KR100903743B1 - Food composition for improving and preventing digestive system diseases - Google Patents

Food composition for improving and preventing digestive system diseases Download PDF

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KR100903743B1
KR100903743B1 KR1020070086396A KR20070086396A KR100903743B1 KR 100903743 B1 KR100903743 B1 KR 100903743B1 KR 1020070086396 A KR1020070086396 A KR 1020070086396A KR 20070086396 A KR20070086396 A KR 20070086396A KR 100903743 B1 KR100903743 B1 KR 100903743B1
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powder
weight
extract powder
aloe
food composition
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KR20090021683A (en
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전병태
김상민
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전병태
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

본 발명은 천연물질을 혼합하여 만든 식도, 위장, 장 등의 소화기장애 개선을 위한 건강식품 조성물에 관한 것이다. 특히 본 발명은 천연식품원료추출물을 재료로 구성함으로 인체에 독성 및 부작용을 유발하지 않으며, 식품으로 용이하게 복용가능 할 뿐만 아니라, 신경성장인자(Never Growth Factor) 활성물질 과 β-D glucan이 다량 함유된 노루궁뎅이버섯분말, 위와 장 건강, 배변활동에 도움을 주는 알로에베라겔분말 외에 천연물질 등을 적당한 배합 조건하에서 혼합 및 교반과정을 거치도록 함으로써 장기간 복용해도 부작용이 없는 소화기계 질환개선 및 예방용 식품 조성물을 제공 한다The present invention relates to a health food composition for improving digestive disorders of the esophagus, stomach, intestines, etc. made by mixing natural substances. In particular, the present invention does not cause toxicity and side effects to the human body by forming a natural food raw material extract, as well as can be easily taken as food, nerve growth factor (Never Growth Factor) active substance and β-D glucan in a large amount For the improvement and prevention of diseases of the digestive system that have no side effects even if taken for a long period of time by mixing and stirring natural nutrients in addition to Aloe vera gel powder, which contains the scab powder, and the aloe vera gel powder that helps bowel health and bowel movements. Provide food composition

노루궁뎅이버섯분말, 알로에겔분말, 차조기추출물분말, 카모마일추출분말, 감토추출분말, 회향추출분말, 난황분말, 자당지방산에스테르, 맥주효모, 수산화마그네슘, L-글루타민, 진피추출분말, β-D glucanRoe deer powder powder, aloe gel powder, perilla extract powder, chamomile extract powder, ground extract powder, fennel extract powder, egg yolk powder, sucrose fatty acid ester, beer yeast, magnesium hydroxide, L-glutamine, dermis extract powder, β-D glucan

Description

소화기계 질환개선 및 예방용 식품 조성물{omitted}Food composition for improving and preventing digestive system diseases

본 발명은 천연추출혼합물을 포함하는 소화기계 질환개선 및 예방 식품조성물에 관한 것으로, 보다 상세하게는 인체에 독성 및 부작용을 유발하지 않으며, 식품으로 용이하게 복용가능 할 뿐만 아니라, 합성 소화기제재약품의 대체품으로 이용할 수 있는 소화기계 질환개선 및 예방식품 조성물에 관한 것이다.The present invention relates to a food composition for improving and preventing digestive system diseases, including natural extract mixtures, and more specifically, does not cause toxicity and side effects to the human body, and can be easily taken as food. It relates to a digestive system disease improvement and preventive food composition that can be used as a substitute.

소화는 생체에 투여된 고분자의 영양소를 저분자의 물질로 가수분해하여 흡수하기 쉬운 상태로 만드는 것을 말하며 이를 주관하는 기관을 소화기계라고 한다. 이때 위장운동을 증진시키는 약을 소화제라 하는데 소화액의 분비를 증가시키거나 소화액의 분비부족을 보충하는 소화효소제가 있다.Digestion refers to the digestion of macromolecules administered into living organisms into low-molecular-weight substances that are easily absorbed. The organ that manages them is called the digestive system. At this time, a drug that promotes gastrointestinal movement is called a digestive agent, and there are digestive enzymes that increase the secretion of digestive juice or supplement the secretion of digestive juice.

위산과다 및 소화성 궤양의 치료제로는 제산제를 사용하는데 위액의 염산을 화학적으로 중화하는 작용을 하는 것이다. 약물은 염기성 염류, 교질성 제산제 및 소화성궤양 치료제로 나눌 수 있다. 염기성 염류제로서는 NaHCO3 , CaCO3 , MgO, MgCO3 등을 사용하며, 위산의 중화작용이 있지만 과량투여로는 알칼로시스(alkalosis)를 일으킨다. 교질성 제산제로는 aluminium hydroxide gel (Al(OH)3 와 Al2O3 의 현탁액), aluminium phosphate등이 사용되며 작용은 염기성 염류제보다 완만하며 궤양표면을 피복하여 보호하는 작용이 있다. 이것은 알칼로시스(alkalosis)를 일으킬 위험성은 없지만 인체의 면역기능을 떨어뜨릴 수 있다. 소화성 궤양은 위 및 십이지장 등에 많이 발생하며 변비, 위하수, 만성복부 질환 등을 동반한다. 소화성 궤양에는 안정 및 진정제 사용, 식이요법, 제산제의 투여, 부교감 신경 차단제, histidine투여, 외과적 수술 등의 방법으로 치료할 수 있기 때문에 면역기능을 떨어뜨리거나 타 인체 기관에 손상을 주는 부작용을 동반할 수 있다.As an agent for the treatment of hyperacidity and peptic ulcer, antacids are used to chemically neutralize the hydrochloric acid of gastric juice. Drugs can be divided into basic salts, colloidal antacids, and peptic ulcer drugs. As basic salts, NaHCO 3 , CaCO 3 , MgO, MgCO 3, and the like are used. Although neutralization of gastric acid occurs, overdose causes alkalosis. As the colloidal antacid, aluminum hydroxide gel (a suspension of Al (OH) 3 and Al 2 O 3 ), aluminum phosphate, etc. are used. It is not at risk of developing alkalosis, but it can compromise the body's immune function. Peptic ulcers occur frequently in the stomach and duodenum and are accompanied by constipation, stomach and sewage, and chronic abdominal diseases. Peptic ulcers can be treated with methods such as stabilization and sedation, diet, antacids, parasympathetic blockers, histidine administration, and surgical procedures. Can be.

따라서 이와 같은 제제들은 치료효과가 높은데 반하여 부작용 및 재발비율이 높다. 이는 상기 제제들이 국부치료를 목적으로 한 화학적 제제이며 위산분비 억제에 주로 작용하기 때문이다. 이러한 이유로 최근 부작용이 없는 천연물을 이용한 위염, 위궤양, 십이지장궤양 등 소화기장애개선 물질이 연구되고 있다.Therefore, these agents have a high therapeutic effect while high side effects and relapse rate. This is because these agents are chemical agents intended for topical treatment and mainly act on inhibition of gastric acid secretion. For these reasons, gastrointestinal disorders such as gastritis, gastric ulcer and duodenal ulcer using natural products have been studied recently.

본 발명은 상기한 종래 기술의 사정을 감안하여 이루어진 것으로, 화학 합성물질이 아닌 천연 물질 및 천연물질 추출물로 그 재료로 구성하고, 그 천연물질들을 적당한 조건하에서 혼합 및 교반 과정을 거치고 정제 및 캡슐로 만들어 섭취를 쉽게 하여 인체의 면역력을 증강시키며 소화기에 직접 작용하여 화학 합성물질의 부작용을 없게 하고 장기 복용하여도 전혀 인체에 이상이 없이 소화기에 효과가 발생되도록 한 천연 물질을 주원료로 하는 소화기계 질환개선 및 예방식품 조성물을 제공함에 그 목적이 있다The present invention has been made in view of the above-described prior art, and is composed of natural materials and extracts of natural materials, not chemical synthetic materials, and the natural materials are mixed and stirred under appropriate conditions to tablets and capsules. Gastrointestinal disease, which is made from natural materials that make it easy to ingest, enhance immunity of the human body, act directly on the digestive organs, eliminate side effects of chemical synthetic substances, and produce effects on the digestive organs without any abnormalities even after long-term administration Its purpose is to provide improved and preventive food compositions.

상기한 목적을 달성하기 위해, 본 발명의 바람직한 실시예에 따르면 전체 100중량％ 대비 알로에겔분말 10중량％ 내지 20중량％, 노루궁뎅이버섯분말 15중량％ 내지 30중량％, 차조기추출분말 1중량％ 내지 2중량％, 카모마일추출분말 1중량％ 내지 2중량％, 감초추출분말 1중량％ 내지 2중량％, 회향추출분말 1중량％ 내지 2중량％, 난황분말 0.5중량％ 내지 5중량％, 자당지방산에스테르 1중량％ 내지 3중량％, 맥주효모 20중량％ 내지 45중량％, 수산화마그네슘 0.5중량％ 내지 1중량％, 진피추출분말 1중량％ 내지 2중량％, L-글루타민 1중량％ 내지 2중량％, 비타민 0.5중량％ 내지 2중량％, 히드록시프로필메틸셀룰로오스(HPMC) 0.5중량％ 내지 1중량％ 및 유당 2중량％ 내지 5중량％ 중 배합비를 결정하여 이루어진 것을 특징으로 하는 소화기계 질환예방 및 식품 조성물을 제공한다. 상기 배합비는 상기조성물을 제조함에 있어 인체 내에서 분해가 용이하고 제형을 쉽게 하기 위하여 결정하였으며 또한 상기 조성물의 경제성을 고려하여 배합비 범위를 결정하였다.In order to achieve the above object, according to a preferred embodiment of the present invention, 10% to 20% by weight of the aloe gel powder, 15% to 30% by weight of the wormwood mushroom powder, 1% by weight of perilla extract powder To 2% by weight, chamomile extract powder 1% to 2%, licorice extract powder 1% to 2%, fennel extract powder 1% to 2%, egg yolk powder 0.5% to 5%, sucrose fatty acid 1% to 3% by weight of ester, 20% to 45% by weight of beer yeast, 0.5% to 1% by weight of magnesium hydroxide, 1% to 2% by weight of dermis extract powder, 1% to 2% by weight of L-glutamine Digestive system disease prevention and food, characterized in that the compounding ratio of 0.5 to 2% by weight, hydroxypropyl methyl cellulose (HPMC) 0.5 to 1% by weight and 2 to 5% by weight lactose is determinedIt provides holy. The compounding ratio was determined in order to facilitate the decomposition and easy formulation in the human body in the preparation of the composition, and also determined the compounding ratio range in consideration of the economics of the composition.

본 발명에 따르면, 일반적인 소화기계 질환 치료제인 염기성 염류, 교질성제산제 및 소화성궤양 치료제를 장기 복용할 때에 내성이 생기는 등의 부작용을 최대한 줄이고, 체질에 관계없이 경구 투여하여 소화기계 궤양, 변비, 역류성 식도염, 위염, 나아가서는 소화기암 등의 모든 소화기계 질병을 개선하고 예방 하는데 매우 효과적으로 사용할 수 있다.According to the present invention, the side effects such as resistance to the long-term administration of basic salts, colloidal antacids, and peptic ulcer drugs, which are general treatments for diseases of the digestive system, are reduced as much as possible, and oral administration regardless of constitution is used to treat ulcers, constipation, and reflux. It can be used very effectively to improve and prevent all digestive system diseases such as esophagitis, gastritis and even digestive cancer.

상기의 목적을 달성하기 위하여, 대한민국 식품공전 및 건강기능식품에 공시된 식용으로 사용가능한 식품의 원료인 알로에겔분말, 노루궁뎅이버섯, 차조기추출분말, 카모마일추출분말, 감초추출분말, 회향추출분말, 난황분말, 자당지방산에스테르, 맥주효모와 수산화마그네슘, 진피추출분말과, L-글루타민, 비타민, 히드록시프로필메틸셀룰로오스(HPMC), 유당을 포함하는 소화기계 질환개선 및 예방식품 조성물을 제공한다.In order to achieve the above object, aloe gel powder, roe deer mushroom, green tea extract powder, chamomile extract powder, licorice extract powder, fennel extract powder, raw materials of foods available for use as disclosed in the Korea Food Code and health functional food It provides egg yolk powder, sucrose fatty acid ester, brewer's yeast and magnesium hydroxide, dermis extract powder, L-glutamine, vitamin, hydroxypropylmethylcellulose (HPMC), lactose, and digestive system disease improvement and preventive food composition.

상기에 있어서, 알로에겔분말은 식용품종(베라, 아보레센스(키타치), 사포나리아)의 잎을 식용에 적합하도록 가공하여 건조 분말한 것을 말한다.In the above, the aloe gel powder refers to a dry powder obtained by processing the leaves of foodstuff species (vera, aboressen (kitachi), saponaria) to be suitable for edible use.

상기에 있어 노루궁뎅이버섯은 노루궁뎅이버섯 자실체를 열풍건조한 것을 제외한 상온자연건조 또는 냉풍, 진공동결건조된 상태를 분말 화한 것을 말한다.In the above, roe deer mushroom is a powdered state of room temperature natural drying or cold air, vacuum freeze-dried state except hot-air dried roe deer mushroom fruiting body.

상기에 있어 난황분말은 'Helicobacter pylori' 에 의한 위염, 위궤양, 위 질환의 예방에 효과가 좋은 단바이오텍의 얼써락을 사용하였다.In the above egg yolk powder, Dan Biotech's erlock, which is effective for the prevention of gastritis, gastric ulcer and gastric diseases caused by 'Helicobacter pylori', was used.

상기에 있어 차조기추출분말, 카모마일추출분말, 감초추출분말, 회향추출분말, 자당지방산에스테르, 맥주효모와 수산화마그네슘, 진피추출분말과, L-글루타민, 비타민과 히드록시프로필메틸셀룰로오스(HPMC), 유당은 대한민국 식품공전에 식품원료로 등재되어 있는 원료를 말한다.Perilla extract powder, chamomile extract powder, licorice extract powder, fennel extract powder, sucrose fatty acid ester, beer yeast and magnesium hydroxide, dermis extract powder, L-glutamine, vitamin and hydroxypropyl methyl cellulose (HPMC), lactose Refers to raw materials listed as food raw materials in the Korean Food Code.

이하 본 발명을 하기 실시예 및 실험예를 통하여 상세히 설명하나, 본 발명이 여기에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail with reference to the following Examples and Experimental Examples, but the present invention is not limited thereto.

[실시예1]Example 1

조성물Ⅰ의 제조Preparation of Composition I

상기에 있어 알로에겔분말, 노루궁뎅이버섯분말, 차조기추출분말, 카모마일추출분말, 감초추출분말, 회향추출분말, 얼써락, 자당지방산에스테르, 맥주효모와 수산화마그네슘, 진피추출분말과, L-글루타민, 비타민과 히드록시프로필메틸셀룰로오스(HPMC), 유당을 하기의 표1과 같은 시료의 조성비로 정제를 만들었다.In the above, aloe gel powder, sesame mushroom powder, perilla extract powder, chamomile extract powder, licorice extract powder, fennel extract powder, ertherac, sucrose fatty acid ester, beer yeast and magnesium hydroxide, dermis extract powder, L-glutamine, Vitamin and hydroxypropyl methyl cellulose (HPMC), lactose was made in the composition ratio of the sample shown in Table 1 below.

Figure 112009500633819-pat00006
Figure 112009500633819-pat00006

[실시예 2]Example 2

조성물 Ⅱ의 제조Preparation of Composition II

상기에 있어 알로에겔분말, 노루궁뎅이버섯분말, 차조기추출분말, 카모마일추출분말, 감초추출분말, 회향추출분말, 난황분말, 자당지방산에스테르, 맥효모와 수산화마그네슘, 진피추출분말과, L-글루타민, 비타민을 하기의 표2과 같은 시료의 조성비로 정제를 만들었다.In the above, aloe gel powder, sesame mushroom powder, perilla extract powder, chamomile extract powder, licorice extract powder, fennel extract powder, egg yolk powder, sucrose fatty acid ester, wort and magnesium hydroxide, dermis extract powder, L-glutamine, Vitamins were made in the composition ratio of the sample as shown in Table 2 below.

Figure 112009500633819-pat00007
Figure 112009500633819-pat00007

[실험예 1]Experimental Example 1

인체적용시험Human application test

상기 실시예 1을 정제로 만들어 소화기계 질환이 있는 25명에게 1회 1g씩, 1일 2회 2개월간 복용하면서 문진으로 개선 효과를 관찰하였다.Example 1 was made into tablets and 25 people with digestive diseases were taking 1 g once a day, twice a day for two months while watching the improvement effect with a paperweight.

실험 결과, 복용자 모두에게서 소화기계 장애 증상이 호전되면서 개선되어 인체 소화기에 효과가 있는 것으로 확인되었다.(표 3 참조)As a result, it was confirmed that the symptoms of digestive system disorders were improved in all the patients, which was effective in the human digestive system (see Table 3).

Figure 112007507610437-pat00003
Figure 112007507610437-pat00003

..

Claims (4)

알로에겔분말 10중량％ 내지 20중량％, 노루궁뎅이버섯분말 15중량％ 내지 30중량％, 차조기추출분말 1중량％ 내지 2중량％, 카모마일추출분말 1중량％ 내지 2중량％, 감초추출분말 1중량％ 내지 2중량％, 회향추출분말 1중량％ 내지 2중량％, 난황분말 0.5중량％ 내지 5중량％, 자당지방산에스테르 1중량％ 내지 3중량％, 맥주효모 20중량％ 내지 45중량％, 수산화마그네슘 0.5중량％ 내지 1중량％, 진피추출분말 1중량％ 내지 2중량％, L-글루타민 1중량％ 내지 2중량％, 비타민 0.5중량％ 내지 2중량％, 히드록시프로필메틸셀룰로오스(HPMC) 0.5중량％ 내지 1중량％ 및 유당 2중량％ 내지 5중량％를 배합하여 제조되는 소화기계 질환개선 및 예방용 식품 조성물10% to 20% by weight of Aloe gel powder, 15% to 30% by weight of roe deer mushroom powder, 1% to 2% by weight of perilla extract powder, 1% to 2% by weight of chamomile extract powder, 1% to licorice extract powder % To 2% by weight, fennel extract powder 1% to 2%, egg yolk powder 0.5% to 5%, sucrose fatty acid ester 1% to 3%, brewer's yeast 20% to 45%, magnesium hydroxide 0.5 wt% to 1 wt%, dermis extract powder 1 wt% to 2 wt%, L-glutamine 1 wt% to 2 wt%, vitamin 0.5 wt% to 2 wt%, hydroxypropylmethylcellulose (HPMC) 0.5 wt% Food composition for the improvement and prevention of diseases of the digestive system prepared by combining to 1% by weight and 2% by weight to 5% by weight lactose 알로에겔분말 10중량％ 내지 20중량％, 노루궁뎅이버섯분말 15중량％ 내지 30％, 차조기추출분말 1중량％ 내지 2중량％, 카모마일추출분말 1중량％ 내지 2중량％, 감초추출분말 1중량％ 내지 2중량％, 회향추출분말 1중량％ 내지 2％, 난황분말 0.5중량％ 내지 5중량％, 자당지방산에스테르 1중량％ 내지 3중량％, 맥주효모 20중량％ 내지 45중량％, 수산화마그네슘 0.5중량％ 내지 1중량％, 진피추출분말과 1중량％ 내지 2중량％, L-글루타민 1중량％ 내지 2중량％ 및 비타민 0.5중량％ 내지 2중량％을 배합하여 제조되는 소화기계 질환개선 및 예방용 식품 조성물10% to 20% by weight of aloe gel powder, 15% to 30% of rotiferous mushroom powder, 1% to 2% by weight of perilla extract powder, 1% to 2% by weight of chamomile extract powder, 1% by weight of licorice extract powder To 2% by weight, fennel extract powder 1% to 2%, egg yolk powder 0.5% to 5%, sucrose fatty acid ester 1% to 3% by weight, beer yeast 20% to 45% by weight, magnesium hydroxide 0.5% Food products for improving and preventing digestive system diseases prepared by mixing% to 1% by weight, dermis extract powder and 1% to 2% by weight, 1% to 2% by weight of L-glutamine, and 0.5% to 2% by weight of vitamins. Composition 청구항 1 또는 청구항 2에 있어서,The method according to claim 1 or 2, 알로에겔분말은 알로에 품종 중 알로에 베라, 알로에 아보레센스, 알로에 사포나리아에서 선택되는 1 종인 소화기계 질환개선 및 예방용 식품 조성물Aloe gel powder is one of the aloe varieties Aloe Vera, Aloe Aborescens, Aloe Saponaria is a food composition for improving and preventing digestive diseases 청구항 1 또는 청구항 2에 있어서,The method according to claim 1 or 2, 노루궁뎅이버섯분말은 노루궁뎅이버섯 자실체를 자연건조, 냉풍건조 또는 동결건조 방법으로 건조하여 분쇄한 소화기계 질환개선 및 예방용 식품 조성물Roe deer mushroom powder is a food composition for improving and preventing diseases of the digestive system obtained by drying the Roe deer mushroom fruit body by natural drying, cold air drying or freeze drying.
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US10584117B2 (en) 2015-07-27 2020-03-10 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
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