CN105902760B - A kind of Chinese medicine for treating rabbit stomach enteritis - Google Patents

A kind of Chinese medicine for treating rabbit stomach enteritis Download PDF

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Publication number
CN105902760B
CN105902760B CN201610412587.6A CN201610412587A CN105902760B CN 105902760 B CN105902760 B CN 105902760B CN 201610412587 A CN201610412587 A CN 201610412587A CN 105902760 B CN105902760 B CN 105902760B
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parts
rabbit
chinese medicine
enteritis
rabbit stomach
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CN105902760A (en
Inventor
邓凯伟
张丁华
王艳丰
尚马飞
酒雅丽
曹智高
陈海燕
刘守铉
庞歌
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Xinyang Agriculture and Forestry University
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Xinyang Agriculture and Forestry University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Abstract

The invention discloses a kind of Chinese medicines for treating rabbit stomach enteritis, belong to Animal Medicine field, which is mainly prepared by the bulk pharmaceutical chemicals of following weight parts: 30 ~ 40 parts of Herba Andrographitis, 50 ~ 70 parts of the bark of ash, 35 ~ 50 parts of honeysuckle, 30 ~ 50 parts of charred RADIX SANGUISORBAE, 50 ~ 70 parts of Chinese yam, 30 ~ 50 parts of stir-baked FRUCTUS CRATAEGI.Chinese medicine provided by the invention is at low cost, and the cure rate for treating rabbit stomach enteritis is high, and due to using pure traditional Chinese medicine raw material, rabbit will not generate drug resistance.

Description

A kind of Chinese medicine for treating rabbit stomach enteritis
Technical field
The invention belongs to Animal Medicine fields, and in particular to a kind of Chinese medicine for treating rabbit stomach enteritis.
Background technique
Rabbit stomach enteritis is mainly since gastrointestinal mucosa is by inflammation caused by long-term abnormal stimulation, feed arrangement discomfort Preferably, the reasons such as feeding quality is bad, freshness is bad, daily ration ratio is improper, modulator approach is unreasonable, sanitary condition is poor can all draw Play gastroenteritis.In addition weather reason can aggravate harmful microorganism in rabbit stomach and intestine and make to the destruction of rabbit stomach and intestine for the variation of food With, and will cause the mild diarrhea of long period, so as to cause the abnormal, inflammation using gastrointestinal mucosa layer as the disease of main feature. Rabbit stomach enteritis is a kind of common disease, the frequently-occurring disease of rabbit, is endangered rabbit very big.Young rabbit after especially weaning, rabbit stomach enteritis Lethality be up to 70% or more.Antibiotic is generallyd use in the treatment of rabbit stomach enteritis at present and chemicals are treated, but It is that the beneficial microbe colony of rabbit stomach enteral can be damaged, while rabbit can also enhance the drug resistance of antibiotic, improves Treatment difficulty, increases production cost.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicines for the treatment of rabbit stomach enteritis that cure rate is high.
Based on above-mentioned purpose, the invention adopts the following technical scheme: a kind of Chinese medicine for treating rabbit stomach enteritis, mainly by following The bulk pharmaceutical chemicals of parts by weight are prepared: 30 ~ 40 parts of Herba Andrographitis, 50 ~ 70 parts of the bark of ash, 35 ~ 50 parts of honeysuckle, charred RADIX SANGUISORBAE 30 ~ 50 Part, 50 ~ 70 parts of Chinese yam, 30 ~ 50 parts of stir-baked FRUCTUS CRATAEGI.
Preferably, 30 parts of Herba Andrographitis, 60 parts of the bark of ash, 45 parts of honeysuckle, 30 parts of charred RADIX SANGUISORBAE, 60 parts of Chinese yam, 30 parts of stir-baked FRUCTUS CRATAEGI.
Preferably, the bulk pharmaceutical chemicals further include 70 ~ 80 parts of pine needle meal, 100 ~ 120 parts of carrot tops.
Preferably, the Chinese medicine is the decocting liquid of each bulk pharmaceutical chemicals.
The Chinese medicine of above-mentioned treatment rabbit stomach enteritis is prepared using following methods: by Herba Andrographitis, the bark of ash, honeysuckle, charred RADIX SANGUISORBAE, mountain Medicine, stir-baked FRUCTUS CRATAEGI, pine needle meal, carrot tops are mixed in proportion, are crushed, and add 3 ~ 4 times of water, and fried 60 ~ 80 minutes;It is filtered to take after fried Decocting liquid;Residual drug add water repetition it is fried, filtering twice;It decocting liquid will be used after mixing three times.
Dosage: daily medication is primary, and depending on the weight of how much foundation rabbits of each dosage, weight is at 4 kilograms or more Rabbit take decocting liquid 15ml;The rabbit that 2 kilograms ~ 4 kilograms of weight takes decocting liquid 12ml;The rabbit that 1 kilogram ~ 2 kilograms of weight takes Decocting liquid 8ml;The rabbit of 1 kilogram of weight once takes decocting liquid 5ml.
Wherein, Herba Andrographitis: bitter, cold in nature, return heart, lung, large intestine, bladder meridian;With clearing heat and detoxicating, cool blood detumescence, antibacterial Anti-inflammatory, antiviral, anti-liver injury enhance immune effect;Cure mainly acute bacillary dysentery, gastroenteritis, flu, epidemic meningitis, tracheitis, lung Inflammation, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, oropharynx swelling and pain, boil carbuncle swells, scald.Present medicine thinks The andrographolide contained in Herba Andrographitis has good curative effect to bacillary dysentery and enteritis.
The bark of ash: bitter, it is cold in nature, enter Liver Channel, gallbladder channel, large intestine channel;With heat-clearing and damp-drying drug, clear liver and improve vision, the function of inducing astrigency stop dysentery Effect;With resisting pathogenic microbes effect, to staphylococcus aureus, Escherichia coli, shigella flexneri, bacterium sonnei, Micrococcus catarrhalis, streptococcus, neisser's diplococcus have inhibiting effect.Clinically it is chiefly used in damp-heat dysentery, tenesmus, bacillary dysentery The treatment of disease.
Honeysuckle: it is sweet in flavor, it is cold in nature, enter lung, the heart, stomach meridian;Have effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind, cures mainly swollen Completely descend disease, warm disease heating, the diseases such as heat toxin large carbuncle and tumour.Modern study proves that honeysuckle contains chlorogenic acid, cyanidenon glycosides etc. Pharmacological component, to the various pathogens such as hemolytic streptococcus, Staphylococcus aureus and infection of the upper respiratory tract Causative virus etc. There is stronger restraint.It is clinically used for, enteritis, bacillary dysentery, morbilli, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, door screen Tail inflammation, skin infection, the treatment of ulcer boils, erysipelas, parotitis, suppurative tonsillitis.
Charred RADIX SANGUISORBAE: property is bitter, sour, cool, enters liver, stomach, large intestine channel;Charred RADIX SANGUISORBAE belongs to hemostatic, has cooling blood and hemostasis, removing toxic substances Sore effect is the common drug for treating the various bleedings of blood-head.
Stir-baked FRUCTUS CRATAEGI: it is sour sweet, enter spleen, stomach, Liver Channel;There is food digesting stomach fortifying, activate blood circulation and disperse blood clots, the function of convergence and dysentery;To meat accumulation It is phlegm retention, feeling of fullness acid regurgitation, dysentery intestines wind, pain in the loins hernia, effective in cure.
Contained by Chinese yam can diastatic diastase, be 3 times of content in radish, when gasteremphraxis is edible, there is rush Into the effect of digestion, malaise symptoms can be removed, being conducive to, which improves taste, digests and assimilates function.
Pine needle meal: it is bitter, puckery, it is warm-natured;With expelling wind and activating blood flow, improving eyesight is calmed the nerves, and removing toxic substances is antipruritic, is eliminated bad breath, is removed dry tongue It is dry, the effect for the treatment of constipation.For influenza, rheumatic arthritis, treating swelling and pain by traumatic injury, yctalopia, high blood pressure, neurasthenia; External application treating chilblain;Rich in amino acid, vitamin necessary to animal growth and various trace elements, to promotion growth of animals or poultry Development, enhancing premunition and raising reproductive function etc. have apparent facilitation.
Carrot tops: it is sweet in flavor, it is mild-natured;Spleen is supported with invigorating the spleen, nourishing the stomach stomach invigorating, blood-supplementing blood-nourishing, Buzhong, improves immunity The effect of;Suitable for the diseases such as hypertension and indigestion, protracted dysentery, yctalopia, malnutrition.
Chinese medicine provided by the invention is at low cost, with antibacterial anti-inflammatory, antidiarrheal, nourishing the stomach stomach invigorating, enhances body resistivity Effect can treat the disease of rabbit stomach enteritis, prevent the generation of rabbit stomach enteritis, and cure rate is high, and due to using pure traditional Chinese medicine raw material, Rabbit will not generate drug resistance.
Specific embodiment
The following describes the present invention in detail with reference to examples.
Embodiment 1
A kind of Chinese medicine for treating rabbit stomach enteritis, is prepared by the bulk pharmaceutical chemicals of following weight parts: Herba Andrographitis 30g, the bark of ash 60g, honeysuckle 45g, charred RADIX SANGUISORBAE 30g, 60 g of Chinese yam, stir-baked FRUCTUS CRATAEGI 30g, pine needle meal 70g, carrot tops 100g.
The Chinese medicine of above-mentioned treatment rabbit stomach enteritis is prepared using following methods: by Herba Andrographitis, the bark of ash, honeysuckle, charred RADIX SANGUISORBAE, mountain Medicine, stir-baked FRUCTUS CRATAEGI, pine needle meal, carrot tops are mixed in proportion, are crushed, and add 1000ml water, and fried 60 ~ 80 minutes;Filtering after fried Take decocting liquid;The remaining dregs of a decoction add water repetition is fried, filter process twice;It decocting liquid will be used after mixing three times.
Embodiment 2
A kind of Chinese medicine for treating rabbit stomach enteritis, is prepared by the bulk pharmaceutical chemicals of following weight parts: Herba Andrographitis 35g, the bark of ash 60g, honeysuckle 40g, charred RADIX SANGUISORBAE 40g, Chinese yam 60g, stir-baked FRUCTUS CRATAEGI 40g, pine needle meal 75g, carrot tops 110g.
Preparation method is same as Example 1.
Embodiment 3
A kind of Chinese medicine for treating rabbit stomach enteritis, is prepared by the bulk pharmaceutical chemicals of following weight parts: Herba Andrographitis 40g, the bark of ash 50g, honeysuckle 35g, charred RADIX SANGUISORBAE 50g, Chinese yam 70g, stir-baked FRUCTUS CRATAEGI 50g, pine needle meal 70g, carrot tops 120g.
Preparation method is same as Example 1.
Embodiment 4
A kind of Chinese medicine for treating rabbit stomach enteritis, is prepared by the bulk pharmaceutical chemicals of following weight parts: 30 g of Herba Andrographitis, the bark of ash 70 G, 50 g of honeysuckle, charred RADIX SANGUISORBAE 30g, Chinese yam 50g, stir-baked FRUCTUS CRATAEGI 30g, pine needle meal 80g, carrot tops 100g.
Preparation method is same as Example 1.
Effect experiment
Test 1
Subjects: certain rabbit warren is grown up beaver rabbit 200.
Symptom and analysis: discovery appetite stimulator, indigestion and mucus in stool.Then occur having loose bowels, arrange scattered paste shape Or water sample excrement, excrement distribute stench, and are mixed with mucus, the mucous membrane that falls off and do not digest complete forage.It is found after dissecting, intestines Oedema, bleeding or necrosis under mucous membrane, after removing necrotic tissue, it is seen that the speck or ulcer left.According to field investigation, the cause of disease Analysis, cardinal symptom and pathological change, judgement are the rabbit stomach enteritis occurred due to the rabbit grain of feeding mildew.
Test process: 200 beaver rabbit stochastic averaginas are divided into 2 groups, every group 100, are denoted as 1 group of test and test 2 respectively The traditional Chinese medicine decoction of the preparation of embodiment 1 is taken in group, 1 group of test, and the traditional Chinese medicine decoction of the preparation of embodiment 2 is taken in 2 groups of test.Daily medication Once, each dosage are as follows: weight takes decocting liquid 15ml in 4 kilograms or more of rabbit;The rabbit that 2 kilograms ~ 4 kilograms of weight takes pan-fried Liquid 12ml;The rabbit that 1 kilogram ~ 2 kilograms of weight takes decocting liquid 8ml;The rabbit of 1 kilogram of weight once takes decocting liquid 5ml.Record is controlled respectively The healing number of lazy rabbit and final death toll, concrete outcome are shown in Table 1 after treatment 3d, 5d.
Figure DEST_PATH_IMAGE002
As can be seen from the data in table 1, Chinese medicine provided by the invention has apparent curative effect, and embodiment to treatment rabbit stomach enteritis 1 curative effect is apparently higher than the curative effect of the Chinese medicine of the preparation of embodiment 2.
Test 2
Subjects: 120 Pili in Fetus of Haired Rabbit of certain raiser raising.
Symptom and analysis: excrement has bubble, is mingled with the mucus of red white nasal mucus sample.Sick rabbit often with formula bowel movement of squatting, and Times of defecation is more and Fecal wastes are few.Oedema, bleeding under intestinal mucosa.According to cardinal symptom and pathological change and laboratory testing, Making a definite diagnosis is the rabbit stomach enteritis occurred due to the rabbit grain of feeding e. coli contamination.
Test process: being divided into 2 groups for 120 Pili in Fetus of Haired Rabbit stochastic averaginas, every group 60, be denoted as test A group and test B group, Test A group takes the traditional Chinese medicine decoction of the preparation of embodiment 1, and test B group takes the traditional Chinese medicine decoction of the preparation of embodiment 2.Daily medication one It is secondary, each dosage are as follows: weight takes decocting liquid 15ml in 4 kilograms or more of rabbit;The rabbit that 2 kilograms ~ 4 kilograms of weight takes decocting liquid 12ml;The rabbit that 1 kilogram ~ 2 kilograms of weight takes decocting liquid 8ml;The rabbit of 1 kilogram of weight once takes decocting liquid 5ml.Record treatment respectively The healing number of Pili in Fetus of Haired Rabbit rabbit and final death toll, concrete outcome are shown in Table 2 after 3d, 5d.
Figure DEST_PATH_IMAGE004
As can be seen from the data in table 1, Chinese medicine provided by the invention has apparent curative effect, and embodiment to treatment rabbit stomach enteritis 1 curative effect is apparently higher than the curative effect of the Chinese medicine of the preparation of embodiment 2.
Test 3
Subjects: certain supports beaver rabbit field rabbit 100, is fed after wean using rabbit grain.
Symptom and analysis: it due to the transitional period for not having rabbit grain to feed, causes rabbit and excludes wet rotten excrement and have evil Stink, belly tympanites.But young rabbit still has appetite, is due to dyspeptic rabbit stomach according to etiological analysis, cardinal symptom and judgement Enteritis.
Test process: every young rabbit takes the decocting liquid 5ml of embodiment 1 daily.The healing of young rabbit after record treatment 3d, 5d Several and final death toll, concrete outcome are shown in Table 3.
Figure DEST_PATH_IMAGE006

Claims (3)

1. a kind of Chinese medicine for treating rabbit stomach enteritis, which is characterized in that be prepared by the bulk pharmaceutical chemicals of following weight parts: Herba Andrographitis 30 ~ 40 parts, 50 ~ 70 parts of the bark of ash, 35 ~ 50 parts of honeysuckle, 30 ~ 50 parts of charred RADIX SANGUISORBAE, 50 ~ 70 parts of Chinese yam, stir-baked FRUCTUS CRATAEGI 30 ~ 50 Part, 70 ~ 80 parts of pine needle meal, 100 ~ 120 parts of carrot tops.
2. the Chinese medicine for the treatment of rabbit stomach enteritis according to claim 1, which is characterized in that 30 parts of Herba Andrographitis, 60 parts of the bark of ash, gold 45 parts of honeysuckle flower, 30 parts of charred RADIX SANGUISORBAE, 60 parts of Chinese yam, 30 parts of stir-baked FRUCTUS CRATAEGI.
3. the Chinese medicine for the treatment of rabbit stomach enteritis according to claim 2, which is characterized in that the Chinese medicine is decocting for each bulk pharmaceutical chemicals Liquid.
CN201610412587.6A 2016-06-14 2016-06-14 A kind of Chinese medicine for treating rabbit stomach enteritis Expired - Fee Related CN105902760B (en)

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CN106177380A (en) * 2016-08-31 2016-12-07 梁小荣 The Chinese medicine preparation of preventing and treating Holland dwarf's rabbit gastroenteritis disease and preparation method

Citations (2)

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CN104147097A (en) * 2014-09-02 2014-11-19 扬中牧乐药业有限公司 Traditional Chinese medicinal granule for treating gastroenteritis of rex rabbit
CN105250825A (en) * 2015-11-09 2016-01-20 陈鹏举 Traditional Chinese medicine composition for treating and preventing livestock, poultry and fur-bearing animal gastroenteritis

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN104147097A (en) * 2014-09-02 2014-11-19 扬中牧乐药业有限公司 Traditional Chinese medicinal granule for treating gastroenteritis of rex rabbit
CN105250825A (en) * 2015-11-09 2016-01-20 陈鹏举 Traditional Chinese medicine composition for treating and preventing livestock, poultry and fur-bearing animal gastroenteritis

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