CN102671011B - Traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets and preparation method thereof - Google Patents
Traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of veterinary drugs, and particularly discloses a traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets and a preparation method of the traditional Chinese medicine compound powder. The traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets is prepared from raw materials including, by weight, from 4 to 8 parts of radix scutellariae, from 3 to 6 parts of purslane, from 3 to 6 parts of flowers of poplar, from 2 to 4 parts of garlic, from 1 to 2 parts of pomegranate grinds and from 16 to 20 parts of rice. Incompatibility of various raw materials in the traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets is avoided, and practice proves that the traditional Chinese medicine compound powder can obviously reduce occurrence rate of the yellow and white scour of the piglets, has an excellent prevention and treatment effect on the yellow and white scour of the piglets and is free of side effects and harmful drag residue and safe in use.
Description
Technical field
The present invention relates to the veterinary drug technical field, be specifically related to a kind of Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet and preparation method thereof.
Background technology
China is the big country of raising pigs, and the live pig amount of delivering for sale, breeding stock and Carnis Sus domestica output all occupy first place in the world, and pig industry is occupied leading position in China's animal husbandry simultaneously, and Carnis Sus domestica has accounted for the overwhelming majority in the meat total output.Yet, in Swine Production, diarrhoea has become and causes piglet growth to be obstructed and the one of the main reasons of high mortality, has seriously hindered the sound development of pig industry.China's piglet diarrhea rate is up to 50-60%, and mortality rate reaches 15-20%.Suffering from diarrhoea modal is yellow scour of piglet, piglet pujos blancos.Yellow scour of piglet claims again the early onset colibacillosis, and piglet pujos blancos is the Delayed onset colibacillosis, and both usually follow generation.Yellow scour of piglet is mainly in the piglet of 1-3 days after birth, and piglet pujos blancos mainly betides 10-30 age in days piglet, without obviously seasonal, during morbidity, take dysentery, discharge milky or faint yellow thickness or medicated porridge sample and be feature with special stench flavor feces.At present, prevention and the treatment for yellow and white dysentery of piglet mainly adopts vaccine immunity and antibiotic therapy etc.But immune effect of vaccine is often uncertain, although antibiotic is rapid-action, cure rate is higher, but antibiotic can make the imbalance of intestine of young pigs normal flora, and impact is digested and assimilated nutrition, make pathogen produce drug resistance, curative effect worse and worse, is used antibiotic can aggravate disease on the contrary sometimes.Maximum problem is easily to produce Resistant strain and drug residue.Along with the antibiotic prolongation of service time, the multi-drug resistant problem is more and more serious, and the appearance of Resistant strain makes human health also be subject to great threat.Many countries are forbidden increasing antibiotic by legislation, and China relies on one of the most serious country of antibiotic in aquaculture, therefore find safety, noresidue, green feed additive replaces antibiotic to become one of study hotspot in recent years efficiently.
The source natural sex of Chinese medicine and security reliability are its outstanding characteristics, derive from the Chinese medicine of animal, plant and mineral, it itself is exactly the ingredient of the earth and living organism, the native state and the biological activity that have kept various constituent structure, for antibiotic, be difficult for producing drug resistance, toxic and side effects is little, in livestock products, does not produce hazard residue.Much there is in addition the composition of nutritive effect in Chinese medicine, in diseases prevention, can also promote growth of animal, improve body resistance against diseases.Therefore, Chinese medicine can fundamentally solve the antibiotic remains problem that puzzlement animal husbandry develops in a healthy way, the development green animal husbandry, and environmental contamination reduction, have important social benefit.Chinese medicine, for the existing a lot of reports of the control of piglet bacillary dysentery, has also been obtained certain clinical effectiveness at present.The Chinese medicine series products used at present is to take oral liquid, injection, several dosage forms of powder as main basically.The following problem of ubiquity in production application: although injection is easy to use, for preventing and treating intestinal tract disease, effect is unsatisfactory; Oral liquid absorbs better, but use inconvenient, also can exist certain stress, may increase the weight of the state of an illness; Powder is easy to use, but the powder of majority is only to adopt general breaking method at present, and assimilation effect is poor, and addition is large.In addition, be three minutes poison of medicine, flavour of a drug are too many or dose is bigger than normal, and Chinese medicine causes larger burden also can to the digestive system of piglet fragility, and increases drug cost.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet.
The present invention also aims to provide a kind of preparation method of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet.
In order to realize above purpose, the technical solution adopted in the present invention is: a kind of Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet, by the raw material of following parts by weight, made: Radix Scutellariae 4-8 part, Herba Portulacae 3-6 part, flower of poplar 3-6 part, Bulbus Allii 2-4 part, Pericarpium Granati 1-2 part, rice 16-20 part.
A kind of preparation method of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet comprises the following steps:
(1) take raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati, rice, by after raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati cold drying, micronizing, obtain ultra micro powder A together;
(2) by the rice parching to brown, be ground into afterwards floury, obtain powder material B;
(3) described ultra micro powder A and described powder material B are directly mixed, make the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet.
Effect at each raw material of Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention is as follows: Radix Scutellariae: heat clearing and damp drying, and eliminating fire and detoxication, hemostasis, its pharmacological action is mainly the resisting pathogenic microbes effect; Herba Portulacae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, detumescence, antiinflammatory, modern medicine study shows, and Herba Portulacae contains abundant vitamin A sample material, and vitamin A sample substance maintains the normal function of epithelial tissue, promotes the reparation of mucosa; Pericarpium Granati: relieving diarrhea with astringents, hemostasis, anthelmintic, can be used for treating bacillary dysentery, intestinal inflammation; Flower of poplar: heat-clearing and toxic substances removing, relieving diarrhea with astringents, removing dampness dysentery relieving, strengthening the spleen and nourishing the stomach can be used for bacillary dysentery, intestinal inflammation; Bulbus Allii: the stagnant gas of row, warming the spleen and stomach, eliminating mass is long-pending, and removing toxic substances, for flu, bacillary dysentery, amebic dysentery, enteritis, eating accumulation, carbuncle skin infection; Rice: after the rice parching to brown, starch has become dextrin, and more easily digestion can warming the spleen and stomach, the protection gastrointestinal mucosa, contributes to recover gastrointestinal function.
There is not incompatibility in each material combination of Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention, facts have proved that this Chinese medicine compound powder can obviously reduce the incidence rate of yellow and white dysentery of piglet, yellow and white dysentery of piglet is had to good preventive and therapeutic action, and have no side effect, use safety, without harmful drug residue.
Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention has the following advantages: one, raw material is easy to get, cheap, and cost is lower; Two, take the medical material of integration of edible and medicinal herbs as main, safe; Three, not only can suppress pathogen, there is the effect of prevention and treatment yellow and white dysentery of piglet, but also can strengthening the spleen and stomach, promote the reparation of intestinal mucosa, reach the effect for the treatment of both the principal and secondary aspects of a disease; Four, Chinese medicine ingredients Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii and the Pericarpium Granati in Chinese medicine compound powder of the present invention made the ultra micro powder through micronizing, the better absorption, and utilization rate is higher; Five, dosage form is powder, easy to use.
Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention also can be used for prevention and the treatment of other bacillary dysenterys of poultry.
The using method of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention:
1, the piglet for not weaning: the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet provided by the invention and appropriate milk powder and white sugar are mixed, add water and make half wet graininess, be placed in rustless steel tray food calling, be used in conjunction 5-10 days;
2, for ablactational baby pig: add the ratio that is 3-6% according to percentage by weight for the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet provided by the invention to daily ration, be used in conjunction 5-7 days;
3, the piglet for not eating: the Glucose Liquid that is 5% by mass percent for the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet provided by the invention is mixed to scattered paste shape, gavage, every day, 50-150g, be used in conjunction 5-7 days.
The specific embodiment
Embodiment 1
The present embodiment, for the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet, is made by the raw material of following parts by weight: 8 parts of Radix Scutellariaes, 3 parts of Herba Portulacaes, 3 parts of flower of poplar, 2 parts, Bulbus Allii, 2 parts of Pericarpium Granatis, 16 parts, rice.
The present embodiment, for the preparation method of the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet, comprises the following steps:
(1) take raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati, rice, by after raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati cold drying, micronizing, obtain ultra micro powder A together;
(2) by the rice parching to brown, be ground into afterwards floury, obtain powder material B;
(3) described ultra micro powder A and described powder material B are directly mixed, make the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet.
Embodiment 2
The present embodiment, for the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet, is made by the raw material of following parts by weight: 4 parts of Radix Scutellariaes, 6 parts of Herba Portulacaes, 6 parts of flower of poplar, 4 parts, Bulbus Allii, 1 part of Pericarpium Granati, 20 parts, rice.
The present embodiment for the preparation method of the Chinese medicine compound powder of prevention and treatment yellow and white dysentery of piglet with the preparation method of embodiment 1.
The extracorporeal bacteria inhibitor test of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that test example 1 embodiment 1, embodiment 2 provide
Experimental technique adopts quick paper disk method, and concrete steps are:
(1) prepare bacterium liquid: the yellow and white dysentery of piglet feces dilution that will collect from pig farm, be applied on ordinary culture medium, 37 ℃ of constant temperature culture 18 hours, cultivate microscopy through maconkey agar and EMB agar medium, be defined as escherichia coli, 1 escherichia coli bacterium colony of picking, be inoculated in the 10mL broth medium and dilute, and mixes, make bacterium liquid, standby;
(2) get respectively the Chinese medicine compound powder 10g for prevention and treatment yellow and white dysentery of piglet that the embodiment of the present invention 1, embodiment 2 provide, put into respectively 100ml water, soak after 30 minutes, add a cover decoction, boil rear with slow fire boiling 30 minutes, decoct altogether three times, the filtrate of three gained is merged, all be concentrated into 1g/mL, obtain the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that embodiment 1 provides and embodiment 2 provide, standby;
(3) preparation of Chinese medicine drug sensitive test paper: get qualitative filter paper, make the circular paper of 6mm diameter with card punch, by autoclaving after scraps of paper sealing, then be placed in drying baker, make its bone dry, with tweezers, the scraps of paper are immersed respectively to the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that embodiment 1 provides and embodiment 2 provide afterwards, make extracting solution soak into the scraps of paper fully, standing drying, make the Chinese medicine drug sensitive test paper, standby;
(4) Chinese medicine Bacteriostatic Effect: with sterilized cotton swabs, dip the bacterium liquid that step (1) makes, be coated in equably on ready nutrient agar panel, treat the media surface drying, get with aseptic nipper the Chinese medicine drug sensitive test paper that step (3) makes, be attached on media surface, every kind of Chinese medicine drug sensitive test paper is done three repetitions, matched group is set in addition, 37 ℃ of constant temperature culture are after 18 hours, observe and measure inhibition zone diameter, the inhibition zone diameter average out to 10.0mm of the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that embodiment 1 provides, the inhibition zone diameter average out to 9.0mm of the Chinese medicine compound powder extracting solution for prevention and treatment yellow and white dysentery of piglet that embodiment 2 provides, the compound Chinese medicinal preparation that matched group is certain commercially available treatment yellow and white dysentery of piglet, its inhibition zone diameter average out to 9.0mm, by comparing inhibition zone diameter, illustrate that the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that the embodiment of the present invention 1 and embodiment 2 provide has In Vitro Bacteriostasis effect preferably to pathogenic Escherichia coli.
The clinical treatment statistical test of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that test example 2 embodiment 1 provide
New born piglet 20 nests in certain pig farm, totally 264, at the 3rd day of birth, wherein there are 237 piglets to start morbidity, suffer from after diagnosing totally 149 of yellow scours in piglet, suffer from totally 88 of Hakuri.The Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that adopts the embodiment of the present invention 1 to provide is treated, the fair piglet for appetite, the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet and appropriate milk powder, white sugar that the embodiment of the present invention 1 is provided mix, make half wet graininess, be placed in rustless steel tray food calling, be used in conjunction 7 days; For the piglet do not eaten, the Glucose Liquid that the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that the embodiment of the present invention 1 is provided is 5% by mass percent mixes scattered paste shape, gavages, and every day, 100g, be used in conjunction 7 days, colony house carried out disinfection simultaneously.After medication 1 week, most of piglet is all cured, and wherein the ill pig of yellow scours is cured 142, cure rate 95.3%, and other 7 the Chinese medicine compound powder treatments that continue to use the embodiment of the present invention 1, after 3 days, are all cured, without dead; The ill pig of Hakuri is cured 85, cure rate 96.6%, and other 3 are continued to use the Chinese medicine compound powder of the embodiment of the present invention 1 to treat after 7 days, 2 healings, 1 death.
The clinical prevention test of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that test example 3 embodiment 1 provide
, there is newborn piglet yellow scours morbidity history on the pig farm, Yanshi, chooses the piglet of five sows of childbirth on the same day and do experiment, and piglet is respectively 12,12,13,13,15, has chosen wherein two nests (12,13) and has been prevented.Give a birth the same day, the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that the embodiment of the present invention 1 is provided mixes with appropriate milk powder and white sugar, adds water and makes half wet graininess, is placed in rustless steel tray food calling, is used in conjunction 7 days, observation every day.The situation of having loose bowels does not appear in the medication piglet, and other three nests all find that there is the situation that piglet is drawn faint yellow loose stool in the 2nd day, 4 days after birth, and final dead 4.The Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that this test explanation embodiment 1 provides has preventive effect preferably to yellow scour of piglet.
The Clinical Treatment Test of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that test example 4 embodiment 1 provide
The Luoyang raiser, totally 76 of a collection of piglets (15-20 age in days), opened food, but not wean, several piglet morbidities are arranged, spirit is depressed, inappetence, and excrement is the canescence pulpous state, abnormal smells from the patient is stench, tail and hind leg faecal contamination, other piglets also have infection in various degree, are piglet pujos blancos after diagnosing.Treatment: the fair piglet for appetite, the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet and appropriate milk powder, white sugar that the embodiment of the present invention 1 is provided mix, and make half wet graininess, are placed in rustless steel tray food calling, are used in conjunction 7 days; For the piglet do not eaten, the Glucose Liquid that the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet that the embodiment of the present invention 1 is provided is 5% by mass percent mixes scattered paste shape, gavages, and every day, 100g, be used in conjunction 7 days; Colony house is carried out disinfection simultaneously.Effect: medication is after 1 week, and most of piglet all takes a turn for the better, and more serious several the piglets of the state of an illness, except 1 (the weak tire that birth weight is lighter) death, have all recovered appetite, by paying a return visit the rehabilitation gradually of sick piglet, there is no recurrence.
Claims (2)
1. the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet, is characterized in that, by the raw material of following parts by weight, made: Radix Scutellariae 4-8 part, Herba Portulacae 3-6 part, flower of poplar 3-6 part, Bulbus Allii 2-4 part, Pericarpium Granati 1-2 part, rice 16-20 part.
2. the preparation method of the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet claimed in claim 1, is characterized in that, comprises the following steps:
(1) take raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati, rice, by after raw material Radix Scutellariae, Herba Portulacae, flower of poplar, Bulbus Allii, Pericarpium Granati cold drying, micronizing, obtain ultra micro powder A together;
(2) by the rice parching to brown, be ground into afterwards floury, obtain powder material B;
(3) described ultra micro powder A and described powder material B are directly mixed, make the Chinese medicine compound powder for prevention and treatment yellow and white dysentery of piglet.
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| CN 201210001000 CN102671011B (en) | 2012-01-04 | 2012-01-04 | Traditional Chinese medicine compound powder for preventing and treating yellow and white scour of piglets and preparation method thereof |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102895355B (en) * | 2012-11-07 | 2013-10-23 | 大理金明动物药业有限公司 | Chinese medicinal injection for treating livestock diarrhea and preparation method thereof |
| CN103191256B (en) * | 2013-03-28 | 2014-03-19 | 重庆市畜牧科学院 | Synbiotics traditional Chinese medicine composition for controlling white scour of piglets, and preparation method thereof |
| CN103893602A (en) * | 2014-04-20 | 2014-07-02 | 张文艳 | Simple and convenient mixed medicine with rapid antidiarrheal effect |
| CN105963688A (en) * | 2016-06-23 | 2016-09-28 | 四川英格瑞生物科技有限公司 | Powder for curing intestinal diseases of piglet and enhancing immunity and preparation method thereof |
| CN107308439A (en) * | 2017-07-06 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of compound poplar flower oral liquid and preparation method thereof |
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2012
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Non-Patent Citations (2)
| Title |
|---|
| 仔猪腹泻的防治措施;姚永韶等;《福建畜牧兽医》;20030630;第25卷(第3期);18 * |
| 姚永韶等.仔猪腹泻的防治措施.《福建畜牧兽医》.2003,第25卷(第3期),18. |
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