CN1679689B - Heat-clearing and toxicity-relieving Chinese medicine preparation and production thereof - Google Patents
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- CN1679689B CN1679689B CN 200510004852 CN200510004852A CN1679689B CN 1679689 B CN1679689 B CN 1679689B CN 200510004852 CN200510004852 CN 200510004852 CN 200510004852 A CN200510004852 A CN 200510004852A CN 1679689 B CN1679689 B CN 1679689B
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- Medicinal Preparation (AREA)
Abstract
A Chinese medicine for antipyresis and detoxication is prepared from 3-9 Chinese-medicinal materials including bulpeurum root, scutellaria root, belamcanda rhizome, honeysuckle flower, etc.
Description
Technical field:
The present invention relates to Chinese medicine preparation of a kind of heat-clearing and toxic substances removing and preparation method thereof, said preparation is by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae, and/or is selected from: the raw material of Chinese medicine of Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Radix Scrophulariae, Flos Chrysanthemi Indici, Rhizoma Polygoni Cuspidati forms through extracting processing and preparing.
Background technology:
Antibacterial, virus are the main pathogenic former of upper respiratory tract infection and pulmonary infection, be the human enemy who resists so far by the beginning, cardinal symptom has hyperpyrexia, micro evil wind, watery nasal discharge, cough, laryngopharynx swelling and pain, floating pulse etc., according to statistics, because the death that heating, pulmonary infection cause, the whole world has at least more than 2,000,000 every year, has a strong impact on the healthy of people.Along with antibiotic extensive use, modern medicine can suppress bacterial infection largely, but viral infection is still lacked good curing method and medicine.Alarmingly be, because antibiotic abuse, produce serious toxic and side effects, a large amount of Resistant strains occur, antibiotic curative effect is had a greatly reduced quality, force the novel antibiotic of continuous research and development, cause research and development to drop into the significant cost height, the medicine costliness, make the patient and the society back heavy financial burden.The tradition Chinese medicine is to antibacterial, virus, and the especially viral respiratory tract infection that causes has superiority than western medicine and medical practitioners, good effect, and price is low, and untoward reaction is few.But most preparation technologies are outmoded for present Chinese medicine preparation, and dosage form falls behind, and there is important disadvantages in some Chinese medicines, and the process for preparation of injection that has falls behind, flavour of a drug are many, complicated component, quality control difficulty, as Rhizoma Belamcandae antiviral injection etc., the untoward reaction that has is serious, as SHUANGHUANGLIAN ZHUSHEYE.Medicine of the present invention is made injection, adopts the technology of reasonable science, and every flavor is formed the extract drugs active component, makes preparation then, has the technology advanced person, and ingredient is clearer and more definite, and is quality controllable, and is antibiotic, antivirus action good, the advantage that untoward reaction is few.
Drug main of the present invention will be made up of Radix Bupleuri, Radix Scutellariae and Rhizoma Belamcandae, and the diffusing wind heat of the hot cool table of Radix Bupleuri is gone into shaoyang channel, clearly the heat of half exterior and half interior.The Radix Scutellariae lunar lung meridian of starting with, but clearing away lung-heat Radix Bupleuri, the normal fit applications of Radix Scutellariae can induce sweat outward, but interior heat clearing away.The heresy of wind heat is invaded human body, all mouth and nose and going into, and throat is the shared pathway of mouth and nose, anemopyretic cold has the laryngopharynx swelling and pain symptom more, therefore treats anemopyretic cold, pay attention to controlling throat, and saying of " controlling using warming therapy and want, be valued for from pharynx and block " therefore, arranged.So the present invention adopts Rhizoma Belamcandae, but the Rhizoma Belamcandae heat-clearing and toxic substances removing, sore-throat relieving, the kind laryngopharynx swelling and pain of controlling.On this basis, if patient's the state of an illness is heavier, can add Flos Lonicerae, Fructus Forsythiae or Fructus Gardeniae to increase the power of heat-clearing and toxic substances removing; As have concurrently damp and hotly, can add Rhizoma Polygoni Cuspidati; If pharyngalgia is heavy, can add Radix Scrophulariae.Chinese medicine preparation treatment anemopyretic cold of the present invention, epidemic febrile disease heating etc. have better curative effect, and hyperpyrexia, cough, laryngopharynx swelling and pain that treatment antibacterial, virus cause have the good curing effect.Modern pharmacological research proves, each component of medicine of the present invention has clear and definite resisting pathogenic microbes, antiinflammatory, effect such as analgesic.Chinese medicine preparation of the present invention by their medicines are formed also proves through pharmacological research, has antibiotic, antivirus action.
Summary of the invention:
The invention provides a kind of Chinese medicine preparation, said preparation is by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae, and/or adding is selected from: the raw material of Chinese medicine of Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Radix Scrophulariae, Flos Chrysanthemi Indici, Rhizoma Polygoni Cuspidati forms through extracting processing and preparing, and said preparation is made by following Chinese medicinal raw materials.
Chinese medicine preparation of the present invention, per 1000 dosage units are by 1500～6000 parts of Radix Bupleuri, 1500～6000 parts of Radix Scutellariaes, 1250～5000 parts of Rhizoma Belamcandae; And/or adding is selected from: the raw material of Chinese medicine of 1500～6000 parts of Flos Loniceraes, 1500～6000 parts of Fructus Forsythiaes, 1500～6000 parts of Fructus Gardeniaes, 1750～7000 parts of Flos Chrysanthemi Indicis, 1750～7000 parts of Radix Scrophulariaes, 1750～7000 parts of Rhizoma Polygoni Cuspidati is made.
Preferably, per 1000 dosage units, raw materials used in weight portion, by 2500～4000 parts of Radix Bupleuri, 2500～4000 parts of Radix Scutellariaes, 2000～3000 parts of Rhizoma Belamcandae, and/or adding is selected from: the raw material of Chinese medicine of 2500～4000 parts of Flos Loniceraes, 2500～4000 parts of Fructus Forsythiaes, 2500～4000 parts of Fructus Gardeniaes, 2500～4500 parts of Flos Chrysanthemi Indicis, 2500～4500 parts of Radix Scrophulariaes, 2500～4500 parts of Rhizoma Polygoni Cuspidati is made.
Particularly preferably be, per 1000 dosage units, raw materials used in weight portion, by 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae, and/or adding is selected from: the raw material of Chinese medicine of 3000 parts of Flos Loniceraes, 3000 parts of Fructus Forsythiaes, 3000 parts of Fructus Gardeniaes, 3500 parts of Flos Chrysanthemi Indicis, 3500 parts of Radix Scrophulariaes, 3500 parts of Rhizoma Polygoni Cuspidati is made.
Specifically can be: 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Radix Scrophulariaes.
Or 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Flos Chrysanthemi Indicis.
Or 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Rhizoma Polygoni Cuspidati.
Or 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Fructus Gardeniaes.
Or 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Fructus Forsythiaes.
Or 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Flos Loniceraes.
Or 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae.
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000ml etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be 1～4, can take altogether 200～1000 times.As granule, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the pharmaceutical preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, capsular every capsules, every of injection etc., in the unit dose, the amount that contains active substance is 5-800mg, preferably 20-500mg.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, oral liquid, syrup, granule, pill, powder, unguentum, sublimed preparation, injection, suppository, cream, spray, drop pill, patch, slow releasing preparation, controlled release preparation.
Pharmaceutical preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Pharmaceutical preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine,-starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
The preparation method of Chinese medicine preparation of the present invention may further comprise the steps:
The preparation of Radix Bupleuri active component: get the Radix Bupleuri pulverizing medicinal materials and become coarse powder, add 55～55% alcohol reflux twice, each ethanol consumption is 5～9 times of amounts, and each extraction time is 1～3 hour.Merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2～4 times of water gagings and stirs 20 minutes, leave standstill after 1 hour centrifugal by tube centrifuge, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 60～75% carries out eluting, collects eluent, concentrating under reduced pressure, the dry Radix Bupleuri active component that gets.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin.
The preparation of Rhizoma Belamcandae active component: get the Rhizoma Belamcandae medical material, be ground into coarse powder, add 80～90% alcohol reflux three times, the ethanol consumption is 5～7 times of amounts at every turn, time is 1～3 hour at every turn, has reclaimed ethanol and has added 1～3 times of water gaging heating for dissolving, crosses tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 1～3 times of amount, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets the Rhizoma Belamcandae active component.
When adding selected son in the pharmaceutical preparation of the present invention: during the Chinese medicine of Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Radix Scrophulariae, Flos Chrysanthemi Indici, Rhizoma Polygoni Cuspidati, preparation method also comprises the operating procedure that is selected from following method:
The preparation of honey suckle active composition: take by weighing Chinese medicine honeysuckle and be ground into coarse powder, the dynamic warm macerating of water (75～90 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 5～8 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 35～65% ethanol elutions, the eluent concentrate under reduced pressure at low temperature is not to there being the alcohol flavor, adds the ethyl acetate extraction 3 times of 2～4 times of amounts, and ethyl acetate adds 0.5～1.2% activated carbon decolorizing, cooled and filtered, filtrate decompression is concentrated on a small quantity, places crystallize, promptly.
The preparation of Flos Chrysanthemi Indici active component: take by weighing the Flos Chrysanthemi Indici pulverizing medicinal materials and become coarse powder, the dynamic warm macerating of water (75～90 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 5～8 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 35～65% ethanol elutions, the eluent concentrate under reduced pressure at low temperature is not to there being the alcohol flavor, adds the ethyl acetate extraction 2 times of 2～4 times of amounts, and ethyl acetate is evaporated on a small quantity, place crystallize, get Flos Chrysanthemi Indici active component, i.e. chlorogenic acid and flavones ingredient.
The preparation of Fructus Forsythiae active component: take by weighing the Fructus Forsythiae pulverizing medicinal materials and become coarse powder, decoct with water secondary, each extraction time is 1～3 hour, and solvent is with being 5～9 times of amounts, extracting liquid filtering, and filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 40～60% ethanol are resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, adds the ethyl acetate extraction 2 times of 2～4 times of amounts, and the ethyl acetate normal pressure is concentrated on a small quantity, and water bath method gets dry thing.
The preparation of Fructus Gardeniae active component: take by weighing the Fructus Gardeniae pulverizing medicinal materials and become coarse powder, decoct with water secondary, each extraction time is 1～3 hour, and solvent is with being 5～9 times of amounts, extracting liquid filtering, and filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 50～70% ethanol are resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets the Fructus Gardeniae active component.
The preparation of Radix Scrophulariae active component: take by weighing the Radix Scrophulariae pulverizing medicinal materials and become coarse powder, decoct with water three times, each extraction time is 1 hour, and solvent is with being 5～9 times of amounts, extracting liquid filtering, and filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 50～70% ethanol are resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets the Radix Scrophulariae active component.
The preparation of Rhizoma Polygoni Cuspidati active component: take by weighing the Rhizoma Polygoni Cuspidati pulverizing medicinal materials and become coarse powder, add 70～75% alcohol reflux twice, with being 5～8 times of amounts, each extraction time is 2 hours at every turn.Merge extractive liquid, is evaporated to does not have the alcohol flavor, adds the ethyl acetate counter-current extraction 2 times of 2～4 times of amounts, and the extract normal pressure is concentrated on a small quantity, and water bath method must dry thing, is the active component of Rhizoma Polygoni Cuspidati.
Medicine of the present invention has good analgesic, antibiotic, antivirus action, and has synergism, following experiment embodiment, but be not limited only to the beneficial effect of following experiment embodiment in order to explanation medicine of the present invention.
Observe antibiotic, the antiviral and the refrigeration function of the anti-sense detoxifcation of medicine of the present invention 1, No. 2, No. 3.
Anti-sense detoxifcation No. 1 injectable powder (contain crude drug 8.5g/ bottle approximately, form) by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae,
Anti-sense detoxifcation No. 2 injectable powder (contain crude drug 11.5g/ bottle approximately, form) by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Flos Lonicerae.
Anti-sense detoxifcation No. 3 injectable powder (contain crude drug 12g/ bottle approximately, form) by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Flos Chrysanthemi Indici.
1, the external bacteriostasis of anti-sense detoxifcation No. 1, No. 2, No. 3
Respectively with No. 1, the anti-sense detoxifcation of the present invention, No. 2, anti-sense detoxifcation, anti-sense detoxifcation adds the dilution of MH10ml broth bouillon for No. 3 as stock solution, reuse MH broth bouillon two-fold dilution, with aseptic straw medicine is put into respectively in the aseptic plate, add agar culture medium (streptococcus pneumoniae wherein more successively, beta hemolysis type streptococcus is with containing blood meida), mixing immediately, after waiting to solidify, promptly become the culture medium that contains different pharmaceutical concentration. will cultivate the fresh bacterium liquid of 18h: staphylococcus aureus, streptococcus pneumoniae, escherichia coli, beta hemolysis type streptococcus etc., streak inoculation is in the zones of different of pastille plate culture medium, place 37 ℃ of incubators to hatch 24h, can observe antibacterial grow in difference contains the culture medium of concentration, the lowest concentration of drug that antibacterial does not grow is the minimum inhibitory concentration (MIC) of this medicine to certain bacterium.
The external bacteriostasis that No. 1～3, the anti-sense detoxifcation of table 1
The result shows, anti-sense detoxifcation No. 1, No. 2 all has certain bacteriostasis to staphylococcus aureus, streptococcus pneumoniae, escherichia coli, beta hemolysis type streptococcus.
2, the extracorporeal antivirus effect effect of anti-sense detoxifcation No. 1, No. 2, No. 3
Half intracorporal method is adopted in this experiment, to resist No. 1, sense detoxifcation, No. 2, anti-sense detoxifcation, No. 3 stock solutions of anti-sense detoxifcation respectively by dilution in 1: 2,1: 4,1: 8,1: 16,1: 32, the medicine of variable concentrations is directly acted on virus respectively, be inoculated in chick embryo allantoic cavity immediately, establish virus control group and normal control group simultaneously.With paraffin wax sealing inoculation hole, put 37 ℃ of incubators and cultivate, gathered in the crops the allantoic fluid of every embryo in 48 hours, judge the antiviral activity of medicine, the results are shown in Table 2.
1～No. 3 influence of the anti-sense detoxifcation of table 2 to first, Influenza B virus
Annotate :-virus-free growth ,+a small amount of viral growth, ++ more viral growth, +++viral growth.
Experiment shows, No. 1,2,3, anti-sense detoxifcation all has certain inhibition deactivation to first, Influenza B virus.
3, No. 1, No. 2, No. 3 heat clearing away effects of anti-sense detoxifcation to fever in rabbit
After giving healthy 2 anus temperature of New Zealand white rabbit measurement, injection typhoid Vi polysaccharide vaccine, after 〉=1 ℃ of the actuating thing heating, No. 1, anti-sense detoxifcation, No. 2, No. 3 the treatment group resists No. 1, sense detoxifcation through the auricular vein injection respectively, No. 2, No. 3, the model group injection gives normal saline, after the administration, survey the anus temperature 1 time every 30min, behind the gastric infusion 1,2,3h, No. 1 mean body temperature of anti-sense detoxifcation hangs down 0.4 respectively than model control group, 0.7,0.9 ℃, No. 2 mean body temperatures of anti-sense detoxifcation hang down 0.6 respectively than model control group, 0.9,1.0 ℃, No. 3 mean body temperatures of anti-sense detoxifcation hang down 0.5 respectively than model control group, 0.8,1.0 ℃, No. 1, anti-sense detoxifcation is described, No. 2, No. 3 the better antipyretic effect is arranged.
A kind of antiviral Chinese medicine preparation of the present invention can be an injection, solution, suspensoid, tablet, capsule, granule, pill, powder, drop pill; Preferred injection, capsule, tablet, granule; More preferably injection, capsule.Specific embodiment is as follows, includes but not limited to the following example.
Concrete true mode:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1
It is characterized in that containing three kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae and Rhizoma Belamcandae.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 81.4g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.2g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.4g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7.5, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (450mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 80.9g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 159.7g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 54.1g.
Get that above three kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
The preparation method of granular preparation is as follows:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.4g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.2g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 55.3g.
After getting above three kinds of active component pulverizing, mix homogeneously, add a certain amount of adjuvant mix homogeneously, make soft material in right amount with ethanol, the system granule, cold drying, granulate gets granule 1000g, is distributed into bag (a 1g/ bag).
The preparation method of tablet is as follows:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid. centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 81.6g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 158.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.4g.
After getting above three kinds of active component pulverizing, mix homogeneously, add a certain amount of adjuvant mix homogeneously, make soft material in right amount with ethanol, the system granule, cold drying, tabletting behind the granulate gets 1000 (0.5g/ sheet).
Being prepared as follows of soft capsule preparation:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.6g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.4g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 55.7g.
Get above three kinds of active component and add a certain amount of substrate and make emulsion, make 1000 soft capsules, reinstall in the bottle after aluminum-plastic packaged and seal with pressing.
The preparation method of drop pill is as follows:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid. centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 81.5g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.4g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 57.8g.
Get above three kinds of active component and add a certain amount of substrate and make drop pill, make 10000 altogether, seal in the bottle of packing into.
Embodiment 2
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Flos Lonicerae.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 79.6g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 159.7g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 50.7g.
The preparation of honey suckle active composition: take by weighing Chinese medicine honeysuckle 2500g and be ground into coarse powder, the dynamic warm macerating of water (85 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 7 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 40% ethanol elution, eluent low temperature (＜60 ℃) is evaporated to does not have the alcohol flavor, adds the ethyl acetate extraction 3 times of 2 times of amounts, and acetic acid ethyl fluid adds 0.8% activated carbon decolorizing, cooled and filtered, filtrate decompression is concentrated on a small quantity, places crystallize, gets honey suckle active composition 97.3g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (500mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.5g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 168.1g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.6g.
The preparation of honey suckle active composition: take by weighing Chinese medicine honeysuckle 2500g and be ground into coarse powder, the dynamic warm macerating of water (85 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 7 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 40% ethanol elution, eluent low temperature (＜60 ℃) is evaporated to does not have the alcohol flavor, adds the ethyl acetate extraction 3 times of 2 times of amounts, and acetic acid ethyl fluid adds 0.8% activated carbon decolorizing, cooled and filtered, filtrate decompression is concentrated on a small quantity, places crystallize, gets honey suckle active composition 101.2g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
Embodiment 3
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Fructus Forsythiae.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 80.6g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary, add for the first time 8 times of water gagings, extracted 1 hour, and added 6 times of water gagings for the second time, extracted 1 hour. filter, and squeeze out medicinal liquid in the filtering residue, merging with extracted twice liquid, filter. filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, left standstill 4 hours, to filter. filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ of insulations 1 hour down must precipitate. and get precipitation and add NaOH solution and make dissolving fully, add 0.5% active carbon, fully stir, and 50 ℃ being incubated 30 minutes, filtration. filtrate adds hydrochloric acid and transfers pH value 2.0, filter to such an extent that precipitate. get precipitation and add washing with alcohol, promptly get baicalin 158.7g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 58.3g.
The preparation of Fructus Forsythiae active component: take by weighing Fructus Forsythiae medical material 2500g and be ground into coarse powder, decoct with water secondary, add 9 times of water gagings for the first time and extracted 2 hours, add 8 times of water gagings for the second time and extracted 2 hours, extracting liquid filtering, filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 50% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, adds the ethyl acetate extraction 2 times of 3 times of amounts, and the ethyl acetate normal pressure is concentrated on a small quantity, and water bath method gets dry thing 54.6g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7.5, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (500mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 84.3g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.0g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 55.5g.
The preparation of Fructus Forsythiae active component: take by weighing Fructus Forsythiae medical material 2500g and be ground into coarse powder, decoct with water secondary, add 9 times of water gagings for the first time and extracted 2 hours, add 8 times of water gagings for the second time and extracted 2 hours, extracting liquid filtering, filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 50% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, adds the ethyl acetate extraction 2 times of 3 times of amounts, and the ethyl acetate normal pressure is concentrated on a small quantity, and water bath method gets dry thing 50.2g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
Embodiment 4
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Flos Chrysanthemi Indici.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.1g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 158.6g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 53.2g.
The preparation of Flos Chrysanthemi Indici active component: take by weighing Flos Chrysanthemi Indici medical material 3500g and be ground into coarse powder, the dynamic warm macerating of water (90 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 8 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 55% ethanol elution, the eluent concentrate under reduced pressure at low temperature is not to there being the alcohol flavor, adds the ethyl acetate extraction 2 times of 2 times of amounts, and ethyl acetate is evaporated on a small quantity, place crystallize, get Flos Chrysanthemi Indici active component, i.e. chlorogenic acid and flavones ingredient 61.1g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (500mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 85.3g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 154.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.6g.
The preparation of Flos Chrysanthemi Indici active component: take by weighing Flos Chrysanthemi Indici medical material 3500g and be ground into coarse powder, the dynamic warm macerating of water (90 ℃) three times (1 hour, 1 hour, 0.5 hour), each amount of water is 8 times of amounts, immersion filters, and merges, and crosses D
101Macroporous resin, it is colourless that water is eluted to effluent, reuse 55% ethanol elution, the eluent concentrate under reduced pressure at low temperature is not to there being the alcohol flavor, adds the ethyl acetate extraction 2 times of 2 times of amounts, and ethyl acetate is evaporated on a small quantity, place crystallize, get Flos Chrysanthemi Indici active component, i.e. chlorogenic acid and flavones ingredient 59.6g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
Embodiment 5
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Radix Scrophulariae.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 84.1g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 159.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 54.1g.
The preparation of Radix Scrophulariae active component: take by weighing Radix Scrophulariae medical material 3500g and be ground into coarse powder, decoct with water three times, each extraction time is 1 hour, and the solvent consumption is respectively 7 times of amounts, 6 times of amounts, 6 times of amounts, extracting liquid filtering, and filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 70% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets Radix Scrophulariae active component 141.2g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7.5, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (500mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid. centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 84.1g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 160.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 57.4g.
The preparation of Radix Scrophulariae active component: take by weighing Radix Scrophulariae medical material 3500g and be ground into coarse powder, decoct with water three times, each extraction time is 1 hour, and the solvent consumption is respectively 7 times of amounts, 6 times of amounts, 6 times of amounts, extracting liquid filtering, and filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 70% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets Radix Scrophulariae active component 139.6g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
Embodiment 6
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Fructus Gardeniae.
The preparation method of injection:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 80.5g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 154.6g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 50.9g.
The preparation of Fructus Gardeniae active component: take by weighing Fructus Gardeniae medical material 3000g and be ground into coarse powder, decoct with water secondary, add 8 times of water gagings for the first time and extracted 2 hours, add 6 times of water gagings for the second time and extracted 1.5 hours, extracting liquid filtering, filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 70% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets Fructus Gardeniae active component 87.6g.
Get above active component and add water for injection, heated and stirred makes dissolving, transfers pH value to 6～7.5, adds active carbon heating 15 minutes, cooling filters, and adds the volume that the injection water is settled to regulation, with the 0.2 μ m microporous filter membrane fine straining of sterilizing, degerming, bottling, lyophilization gets 1000 bottles (500mg/ bottles).
The preparation method of capsule preparations:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.1g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 161.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.6g.
The preparation of Fructus Gardeniae active component: take by weighing Fructus Gardeniae medical material 3000g and be ground into coarse powder, decoct with water secondary, add 8 times of water gagings for the first time and extracted 2 hours, add 6 times of water gagings for the second time and extracted 1.5 hours, extracting liquid filtering, filtrate is crossed D
101Macroporous resin adsorption, with the remove impurity of purified water eluting, reuse 70% ethanol is resolved, and desorbed solution reclaims ethanol to there not being the alcohol flavor, and spray drying gets Fructus Gardeniae active component 88.6g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
Embodiment 7
It is characterized in that containing four kinds of natural drug materials, Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae and Rhizoma Polygoni Cuspidati.
The preparation method of capsule:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 82.5g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated-1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 163.5g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 55.4g.
The preparation of Rhizoma Polygoni Cuspidati active component: take by weighing Rhizoma Polygoni Cuspidati medical material 3500g and be ground into coarse powder, add 70% alcohol reflux twice, add 7 times of amount ethanol extractions 2 hours for the first time, add 5 times of amount ethanol extractions 2 hours for the second time.Merge extractive liquid, is evaporated to does not have the alcohol flavor, adds the ethyl acetate counter-current extraction 2 times of 2 times of amounts, and the extract normal pressure is concentrated on a small quantity, and water bath method must dry thing 71.2g.
Get that above four kinds of active component are pulverized, behind the mix homogeneously, add a certain amount of adjuvant mix homogeneously and incapsulate, make 1000 capsules (0.5g/ grain), aluminum-plastic packaged after package encapsulation again.
The preparation method of granular preparation is as follows:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 81.9g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 159.6g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 54.3g.
The preparation of Rhizoma Polygoni Cuspidati active component: take by weighing Rhizoma Polygoni Cuspidati medical material 3500g and be ground into coarse powder, add 70% alcohol reflux twice, add 7 times of amount ethanol extractions 2 hours for the first time, add 5 times of amount ethanol extractions 2 hours for the second time.Merge extractive liquid, is evaporated to does not have the alcohol flavor, adds the ethyl acetate counter-current extraction 2 times of 2 times of amounts, and the extract normal pressure is concentrated on a small quantity, and water bath method must dry thing 74.3g.
After getting above four kinds of active component pulverizing, mix homogeneously, add a certain amount of adjuvant mix homogeneously, make soft material in right amount with ethanol, the system granule, cold drying, granulate gets granule 1000g, is distributed into bag (a 1g/ bag).
The preparation method of tablet is as follows:
The preparation of Radix Bupleuri active component: get Radix Bupleuri medical material 3000g and be ground into coarse powder, add twice of 60% alcohol reflux, add for the first time 7 times of amount ethanol extractions 2 hours, the ethanol extraction 1.5 hours that adds for the second time 5 times of amounts, merge extracted twice liquid, being evaporated to does not have the alcohol flavor, adds 2 times of water gagings and stirs 20 minutes, leave standstill after 1 hour by tube centrifuge centrifugal, centrifugal liquid.Centrifugal liquid is crossed D
101Macroporous adsorbent resin is eluted to no color with purified water, and the ethanol of reuse 70% carries out eluting, collects eluent, and concentrating under reduced pressure, vacuum drying get Radix Bupleuri active component 81.6g.
Radix Scutellariae extracts baicalin: get radix scutellariae medicinal materials 3000g, be ground into coarse powder, the extracting in water secondary adds 8 times of water gagings for the first time, extracts 1 hour, adds 6 times of water gagings for the second time, extracts 1 hour.Filter, and squeeze out medicinal liquid in the filtering residue, merge, filter with extracted twice liquid.Filtrate adds 40% NaOH accent pH value to 8.0, fully stirs evenly, and leaves standstill 4 hours, filters.Filtrate is transferred pH value to 2.0 with hydrochloric acid, and 80 ℃ are incubated 1 hour down, must precipitate.Get precipitation and add NaOH solution and make fully dissolving, add 0.5% active carbon, fully stir, and 50 ℃ of insulations 30 minutes, filter.Filtrate adds hydrochloric acid and transfers pH value 2.0, filters to such an extent that precipitate.Get precipitation and add washing with alcohol, promptly get baicalin 158.3g.
The preparation of Rhizoma Belamcandae active component: get Rhizoma Belamcandae medical material 2500g, be ground into coarse powder, add 85% alcohol reflux three times, add for the first time 7 times of amount ethanol extractions 2 hours, add for the second time 5 times of amount ethanol extractions 1 hour, add 5 times of amount ethanol extractions 1 hour for the third time, merge three times extracting solution, reclaimed ethanol and added 2 times of water gaging heating for dissolving, cross tube centrifuge, twice of ethyl acetate extraction of centrifugal liquid, each consumption is 2 times of amounts, and normal pressure has reclaimed ethyl acetate, places and separates out precipitate, precipitate adds 95% ethyl alcohol recrystallization, gets Rhizoma Belamcandae active component 52.4g.
The preparation of Rhizoma Polygoni Cuspidati active component: take by weighing Rhizoma Polygoni Cuspidati medical material 3500g and be ground into coarse powder, add 70% alcohol reflux twice, add 7 times of amount ethanol extractions 2 hours for the first time, add 5 times of amount ethanol extractions 2 hours for the second time.Merge extractive liquid, is evaporated to does not have the alcohol flavor, adds the ethyl acetate counter-current extraction 2 times of 2 times of amounts, and the extract normal pressure is concentrated on a small quantity, and water bath method must dry thing 71.2g.
After getting above four kinds of active component pulverizing, mix homogeneously, add a certain amount of adjuvant mix homogeneously, make soft material in right amount with ethanol, the system granule, cold drying, tabletting behind the granulate gets 1000 (0.5g/ sheet).
Claims (10)
1. the Chinese medicine preparation of a heat-clearing and toxic substances removing, it is characterized in that, by Radix Bupleuri, Radix Scutellariae, Rhizoma Belamcandae be selected from: the raw material of Chinese medicine of Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Radix Scrophulariae, Flos Chrysanthemi Indici, Rhizoma Polygoni Cuspidati is made, in the preparation of per 1000 unit dose, raw materials used weight portion is as follows: 1500～6000 parts of Radix Bupleuri, 1500～6000 parts of Radix Scutellariaes, 1250～5000 parts of Rhizoma Belamcandae; 1500～6000 parts of Flos Loniceraes, 1500～6000 parts of Fructus Forsythiaes, 1500～6000 parts of Fructus Gardeniaes, 1750～7000 parts of Flos Chrysanthemi Indicis, 1750～7000 parts of Radix Scrophulariaes, 1750～7000 parts of Rhizoma Polygoni Cuspidati.
2. the Chinese medicine preparation of claim 1, it is characterized in that, in the preparation of per 1000 unit dose, raw materials used weight portion is as follows: 2500～4000 parts of Radix Bupleuri, 2500～4000 parts of Radix Scutellariaes, 2000～3000 parts of Rhizoma Belamcandae, 2500～4000 parts of Flos Loniceraes, 2500～4000 parts of Fructus Forsythiaes, 2500～4000 parts of Fructus Gardeniaes, 2500～4500 parts of Flos Chrysanthemi Indicis, 2500～4500 parts of Radix Scrophulariaes, 2500～4500 parts of Rhizoma Polygoni Cuspidati.
3. the Chinese medicine preparation of claim 1, it is characterized in that, in the preparation of per 1000 unit dose, raw materials used weight portion is as follows: 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae, 3000 parts of Flos Loniceraes, 3000 parts of Fructus Forsythiaes, 3000 parts of Fructus Gardeniaes, 3500 parts of Flos Chrysanthemi Indicis, 3500 parts of Radix Scrophulariaes, 3500 parts of Rhizoma Polygoni Cuspidati.
4. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Radix Scrophulariaes.
5. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Flos Chrysanthemi Indicis.
6. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Rhizoma Polygoni Cuspidati.
7. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Fructus Gardeniaes.
8. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Fructus Forsythiaes.
9. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 3000 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes, 2500 parts of Rhizoma Belamcandae and Flos Loniceraes.
10. the Chinese medicine preparation of claim 3 is characterized in that, the preparation of per 1000 unit dose is made by following Chinese medicinal raw materials, 2500 parts of 3000 parts of Radix Bupleuri, 3000 parts of Radix Scutellariaes and Rhizoma Belamcandae.
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| CN104435558B (en) * | 2014-12-29 | 2018-02-23 | 北京中研同仁堂医药研发有限公司 | A kind of Chinese medicine composition of dispelling wind cough-relieving and its preparation method and application |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102512533B (en) * | 2011-12-16 | 2013-08-28 | 曲靖开发区格力康生物科技发展有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof |
| CN107929359A (en) * | 2016-10-13 | 2018-04-20 | 广西普大动物保健品有限公司 | A kind of preparation process of high stability YINHUANG ZHUSHEYE |
| CN108992580B (en) * | 2018-09-25 | 2021-08-20 | 广西中医药大学附属瑞康医院 | Traditional Chinese medicine composition for eliminating phlegm and relieving cough and preparation method thereof |
| CN110538250A (en) * | 2019-08-27 | 2019-12-06 | 遵义医科大学第五附属(珠海)医院 | Traditional Chinese medicine composition for rapidly relieving throat pain and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1182616A (en) * | 1997-11-18 | 1998-05-27 | 付强 | Medicine for curing viral hepatitis |
| CN1398616A (en) * | 2002-08-21 | 2003-02-26 | 深圳市卓海科技文化实业有限公司 | Medicine for treating upper respiratory tract infection and its prepn |
-
2005
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1182616A (en) * | 1997-11-18 | 1998-05-27 | 付强 | Medicine for curing viral hepatitis |
| CN1398616A (en) * | 2002-08-21 | 2003-02-26 | 深圳市卓海科技文化实业有限公司 | Medicine for treating upper respiratory tract infection and its prepn |
Non-Patent Citations (4)
| Title |
|---|
| 张华年.肺炎喘舒液质量控制方法的研究.中国医院药学杂志19 1.1999,19(1),13-15. |
| 张华年.肺炎喘舒液质量控制方法的研究.中国医院药学杂志19 1.1999,19(1),13-15. * |
| 阿荣高娃.柴胡与黄芩伍用的抗病毒作用.内蒙古中医药18 增刊.1999,18(增刊),98. |
| 阿荣高娃.柴胡与黄芩伍用的抗病毒作用.内蒙古中医药18 增刊.1999,18(增刊),98. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435558B (en) * | 2014-12-29 | 2018-02-23 | 北京中研同仁堂医药研发有限公司 | A kind of Chinese medicine composition of dispelling wind cough-relieving and its preparation method and application |
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