
In extraction process by water research, be index with the puerarin rate of transform, amount of water, extraction time, extraction time three factors have been carried out the orthogonal experiment investigation.The result shows that optimised process is: the extraction process of seven flavor medicine materials such as Radix Puerariae is: medical material adds 11 times of water gagings, and reflux, extract, 2.0 hours filters, and medicinal residues add 10 times of water gagings again, and reflux, extract, 2.0 hours filters, and the water extract merges; Medicinal liquid is standby.
(2) Fructus Forsythiae, Herba Menthae are respectively ministerial drug and adjuvant drug in this prescription, and two flavor medical materials mainly contain aqueous soluble active constituent [3], effects such as according to the literature, that the Fructus Forsythiae decocting liquid has is analgesic, antiinflammatory, and the Herba Menthae decocting liquid has antiviral, effect such as antibiotic; And Fructus Forsythiae, Herba Menthae two flavor medical materials all contain volatile oil component, and volatile oil has certain drug effect; Adopt steam distillation, collect volatile oil, not only extracted effective ingredient, and kept volatile oil; Volatile oil adopts beta-cyclodextrin inclusion compound, guarantees the content of volatile oil in preparation.
This part is at first carried out volatile oil and is extracted prerun, determines extraction time and amount of water that volatile oil extracts, investigates through parallel laboratory test, is defined as: 10 times of water gagings, distillation time 3 hours.
Inclusion essential oil experiment serves as to investigate index with clathrate yield and inclusion essential oil rate, and influence factors such as beta-schardinger dextrin-and volatile oil proportioning, enclose temperature, enclose time have been carried out the orthogonal experiment investigation.The result shows that optimised process is: get the beta-schardinger dextrin-of 8 times of amounts of volatile oil, add in the entry, be warming up to 60 ℃ and make saturated aqueous solution, slowly drip volatile oil under 100r/min stirs, added behind the volatile oil 60 ℃ of insulated and stirred 3 hours; 4 ℃ of cold preservation 12 hours is filtered, and with a small amount of petroleum ether filtering residue, twice gained precipitation merges, drying at room temperature, and grinding promptly gets the white powder clathrate.
In extraction process by water research, be index with the phillyrin rate of transform, to solvent multiple, extraction times two factor carried out the orthogonal experiment investigation.The result shows that optimised process is: medical material adds 10 times of amounts of water for the first time, and reflux, extract, 3.0 hours is collected volatile oil simultaneously, filters, and medicinal residues add 8 times of amounts of water again, and reflux, extract, 2.0 hours filters, and the water extract merges, and is standby.
(3) above-mentioned aqueous extract contains impurity such as medicinal residues, tannin, protein, starch, phlegmatic temperament and resin, gets content in order to improve effective ingredient, selects for use ethanol precipitation that the water extract is carried out purification (making with extra care), and method is simple for this, process stabilizing.
In alcohol precipitation process research, be index with the puerarin rate of transform, concentrated solution relative concentration, alcohol precipitation concentration, precipitate with ethanol times three factor have been carried out the orthogonal experiment investigation.The result shows that optimised process is: two groups of water of medical material are guided and supported merging, are concentrated into to contain crude drug 1.0g/ml, add 95% ethanol to containing alcohol amount 70%, place 18 hours, filter, and get alcohol deposit fluid, and are standby.
(4) after the precipitate with ethanol mother solution filters,, decompression (0.085Mpa), advanced technologies such as low temperature (＜80 ℃) thin film concentration and spray drying have been adopted in order to reduce loss of active ingredients in concentrated and the drying process.
(5) dry granulation is compared with wet granulation, have to shorten man-hour, reduce production costs, wet, heat-labile medicine is destroyed advantages such as little, still adopt dry granulation.
(6) above-mentioned medicinal liquid, spray drying is made dry powder, with the volatile oil mix homogeneously of beta-cyclodextrin inclusion compound, further adds the adjuvant of tablet molding again, after granulating, is pressed into plain sheet.
(7) for the moisture absorption that solves plain sheet and the loss problem of volatile oil, we have adopted the thin film coating material of Shanghai Colorcon Coating Technology Co., Ltd---Opadry, select for use moistureproof film-coat material to carry out coating.
Below by pharmacodynamics test beneficial effect of the present invention is described.
The experiment medicine is the medicine of the embodiment of the invention 1 method preparation, at this called after: the YINQIAO sheet that relieves internal heat.
The test of pesticide effectiveness
1, extracorporeal bacteria inhibitor test [1] test tube method: the YINQIAO sheet that relieves internal heat has bacteriostasis preferably to clinical separation Diplococcus pneumoniae, staphylococcus epidermidis, staphylococcus aureus, escherichia coli, Bacillus proteus, MIC is at 25mg (crude drug, down with)/ml-100mg/ml between, prompting: the YINQIAO sheet that relieves internal heat has the good in-vitro bacteriostasis.[2] flat band method: YINQIAO relieves internal heat sheet to standard gold Staphylococcus aureus, escherichia coli, clinical SEPARATION OF GOLD Staphylococcus aureus, Diplococcus pneumoniae, staphylococcus epidermidis, escherichia coli, section have bacteriostasis preferably for staphylococcus, kerekou pneumonia Salmonella, dissolving staphylococcal bacteria, middle staphylococcus, MIC is between 50mg/ml-100mg/ml, and prompting: the YINQIAO sheet that relieves internal heat has the good in-vitro bacteriostasis.
2, antibacterial tests in the body: [1] YINQIAO heavy dose of group of sheet that relieves internal heat can reduce infection of staphylococcus aureus dead mouse number, but not statistically significant.Can prolong the survival natural law of infecting mouse; Relatively have significant difference (P＜0.05) with model group, prompting: the YINQIAO sheet that relieves internal heat has the certain protection effect to the infection of staphylococcus aureus mice.[2] relieve internal heat dosage group and heavy dose of group in the sheet of YINQIAO can obviously improve the survival rate of infecting mouse to the Diplococcus pneumoniae infecting mouse; and can prolong the survival natural law of Diplococcus pneumoniae infecting mouse; relatively have significant difference (P＜0.05) with model group, prompting: the YINQIAO sheet that relieves internal heat has the better protect effect to the Diplococcus pneumoniae infecting mouse.
3, interior resisting virus test shows: relieve internal heat in sheet dosage group and heavy dose of group of [1] YINQIAO can obviously prolong influenza a virus infection mice survival natural law, relatively has significant difference (P＜0.05) with the virus control group.Three dosage groups all can reduce the infecting mouse mortality rate.But not statistically significant.Prompting: the YINQIAO sheet that relieves internal heat has the certain protection effect to the influenza a virus infection mice.[2] relieve internal heat dosage group and heavy dose of group of lung exponential quantity that can obviously reduce the influenza a virus infection mice in the sheet of YINQIAO, with virus control group tool significant difference (P＜0.05) relatively, lung index suppression ratio is respectively 19.56% and 23.81%.Prompting: the YINQIAO sheet that relieves internal heat has certain therapeutical effect to pulmonary infection disease due to the influenza A virus.[3] the YINQIAO heavy dose of group of sheet that relieves internal heat can obviously prolong Influenza B virus infecting mouse survival natural law; reduce death toll; relatively have significant difference (P＜0.05) prompting with the virus control group: the YINQIAO sheet that relieves internal heat has the better protect effect to the Influenza B virus infecting mouse.[4] the YINQIAO heavy dose of group of sheet that relieves internal heat can obviously reduce the lung exponential quantity of Influenza B virus infecting mouse, lung index suppression ratio 33.1%.Prompting: the YINQIAO sheet that relieves internal heat has certain therapeutical effect to pulmonary infection disease due to the Influenza B virus.
4. the antiinflammatory result of the test shows: 1. YINQIAO relieve internal heat sheet little, in, can reduce auricle swelling degree due to the dimethylbenzene greatly, with model group notable difference (P＜0.05, P＜0.01) is arranged relatively.2. YINQIAO relieves internal heat in the sheet, can reduce the optical density value of abdominal cavity eluate greatly, with model group notable difference (P＜0.05, P＜0.01) is arranged relatively, prompting: the YINQIAO sheet that relieves internal heat has certain antiinflammatory action.
5. analgesic result of the test shows: 1. YINQIAO relieve internal heat sheet little, in, big three dosage groups can reduce that rat temperature raises due to the dry yeast, with model group notable difference (P＜0.05) are arranged relatively.2. YINQIAO relieve internal heat sheet little, in, big two dosage groups can reduce that rabbit body temperature raises due to the endotoxin, with model group notable difference (P＜0.05, P＜0.01) are arranged relatively.Prompting: the YINQIAO sheet that relieves internal heat has certain refrigeration function.
6. the analgesic test result shows: 1. YINQIAO relieve internal heat sheet little, in, big three dosage group Dichlorodiphenyl Acetate induced mice writhing responses do not have obvious protective effect, with model group relatively (P＞0.05).2. YINQIAO relieve internal heat sheet little, in, big three dosage groups do not have obvious influence to the pain threshold of mice, with model group relatively (P＞0.05).The prompting YINQIAO relieves internal heat sheet to chemical, the no obvious analgesic activity of physical property stimulation.
Acute toxicity test
The maximum dosage-feeding test of oral administration has been carried out in acute toxicity test to mice and rat.The result shows: the abnormal conditions that there is no mice and rat after administration take place.The clinical adult one consumption per day 15g/60kg of sheet if YINQIAO relieves internal heat (press the crude drug amount and calculate, down together), then: 1. the mice maximum dosage-feeding of twice oral administration gavage administration is 561.6g/kg in one day, is 2246 times of clinical adult's one consumption per day; 2. the rat maximum dosage-feeding of twice oral administration gavage administration is 351g/kg in one day, is 1404 times of clinical adult's one consumption per day.
Show that the YINQIAO sheet oral administration degree of safety that relieves internal heat is bigger.
In sum: the YINQIAO of the present invention preparation that relieves internal heat has therapeutical effect preferably.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 2
Flos Lonicerae 100g Radix Puerariae 75g Fructus Forsythiae 100g Fructus Arctii 60g
Herba Menthae 60g Radix Isatidis 60g Rhizoma Anemarrhenae 75g Rhizoma Cimicifugae 50g
Periostracum Cicadae 30g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 3
Flos Lonicerae 400g Radix Puerariae 300g Fructus Forsythiae 400g Fructus Arctii 240g
Herba Menthae 240g Radix Isatidis 240g Rhizoma Anemarrhenae 300g Rhizoma Cimicifugae 200g
Periostracum Cicadae 120g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 4
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made relieve internal heat 1000 of capsules of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), put and be chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, No. 1 capsule of packing, promptly.
Embodiment 5
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made the YINQIAO granule 1000g that relieves internal heat.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), put and be chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, packing, promptly.
Embodiment 6
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made the YINQIAO oral liquid 1000ml that relieves internal heat.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), add above-mentioned volatile oil clathrate compound, sucrose, water is to 1000ml, packing, promptly.
Claims (7)
1, a kind of heat-clearing and detoxifying herb preparation is characterized in that, is made by following Chinese medicinal raw materials
Flos Lonicerae 100-400g Radix Puerariae 75-300g Fructus Forsythiae 100-400g Fructus Arctii 60-240g
Herba Menthae 60-240g Radix Isatidis 60-240g Rhizoma Anemarrhenae 75-300g Rhizoma Cimicifugae 50-200g
Periostracum Cicadae 30-120g.
2, the Chinese medicine preparation of claim 1 is characterized in that, is made by following Chinese medicinal raw materials
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g.
3, the Chinese medicine preparation of claim 1 is characterized in that, is selected from tablet, capsule, oral liquid, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, suppository, unguentum, drop pill or patch.
4, the Chinese medicine preparation of claim 1 is a tablet.
5, the preparation method of the Chinese medicine preparation of claim 1 is characterized in that, the process following steps:
Fructus Forsythiae, Herba Menthae two flavors, steam distillation extracts volatile oil, and gained volatile oil gets clathrate with beta-cyclodextrin inclusion compound, and extracting solution filters, and is standby; Carry oil back medicinal residues extracting in water, filter, filtrate and vapor distillation extracting solution merge, and be standby;
All the other seven flavors decoct with water, and extracting solution concentrates, and put coldly, add ethanol, leave standstill, and filter, and reclaim ethanol, drying, dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
6, the preparation method of the Chinese medicine preparation of claim 5 is characterized in that, the process following steps:
Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, and steam distillation extracts volatile oil, and 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09, puts and is chilled to room temperature, slowly adds ethanol and makes and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, and filtered, decompression filtrate recycling ethanol is to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05, spray drying gets dry powder, adds above-mentioned volatile oil clathrate compound, obtains active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation according to the galenic pharmacy routine techniques.
7, the application of the pharmaceutical preparation of claim 1 in preparation heat-clearing and toxic substances removing medicine.
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| CN2006101618308A CN1970032B (en) | 2006-12-05 | 2006-12-05 | Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101361895B (en) * | 2008-08-23 | 2010-10-13 | 宫兆荣 | Traditional Chinese medicine combination for treating measles complicated pneumonia |
| CN106074908A (en) * | 2016-07-30 | 2016-11-09 | 南京正宽医药科技有限公司 | A kind of ventilating nasal patch |
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| CN107929494A (en) * | 2018-01-02 | 2018-04-20 | 威海惠高生物科技有限公司 | It is a kind of to be used to treat Chinese medicine composition of abscess of throat and preparation method thereof |
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| CN1057451C (en) * | 1994-08-16 | 2000-10-18 | 欧致新 | Children coryza medicine and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101361895B (en) * | 2008-08-23 | 2010-10-13 | 宫兆荣 | Traditional Chinese medicine combination for treating measles complicated pneumonia |
| CN106118867A (en) * | 2016-07-21 | 2016-11-16 | 桐城市佳明农业发展有限公司 | A kind of anti-Oleum Helianthi and preparation method thereof of getting angry |
| CN106074908A (en) * | 2016-07-30 | 2016-11-09 | 南京正宽医药科技有限公司 | A kind of ventilating nasal patch |
| CN106138835A (en) * | 2016-08-22 | 2016-11-23 | 黄平学 | The preparation method of the oral liquid that treatment heat-damp in summer sexuality emits |
| CN107929494A (en) * | 2018-01-02 | 2018-04-20 | 威海惠高生物科技有限公司 | It is a kind of to be used to treat Chinese medicine composition of abscess of throat and preparation method thereof |
| CN110801486A (en) * | 2019-11-14 | 2020-02-18 | 广州中医药大学(广州中医药研究院) | Traditional Chinese medicine compound preparation and preparation method and application thereof |
| CN110801486B (en) * | 2019-11-14 | 2021-12-21 | 广州中医药大学(广州中医药研究院) | Traditional Chinese medicine compound preparation and preparation method and application thereof |
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| CN1970032B (en) | 2011-07-20 |
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Effective date of registration: 20200509 Address after: 222047 Jiangning economic and Technological Development Zone, Jiangsu, Lianyungang industrial city Patentee after: JIANGSU KANION PHARMACEUTICAL Co.,Ltd. Address before: 100070, room 1, building 2, 5358 Fu Heng street, Fengtai District Science Town, Beijing, China Patentee before: BEIJING TIANLI ZHENGYUAN MEDICINE TECHNOLOGY DEVELOPMENT Ltd. |