CN104435558B - A kind of Chinese medicine composition of dispelling wind cough-relieving and its preparation method and application - Google Patents
A kind of Chinese medicine composition of dispelling wind cough-relieving and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition of dispelling wind cough-relieving, the Chinese medicine composition is formed by the parts by weight of radix bupleuri 6 10, the parts by weight of radix scutellariae 6 10, the parts by weight of schizonepeta 6 10, windproof 6 10 parts by weight, the parts by weight of sweet tussilago 6 10, stir-fry semen armeniacae amarae 69 parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 10 15, the parts by weight of dark plum 6 10, the parts by weight of rhizoma dioscoreae nipponicae 10 15, the parts by weight of giant knotweed 10 15, the parts by weight of blackberry lily 6 10, the parts by weight compatibility of licorice 36.The effect of Chinese medicine composition has dispelling wind facilitaing lung, relieving cough and reducing sputum, and spasmolysis is relievingd asthma, there is significant therapeutic effect especially in terms of cough variant asthma is treated, it is with strong points, recurrent exerbation is not easy after healing.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of Chinese medicine composition of dispelling wind cough-relieving and preparation method thereof and
Using.
Background technology
Cough variant asthma (Cough variant asthma, CVA) is also known as concealment type asthma or cough variant asthma, is
A kind of asthma of specific type, cough are its solely or mainly clinical manifestations, the Sx such as nothing is substantially panted, shortness of breath, but
It is due to that the respiratory tract of asthmatic patient persistently has the inflammation of allergy, bronchiolar epithelium swelling so that air flue is subendothelial
Stimulation receptor excitement threshold values be less than normal person, therefore have airway hyperreactivity, the irritability of various environmental stimuli things increased
Height, slightly stimulate and asthma just occurs, and be difficult to cure, easy recurrent exerbation, such as flu, cold air, dust, oil smoke are easy
Induce or aggravate cough.One of the main reason for CVA is chronic cough, in reporting at home, children CVA accounts for children chronic cough
34%.According to gram side's statistics is relied, in the cause of disease of Adult chronic's cough, CVA accounts for 10%-50%.Done in hospital of Tongji University
Found in one investigation, cough variant asthma is the most common reason for causing the elderly and non-senile chronic cough, respectively
34.6 and 41.5% are accounted for, adult CVA patient at least 30% can develop into typical asthma within a few years.Therefore, answering for CVA is prevented and treated
It is most important to send out and prevent that it from developing into typical asthma.CVA has increasingly caused the extensive concern of clinically doctor at present.
Cough variant asthma main clinical manifestation is excitant dry cough, and generally cough is more violent, and nocturnal cough is it
Key character.Flu, cold air, dust, oil smoke etc. easily induce or aggravated cough.
Though cough variant asthma will not threat to life continue and more in night-time attack or the spy of aggravation because it is long-term
Sign significantly reduces the quality of life of patient, if being treated without correct early intervention, not only easily recurrence, and easily developing
Into typical asthma.Again because CVA almost pants and symptom of have difficulty in breathing any, thus often failed to pinpoint a disease in diagnosis, mistaken diagnosis, misdiagnosis, many
Patient causes protracted inflammation to aggravate because of prolonged and repeated invalid use antibiotic and antitussive medicine.
The pathogenesis of cough variant asthma is not fully understood at present, its pathogenesis and typical bronchial astehma phase
Together, its pathomechanism is due to that large amount of cell factor, adhesion molecule, inflammatory cell and inflammatory mediator participate in airway allergic inflammation
Regulation.The modern medicine treatment sick to this, it is such more based on bronchodilator, powder for inhalation, leukotriene receptor regulation
Medicine short term efficacy is fine, but easily recurrence, and be also easy to produce resistance and toxicity, side effect is coughed after being discontinued, and patient compliance is poor,
Fundamentally chronic airway inflammation can not be made to be effectively controlled so that airway hyperreactivity declines, Cough reflex sensitivity reduces.Cause
And explore and find more effective treatment method and medicine be always the disease research an emphasis.
In recent years, the clinical practice of research and clinician for many years by traditional Chinese medicine extensively and profoundly, it was demonstrated that it not only has
There is good clinical efficacy, and compensate for the deficiencies of Western medicine clinical efficacy is bad and side effect is larger, therefore, controlled using traditional Chinese medicine
Cough variant asthma is treated more and more widely to be paid close attention to.Therefore, the invention provides one kind for treatment cough variant
The dispelling wind cough relief traditional Chinese medicine composition of asthma.
The content of the invention
Therefore, the technical problems to be solved by the invention are to provide a kind of Chinese medicine composition of dispelling wind cough-relieving, the Chinese medicine
The effect of composition has dispelling wind facilitaing lung, relieving cough and reducing sputum, and spasmolysis is relievingd asthma, have especially in terms of cough variant asthma is treated aobvious
The therapeutic effect of work, it is with strong points, recurrent exerbation is not easy after healing；And further disclose its preparation method and application.
In order to solve the above technical problems, the invention provides a kind of Chinese medicine composition of dispelling wind cough-relieving, the Chinese traditional medicine composition
The bulk drug of thing forms：Radix bupleuri 6-10 parts by weight, radix scutellariae 6-10 parts by weight, schizonepeta 6-10 parts by weight, windproof 6-10 parts by weight,
Sweet tussilago 6-10 parts by weight, fry semen armeniacae amarae 6-9 parts by weight, stir-baked RADIX PAEONIAE ALBA 10-15 parts by weight, dark plum 6-10 parts by weight, rhizoma dioscoreae nipponicae
10-15 parts by weight, giant knotweed 10-15 parts by weight, blackberry lily 6-10 parts by weight, licorice 3-6 parts by weight.
The Chinese medicine composition of described dispelling wind cough-relieving, the bulk drug composition of the Chinese medicine composition are：The parts by weight of radix bupleuri 8,
The parts by weight of radix scutellariae 8, the parts by weight of schizonepeta 8, windproof 8 parts by weight, the parts by weight of sweet tussilago 8, stir-fry semen armeniacae amarae 7 parts by weight, stir-baked RADIX PAEONIAE ALBA 13
Parts by weight, the parts by weight of dark plum 8, the parts by weight of rhizoma dioscoreae nipponicae 13, the parts by weight of giant knotweed 13, the parts by weight of blackberry lily 8, the parts by weight of licorice 4；Or
The parts by weight of radix bupleuri 6, the parts by weight of radix scutellariae 10, the parts by weight of schizonepeta 6, windproof 10 parts by weight, the parts by weight of sweet tussilago 6, stir-fry
The parts by weight of semen armeniacae amarae 9, the parts by weight of stir-baked RADIX PAEONIAE ALBA 10, the parts by weight of dark plum 10, the parts by weight of rhizoma dioscoreae nipponicae 10, the parts by weight of giant knotweed 15, the weight of blackberry lily 6
Measure part, the parts by weight of licorice 6；Or
The parts by weight of radix bupleuri 10, the parts by weight of radix scutellariae 6, the parts by weight of schizonepeta 10, windproof 6 parts by weight, the parts by weight of sweet tussilago 10, stir-fry
The parts by weight of semen armeniacae amarae 6, the parts by weight of stir-baked RADIX PAEONIAE ALBA 15, the parts by weight of dark plum 6, the parts by weight of rhizoma dioscoreae nipponicae 15, the parts by weight of giant knotweed 10, the weight of blackberry lily 10
Measure part, the parts by weight of licorice 3；Or
The parts by weight of radix bupleuri 7, the parts by weight of radix scutellariae 9, the parts by weight of schizonepeta 7, windproof 9 parts by weight, the parts by weight of sweet tussilago 7, stir-fry are bitter
The parts by weight of almond 8, the parts by weight of stir-baked RADIX PAEONIAE ALBA 12, the parts by weight of dark plum 9, the parts by weight of rhizoma dioscoreae nipponicae 12, the parts by weight of giant knotweed 14, the weight of blackberry lily 7
Part, the parts by weight of licorice 5；Or
The parts by weight of radix bupleuri 9, the parts by weight of radix scutellariae 7, the parts by weight of schizonepeta 9, windproof 7 parts by weight, the parts by weight of sweet tussilago 9, stir-fry are bitter
The parts by weight of almond 7, the parts by weight of stir-baked RADIX PAEONIAE ALBA 14, the parts by weight of dark plum 7, the parts by weight of rhizoma dioscoreae nipponicae 14, the parts by weight of giant knotweed 11, the weight of blackberry lily 9
Part, the parts by weight of licorice 4.
By above-mentioned Chinese medicine composition selectively addition customary adjuvant, clinically-acceptable system is made according to common process
Agent.
Preferably, described preparation includes granule, capsule, oral liquid, powder, pill or tablet.
The invention provides a kind of method for the Chinese medicine composition for preparing described dispelling wind cough-relieving, methods described includes as follows
Step：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA,
Dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder extracting in water is taken, filters and gained filtrate decompression is concentrated into acquisition clear cream；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to routine
Clinically acceptable formulation is made in technique.
Preferably, the preparation method of the Chinese medicine composition of described dispelling wind cough-relieving, methods described comprise the following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA,
Dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 1-3 times, each 1-3 hours, each 8-12 times of fine powder weight of addition
Water, filter and gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.10-1.30；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to routine
Clinically acceptable formulation is made in technique.
Preferably, the preparation method of the Chinese medicine composition of described dispelling wind cough-relieving, methods described comprise the following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA,
Dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, the
The secondary water for adding 8 times of fine powder weight, filters and gained filtrate decompression is concentrated into relative density 1.10-1.30 at 50 DEG C
Clear cream；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to routine
Clinically acceptable formulation is made in technique.
Preferably, the preparation method of the Chinese medicine composition of described dispelling wind cough-relieving, methods described comprise the following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA,
Dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, the
The secondary water for adding 8 times of fine powder weight, filters and gained filtrate decompression is concentrated into relative density 1.10-1.15 at 50 DEG C
Clear cream；
(3) clear cream of acquisition is spray-dried, dried cream powder is made, then selective addition customary adjuvant, according to
Clinically acceptable formulation is made in common process.
Preferably, the preparation method of the Chinese medicine composition of described dispelling wind cough-relieving, methods described comprise the following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA,
Dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, the
The secondary water for adding 8 times of fine powder weight, filters and gained filtrate decompression is concentrated into relative density 1.25-1.30 at 50 DEG C
Clear cream；
(3) clear cream of acquisition is subjected to vacuum belt type drying, dried cream powder is made, then selective addition customary adjuvant,
Clinically acceptable formulation is made according to common process.
Preferably, the preparation method of described dispelling wind cough relief traditional Chinese medicine composition, in the step (3), the accessory package
Include Steviosin, silica and dextrin.
The invention provides a kind of Chinese medicine composition being prepared by above-mentioned method.
Present invention also offers a kind of described Chinese medicine composition in the medicine for preparing treatment cough variant asthma
Purposes.
The Chinese medicine composition of dispelling wind cough-relieving of the present invention, with radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry it is bitter
Almond, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily and licorice are that bulk drug is made with dispelling wind facilitaing lung, relieving cough and reducing sputum, solution
The Chinese medicine composition for the effect of convulsion is relievingd asthma.In described pharmaceutical composition, using radix bupleuri, radix scutellariae as monarch, the few sun of profit is dredged, and in inducing diaphoresis,
Removing heat from the lung to relieve cough.In ministerial drug：Schizonepeta, windproof, the saturating table of dispelling wind, facilitaing lung cough-relieving in side；Almond, coltsfoot, respectful lung drop is inverse, and cough-relieving is put down
Asthma, is combined into ministerial drug, and the one rise and one drop of this compatibility, one opens a conjunction, and lung qi can be helped to recover its a surname's hair, physiological function of respectful drop.Helping
In medicine：The root of herbaceous peony, dark plum are sour, soft liver spasmolysis, astringe the lung to stop cough；Blackberry lily bitter cold, clearing heat and detoxicating, relieving sore-throat dissolving phlegm；Rhizoma dioscoreae nipponicae mild in medicine property
With kobadrin, spasmolysis is relievingd asthma；Giant knotweed is clearing heat and detoxicating, relieving cough and reducing sputum, clear purging the lung of pathogenic fire and the heat of large intestine, rushes down intestines and protects lung；All medicines close and
Relieving cough and reducing sputum with removing heat from the lung and relieving sorethroat, spasmolysis is relievingd asthma function.Using licorice as medicine is made, there is clearing heat and detoxicating, relieving cough and reducing sputum, mediation
The energy of all medicines.
Pharmaceutical composition primary treatment cough variant asthma illness of the present invention, in treatment cough variant asthma side
Mask is targetedly strong, and therapeutic effect is notable, and is not easy the notable technique effect such as recurrent exerbation, feeds back afterwards by clinic application, should
Side's treatment cough variant asthma is safely, effectively；Pharmaceutical composition of the present invention is foundation traditional medical theory, and combines Shen
Ask someone clinical experience for many years, for the etiology and pathogenesis of cough variant asthma, establish with dispelling wind facilitaing lung, relieving cough and reducing sputum, spasmolysis
The method compatibility prescription relievingd asthma, the prescription are added and subtracted by traditional recipe Xiao Chaihu Tang, are followed the example of Xiao Chaihu Tang harmonizing Sharyang, are dredged
Meaning in sharp mechanism of qi, sensible table, relieving cough and reducing sputum in the hope of dispelling wind facilitaing lung, the work(that spasmolysis is relievingd asthma.
The Chinese medicine composition preparation method of dispelling wind cough-relieving of the present invention is simple, easy to operate, is selected by adjusting bulk drug
Select suitable extracting method so that active constituent content improves in manufactured Chinese medicine composition, and then improves to cough variant
The therapeutic effect of asthma.
Experimental example
The mouse ammoniacal liquor antibechic experimental study of dispelling wind cough-relieving side decocting liquid described in experimental example 1
1. experiment purpose
Tested by mouse ammoniacal liquor antibechic, observation dispelling wind cough-relieving side's decocting liquid is to the cough caused number of mouse Ammonia Process and cough
Cough preclinical influence, the antitussive effect of preliminary assessment dispelling wind cough-relieving side decocting liquid.
2. experiment material
2.1 test medicine
Dispelling wind cough-relieving side decocting liquid is prepared as steps described below：(1) radix bupleuri 6g, radix scutellariae 10g, schizonepeta are weighed respectively
6g, windproof 10g, sweet tussilago 6g, fry semen armeniacae amarae 9g, stir-baked RADIX PAEONIAE ALBA 10g, dark plum 10g, rhizoma dioscoreae nipponicae 10g, giant knotweed 15g, blackberry lily 6g,
Licorice 6g, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) take above-mentioned fine powder to add water to cook 1 time, add the water of 12 times of fine powder weight, decoct 3 hours, merging and mistake
Filter gained decoction liquor, produces dispelling wind cough-relieving side decocting liquid, specification is 130ml decocting liquids crude drug containing 130g.
2.2 reagent
Ammoniacal liquor：Specification is pure to analyze, and is provided by Xilong Chemical Co., Ltd, lot number 120229.2.3 experimental animal
And raising situation
(1) experimental animal
ICR mouse, SPF levels, male, body weight 18g-22g, purchased from Laboratory Animal Science portion of Department Of Medicine, Peking University.License
Card numbering：SCXK (capital) 2011-0012.
(2) feed
Mouse material is maintained, is pulled together feed corporation,Ltd purchased from Beijing Australia of section.Credit number：SCXK (capital) 2009-0012.
(3) rearing conditions
By above-mentioned experimental animal feeding in SPF levels animal housing, using fluorescent lamp lighting, the 12h light and shade cycles alternately raise,
Free water, diet, 22 DEG C ± 2 DEG C of environment temperature, blow 6 times -10 times/h.
2.4 laboratory apparatus
Stethoscope.
Glass funnel.
Europe Asia WB388 electronic timers, purchased from Europe Asia trade (Shanghai) Co., Ltd..
Haier BCD-257SL refrigerating refrigerators, purchased from Qingdao HaiEr Co., Ltd.
H102-4 Manual counters.
3. experimental method
3.1 dosages are set
(1) dispelling wind cough-relieving side decocting liquid
Dosage setting is carried out according to compound quantity.Clinical polypharmacy amount is 130g/ people/day, orally.Decocting liquid is given birth to
Medicine content is 130g crude drugs/130ml decocting liquids (1：1).
This experiment setting 9 times of mouse bioequivalence dosage behaviour clinical application amount, people's standard weight are drafted as 60kg,
Therefore the equivalent dosage of mouse is 130g crude drug ÷ 60kg × 9=19.5g crude drugs/kg ≈ 20g crude drugs/kg, and this behaviour is faced
Bed dose,equivalent.
3.2 medicines are prepared
(1) by 1 times of distilled water diluting of the test medicine, it is configured to (1：2) dilution.
3.3 zooperies are grouped
After experimental animal adaptability is raised 3 days, mouse is randomly divided into 3 groups, every group 12 by body weight.Respectively：Model group,
Dispelling wind cough-relieving side decocting liquid high dose group, dispelling wind cough-relieving side decocting liquid low dose group.
3.3 medication
Method of administration is oral pipe gastric infusion, and gastric infusion volume is 0.2ml/10g body weight mouse.
Dispelling wind cough-relieving side decocting liquid high dose group gives dispelling wind cough-relieving side decocting liquid 0.2ml/10g body weight mouse, and (20g gives birth to
Medicine/kg)；Dispelling wind cough-relieving side decocting liquid low dose group gives dispelling wind cough-relieving side decocting liquid dilution 0.2ml/10g body weight mouse
(10g crude drugs/kg)；Model group gives isometric distilled water.
3.4 experimental method
Gavage gives institute's reagent thing to each group mouse respectively, 1 times/day, successive administration 5 days.1h after last dose, mouse is put
In the interior glass funnel for putting ammoniacal liquor infiltration cotton balls (μ l of ammoniacal liquor 70 is added dropwise in 10mg ± 0.1mg, every cotton balls in cotton balls quality control)
In, being listened to stethoscope and recording mouse ammoniacal liquor in 5min stimulates caused cough latent period and cough number.
4. statistical method
Experimental data is with " mean+SD" represent.Data first carry out homogeneity test of variance.Variance is neat
From One-Way ANOVA methods between each group compare；Heterogeneity of variance is examined from t ' and compare between group.
5. experimental result
The dispelling wind cough-relieving side decocting liquid of table 1 causes the influence of mouse cough incubation period and number to ammoniacal liquor
Compared with model group：*P<0.05；**P<0.01；***P<0.001。
Experimental result shows that dispelling wind cough-relieving side decocting liquid high and low dose group can extend the latent of ammoniacal liquor induced mice cough
Fu Qi, relatively there is significant difference (equal p with model group<0.001).Two groups of medicines can reduce cough in ammoniacal liquor induced mice 5min
The number coughed, relatively there is significant difference (p respectively with model group<0.01, p<0.05).
As a result show that dispelling wind cough-relieving side decocting liquid high and low dose group has good mouse Ammonia Process antibechic effect, respectively
Equivalent to 1 times and 1/2 times of clinical crude drug dosage.
The dispelling wind cough-relieving side decocting liquid of experimental example 2 is to cavy citric acid antibechic experimental study
1. experiment purpose
Tested by cavy citric acid antibechic, observation dispelling wind cough-relieving side's decocting liquid is to the cough caused number of cavy citron acid system
Influence, the antitussive effect of preliminary assessment dispelling wind cough-relieving side decocting liquid.
2. experiment material
2.1 test medicine
Dispelling wind cough-relieving side decocting liquid is prepared as steps described below：(1) radix bupleuri 6g, radix scutellariae 10g, schizonepeta are weighed respectively
6g, windproof 10g, sweet tussilago 6g, fry semen armeniacae amarae 9g, stir-baked RADIX PAEONIAE ALBA 10g, dark plum 10g, rhizoma dioscoreae nipponicae 10g, giant knotweed 15g, blackberry lily 6g,
Licorice 6g, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) take above-mentioned fine powder to add water to cook 1 time, add the water of 12 times of fine powder weight, decoct 3 hours, merging and mistake
Filter gained decoction liquor, produces dispelling wind cough-relieving side decocting liquid；Specification：6.792g crude drugs/g decocting liquids.
2.2 reagent
Citric acid：Specification is pure to analyze, and is provided by Beijing Chemical Plant, lot number 20091009.
2.3 experimental animals and raising situation
(1) experimental animal
Cavy, regular grade, male, body weight 180g-220g, purchased from auspicious sign experimental animal plant of Beijing sea section.Licensing
Numbering：SCXK (capital) 2011-0009.
(2) feed
Common cavy full-valence pellet feed II, pull together feed corporation,Ltd purchased from Beijing Australia of section.Credit number：SCXK
(capital) 2009-0012.
(3) rearing conditions
By above-mentioned experimental animal feeding in Ordinary Animal Lab, using fluorescent lamp lighting, the 12h light and shade cycles alternately raise
Support, free water, diet, 22 DEG C ± 2 DEG C of environment temperature, blow 6 times -10 times/h.
2.4 laboratory apparatus
4L glass desicators.
Europe Asia WB388 electronic timers：Europe Asia trade (Shanghai) Co., Ltd..
Haier BCD-257SL refrigerating refrigerators, purchased from Qingdao HaiEr Co., Ltd.
H102-4 Manual counters.
402AL ultrasonic atomizers, purchased from Jiangsu Yuyue Medical Equipment Inc.
3. experimental method
3.1 dosages are set
(1) dispelling wind cough-relieving side decocting liquid
Dosage setting is carried out according to compound people quantity.Clinical polypharmacy amount is 130g/ people/day, orally.Extract
Crude drug content is 6.792g crude drugs/g decocting liquids.
This experiment setting 6 times of cavy bioequivalence dosage behaviour clinical application amount, people's standard weight are drafted as 60kg,
Therefore the equivalent dosage of cavy is 130g crude drug ÷ 60kg × 6=13g crude drugs/kg, and being converted to extract doses is
1.914g/kg, this behaviour clinical equivalent dosage.
3.2 medicines are prepared
(1) test medicine is configured to 3.83% and 1.915% aqueous solution respectively with distilled water.
(2) citric acid：Citric acid is configured to 17.5% aqueous solution with distilled water.
3.3 zooperies are grouped
After experimental animal adaptability is raised 3 days, the screening of qualified cavy is carried out.Screening technique is as follows：
Cavy is placed in closed 4L driers, drying is sprayed into after 17.5% citric acid is atomized with ultrasonic atomizer
In device, spray time 1min, after observation spraying in 5min cavy cough number, cavy of the cough number less than 10 times picked
Remove.Qualified cavy is randomly divided into 3 groups, every group 12, is respectively：Model group, dispelling wind cough-relieving side decocting liquid high dose group, dispelling wind
Cough-relieving side's decocting liquid low dose group.
3.4 medication
Method of administration is oral pipe gastric infusion, and gastric infusion volume is 0.5ml/100g body weight cavys.
Dispelling wind cough-relieving side decocting liquid high dose group gives dispelling wind cough-relieving side decocting liquid 1.914g/kg (13g crude drugs/kg)；Dredge
Wind cough-relieving side decocting liquid low dose group gives dispelling wind cough-relieving side decocting liquid 0.957g/kg (6.5g crude drugs/kg)；Model group is given
Volume distilled water.
3.5 experimental method
Gavage gives institute's reagent thing to each group cavy respectively, 1 times/day, successive administration 3 days.1h after last dose, according to above-mentioned
Animal screening procedure carries out cavy citric acid irritative cough experiment, and listening to and recording cavy citric acid in 5min stimulates caused cough
Cough incubation period and cough number.
4. statistical method
Experimental data is with " mean+SD" represent.Data first carry out homogeneity test of variance.Variance is neat
From One-Way ANOVA methods between each group compare；Heterogeneity of variance is examined from t ' and compare between group.
5. experimental result
The dispelling wind cough-relieving side decocting liquid of table 2 causes the influence of guinea pig cough's incubation period and number to citric acid
Compared with model group：*P<0.05。
Experimental result shows, guinea pig cough's caused by dispelling wind cough-relieving side decocting liquid high and low dose group can extend citric acid
In incubation period, relatively there is significant difference (equal p with model group<0.05).Dispelling wind cough-relieving side decocting liquid low dose group can reduce citron
The number of cough, relatively there is significant difference (p with model group in cavy 5min caused by acid<0.05).
As a result show that dispelling wind cough-relieving side decocting liquid high and low dose group has good antibechic effect, be respectively equivalent to clinic
1 times of crude drug dosage and 1/2 times.
Dispelling wind cough-relieving formula extraction dose gradient screening pharmacodynamic experiment research-mouse ammoniacal liquor antibechic is real described in experimental example 3
Test
1. experiment purpose
Tested by mouse ammoniacal liquor antibechic, observation dispelling wind cough-relieving formula extraction difference graded doses are to caused by mouse Ammonia Process
The influence for number and the cough latent period of coughing, it is pharmacodynamics, safety evaluatio and the dosage of preparation process research of tested material
Set and reference data is provided.
2. experiment material
2.1 test medicine
(1) Godeine and Guaifenesin Syrup：Beijing Huarun High-Tech Natural Pharmaceutical Co., Ltd., lot number 271014.
(2) the dispelling wind cough-relieving formula extraction is prepared as steps described below：(1) radix bupleuri 6g, radix scutellariae 10g, chaste tree are weighed respectively
Mustard 6g, windproof 10g, sweet tussilago 6g, stir-fry semen armeniacae amarae 9g, stir-baked RADIX PAEONIAE ALBA 10g, dark plum 10g, rhizoma dioscoreae nipponicae 10g, giant knotweed 15g, blackberry lily
6g, licorice 6g, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) take above-mentioned fine powder to add water to cook 1 time, add the water of 12 times of fine powder weight, decoct 3 hours, merging and mistake
Filter gained decoction liquor, gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.15, produced, lot number is
20131209；Character is light yellowish brown powder, and mildly bitter flavor, acid are soluble in water；Specification is 4.0g crude drugs/g extracts.
2.2 reagent
Ammoniacal liquor：Specification is pure to analyze, and is provided by Xilong Chemical Co., Ltd, lot number 120229.2.3 experimental animal
And raising situation
(1) experimental animal
ICR mouse, SPF levels, male and female half and half, body weight 18g-22g, purchased from Laboratory Animal Science portion of Department Of Medicine, Peking University.
Licensing is numbered：SCXK (capital) 2011-0012.
(2) feed
Mouse material is maintained, is pulled together feed corporation,Ltd purchased from Beijing Australia of section.Credit number：SCXK (capital) 2009-0012.
(3) rearing conditions
By above-mentioned experimental animal feeding in SPF levels animal housing, using fluorescent lamp lighting, the 12h light and shade cycles alternately raise,
Free water, diet, 22 DEG C ± 2 DEG C of environment temperature, blow 6 times -10 times/h.
2.4 laboratory apparatus
Stethoscope.
Glass funnel.
Europe Asia WB388 electronic timers：Europe Asia trade (Shanghai) Co., Ltd..
Haier BCD-257SL refrigerating refrigerators：Qingdao HaiEr Co., Ltd.
H102-4 Manual counters.
3. experimental method
3.1 dosages are set
The dispelling wind cough-relieving formula extraction crude drug content is " 4g crude drugs/g extracts ", and people's clinic crude drug dose is
" 130g crude drugs/day/", human body, which is reseted, is set to 60kg, and it is " 33g extracts/day " to take dispelling wind cough-relieving formula extraction dosage equivalent day.
Dose gradient screening study sets 5 dose gradients altogether：With " 33g extracts/day " for maximum dose；Using 12g as ladder
Degree, equal difference, which is successively decreased, sets 2 dosage, is respectively " 21g extracts/day ", " 9g extracts/day "；" 9g extracts/day " using 3g as
Gradient, equal difference, which is successively decreased, sets 2 dosage, is respectively " 6g extracts/day ", " 3g extracts/day ".This stops to intend the dispelling wind of research
Cough formula extraction people's extract doses.
Dose gradient exploratory development is mouse from experimental animal, be converted into mouse dosage for " 4.95g extracts/kg,
3.15g extracts/kg, 1.35g extract/kg, 0.90g extract/kg, 0.45g extract/kg ", are respectively equivalent to crude drug agent
Measure as " 19.80g crude drugs/kg, 12.60g crude drug/kg, 3.60g crude drug/kg, 1.80g crude drug/kg, 0.90g crude drug/kg ".
Godeine and Guaifenesin Syrup day for human beings dose is 30ml/60kg/ days, and the dose for being converted into mouse is 4.5ml/kg/ days.
The given the test agent mouse taking dose of table 3
3.2 medicines are prepared
The extract medicine of various dose is configured according to above-mentioned mouse dose and mouse stomach volume, mouse stomach body
Product is 20ml/kg body weight, and solvent is water.
The given the test agent mouse stomach solution concentration of table 4
3.3 zooperies are grouped
After experimental animal adaptability is raised 3 days, mouse is randomly divided into 7 groups, every group 10.Respectively：Model group, can be more sugared
Slurry group, dispelling wind cough-relieving formula extraction dosage I groups, dispelling wind cough-relieving formula extraction dosage II groups, dispelling wind cough-relieving formula extraction dosage III
Group, dispelling wind cough-relieving formula extraction dosage IV groups, dispelling wind cough-relieving formula extraction dosage V.
3.4 experimental method
Gavage gives institute's reagent thing to each group mouse respectively, 1 times/day, successive administration 5 days.1h after last dose, mouse is put
In the interior glass funnel for putting ammoniacal liquor infiltration cotton balls (μ l of ammoniacal liquor 70 is added dropwise in 10mg ± 0.1mg, every cotton balls in cotton balls quality control)
In, being listened to stethoscope and recording mouse ammoniacal liquor in 5min stimulates caused cough latent period and cough number.
4. statistical method
Experimental data is with " mean+SD" represent.Data first carry out homogeneity test of variance.Variance is neat
From One-Way ANOVA methods between each group compare；Heterogeneity of variance is examined from t ' and compare between group.
5. experimental result
Influence of the dispelling wind cough-relieving formula extraction of table 5 to mouse ammoniacal liquor cough latent period and cough number
Compared with model group：*P<0.05, * * P<0.01, * * * P<0.001.
Experimental studies results are shown, compared with model group, it is small that Godeine and Guaifenesin Syrup group (4.5ml/kg) can significantly extend ammoniacal liquor cause
Mouse cough latent period and interior cough number (the equal p of reduction mouse 5min<0.001).Compared with model group, dispelling wind cough-relieving formula extraction
Dosage V groups (0.45g/kg) cause mouse cough incubation period and cough number not to make significant difference (p to ammoniacal liquor>0.05)；Dispelling wind stops
Cough formula extraction dosage I, II, III group (4.95g/kg, 3.15g/kg, 1.35g/kg) can extend ammoniacal liquor and cause mouse cough to dive
Volt phase (p respectively<0.01,0.05,0.05)；Dispelling wind cough-relieving formula extraction dosage I, II, III, IV group (4.95g/kg, 3.15g/
Kg, 1.35g/kg, 0.90g/kg) it can reduce ammoniacal liquor cause mouse cough number (p respectively<0.001,0.01,0.05,0.05).
This result of study shows that the effective dose of dispelling wind cough-relieving formula extraction mouse ammoniacal liquor antibechic experiment is 0.90g/kg,
Equivalent people is 0.9g/kg (mouse) ÷ 9 (conversion factor 9) × 60kg (drafting body weight for each person)=6g/60kg/ with dosage
Day.
According to the studies above result, pharmacodynamic experiment research dispelling wind cough-relieving formula extraction middle dosage is set as 6g/60kg/ people
Day, high dose is 9g/60kg/ people/day, and low dosage installation warrants are according to the following formula：
X=4, i.e. low dosage are 4g/60kg/ people/day.
The extraction process screening test of experimental example 4
1. experiment purpose
Tested by mouse ammoniacal liquor antibechic, Chinese medicine composition prepared by observation dispelling wind cough-relieving side different process route is to mouse
The influence of the cough caused number of Ammonia Process and cough latent period, pharmacodynamic study is carried out to the reasonability of different process route, is
Further process route confirms to provide pharmacodynamic experiment data.
2. experiment material
2.1 test medicine
(1) Godeine and Guaifenesin Syrup：The double crane high-tech natural drug Co., Ltds in Beijing, lot number 271342.
(2) technique I extracts (obtained clear cream after the contracting of the reclaimed water concentrate of embodiment 1)：Specification is 2.106g crude drugs/g extractions
Thing.
(3) technique II extracts (add the ethanol that mass concentration is 50-80% in the Aqueous extracts obtained into embodiment 1
Solution, alcohol precipitation, filtering, produce)；Specification is 3.514g crude drugs/g extracts.
(4) technique III extracts：Prepared according to method described in embodiment 1, it is differed only in：Take radix bupleuri, schizonepeta,
Windproof, sweet tussilago, semen armeniacae amarae is fried, add water to cook gained decoction liquor；And remaining radix scutellariae, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed,
Blackberry lily, licorice, the ethanol solution that mass concentration is 70% is added after crushing and sieving and is extracted, obtains alcohol extract；Described in merging
Decoction liquor and alcohol extract, are concentrated into clear cream：Specification is 2.259g crude drugs/g extracts.
2.2 reagent
Ammoniacal liquor：Specification is pure to analyze, and is provided by Xilong Chemical Co., Ltd, lot number 120229.
2.3 experimental animals and raising situation
(1) experimental animal
ICR mouse, SPF levels, male, body weight 18g-22g, purchased from Laboratory Animal Science portion of Department Of Medicine, Peking University.License
Card numbering：SCXK (capital) 2011-0012.
(2) feed
Mouse material is maintained, is pulled together feed corporation,Ltd purchased from Beijing Australia of section.Credit number：SCXK (capital) 2009-0012.
(3) rearing conditions
By above-mentioned experimental animal feeding in SPF levels animal housing, using fluorescent lamp lighting, the 12h light and shade cycles alternately raise,
Free water, diet, 22 DEG C ± 2 DEG C of environment temperature, blow 6 times -10 times/h.
2.4 laboratory apparatus
Glass beaker.
Europe Asia WB388 electronic timers, provided by Europe Asia trade (Shanghai) Co., Ltd..
Haier BCD-257SL refrigerating refrigerators, are provided by Qingdao HaiEr Co., Ltd.
H102-4 Manual counters.
3. experimental method
3.1 dosages are set
Crude drug amount contained by the extract prepared according to different process and people's clinical application amount carry out mouse dose setting, each
Than (0.65) 3 dose gradients such as technique extract setting.The dose gradient of people's clinic crude drug dosage be 130g, 84.50g,
54.93g crude drugs/60kg/ days；Being converted into mouse dosage, (people and mouse dose change for 19.50g, 12.68g, 8.24g crude drug/kg/ days
Coefficient is calculated as 9), given the test agent mouse taking dose see the table below.
Godeine and Guaifenesin Syrup day for human beings dose is 30ml/60kg/ days, and the dose of equivalent mouse is 4.5ml/kg/ days, test sample
Product mouse taking dose see the table below.
The given the test agent mouse taking dose of table 6
3.2 medicines are prepared
Extract medicine prepared by different process is configured according to above-mentioned mouse dose and mouse stomach volume, and mouse fills
Stomach volume is 20ml/kg body weight, and solvent is water, given the test agent mouse stomach solution concentration.
The given the test agent mouse stomach solution concentration of table 7
3.3 zooperies are grouped
After experimental animal adaptability is raised 3 days, mouse is randomly divided into 11 groups, every group 12.Respectively：Technique I extracts
High, medium and low dosage group, the high, medium and low dosage group of technique II extracts, the high, medium and low dosage group of technique III extracts can be more sugared
Slurry group, model group.
3.4 experimental method
Gavage gives given the test agent to each group mouse respectively, 1 times/day, successive administration 5 days.1h after last dose, mouse is put
Infiltrated in interior ammoniacal liquor of putting in the beaker of cotton balls (μ l of ammoniacal liquor 100 is added dropwise in 30mg ± 0.1mg, every cotton balls in cotton balls quality control),
Observing and recording mouse ammoniacal liquor in 5min stimulates caused cough latent period and cough number.
4. statistical method
Experimental data is with " mean+SD" represent.Data first carry out homogeneity test of variance.Variance is neat
From One-Way ANOVA methods between each group compare；Heterogeneity of variance is examined from t ' and compare between group.
5. experimental result
Influence of the dispelling wind cough-relieving extraction by different technology thing of table 8 to mouse ammoniacal liquor cough latent period and cough number
Compared with model group：*P<0.05, * * P<0.01, * * * P<0.001.
Experimental studies results are shown, compared with model group, it is small that Godeine and Guaifenesin Syrup group (4.5ml/kg) can significantly extend ammoniacal liquor cause
Mouse cough latent period (p<0.05) and in reduction mouse 5min cough number (p<0.001), there is preferable antibechic effect.
The high, medium and low dosage group of technique I extracts can significantly extend ammoniacal liquor and cause mouse cough incubation period, (p respectively<0.5,
0001,0.01)；Three groups can reduce cough number in mouse 5min, relatively there is significant difference (p respectively with model group<
0.001,0.01,0.001).Show that technique I extracts have preferable antibechic effect.
Although the high, medium and low dosage group of technique II extracts, which has, extends the ammoniacal liquor cause preclinical trend of mouse cough, with
Model group compares no difference of science of statistics, (equal p>0.05)；Three groups can reduce cough number in mouse 5min, compared with model group
There is significant difference (p respectively<0.05,0.01,0.05).Show that technique II extracts also have preferable antibechic effect.
Although the high, medium and low dosage group of technique III extracts, which has, extends the ammoniacal liquor cause preclinical trend of mouse cough,
The no difference of science of statistics compared with model group, (equal p>0.05)；Three groups can reduce cough number in mouse 5min, with model group ratio
Relatively there is significant difference (p respectively<0.01,0.05,0.05).Show that technique III extracts also have preferable antibechic effect.
Above-mentioned experimental result shows that three technique extracts, which are stimulated mouse ammoniacal liquor, different degrees of antibechic effect.
Three kinds of extraction processes prepare extract in the case of identical crude drug taking dose, and technique I antibechic effect is the most notable, can be simultaneously
Extend cough latent period and reduce cough number；Technique II, III extract only has an impact to cough number, but latent to coughing
Phase does not make significant difference.
In summary, the extract that prepared by three kinds of processes can reach preferable antibechic effect, wherein technique I extractions
Thing effect is the most notable, and technique I preparation methods are based on water extraction, high with clinical prescription decocting preparation method uniformity, can make
Carry out follow-up pharmaceutical procedures research for selection process.
Embodiment
Embodiment 1
【Prescription】Radix bupleuri 6g, radix scutellariae 10g, schizonepeta 6g, windproof 10g, sweet tussilago 6g, fry semen armeniacae amarae 9g, stir-baked RADIX PAEONIAE ALBA 10g,
Dark plum 10g, rhizoma dioscoreae nipponicae 10g, giant knotweed 15g, blackberry lily 6g, licorice 6g.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) take above-mentioned fine powder to add water to cook 1 time, add the water of 12 times of fine powder weight, decoct 3 hours, merging and mistake
Filter gained decoction liquor, gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.30；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to routine
Clinically acceptable granule is made in technique.
Embodiment 2
【Prescription】Radix bupleuri 10g, radix scutellariae 6g, schizonepeta 10g, windproof 6g, sweet tussilago 10g, fry semen armeniacae amarae 6g, stir-baked RADIX PAEONIAE ALBA 15g,
Dark plum 6g, rhizoma dioscoreae nipponicae 15g, giant knotweed 10g, blackberry lily 10g, licorice 3g.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) take above-mentioned fine powder to add water to cook 3 times, 3 hours every time, add the water of 8 times of fine powder weight every time, merge simultaneously
Filtering gained decoction liquor, gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.10；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to routine
Clinically acceptable oral liquid is made in technique.
Embodiment 3
【Prescription】The parts by weight of radix bupleuri 7, the parts by weight of radix scutellariae 9, the parts by weight of schizonepeta 7, windproof 9 parts by weight, the weight of sweet tussilago 7
Part, fry semen armeniacae amarae 8 parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 12, the parts by weight of dark plum 9, the parts by weight of rhizoma dioscoreae nipponicae 12, the parts by weight of giant knotweed 14, penetrate
Dry 7 parts by weight, the parts by weight of licorice 5.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) take above-mentioned fine powder to add water to cook 2 times, 2 hours every time, add the water of 10 times of fine powder weight every time, merge
And gained decoction liquor is filtered, gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.12；
(3) clear cream of acquisition is spray-dried, dried cream powder is made, then add Steviosin 1g and silica 5g and
Appropriate dextrin is well mixed, and clinically acceptable scattered type is made according to common process.
Embodiment 4
【Prescription】The parts by weight of radix bupleuri 9, the parts by weight of radix scutellariae 7, the parts by weight of schizonepeta 9, windproof 7 parts by weight, the weight of sweet tussilago 9
Part, fry semen armeniacae amarae 7 parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 14, the parts by weight of dark plum 7, the parts by weight of rhizoma dioscoreae nipponicae 14, the parts by weight of giant knotweed 11, penetrate
Dry 9 parts by weight, the parts by weight of licorice 4.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) take above-mentioned fine powder to add water to cook 3 times, add the water of 10 times of fine powder weight for the first time, decoct 2 hours, the
The secondary water for adding 8 times of fine powder weight, is decocted 3 hours, and third time adds the water of 9 times of fine powder weight, and it is small to decoct 1
When, merge and filter gained decoction liquor, gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.25；
(3) clear cream of acquisition is subjected to vacuum belt type drying, dried cream powder is made, then add Steviosin 5g and silica
1g and appropriate dextrin are well mixed, and clinically acceptable pill is made according to common process.
Embodiment 5
【Prescription】The parts by weight of radix bupleuri 8, the parts by weight of radix scutellariae 8, the parts by weight of schizonepeta 8, windproof 8 parts by weight, the weight of sweet tussilago 8
Part, fry semen armeniacae amarae 7 parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 13, the parts by weight of dark plum 8, the parts by weight of rhizoma dioscoreae nipponicae 13, the parts by weight of giant knotweed 13, penetrate
Dry 8 parts by weight, the parts by weight of licorice 4.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, the
The secondary water for adding 8 times of fine powder weight, merge and filter gained decoction liquor, gained filtrate decompression is concentrated into phase at 50 DEG C
To the clear cream that density is 1.13；
(3) clear cream of acquisition is spray-dried, dried cream powder is made, then add Steviosin 3g and silica 3g and
Appropriate dextrin is well mixed, and clinically acceptable granule is made according to common process.
Embodiment 6
【Prescription】The parts by weight of radix bupleuri 8, the parts by weight of radix scutellariae 8, the parts by weight of schizonepeta 8, windproof 8 parts by weight, the weight of sweet tussilago 8
Part, fry semen armeniacae amarae 7 parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 13, the parts by weight of dark plum 8, the parts by weight of rhizoma dioscoreae nipponicae 13, the parts by weight of giant knotweed 13, penetrate
Dry 8 parts by weight, the parts by weight of licorice 4.
【Preparation method】(1) radix bupleuri, radix scutellariae weighed according to selected parts by weight, schizonepeta, windproof, sweet tussilago, fry bitter apricot
Benevolence, stir-baked RADIX PAEONIAE ALBA, dark plum, rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, it is ground into after mixing or mix after being respectively crushed into fine powder thin
Powder, sieving for standby；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, the
The secondary water for adding 8 times of fine powder weight, merge and filter gained decoction liquor, gained filtrate decompression is concentrated into phase at 50 DEG C
To the clear cream that density is 1.27；
(3) clear cream of acquisition is subjected to vacuum belt type drying, dried cream powder is made, then add Steviosin 3g and silica
3g and appropriate dextrin are well mixed, and clinically acceptable capsule is made according to common process.
Obviously, above-described embodiment is only intended to clearly illustrate example, and is not the restriction to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of change or
Change.There is no necessity and possibility to exhaust all the enbodiments.And the obvious change thus extended out or
Among changing still in the protection domain of the invention.
Claims (9)
1. a kind of Chinese medicine composition of dispelling wind cough-relieving, it is characterised in that the bulk drug of the Chinese medicine composition, which forms, is：Radix bupleuri 6-
10 parts by weight, radix scutellariae 6-10 parts by weight, schizonepeta 6-10 parts by weight, windproof 6-10 parts by weight, sweet tussilago 6-10 parts by weight, stir-fry are bitter
Almond 6-9 parts by weight, stir-baked RADIX PAEONIAE ALBA 10-15 parts by weight, dark plum 6-10 parts by weight, rhizoma dioscoreae nipponicae 10-15 parts by weight, giant knotweed 10-15 weights
Measure part, blackberry lily 6-10 parts by weight, licorice 3-6 parts by weight.
2. the Chinese medicine composition of dispelling wind cough-relieving according to claim 1, it is characterised in that the raw material of the Chinese medicine composition
Medicine forms：The parts by weight of radix bupleuri 8, the parts by weight of radix scutellariae 8, the parts by weight of schizonepeta 8, windproof 8 parts by weight, the parts by weight of sweet tussilago 8, stir-fry are bitter
The parts by weight of almond 7, the parts by weight of stir-baked RADIX PAEONIAE ALBA 13, the parts by weight of dark plum 8, the parts by weight of rhizoma dioscoreae nipponicae 13, the parts by weight of giant knotweed 13, the weight of blackberry lily 8
Part, the parts by weight of licorice 4；Or
The parts by weight of radix bupleuri 6, the parts by weight of radix scutellariae 10, the parts by weight of schizonepeta 6, windproof 10 parts by weight, the parts by weight of sweet tussilago 6, the bitter apricot of stir-fry
The parts by weight of benevolence 9, the parts by weight of stir-baked RADIX PAEONIAE ALBA 10, the parts by weight of dark plum 10, the parts by weight of rhizoma dioscoreae nipponicae 10, the parts by weight of giant knotweed 15, the weight of blackberry lily 6
Part, the parts by weight of licorice 6；Or
The parts by weight of radix bupleuri 10, the parts by weight of radix scutellariae 6, the parts by weight of schizonepeta 10, windproof 6 parts by weight, the parts by weight of sweet tussilago 10, the bitter apricot of stir-fry
The parts by weight of benevolence 6, the parts by weight of stir-baked RADIX PAEONIAE ALBA 15, the parts by weight of dark plum 6, the parts by weight of rhizoma dioscoreae nipponicae 15, the parts by weight of giant knotweed 10, the weight of blackberry lily 10
Part, the parts by weight of licorice 3；Or
The parts by weight of radix bupleuri 7, the parts by weight of radix scutellariae 9, the parts by weight of schizonepeta 7, windproof 9 parts by weight, the parts by weight of sweet tussilago 7, stir-fry semen armeniacae amarae 8
Parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 12, the parts by weight of dark plum 9, the parts by weight of rhizoma dioscoreae nipponicae 12, the parts by weight of giant knotweed 14, the parts by weight of blackberry lily 7, life
The parts by weight of radix glycyrrhizae 5；Or
The parts by weight of radix bupleuri 9, the parts by weight of radix scutellariae 7, the parts by weight of schizonepeta 9, windproof 7 parts by weight, the parts by weight of sweet tussilago 9, stir-fry semen armeniacae amarae 7
Parts by weight, the parts by weight of stir-baked RADIX PAEONIAE ALBA 14, the parts by weight of dark plum 7, the parts by weight of rhizoma dioscoreae nipponicae 14, the parts by weight of giant knotweed 11, the parts by weight of blackberry lily 9, life
The parts by weight of radix glycyrrhizae 4.
3. as the selectively addition customary adjuvant of the Chinese medicine composition described in claim 1 or 2, clinic is made according to common process can
The preparation of receiving.
4. preparation according to claim 3, it is characterised in that described preparation include granule, capsule, oral liquid,
Powder, pill or tablet.
A kind of 5. method of the Chinese medicine composition of the dispelling wind cough-relieving prepared described in claim 1 or 2, it is characterised in that the side
Method comprises the following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA, dark plum,
Rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder extracting in water is taken, filters and gained filtrate decompression is concentrated into acquisition clear cream；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to common process
Clinically acceptable formulation is made.
6. the preparation method of the Chinese medicine composition of dispelling wind cough-relieving according to claim 5, it is characterised in that methods described bag
Include following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA, dark plum,
Rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 1-3 times, the water of each 1-3 hours, every time the 8-12 times of fine powder weight of addition, mistake
Filter and gained filtrate decompression is concentrated into the clear cream that relative density at 50 DEG C is 1.10-1.30；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to common process
Clinically acceptable formulation is made.
7. the preparation method of the Chinese medicine composition of dispelling wind cough-relieving according to claim 6, it is characterised in that methods described bag
Include following steps：
(1) according to selected parts by weight weigh radix bupleuri, radix scutellariae, schizonepeta, windproof, sweet tussilago, fry semen armeniacae amarae, stir-baked RADIX PAEONIAE ALBA, dark plum,
Rhizoma dioscoreae nipponicae, giant knotweed, blackberry lily, licorice, fine powder, sieving for standby are ground into after mixing or mix after being respectively crushed into fine powder；
(2) above-mentioned fine powder is taken to add water to cook 2 times, 2 hours every time, first time added the water of 10 times of fine powder weight, for the second time
The water of 8 times of fine powder weight is added, filters and gained filtrate decompression is concentrated into the clear of relative density 1.10-1.30 at 50 DEG C
Cream；
(3) clear cream of acquisition is dried, dried cream powder is made, then selective addition customary adjuvant, according to common process
Clinically acceptable formulation is made.
8. the preparation method of the Chinese medicine composition of dispelling wind cough-relieving according to claim 5, it is characterised in that the accessory package
Include Steviosin, silica and dextrin.
9. the Chinese medicine composition being prepared by any described methods of claim 5-8.
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| CN1679689B (en) * | 2005-02-02 | 2010-05-05 | 北京阜康仁生物制药科技有限公司 | Heat-clearing and toxicity-relieving Chinese medicine preparation and production thereof |
| CN101862409A (en) * | 2009-04-14 | 2010-10-20 | 苏德才 | Chinese medicament for treating wind-chill cold |
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| CN1679689B (en) * | 2005-02-02 | 2010-05-05 | 北京阜康仁生物制药科技有限公司 | Heat-clearing and toxicity-relieving Chinese medicine preparation and production thereof |
| CN101862409A (en) * | 2009-04-14 | 2010-10-20 | 苏德才 | Chinese medicament for treating wind-chill cold |
Non-Patent Citations (2)
| Title |
|---|
| 中西医结合治疗支气管哮喘58 例临床观察;吴淑红;《浙江中西医结合杂志》;20051231;第15卷(第7期);第428-429页，尤其是第428页右栏第2节，第429页右栏第1段 * |
| 疏风宣肺法治疗感冒后咳嗽110例;肖立成;《山西中医》;20080831;第24卷(第10期);第10页左栏第2.1节及最后一段 * |
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