CN104721256A - Anwei Yang extract as well as preparation method and medical application thereof - Google Patents

Anwei Yang extract as well as preparation method and medical application thereof Download PDF

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Publication number
CN104721256A
CN104721256A CN201510085402.0A CN201510085402A CN104721256A CN 104721256 A CN104721256 A CN 104721256A CN 201510085402 A CN201510085402 A CN 201510085402A CN 104721256 A CN104721256 A CN 104721256A
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glycyrrhiza
stomach
extract
peace
peptic ulcer
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彭一峰
杨应梅
周寒利
尹洪强
王峄
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XINJIANG QUANAN PHARMACEUTICAL CO Ltd
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XINJIANG QUANAN PHARMACEUTICAL CO Ltd
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Abstract

The invention provides a natural traditional Chinese medicine extract Anwei Yang and a preparation method thereof. The Anwei Yang takes glycyrrhiza inflata batalin and/or glycyrrhiza uralsensis fisch as a raw material and contains a liquorice flavonoid compound. The invention also provides an application of the Anwei Yang in preparation of a medicine used for treating peptic ulcer, especially liver-stomach gloomy heat type peptic ulcer.

Description

A kind of peace stomach infections extract and preparation method thereof and medical usage
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Radix Glycyrrhizae extract and preparation method thereof medical usage.
Background technology
Peptic ulcer mainly refers to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein the Digestion of acidic gastric juice to mucosa is the Fundamentals of ulcer, hence obtains one's name.Ulcer due to the overwhelming majority betides duodenum stomach function regulating, therefore also known as taste-blindness rate.
Primary disease ownership Chinese medicine " gastric abscess ", " noisy ", " feeling of fullness " etc.Chinese medicine is thought, peptic ulcer pathogenesis is angry owing to being worried, and seven emotions stimulate, the liver failing to maintain the normal flow of QI, horizontal criminal's stomach internal organs; Stagnation of spleen-QI, dysfunction of the spleen in transportation and transformation; Intemperance of taking food or partially addicted to, impairing the spleen and stomach; Or burnt in damp and hot heap soil or fertilizer over and around the roots knot, stomach film is impaired; And long-term muscle power or mental work excessive, impairment of the spleen consumption gas, transporting is sluggish, and QI and blood is lost smooth, the not life of stomach film.Therefore, peptic ulcer can be divided into spleen-stomach deficiency-cold, caused by hepatic stagnation qi stagnation, liver stomach wind-cold type by the Pathogenesis Theory of the traditional Chinese medical science.Spleen-stomach deficiency-cold digestive tract ulcer, primary symptom has stomachache indistinctly, desire for warm and being pressed, and pain of empty stomach very, obtains food and then delays, time vomiting watery fluid, poor appetite abdominal distention, spiritlessness and weakness, the hands and feet being not warm, large loose stool is thin.Pale tongue, white and thin fur, thready and weak pulse.Method for the treatment of is with warming middle-Jiao and tonifying deficiency, and stomach function regulating relieving spasm to stop pain is for wanting.Clinical conventional Jian Zhong Tonga subtracts, and main flavour of a drug have 15 tastes such as the Radix Astragali, Ramulus Cinnamomi, the Radix Paeoniae Alba, Concha Arcae (calcined), Rhizoma Zingiberis, Radix Codonopsis, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Amomi, Rhizoma Alpiniae Officinarum.Caused by hepatic stagnation qi stagnation, main manifestations is the swollen pain of gastral cavilty painful abdominal mass, or attacks and alter the side of body back of the body, and depressed emotion then increases the weight of, and heating installation is frequently done, or pantothenic acid water, thin white fur of tongue, stringy pulse.Method for the treatment of is depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain.Commonly use prescription with Radix Bupleuri Shugan Decoction for representative.The party is made up of Radix Bupleuri, Fructus Aurantii, Rhizoma Chuanxiong, Rhizoma Cyperi, Radix Paeoniae, Pericarpium Citri Reticulatae, Radix Et Rhizoma Rhei etc.Liver stomach wind-cold type digestive tract ulcer, clinical main manifestations is gastral cavilty portion pain and has burning sensation, and pain gesture is urgent, and susceptible to lose temper due to restlessness, pantothenic acid is noisy, dry mouth with bitter taste, constipation.Red tongue, yellow and greasy fur, stringy pulse or stringy and rapid pulse.Method for the treatment of is with dispersing the stagnated live-QI to relieve the stagnation of QI, and the stomach function regulating that expels the heat-evil is main.Conventional Chinese medicine prescription Liver-Comforting Decoction clinically, the party is made up of 13 taste Chinese crude drugs such as Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Concha Arcae (calcined), Radix Bupleuri, Rhizoma Coptidis, Fructus Evodiaes.
Peptic ulcer rate is high, and the people in the whole world about 10 ~ 20%% suffered from that this is sick, wherein about 1% can be converted into human primary gastrointestinal cancers, is classified as disease before cancer by World Health Organization (WHO) (WHO), very big to human health risk.
Summary of the invention
For the problems referred to above, one object of the present invention is to provide a kind of Chinese medicine extract peace stomach infections various types of peptic ulcer being had to good therapeutical effect.Prove through clinical research, described peace stomach infections especially has good curative effect to liver stomach wind-cold type peptic ulcer.
In order to solve the problems of the technologies described above, present invention employs following technical scheme:
A kind of peace stomach infections extract, is extracted by Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis Fisch. and prepares.
Preferably, described peace stomach infections extract, liquorice flavonoids compound content is more than 82%; Preferred, liquorice flavonoids compound content is more than 88%.
The present invention also will provide the preparation method of described peace stomach infections extract, comprises the steps:
Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder and/or the glycyrrhiza residue of Glycyrrhiza uralensis Fisch., add in extraction vessel, extract 1 ~ 3 time with weight percent concentration 90% ~ 100% alcohol heating reflux, each 0.5 ~ 3 hour at every turn, each extracting solution merging is concentrated into thick paste, add 2% sodium carbonate liquor after cooling to dissolve, staticly settle 24 hours, get supernatant, pH=2 ~ 3 are adjusted with 10% hydrochloric acid solution, filter, precipitate washes with water to pH=5 ~ 6,40 DEG C of dryings.
In above-mentioned preparation method, the weight percent concentration of ethanol is preferably 93%.
The volume of ethanol and the envelope-bulk to weight ratio of described glycyrrhiza residue are preferably 2:1 ~ 10:1, are more preferably 3:1 ~ 6:1, most preferably are 4:1 ~ 5:1.
Extraction time is preferably 2 times.
Each extraction time is preferably 1 ~ 2 hour, most preferably is 1 hour.
As the preferred embodiment of one, the invention provides a kind of preparation method of described peace stomach infections extract, specifically comprise the steps:
Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder and/or the glycyrrhiza residue of Glycyrrhiza uralensis Fisch., add in extraction vessel, 2 times are extracted with weight percent concentration 93% alcohol heating reflux, each 1 hour, the volume of ethanol is 4.5 times of described glycyrrhiza residue weight for the first time, and the volume of second time ethanol is 4 times of described glycyrrhiza residue weight; Extracted twice liquid merges, and is concentrated into thick paste, and add 2% sodium carbonate liquor after cooling and dissolve, staticly settle 24 hours, get supernatant, adjust pH=2 ~ 3 with 10% hydrochloric acid solution, filter, precipitate washes with water to pH=5 ~ 6, and 40 DEG C dry, pulverize.
A further object of the invention is, provides the application of above-mentioned peace stomach infections extract in the medicine of preparation treatment peptic ulcer.
Preferably, described peptic ulcer comprises one or more in spleen-stomach deficiency-cold, caused by hepatic stagnation qi stagnation and liver stomach wind-cold type.
Preferred, described peptic ulcer is liver stomach wind-cold type.
Preferably, the medicine of described treatment peptic ulcer, can comprise, and also can not comprise pharmaceutically acceptable adjuvant.
Pharmaceutically acceptable adjuvant of the present invention, can comprise: 1) filler, such as, can be selected from lactose, mannitol, dextrin, starch, microcrystalline cellulose, calcium carbonate, calcium sulfate etc.; 2) binding agent, such as, can be selected from starch, dextrin, sodium carboxymethyl cellulose, Polyethylene Glycol, polyvidone, gelatin, arabic gum; 3) disintegrating agent, such as, can be selected from starch, microcrystalline Cellulose, alginic acid, ion exchange resin, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, microcrystalline cellulose etc.; 4) lubricant, such as can be selected from magnesium stearate, micropowder silica gel, Macrogol 4000 or 6000, sodium lauryl sulphate, Brij30 etc.; 5) fluidizer, such as, can be selected from Pulvis Talci, micropowder silica gel etc.; 6) anti stickness agent, such as, can be selected from Pulvis Talci, micropowder silica gel, wheaten starch etc.
Spleen-stomach deficiency-cold peptic ulcer, primary symptom is shown in vague epigastralgia, desire for warm and being pressed; Cold or fatigue easily shows effect or increases the weight of whenever; Seriously ill on an empty stomach, obtain food alleviation of pain, abdominal distention after meal; Pale and tender tongue, while there is tooth to print, white and thin fur, deep-thready pulse or slow.Secondary disease is seen indolent and listless weak, spiritlessness and sparing of words; Aversion to cold and cold limbs; Large loose stool is thin; Vomit clear saliva.Method for the treatment of is with warming middle-Jiao and tonifying deficiency, and stomach function regulating relieving spasm to stop pain is for wanting.Conventional Huangqijianzhongtangas as main prescription.
Caused by hepatic stagnation qi stagnation peptic ulcer, primary symptom is shown in epigastric distending pain, two side of body feeling of distension and oppression; Meet feelings will unsuccessful, increase the weight of; Because heating installation or arrow gas then relax; Susceptible to get angry and heaving a deep sigh; Secondary disease sees lack of appetite uncomfortable in chest; General acid regurgitation water; Bitter taste is dizzy; Thin white fur of tongue, stringy pulse.With depressed liver-energy dispersing and QI regulating and stomach and alleviating pain for method for the treatment of.
Liver stomach wind-cold type peptic ulcer, primary symptom is shown in that gastric abscess gesture urgently has burning sensation; Eat pain without obviously alleviating or eating easy pain; Red tongue with yellow fur, stringy pulse or number; Xerostomia and bitter.Secondary disease sees desire for cold drinks; Acid regurgitation is noisy; Fidgety irritability; Constipation.Be more common in the active stage of peptic ulcer.Method for the treatment of is with dispersing the stagnated live-QI to relieve the stagnation of QI, and the stomach function regulating that expels the heat-evil is for wanting.Conventional Liver-Comforting Decoction, prescription is: Pericarpium Citri Reticulatae 12g, Pericarpium Citri Reticulatae Viride 10g, Concha Arcae (calcined) 15g, Radix Bupleuri 10g, Rhizoma Coptidis 9g, Fructus Evodiae 3g, Cortex Moutan, Fructus Gardeniae 12g, Radix Paeoniae Alba 15g, Fructus Citri Sarcodactylis 12g, Rhizoma Atractylodis Macrocephalae 12g, Herba Taraxaci 15g, Radix Glycyrrhizae 6g.
Be distinguishing to the therapeutic rules of the peptic ulcer of above-mentioned three kinds of Syndrome Classifications in prior art, accordingly, medicine used is also different.Peace stomach infections extract of the present invention, not only has good curative effect to spleen-stomach deficiency-cold and caused by hepatic stagnation qi stagnation peptic ulcer, also has significant curative effect to liver stomach wind-cold type peptic ulcer.Through clinical observation on the therapeutic effect, peace stomach infections extract of the present invention is to liver stomach wind-cold type peptic ulcer, and cure rate reaches more than 70%, and healing+obvious effective rate is more than 80%.And the cure rate of the caused by hepatic stagnation qi stagnation that the same period observes and spleen-stomach deficiency-cold peptic ulcer is only about 60%.For the modern that surfeit delicious food, stress are large, this outstanding therapeutic effect of peace stomach infections extract of the present invention, has special significance.
Detailed description of the invention
Peace stomach infections extract of the present invention, with Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis Fisch., the glycyrrhiza residue after extraction Radix Glycyrrhizae extractum and glycyrrhizic acid powder is for initiation material, extracts, alkali extraction-acid precipitation, and prepare through ethanol heat.In extract, the content of licoflavone class is more than 82%.
Referring to specific embodiment, the present invention is described.It will be appreciated by those skilled in the art that these embodiments are only for illustration of the present invention, its scope do not limited the present invention in any way.
Experimental technique in following embodiment, if no special instructions, is conventional method.Medicinal raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.
embodiment 1the preparation of peace stomach infections extract
Glycyrrhiza residue 400 ㎏ of the Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder, adds in extraction pot, with 1.8M 3, 1.6M 393% ethanol difference heating and refluxing extraction 2 times, each 1 hour at every turn, extracting solution merging was concentrated into thick paste, dissolves, precipitate 24 hours, get supernatant after cooling through 2% sodium carbonate liquor, adjusts pH=2 ~ 3 with 10% hydrochloric acid solution, filters.Precipitate washes with water to pH=5 ~ 6, and 40 DEG C of dryings, pulverizing, must pacify stomach infections extract.
embodiment 2the content detection of peace stomach infections extract
1. the assay of flavone compound
The peace stomach infections extract taking embodiment 1 preparation is about 1g, puts 105 DEG C of dryings 3 hours, porphyrize, precision takes about 0.5g, puts in 50ml measuring bottle, and hydro-oxidation sodium test solution is to scale, shake up, dissolving is filtered, discard just filtrate, accurate absorption subsequent filtrate 20ml, carefully drips hydrochloric acid, adjust ph to 3, leave standstill a moment, use the sintered filter funnel of constant weight to filter, wash with water and be precipitated to washing liquid pH about 5,105 DEG C of dryings 3 hours, calculate, the content of flavone compound is 89.2%.
2. the inspection of glycyrrhizic acid
Peace stomach infections extract 0.1g prepared by Example 1, add hydrochloric acid 1ml and chloroform 15ml, reflux 1 hour, lets cool, filters, filtrate evaporate to dryness, and residue adds ethanol 1ml makes dissolving, as need testing solution.Another extracting liquorice subacid reference substance, adds anhydrous alcohol solution.Test according to thin layer chromatography (Chinese Pharmacopoeia nineteen ninety-five version annex VI B), draw each 1 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with petroleum ether (30-60 DEG C)-benzene-ethyl acetate-glacial acetic acid (10:20:7:0.5) for developing solvent, launch, take out, dry, spray is with 10% phosphomolybdic acid ethanol solution, dry about 5 minutes, in test sample chromatograph, on the position corresponding to reference substance chromatograph at 105 DEG C, the blue spot that shows, background correction color must not be deeper than reference substance the blue spot that shows.
embodiment 3the preparation of peace stomach infections extract
Glycyrrhiza residue 400 ㎏ of the Glycyrrhiza uralensis Fisch. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder, adds in extraction pot, with 2.0M 3, 1.6M 395% ethanol difference heating and refluxing extraction 2 times, each 1 hour at every turn, extracting solution merging was concentrated into thick paste, dissolves, precipitate 24 hours, get supernatant after cooling through 2% sodium carbonate liquor, adjusts pH=2 ~ 3 with 10% hydrochloric acid solution, filters.Precipitate washes with water to pH=5 ~ 6,40 DEG C of dryings, pulverizing, obtains Chinese medicine extract peace stomach infections.
Adopt the detection method of embodiment 2, the flavones content measuring peace stomach infections prepared by the present embodiment is 84.6%.
embodiment 4the preparation of peace stomach infections extract
Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder and glycyrrhiza residue totally 400 ㎏ of Glycyrrhiza uralensis Fisch., add in extraction pot, with 2.4M 3100% alcohol heating reflux extracts 1 time, extracts 3 hours, and extracting solution merging is concentrated into thick paste, dissolves, precipitate 24 hours, get supernatant after cooling through 2% sodium carbonate liquor, adjusts pH=2 ~ 3 with 10% hydrochloric acid solution, filters.Precipitate washes with water to pH=5 ~ 6,40 DEG C of dryings, pulverizing, obtains Chinese medicine extract peace stomach infections.
Adopt the detection method of embodiment 2, the flavones content measuring peace stomach infections prepared by the present embodiment is 90.5%.
Embodiment 5 one kinds peace gastric ulcer capsule
Peace stomach infections extract prepared by embodiment 1, adds the starch of peace stomach infections extract weight 5%, mix homogeneously, encapsulated, 0.2g/ grain.
Consumption usage: each two, every day four times.
test example 1the clinical research of peace gastric ulcer capsule
1. test objective: research peace stomach infections is to the therapeutical effect of the peptic ulcer of various Chinese medical discrimination type.
2. test medicine: the peace gastric ulcer capsule prepared according to method described in embodiment 5.
3. case selection:
3.1 subjects must turn out to be gastric ulcer or duodenal ulcer patients through gastroscope in medication in first 10 days, and the two is observation and appraisal respectively, does biopsy, to get rid of gastric cancer cases to patients w ith peptic ulcer disease.
3.2 Syndrome Differentiation of Traditional Chinese Medicine
Study subject is all dialectical through there being experience doctor to carry out before medication, and carries out differentiation of symptoms and signs for classification of syndrome with reference to the guideline of clinical investigations for the treatment of by Chinese herbs peptic ulcer, is divided into Qi-stagnation type, stagnated heat type, asthenic cold type three type.
1) Qi-stagnation type
Primary symptom: epigastric distending pain, two side of body feeling of distension and oppression; Meet feelings will unsuccessful, increase the weight of; Because heating installation or arrow gas then relax; Susceptible to get angry and heaving a deep sigh.
Secondary disease: lack of appetite uncomfortable in chest; General acid regurgitation water; Bitter taste is dizzy; Thin white fur of tongue, stringy pulse.With depressed liver-energy dispersing and QI regulating and stomach and alleviating pain for method for the treatment of.
Diagnosis: primary symptom two adds time disease two.
2) stagnated heat type
Primary symptom: gastric abscess gesture urgently has burning sensation; Eat pain without obviously alleviating or eating easy pain; Red tongue with yellow fur, stringy pulse or number; Xerostomia and bitter.
Secondary disease: desire for cold drinks; Acid regurgitation is noisy; Fidgety irritability; Constipation.
Diagnosis: primary symptom two adds time disease two.
3) asthenic cold type
Primary symptom: vague epigastralgia, desire for warm and being pressed; Cold or fatigue easily shows effect or increases the weight of whenever; Seriously ill on an empty stomach, obtain food alleviation of pain, abdominal distention after meal; Pale and tender tongue, while there is tooth to print, white and thin fur, deep-thready pulse or slow.
Secondary disease: indolent and listless weak, spiritlessness and sparing of words; Aversion to cold and cold limbs; Large loose stool is thin; Vomit clear saliva.
Diagnosis: primary symptom two adds time disease two.
3.3 include case standard in
1) Western medicine diagnose and differential diagnosis in tcm diagnostic criteria person is met;
2) age is within 16 ~ 65 years old scope;
3) ulcer area is at 0.2 × 0.2cm 2above.
3.4 Excluded cases standards
1) all not meeting includes case standard in, not medication according to the rules, cannot judge curative effect person;
2) severe primary disease and the psychotics such as cardiovascular, liver, kidney and hemopoietic system is merged;
3) giving a farfetched interpretation property ulcer, the Frost's Descent sample ulcer, and test in first 30 days and complication occur and row operator;
4) anemia of pregnant woman or women breast-feeding their children and those who are allergic to this drug;
5) indulge in excessive drinking or have other should not do this medicine experimenter;
All one having above situation, not as the object of observation.
4. study subject physical data
Study subject is being in hospital and outpatient of hospital, amounts to 435 examples; Wherein stagnated heat type 235 example, 37.87 years old mean age; Qi-stagnation type 102 example, 31.76 years old mean age; Asthenic cold type 98 example, 41.23 years old mean age.In addition, male 440 example, women 191 example.
5. dosage and instructions of taking:
Oral, each 2 capsules (altogether 0.4g), four times a day, three take medicine before the meal and before sleeping, and 4 ~ 8 weeks courses for the treatment of, a few patients was taken medicine to 9 weeks.Tested period, must not use the influential other medicines of Peptic Ulcers.
6. Outcome measure
6.1 Syndrome Classification criterions of therapeutical effect
1) clinical cure: primary symptom and time disease all disappear or part syndrome sign as body of the tongue or pulse condition, be clearly better though have no by general inspection method, also without poorer person.
2) effective: primary symptom all has clear improvement with time disease, or indivedual primary symptom is slightly improved, but other primary and secondary symptom all disappears.
3) effective: primary and secondary disease is all improved, or primary symptom is not improved, but secondary disease all disappears.
4) invalid: the equal thing of primary and secondary disease improves.
Symptom weight change calibration with reference to treatment by Chinese herbs the spleen-stomach disease each syndrome guideline determine.
6.2 gastroscope criterions
1) clinical recovery: ulcer disappears completely, local is slightly rubescent, without obvious edema.
2) effective: ulcer disappears substantially, still have inflammation.
3) effective: ulcer size reduction is more than 50% or 50%.
4) invalid: ulcer size reduction is not as good as 50%.
7. efficacy analysis
7.1 pacify gastric ulcer capsules to the impact of tcm syndrome, specifically in table 1.
The impact of gastric ulcer capsule on tcm syndrome pacified by table 1
Wherein, stagnated heat type healing+obvious effective rate is 82.1%,
Qi-stagnation type healing+obvious effective rate is 72.5%,
Asthenic cold type healing+obvious effective rate is 71.4%.
7.2 peace gastric ulcer capsule gastroscopes judge curative effect
Wherein, stagnated heat type healing+obvious effective rate is 82.6%,
Qi-stagnation type healing+obvious effective rate is 66.6%,
Asthenic cold type healing+obvious effective rate is 70.4%.
7.3 toxicity general comments
At whole viewing duration, the untoward reaction such as experimenter does not occur vomiting, feels sick, diarrhoea, jaundice, indigestion and loss of appetite, insomnia, oliguria, edema and drug-induced stomachache is aggravated, allergy.
8. sum up:
By the clinical observation on the therapeutic effect to 435 routine patients with peptic ulcer, find that the peptic ulcer of peace gastric ulcer capsule to various tcm syndrome type has good curative effect.Syndrome in TCM marquis before and after treatment, healing+obvious effective rate is more than 70%; Judge curative effect from gastroscope, healing+obvious effective rate is more than 66%.And two kinds of curative effect judging standard analysis results, all demonstrate peace gastric ulcer capsule and are better than Qi-stagnation type and asthenic cold type to the evident in efficacy of stagnated heat type peptic ulcer.This clinical observation on the therapeutic effect, significant to instructing clinical application.By tcm syndrome, patient is segmented, thus provide more effective Therapeutic Method and means for patient, patient is received benefits.
Specific description of embodiments of the present invention does not above limit the present invention, and those skilled in the art can make various change or distortion according to the present invention, only otherwise depart from spirit of the present invention, all should belong to the scope of claims of the present invention.

Claims (8)

1. pacify a stomach infections extract, extracted by Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis Fisch. and prepare, containing liquorice flavonoids compound.
2. peace stomach infections extract according to claim 1, it is characterized in that, liquorice flavonoids compound content is more than 82%; Preferably, liquorice flavonoids compound content is more than 88%.
3. the preparation method of the peace stomach infections extract described in claim 1 or 2, comprises the steps:
Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder and/or the glycyrrhiza residue of Glycyrrhiza uralensis Fisch., add in extraction vessel, extract 1 ~ 3 time with weight percent concentration 90% ~ 100% alcohol heating reflux, each 0.5 ~ 3 hour at every turn, each extracting solution merging is concentrated into thick paste, add 2% sodium carbonate liquor after cooling to dissolve, staticly settle 24 hours, get supernatant, pH=2 ~ 3 are adjusted with 10% hydrochloric acid solution, filter, precipitate washes with water to pH=5 ~ 6,40 DEG C of dryings.
4. preparation method according to claim 3, is characterized in that, the weight percent concentration of ethanol is preferably 93%;
Preferably, the volume of ethanol and the envelope-bulk to weight ratio of described glycyrrhiza residue are 2:1 ~ 10:1, are more preferably 3:1 ~ 6:1, most preferably are 4:1 ~ 5:1.
5. the preparation method according to claim 3 or 4, is characterized in that, extraction time is 2 times;
Preferably, each extraction time is 1 ~ 2 hour, most preferably is 1 hour.
6. preparation method according to claim 3, is characterized in that, specifically comprises the steps:
Glycyrrhiza inflata Bat. after extracting Radix Glycyrrhizae extractum and glycyrrhizic acid powder and/or the glycyrrhiza residue of Glycyrrhiza uralensis Fisch., add in extraction vessel, 2 times are extracted with weight percent concentration 93% alcohol heating reflux, each 1 hour, the volume of ethanol is 4.5 times of described glycyrrhiza residue weight for the first time, and the volume of second time ethanol is 4 times of described glycyrrhiza residue weight; Extracted twice liquid merges, and is concentrated into thick paste, and add 2% sodium carbonate liquor after cooling and dissolve, staticly settle 24 hours, get supernatant, adjust pH=2 ~ 3 with 10% hydrochloric acid solution, filter, precipitate washes with water to pH=5 ~ 6, and 40 DEG C dry, pulverize.
7. the peace stomach infections extract described in claim 1 or 2, or the application of the peace stomach infections prepared any one of claim 3 to 6 in the medicine of preparation treatment peptic ulcer.
8. application according to claim 7, is characterized in that, described peptic ulcer comprises spleen-stomach deficiency-cold, caused by hepatic stagnation qi stagnation and/or liver stomach wind-cold type;
Preferably, described peptic ulcer is liver stomach wind-cold type.
CN201510085402.0A 2015-02-15 2015-02-15 Anwei Yang extract as well as preparation method and medical application thereof Pending CN104721256A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106333942A (en) * 2016-08-30 2017-01-18 新疆全安药业股份有限公司 Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis
CN106376820A (en) * 2016-08-30 2017-02-08 新疆全安药业股份有限公司 Solid drink for dispelling stomach cold and protecting gastric mucosa and preparation method thereof

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