CN107496532A - A kind of Chinese medicine composition for treating chicken dysentery and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chicken dysentery and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention provides a kind of Chinese medicine composition for treating chicken dysentery and preparation method thereof, granatum, pine bark, hairyvein agrimony are used as raw material, after rational compatibility, so that the effect of collaboration is formed between medicine, and then it can effectively treat chicken dysentery, by the regulation and control to technological parameter, the utilization rate of Chinese medicine is improved；Medicine usage amount of the present invention is that feed per ton adds 500~750g, and dosage is relatively low, and preventive effect is good, rapid-action, has no toxic side effect, and raw material is easy to get, no chemical synthesis substance, and market application foreground is extensive.
Description
Technical field
The present invention relates to the medicine of poultry disease, be specifically related to a kind of Chinese medicine composition for treating chicken dysentery and its
Preparation method.
Background technology
Chicken rush down dysentery is a kind of common infectious disease of the digestive tract as caused by shigella dysenteriae, suffers from chicken fear occurred in summer and autumn
Cold heating, general malaise, followed by abdominal pain diarrhea, for defecation on the one for several times to tens times, stool is dilute at first or less in water sample, excrement
It is every time then later a small amount of blood and mucus, and have and pull at not smooth bearing down containing purulence blood and volume mucus, it is anxious in being referred to as
If it is timely to weigh treatments afterwards, it can fully recover within 5th~7, but affect preventing and treating adversely to make that sb.'s illness took a turn for the worse and cause circulatory failure and dead
And avian dysentery mainly includes the general name of the symptom of diarrhea as caused by the various factors such as bacterium, virus, parasite.It is long
Phase serious dysentery, can lose large quantity of moisture, salt and alkaline matter, different degrees of dehydration, salt deficiency and acid poisoning, blood occurs
Liquid becomes concentration, so as to influence the normal circulation of body fluid, finally causes heart failure to cause death.The smaller incidence of disease of poultry age in days is got over
Height, case fatality rate is also higher, between generally 10%-40%.This disease can occur throughout the year, be the master for endangering poultry farming
Want one of disease.Western medical treatment is mainly bactericidal antiphlogistic and supplement body fluid, and the traditional Chinese medical science thinks this disease mainly heat toxin product in stomach and intestine
Caused dysentery, excessive heat syndrome in category, treatment preferably use the principle of clearing heat and detoxicating excreting dampness inducing astrigency.
Chicken dysentery almost spreads over all livestock culturing countries of the world, is widely distributed.At present, it is the most frequently used to treat the disease
It is Chinese medicine and Western medicine, for Chinese medicine because its prescription is unreasonable or simply simple crushing, particle diameter is excessive, and insoluble drug release is slower, causes
Its bioavilability is relatively low, and clinical effectiveness is not fine；And Western medicine is because its toxic side effect is strong, be also easy to produce drug resistance and medicine is residual
The problems such as staying, clinical practice are very limited or prohibitted the use of.
Therefore research and develop that a kind of insoluble drug release for treating chicken dysentery is very fast, bioavilability is higher, clinical effectiveness is preferable
Tcm product is the field scientific research technical staff new problem anxious to be resolved.
The content of the invention
In order to solve the above technical problems, the invention provides a kind of Chinese medicine composition for treating chicken dysentery and its preparation side
Method.
It is achieved especially by following technical scheme：
A kind of Chinese medicine composition for treating chicken dysentery, raw material in parts by weight for 40~60 parts of granatum, pine bark 25~
35 parts, 20~30 parts of hairyvein agrimony.
The raw material is 45 parts of granatum, 30 parts of pine bark, 25 parts of hairyvein agrimony in parts by weight.
The Chinese medicinal preparation method, comprises the following steps：Rear each medicine is weighed by formula rate, is ground into 30-200 mesh, is stirred
Uniformly, you can.
Further, it is ground into 80-150 mesh.
The Chinese medicine can also be prepared as follows：Rear each medicine is weighed by formula rate, its weight 8 is added after mixing
~11 times of water 150~180min of boiling, filter to get filtrate A, and filter residue adds 6~8 times of water 80~100min of boiling of its weight, filtering
Liquor B is obtained afterwards, after filtrate A and liquor B are merged, is concentrated under the conditions of 65~70 DEG C and is condensed into thick paste, dried and be crushed to
30~200 mesh, stir, you can.
The usage amount of the Chinese medicine is that 500~750g is added in feed per ton.
The foundation of technical solution of the present invention is as follows：
Root skin alkali contained by granatum in prescription of the present invention, has inhibitory action to typhoid bacillus, shigella dysenteriae, granatum is also
Intestinal mucosa can be restrained, secretion is reduced, so the diseases such as diarrhoea, dysentery can be effectively treated, the special efficacy for having relieving diarrhea with astringents；
Hairyvein agrimony cures mainly the diseases such as spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, uterine bleeding, bloody flux, malaria, diabete hidrosis, overstrain cough, controls trichomonad outside
The diseases such as property vaginitis, furuncle sore carbuncle swells, hemorrhoid；Pine bark be used for dispelling wind and eliminating dampness, promoting blood circulation and hemostasis, expelling pus and promoting granulation, cure mainly treating rheumatic ostealgia,
Traumatic injury, incised wound, discharging fresh blood stool, protracted dysentery, eczema, burn and scald, ulcer do not close up long.
In order that those of ordinary skill in the art are better understood from the present invention, the applicant has carried out a series of experiments and ground
Study carefully, to prove the effect of the present invention：
Compliance test result：
Test group：The medicine for using granatum, pine bark, hairyvein agrimony to be prepared for raw material；
Control group 1:The medicine for using granatum, hairyvein agrimony to be prepared for raw material
Control group 2：The medicine for using granatum, pine bark to be prepared for raw material；
Control group 3：The medicine for using pine bark, hairyvein agrimony to be prepared for raw material；
Control group 4：Using Ofloxacin soluble powder；
Application method：Medicine prepared by test group 1~7, according to 600g is added in feed per ton, feeding daily
Subjects：From 20 ages in days, body weight in 0.8kg-0.9kg, Laboratory Diagnosed is the ill broiler chicken of white diarrhea, is counted
Measure as 20, be used continuously same formula feeding 7-10 days, daily feeding 2 times.
As a result situation：
From above-mentioned experiment, test group is preferable to the therapeutic effect of white diarrhea, and action speed is fast, and it is fast to cure speed.
The beneficial effects of the present invention are：
The present invention uses granatum, pine bark, hairyvein agrimony as raw material, after rational compatibility so that shape between medicine
Into the effect of collaboration, and then chicken dysentery can be effectively treated, by the regulation and control to technological parameter, improve the utilization of Chinese medicine
Rate；Medicine usage amount of the present invention is that feed per ton adds 500~750g, and dosage is relatively low, and preventive effect is good, rapid-action, nontoxic pair
Effect, and raw material is easy to get, no chemical synthesis substance, and market application foreground is extensive.
Embodiment
Be described further below technical scheme, but claimed scope be not limited to it is described.
Embodiment 1
A kind of Chinese medicine composition for treating chicken dysentery, is mainly made up of the raw material of following percentage composition：Granatum 400g, pine
Bark 250g, hairyvein agrimony 200g.
Rear each medicine is weighed by formula rate, 30 mesh is ground into, stirs, you can.
The usage amount of the Chinese medicine is to add 500g in feed per ton.
Embodiment 2
A kind of Chinese medicine composition for treating chicken dysentery, is mainly made up of the raw material of following percentage composition：Granatum 600g, pine
Bark 350g, hairyvein agrimony 300g.
Rear each medicine is weighed by formula rate, 200 mesh is ground into, stirs, you can.
The usage amount of the Chinese medicine is to add 750g in feed per ton.
Embodiment 3
A kind of Chinese medicine composition for treating chicken dysentery, raw material are granatum 450g, pine bark 300g, red crowned crane in parts by weight
Careless 250g.
Each medicine is weighed according to formula ratio, 8 times of water boiling 150min of its weight are added after mixing, filter to get filtrate A, and filter residue adds
Enter 6 times of water boiling 80min of its weight, liquor B is obtained after filtering, after filtrate A and liquor B are merged, be concentrated under the conditions of 65 DEG C
Thick paste is condensed into, dries and is crushed to 180 mesh, stir, you can.
The usage amount of the Chinese medicine is to add 600g in feed per ton.
Embodiment 4
A kind of Chinese medicine composition for treating chicken dysentery, raw material are granatum 400g, pine bark 350g, red crowned crane in parts by weight
Careless 200g.
Rear each medicine is weighed by formula rate, 80 mesh is ground into, stirs, you can.
The usage amount of the Chinese medicine is to add 650g in feed per ton.
Embodiment 5
A kind of Chinese medicine composition for treating chicken dysentery, raw material are granatum 600g, pine bark 250g, red crowned crane in parts by weight
Careless 300g.
Rear each medicine is weighed by formula rate, 150 mesh is ground into, stirs, you can.
The usage amount of the Chinese medicine is to add 550g in feed per ton.
Embodiment 6
A kind of Chinese medicine composition for treating chicken dysentery, raw material are granatum 450g, pine bark 300g, red crowned crane in parts by weight
Careless 250g.
Each medicine is weighed according to formula ratio, 8 times of water boiling 150min of its weight are added after mixing, filter to get filtrate A, and filter residue adds
Enter 6 times of water boiling 80min of its weight, liquor B is obtained after filtering, after filtrate A and liquor B are merged, be concentrated under the conditions of 65 DEG C
Thick paste is condensed into, dries and is crushed to 30 mesh, stir, you can.
The usage amount of the Chinese medicine is to add 500g in feed per ton.
Embodiment 7
A kind of Chinese medicine composition for treating chicken dysentery, raw material are granatum 550g, pine bark 250g, red crowned crane in parts by weight
Careless 300g.
Each medicine is weighed according to formula ratio, 11 times of water boiling 150min of its weight are added after mixing, filter to get filtrate A, filter residue
8 times of water boiling 100min of its weight are added, liquor B is obtained after filtering, after filtrate A and liquor B are merged, are concentrated under the conditions of 70 DEG C
To thick paste is condensed into, dries and be crushed to 200 mesh, stir, you can.
The usage amount of the Chinese medicine is to add 750g in feed per ton.
Clinical test：
Randomly select by band diseased chicken 1800, wherein the cardinal symptom with diseased chicken is lassitude, appetite is poor, under wing
Hang down, loose random, cockscomb atrophy, face are turned white, and are short of breath, and drinking-water increases, and happiness is squatted, row's white slimy shape, it is faint yellow or
Green excrement；Through cut open inspection pathological change and Virus monitory, S. pullonum and coli-infection are diagnosed as.
1800 chickens are divided into 9 groups, every group 200, (being spaced out between group and group, do not spread disease mutually), organized into groups
Medication；Wherein test group 1-7 is successively using the obtained Chinese medicines for treating chicken dysentery of embodiment 1-7 and according to corresponding application method
To carry out the collocation of feed, i.e. mixed feeding：2 times a day；Control group uses 5% Ofloxacin soluble powder, mixed feeding：2 times a day, often
Secondary 100g adds feed 100kg；Blank group is without using drug therapy, daily diet feed and drinking-water；Test period：10 days；
The purpose for reaching treatment disease is absorbed after oral by intestines and stomach；Computational methods：The death rate=dead animal number/experimental animal number
× 100%, cure rate=healing number of animals/experimental animal number × 100%；Result of the test see the table below 1.
The result of the test of table 1
From upper table result, the present invention has the effect of fine to treatment chicken dysentery, wherein prepared with the scheme of embodiment 3
Medicine total effective rate has reached 100%, and the therapeutic effect of test group 1~7 is superior to existing conventional Ofloxacin method.
The wherein criterion of dysentery treatment effect：
(1) fully recover：Clinical symptom and sign is disappeared, and diet is intended to and mental restoration is normal；
(2) effectively：Clinical symptoms, sign have symptom at the end of mitigating：Clinical symptoms, which do not improve, even to be aggravated.
Safety testing：
- 30 age health broiler chicken 60 on the 20th are chosen, 5 times according to the made composition recommended dose of the embodiment of the present invention 3 are mixed
Material is drunk water 5 days, and during medication, healthy broiler chicken does not have the performance of any bad or abnormal behaviour, and feeding drinking-water is normal, increased weight
It is not notable that difference is compared with blank control group (i.e. healthy not administration group).
Claims (6)
- A kind of 1. Chinese medicine composition for treating chicken dysentery, it is characterised in that：Raw material is in parts by weight 40~60 parts of granatum, pine 25~35 parts of bark, 20~30 parts of hairyvein agrimony.
- 2. the Chinese medicine composition for the treatment of chicken dysentery as claimed in claim 1, it is characterised in that：The raw material is stone in parts by weight 45 parts of pomegranate skin, 30 parts of pine bark, 25 parts of hairyvein agrimony.
- 3. the Chinese medicine composition preparation method for the treatment of chicken dysentery as claimed in claim 1 or 2, it is characterised in that：Including following step Suddenly：Rear each medicine is weighed by formula rate, 30-200 mesh is ground into, stirs, you can.
- 4. the Chinese medicine composition preparation method for the treatment of chicken dysentery as claimed in claim 3, it is characterised in that：It is described to be ground into 80- 150 mesh.
- 5. the Chinese medicine composition preparation method for the treatment of chicken dysentery as claimed in claim 3, it is characterised in that：Weighed by formula rate Each medicine afterwards, 8~11 times of water 150~180min of boiling of its weight are added after mixing, filter to get filtrate A, filter residue add its weight 6~ 8 times of water 80~100min of boiling, liquor B is obtained after filtering, after filtrate A and liquor B are merged, be condensed under the conditions of 65~70 DEG C Thick paste, dry and be crushed to 30~200 mesh, stir, you can.
- 6. the Chinese medicine composition for the treatment of chicken dysentery as claimed in claim 1 or 2, it is characterised in that：The usage amount of the Chinese medicine is every 500~750g is added in ton feed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112402497A (en) * | 2020-11-03 | 2021-02-26 | 贵州慧创科技发展有限公司 | Chinese herbal medicine formula for treating animal diarrhea |
Citations (2)
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| US20130084271A1 (en) * | 2011-10-03 | 2013-04-04 | Kelly Foods Corporation | Probiotic composition for pets and method of providing the same |
| CN104547126A (en) * | 2014-11-28 | 2015-04-29 | 河南省农业高新科技园有限公司 | Traditional Chinese medicine composition for treating bacterial diarrhea of poultry |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130084271A1 (en) * | 2011-10-03 | 2013-04-04 | Kelly Foods Corporation | Probiotic composition for pets and method of providing the same |
| CN104547126A (en) * | 2014-11-28 | 2015-04-29 | 河南省农业高新科技园有限公司 | Traditional Chinese medicine composition for treating bacterial diarrhea of poultry |
Non-Patent Citations (2)
| Title |
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| 夏道伦，: "石榴皮可治疗动物的多种疾病", 《广东饲料》 * |
| 无: ""七 急慢性痢疾"", 《广西中医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112402497A (en) * | 2020-11-03 | 2021-02-26 | 贵州慧创科技发展有限公司 | Chinese herbal medicine formula for treating animal diarrhea |
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Application publication date: 20171222 |