CN105213780B - A kind of Chinese medicine composition that treating chronic gastritis and its application - Google Patents
A kind of Chinese medicine composition that treating chronic gastritis and its application Download PDFInfo
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- CN105213780B CN105213780B CN201510755687.4A CN201510755687A CN105213780B CN 105213780 B CN105213780 B CN 105213780B CN 201510755687 A CN201510755687 A CN 201510755687A CN 105213780 B CN105213780 B CN 105213780B
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating chronic gastritis, the Chinese medicine composition is made of following bulk pharmaceutical chemicals：Paniculate swallowwort, Sculellaria barbata, dried orange peel, Radix Glycyrrhizae, pueraria lobata, Rhizoma Chuanxiong, grass-leaved sweetflag, Rhizoma Atractylodis Macrocephalae, Flos Albiziae, cassia seed, sea-buckthorn, Radix Salviae Miltiorrhizae, Schisandra chinensis, Ramulus Taxilli, Radix Ophiopogonis.The present invention also provides the applications of the Chinese medicine composition.Its advantage is shown：The Chinese medicine composition of the present invention can effectively treat chronic gastritis, inhibit ulcer, reduce ulcer area, perforation, have Helicobacter Pylori in Vitro activity.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically, being a kind of Chinese medicine composition that treating chronic gastritis and its answering
With.
Background technology
Chronic gastritis is the common disease of digestive system, and patient groups are wide, and incidence is high, hence it is evident that influences the life of patient
Quality.Chronic gastritis can cause because of factors such as Helicobacter pylori infection, diet and environmental factor and autoimmunities, clinically
Symptoms, some patientss such as Upper abdominal pain, feeling of fullness abdominal distension, loss of appetite, Nausea and vomiting, belch, constipation or diarrhea are shown as also may be used
Non-evident sympton.
Due to the chronic gastritis cause of disease interpretation of the cause, onset and process of an illness, the diversity of clinical symptoms, showed under mirror also without clear boundary, and the master of scope
Sight factor and disturbing factor are more, often result in the inconsistent of Gastroscope Diagnosis and Tissue pathological diagnosis, at present its sorting technique
Worldwide not yet form unified standard that is specific, accepting extensively.
There is the report of the much Chinese medicine about treatment chronic gastritis in technical paper, patent document, such as：Chinese patent text
Offer CN103055257A disclose a kind of Chinese medicine that treating chronic gastritis include the coptis, it is radix scutellariae, dried orange peel, rhizoma pinellinae praeparata, Poria cocos, white
Art, coix seed, moxibustion Radix Glycyrrhizae, curcuma zedoary, hairyvein agrimony, madder, cuttlebone, fritillaria thunbergii.Chinese patent literature CN1634343 discloses one
Kind treats the compound Chinese medicinal preparation of chronic gastritis accompanied with Helicobacter pylori infection.It is former for treatment with QI invigorating tonifying spleen, eliminating dampness qi-regulating removing toxic substances
Then, it uses Chinese medicine Radix Astragali, Radix Codonopsis and hairyvein agrimony and hairy grape stem etc. for main ingredient, is equipped with auxiliary material, it is chronic gastritis accompanied that treatment is made
The compound Chinese medicinal preparation of helicobacter pylori infections.But about a kind of Chinese medicine composition that treating chronic gastritis of the present invention and its
It is reported using yet there are no.
Invention content
The purpose of the present invention is being directed to deficiency in the prior art, a kind of Chinese medicine composition for treating chronic gastritis is provided.
Another purpose of the present invention is to provide a kind of application of Chinese medicine composition that treating chronic gastritis.
To achieve the above object, the technical solution adopted by the present invention is that：A kind of Chinese medicine composition for treating chronic gastritis, institute
The Chinese medicine composition stated is made of the bulk pharmaceutical chemicals of following parts by weight：18-22 parts of paniculate swallowwort, 21-25 parts of Sculellaria barbata, dried orange peel 18-22
Part, 18-22 parts of pueraria lobata, 8-12 parts of Rhizoma Chuanxiong, 16-20 parts of grass-leaved sweetflag, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 4-6 parts of Flos Albiziae, is determined at 14-18 parts of Radix Glycyrrhizae
9-13 parts of pine torch, 4-6 parts of sea-buckthorn, 10-14 parts of Radix Salviae Miltiorrhizae, 13-17 parts of Schisandra chinensis, 22-26 parts of Ramulus Taxilli, Radix Ophiopogonis 13-17 part.
The Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：19-21 parts of paniculate swallowwort, 22-24 parts of Sculellaria barbata,
19-21 parts of dried orange peel, 15-17 parts of Radix Glycyrrhizae, 19-21 parts of pueraria lobata, 9-11 parts of Rhizoma Chuanxiong, 17-19 parts of grass-leaved sweetflag, 9-11 parts of Rhizoma Atractylodis Macrocephalae, silk tree
4.5-5.5 parts of flower, 10-12 parts of cassia seed, 4.5-5.5 parts of sea-buckthorn, 11-13 parts of Radix Salviae Miltiorrhizae, 14-16 parts of Schisandra chinensis, Ramulus Taxilli 23-25
Part, Radix Ophiopogonis 14-16 part.
The Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：20 parts of paniculate swallowwort, 23 parts of Sculellaria barbata, dried orange peel 20
Part, 16 parts of Radix Glycyrrhizae, 20 parts of pueraria lobata, 10 parts of Rhizoma Chuanxiong, 18 parts of grass-leaved sweetflag, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Flos Albiziae, 11 parts of cassia seed, sea-buckthorn 5
Part, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 24 parts of Ramulus Taxilli, 15 parts of Radix Ophiopogonis.
To realize above-mentioned second purpose, the technical solution adopted by the present invention is that：The Chinese medicine composition is controlled in preparation
Treat the application in the drug of chronic gastritis.
The invention has the advantages that：
1, each herbal medicine of Chinese medicine composition " monarch " of the invention, complements each other, can effectively be controlled through clinical test
Treat chronic gastritis.
2, animal experiment proves that can effectively inhibit ulcer, reduction ulcer area, perforation have Chinese medicine composition of the invention
There is Helicobacter Pylori in Vitro active.
Specific implementation mode
It elaborates to specific implementation mode provided by the invention with reference to embodiment.
A kind of Chinese medicine composition for treating chronic gastritis, the Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals system
At：18-22 parts of paniculate swallowwort, 21-25 parts of Sculellaria barbata, 18-22 parts of dried orange peel, 14-18 parts of Radix Glycyrrhizae, 18-22 parts of pueraria lobata, Rhizoma Chuanxiong 8-12
Part, 16-20 parts of grass-leaved sweetflag, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 4-6 parts of Flos Albiziae, 9-13 parts of cassia seed, 4-6 parts of sea-buckthorn, 10-14 parts of Radix Salviae Miltiorrhizae, five
13-17 parts of taste, 22-26 parts of Ramulus Taxilli, Radix Ophiopogonis 13-17 part.
Preferably, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：19-21 parts of paniculate swallowwort, Sculellaria barbata
22-24 parts, 19-21 parts of dried orange peel, 15-17 parts of Radix Glycyrrhizae, 19-21 parts of pueraria lobata, 9-11 parts of Rhizoma Chuanxiong, 17-19 parts of grass-leaved sweetflag, Rhizoma Atractylodis Macrocephalae 9-11
Part, 4.5-5.5 parts of Flos Albiziae, 10-12 parts of cassia seed, 4.5-5.5 parts of sea-buckthorn, 11-13 parts of Radix Salviae Miltiorrhizae, 14-16 parts of Schisandra chinensis, mulberry are posted
Raw 23-25 parts, Radix Ophiopogonis 14-16 part.
Embodiment 1
20 parts of paniculate swallowwort, 23 parts of Sculellaria barbata, 20 parts of dried orange peel, 16 parts of Radix Glycyrrhizae, 20 parts of pueraria lobata, 10 parts of Rhizoma Chuanxiong, 18 parts of grass-leaved sweetflag,
10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Flos Albiziae, 11 parts of cassia seed, 5 parts of sea-buckthorn, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 24 parts of Ramulus Taxilli, Radix Ophiopogonis 15
Part.
Embodiment 2
19 parts of paniculate swallowwort, 24 parts of Sculellaria barbata, 19 parts of dried orange peel, 17 parts of Radix Glycyrrhizae, 19 parts of pueraria lobata, 11 parts of Rhizoma Chuanxiong, 17 parts of grass-leaved sweetflag,
11 parts of Rhizoma Atractylodis Macrocephalae, 4.5 parts of Flos Albiziae, 12 parts of cassia seed, 4.5 parts of sea-buckthorn, 13 parts of Radix Salviae Miltiorrhizae, 14 parts of Schisandra chinensis, 25 parts of Ramulus Taxilli, Radix Ophiopogonis
14 parts.
Embodiment 3
21 parts of paniculate swallowwort, 22 parts of Sculellaria barbata, 21 parts of dried orange peel, 15 parts of Radix Glycyrrhizae, 21 parts of pueraria lobata, 9 parts of Rhizoma Chuanxiong, 19 parts of grass-leaved sweetflag,
9 parts of Rhizoma Atractylodis Macrocephalae, 5.5 parts of Flos Albiziae, 10 parts of cassia seed, 5.5 parts of sea-buckthorn, 11 parts of Radix Salviae Miltiorrhizae, 16 parts of Schisandra chinensis, 23 parts of Ramulus Taxilli, Radix Ophiopogonis
16 parts.
Embodiment 4
18 parts of paniculate swallowwort, 21 parts of Sculellaria barbata, 22 parts of dried orange peel, 18 parts of Radix Glycyrrhizae, 18 parts of pueraria lobata, 8 parts of Rhizoma Chuanxiong, 20 parts of grass-leaved sweetflag,
8 parts of Rhizoma Atractylodis Macrocephalae, 6 parts of Flos Albiziae, 9 parts of cassia seed, 6 parts of sea-buckthorn, 10 parts of Radix Salviae Miltiorrhizae, 17 parts of Schisandra chinensis, 22 parts of Ramulus Taxilli, 17 parts of Radix Ophiopogonis.
Embodiment 5
22 parts of paniculate swallowwort, 25 parts of Sculellaria barbata, 18 parts of dried orange peel, 14 parts of Radix Glycyrrhizae, 22 parts of pueraria lobata, 12 parts of Rhizoma Chuanxiong, 16 parts of grass-leaved sweetflag,
12 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Flos Albiziae, 13 parts of cassia seed, 4 parts of sea-buckthorn, 14 parts of Radix Salviae Miltiorrhizae, 13 parts of Schisandra chinensis, 26 parts of Ramulus Taxilli, Radix Ophiopogonis 13
Part.
Embodiment 6
Using the preparation method of traditional Chinese herbal decoction routine, i.e. any Chinese medicine compositions of Example 1-5 add water to cook
At decoction.
Embodiment 7
Any Chinese medicine compositions of Example 1-5, add 6-10 times to measure water, decoct 1-3 hours, filter out concoction.Again
Add 6-10 times to measure water, decoct 0.5-2 hours, filter out concoction, merge secondary decocting liquid, stand, leaching supernatant, concentration lets cool, adds
2-3 times of concentrate measures alcohol, stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into；Pharmaceutical aids, vacuum drying, powder is added
Broken granulation, tabletted or filling are encapsulated.
Embodiment 8
Any Chinese medicine compositions of Example 1-5 add 10 times of amount water, decoct 2 hours, filter out concoction.Again plus 8 times
Water is measured, is decocted 1 hour, is filtered out concoction, merge secondary decocting liquid, is stood, leaching supernatant, concentration is let cool, and adds 2 times of amounts of concentrate
Alcohol stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into；Add appropriate pharmaceutical aids, pelletize, dry, whole grain obtains 20g
Grain dispenses 10g/ bags.
Embodiment 9
Any Chinese medicine compositions of Example 1-5 add 10 times of amount water, decoct 2 hours, filter out concoction.Again plus 8 times
Water is measured, is decocted 1 hour, is filtered out concoction, merge secondary decocting liquid, is stood, leaching supernatant, concentration is let cool, and adds 2 times of amounts of concentrate
Alcohol stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into；Add appropriate pharmaceutical aids, mixture, oral solution or syrup is made
Agent.
Embodiment 10
One, general information
Changhai hospital GI Medicine Patients with Chronic Gastritis 80, is randomly divided into 2 groups, treatment group 40, control group 40.Two
The not statistically significant upper differences such as age, gender, the course of disease of group patient, are comparable.
Two, diagnostic criteria
According to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》And State Administration of Traditional Chinese Medicine《Chinese medical disease diagnosis is treated
Criterion is accurate》It formulates.
Inclusion criteria：1. endoscopy meets chronic gastritis diagnostic criteria；2. having gastral cavity pain, sternal rib is glutted, receives difference,
Weak, belch acid regurgitation, the symptoms such as loose stool, the course of disease was at 2 months or more.
Exclusion criteria：1. the red few tongue of tongue or red tongue with yellowish fur person；2. merging peptic ulcer or being suspected to have canceration person；3. closing simultaneously
And there is other systems serious disease person；4. having complication that can affect the treatment to observe or have taboo person to trial drug.
Three, criterion of therapeutical effect
Short Term Clinical is cured：Clinical cardinal symptom for example stomachache with cool feeling, belch, gastral cavilty turgor, indolent and listless weak, anorexia and loose stool,
The diseases such as deep thready pulse or the thin white, indentations at the margin of the tongue of slow, pale and tender tongue, tongue disappear, and gastrocopy, Active inflammation disappears, chronic
Inflammation improves, and pathologic finding confirms that body of gland atrophy seen in gastroscope restores normal or disappears.
It is effective：Clinical cardinal symptom partial disappearance, gastroscope check mucous membrane acute inflammation disappear substantially, and chronic inflammation improves,
Pathologic finding confirms that body of gland atrophy seen in gastroscope, intestines or atypical hyperplasia mitigate.
Effectively：Clinical cardinal symptom is substantially reduced, and gastroscope checks 1/2 or more mucosa infection range shorter, and inflammation is subtracted
Gently, pathologic finding confirms that acute inflammation seen in gastroscope subtracts inflammation, body of gland atrophy, and intestines or atypical hyperplasia mitigate.
In vain：Effective standard is not achieved or is deteriorated.
Four, therapy
Treatment group：The Chinese medicine composition of embodiment 1, paniculate swallowwort 20g, Sculellaria barbata 23g, dried orange peel 20g, Radix Glycyrrhizae 16g, pueraria lobata
20g, Rhizoma Chuanxiong 10g, grass-leaved sweetflag 18g, Rhizoma Atractylodis Macrocephalae 10g, Flos Albiziae 5g, cassia seed 11g, sea-buckthorn 5g, Radix Salviae Miltiorrhizae 12g, Schisandra chinensis 15g, mulberry
Decoction is made in parasitic 24g, Radix Ophiopogonis 15g, decocting method, and daily 1 dose, 2 sub-services sooner or later, 7 days as a course for the treatment of, treats a treatment
Journey.
Control group：Orange osmanthus balosam capsule, 3 times a day, one time 4,7 days as a course for the treatment of, treat a course for the treatment of.
Five, test result
The clinical efficacy correction data for the treatment of group and control group is as shown in table 1.
1 two groups of clinical efficacy comparisons of table
Embodiment 11
One, test material
Kunming mouse, half male and half female, weight 18-22g.8 mouse are one group, are raised in small mouse cage, during experiment
Animal ingestion drinking-water freely, at least raise three days experimental animal before experiment by adaptability.
Two, test method
Treatment group：The Chinese medicine composition of embodiment 1, paniculate swallowwort 20g, Sculellaria barbata 23g, dried orange peel 20g, Radix Glycyrrhizae 16g, pueraria lobata
20g, Rhizoma Chuanxiong 10g, grass-leaved sweetflag 18g, Rhizoma Atractylodis Macrocephalae 10g, Flos Albiziae 5g, cassia seed 11g, sea-buckthorn 5g, Radix Salviae Miltiorrhizae 12g, Schisandra chinensis 15g, mulberry
Decoction 1000ml is made in parasitic 24g, Radix Ophiopogonis 15g, decocting method, daily by weight 0.5ml/10g administrations, is administered 2 weeks.
Control group：Orange osmanthus balosam capsule, 1 adds distilled water that 10ml is made, daily by weight 0.5ml/10g administrations, administration 2
Week.
Blank group：Distilled water is administered 2 weeks daily by weight 0.5ml/10g administrations.
Three, test result
The results are shown in Table 2 for influence to water irritability murine lesion.The drug of the present invention can be substantially reduced murine lesion
Index, ulcer inhibition rate are high.
Influence result of the table 2 to water irritability murine lesion
The results are shown in Table 3 for influence to mouse Pylorus Ligated Gastric Ulcer.The drug of the present invention can be substantially reduced mouse
Ulcer index effectively reduces ulcer area.
Influence result of the table 3 to mouse Pylorus Ligated Gastric Ulcer
The results are shown in Table 4 for influence to mouse Helicobacter Pylori in Vitro.The drug of the present invention can obviously inhibit external
Helicobacter pylori.
Influence result of the table 4 to mouse Helicobacter Pylori in Vitro
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, under the premise of not departing from the method for the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (2)
1. a kind of Chinese medicine composition for treating chronic gastritis, which is characterized in that the Chinese medicine composition is by following parts by weight
Bulk pharmaceutical chemicals are made：20 parts of paniculate swallowwort, 23 parts of Sculellaria barbata, 20 parts of dried orange peel, 16 parts of Radix Glycyrrhizae, 20 parts of pueraria lobata, 10 parts of Rhizoma Chuanxiong, grass-leaved sweetflag 18
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Flos Albiziae, 11 parts of cassia seed, 5 parts of sea-buckthorn, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of Schisandra chinensis, 24 parts of Ramulus Taxilli, Radix Ophiopogonis
15 parts.
2. application of the Chinese medicine composition according to claim 1 in the drug for preparing treatment chronic gastritis.
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| CN105944000A (en) * | 2016-06-16 | 2016-09-21 | 黄春梅 | Traditional Chinese medicine composition for treating chronic gastritis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205891A (en) * | 1998-07-15 | 1999-01-27 | 王朴希 | Chinese medicine capsule for curing gastric cancers |
| CN102423456A (en) * | 2011-11-03 | 2012-04-25 | 徐艳 | Traditional Chinese medicine preparation for treating chronic atrophic gastritis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100903743B1 (en) * | 2007-08-28 | 2009-06-19 | 전병태 | Food composition for improving and preventing digestive system diseases |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205891A (en) * | 1998-07-15 | 1999-01-27 | 王朴希 | Chinese medicine capsule for curing gastric cancers |
| CN102423456A (en) * | 2011-11-03 | 2012-04-25 | 徐艳 | Traditional Chinese medicine preparation for treating chronic atrophic gastritis |
Non-Patent Citations (1)
| Title |
|---|
| 辩证论治胃脘痛40例;石景伟等;《陕西中医》;19950731;第16卷(第7期);第301页，尤其是第301页左栏第1和5段 * |
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