CN101879238A - Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof - Google Patents
Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof Download PDFInfo
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- CN101879238A CN101879238A CN2009100687747A CN200910068774A CN101879238A CN 101879238 A CN101879238 A CN 101879238A CN 2009100687747 A CN2009100687747 A CN 2009100687747A CN 200910068774 A CN200910068774 A CN 200910068774A CN 101879238 A CN101879238 A CN 101879238A
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- chicken colibacillosis
- rhizoma coptidis
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Abstract
The invention provides a medicinal composition for preventing and controlling chicken colibacillosis and a preparation method thereof. The medicinal composition comprises the following components in part by weight: 5 to 20 parts of goldthread, 20 to 40 parts of phellodendron, 20 to 40 parts of baical skullcap root, 15 to 30 parts of gardenia and 0.3 to 1 part of cellulose. The preparation method comprises the following steps of: crushing each component into a coarse dreg with the diameter between 0.05 and 0.5cm; extracting by using an enzyme preparation; and finally obtaining extract, namely brownish red bitter liquid. The medicinal composition has the advantages of quick absorption, obvious effect and convenient use, and has effective effects of preventing the chicken colibacillosis and enhancing resistance capacity of organisms; and in the healing period, the weight of chicken is obviously increased, the medicament resistance is difficult to generate, and medicament residue is not present in the chicken. In the preparation method, active ingredients are subjected to enzymolysis and extraction, so the composition has the advantages of high extraction purity, quick absorption, obvious effect and convenient use.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, pharmaceutical composition of especially a kind of prevention and treatment chicken colibacillosis and preparation method thereof.
Background technology
At present, the aquaculture of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, lack relevant feeding and management and epidemic prevention and control knowledge, cause the sickness rate and the relapse rate of some diseases significantly to increase, and some conditionality pathogenic bacterium such as colibacillosis, salmonellosis antibacterial in therapeutic process is easy to generate drug resistance especially, adding spreading unchecked of Western medicine uses and makes a lot of bacterial strains have been produced drug resistance, therefore pressing for a kind of novel medicament treats above-mentioned disease, and solves above-mentioned drug resistance problem.To this, a lot of veterinary drug producers are devoted to the research and the production of Chinese medicine, give full play to herbal toxic effect little, be difficult for producing drug resistance, drug residue free, do not influence advantage such as outlet.But the Chinese medicine development so far, processing method is too simple, product is difficult to break away from thick, big, black characteristics all the time, especially powder, effective and the invalid target that has kept Chinese crude drug, and diameter of aspirin particle is big, the crude fiber content height, ill domestic animal especially poultry is difficult to digestion and absorbs, and causes that antibiotic or effective antiviral components is difficult to give full play to curative effect in the Chinese crude drug, has also caused a large amount of wastes of Chinese crude drug precious resources simultaneously, though traditional water extracting method is applicable to the extraction of most of medicine, but waste time and energy, produce consumption greatly, it is incomplete to extract composition.Therefore, select for use suitable Chinese medicine to carry out prescription, and pursue the proper method and be extracted in Chinese medicine research, the development and application significant effective ingredient.
Summary of the invention
Technical problem to be solved by this invention is to provide the pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis, described pharmaceutical composition absorbs soon, effect is obvious, easy to use, effectively play preventive effect to chicken colibacillosis, go back the anti-adversity ability of enhancing body simultaneously.
Another technical problem to be solved by this invention is to provide the preparation of drug combination method of above-mentioned prevention and treatment chicken colibacillosis, described preparation method is by carrying out enzymolysis and extraction to the effective ingredient in the prescription, make compositions have the dna purity height, absorb fast, effect advantage obvious, easy to use, and then overcome the problem that exists in the above-mentioned background technology.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis, comprise Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, by 5～20 parts of its parts by weight Rhizoma Coptidis, 20～40 parts of Cortex Phellodendris, 20～40 parts of Radix Scutellariaes, 15～30 parts of Fructus Gardeniaes, 0.3～1 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 15 parts of its parts by weight Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 25 parts of Fructus Gardeniaes, 0.5 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 10 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 20 parts of Fructus Gardeniaes, 0.5 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 20 parts of its parts by weight Rhizoma Coptidis, 40 parts of Cortex Phellodendris, 40 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 1 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 15 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 0.7 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 5 parts of its parts by weight Rhizoma Coptidis, 20 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes, 0.3 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 18 parts of its parts by weight Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes, 0.6 part of cellulase.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is by 10 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 0.8 part of cellulase.
The pharmaceutical composition of above-mentioned prevention and treatment chicken colibacillosis is brown liquid, bitter in the mouth.
The preparation of drug combination method of above-mentioned prevention and treatment chicken colibacillosis, concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.05-0.5cm, takes by weighing by above-mentioned parts by weight;
(2) with above-mentioned composition total weight 8-15 doubly, temperature is 50 ℃, aqueous solution soaking 60-120 minute of pH5.0, filter, extracting solution A;
(3) residue with above-mentioned composition total weight 5-10 doubly, temperature is 50 ℃, aqueous solution soaking 30-60 minute of pH5.0, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter and promptly get product.
In addition, above-mentioned steps (4) gained pharmaceutical composition can be carried out getting finished product after fill, the sealing.
In use, in the oral aforementioned pharmaceutical compositions of the ratio of every chicken 1.5ml or add in the drinking-water of poultry and freely drink, 3 days is a course of treatment.
The invention has the beneficial effects as follows:
1, aforementioned pharmaceutical compositions toxicity is little, and cost is lower, and is easy to use, can directly be added in the drinking-water, plays the preventive effect to chicken colibacillosis, goes back the anti-adversity ability of enhancing body simultaneously;
2, the chicken body weight obviously increases in aforementioned pharmaceutical compositions cure rate height, the healing period, resistance strengthens, be not easy to produce drug resistance, more drug residue free in the chicken body of back;
3, aforementioned pharmaceutical compositions is a pure Chinese medicinal preparation, overcome Chinese medicine powder effective ingredient and be difficult to the shortcoming that stripping, spice are wasted time and energy, thereby have dissolubility good, absorb diseases prevention, the resistant effect of better bringing into play medicine soon;
4, the preparation method of aforementioned pharmaceutical compositions is carried by traditional Chinese crude drug is carried out essence, fully extract effective ingredient wherein, remove impurity, thereby reduced use cost, improve the service efficiency of Chinese crude drug, also saved valuable Chinese material medicine resource simultaneously widely.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is further described.
Embodiment 1:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.1cm, takes by weighing 10 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 20 parts of Fructus Gardeniaes by weight, 0.5 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 90 minutes with the temperature of 10 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 45 minutes with the temperature of 8 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter and promptly get product.
Embodiment 2:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into 0.1 thick slag, takes by weighing 15 parts of Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 25 parts of Fructus Gardeniaes by weight, 0.5 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 120 minutes with the temperature of 12 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 60 minutes with the temperature of 10 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Embodiment 3:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.5cm, takes by weighing 20 parts of Rhizoma Coptidis, 40 parts of Cortex Phellodendris, 40 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes by weight, 1 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 100 minutes with the temperature of 15 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 50 minutes with the temperature of 8 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Embodiment 4:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.4cm, takes by weighing 15 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes by weight, 0.7 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 90 minutes with the temperature of 12 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 45 minutes with the temperature of 6 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Embodiment 5:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into 0.1 thick slag, takes by weighing 5 parts of Rhizoma Coptidis, 20 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes by weight, 0.3 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 60 minutes with the temperature of 8 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 30 minutes with the temperature of 6 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Embodiment 6:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.05cm, takes by weighing 18 parts of Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes by weight, 0.6 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 90 minutes with the temperature of 10 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 30 minutes with the temperature of 8 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Embodiment 7:
The pharmaceutical composition of a kind of prevention and treatment chicken colibacillosis comprises Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, and concrete preparation process is as follows:
(1) each component in the compositions is crushed into the thick slag of 0.3cm, takes by weighing 10 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes by weight, 0.8 part of cellulase;
(2) be 50 ℃, the aqueous solution soaking of pH5.0 120 minutes with the temperature of 12 times of above-mentioned composition total weight, filter, extracting solution A; ,
(3) residue is 50 ℃, the aqueous solution soaking of pH5.0 30 minutes with the temperature of 5 times of above-mentioned composition total weight, filter, extracting solution B;
(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter promptly.
(5) will get finished product after aforementioned pharmaceutical compositions fill, the sealing.
Rhizoma Coptidis described in the above-mentioned composition, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae all meet the relevant regulations in " Chinese veterinary drug allusion quotation ", and cellulase is a commercially available product, meet the company standard regulation.
The effective ingredient of Rhizoma Coptidis, Cortex Phellodendri is a berberine among the present invention, multiple gram negative bacteria there is inhibitory action, comprising escherichia coli, staphylococcus, Hemolytic streptococcus, dysentery bacterium, Salmonella, vibrio cholera, bacillus pyocyaneus etc. are all had good inhibition effect, but heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain, stomach function regulating antidiarrheal, invigorating the stomach and promoting digestion has better curative effect to diarrhoea, the watery diarrhea that causes owing to escherichia coli; Radix Scutellariae has antiviral and antibacterial action, but baicalin is suppressor T cell and HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) when being lower than cell toxicant concentration, at the beginning of HIV-1 is by cell absorption, can stop it to duplicate, and baicalin also there is the extract jasminoidin of inhibitory action, Fructus Gardeniae to have cathartic, analgesia, function of gallbladder promoting, antiinflammatory, treatment soft tissue injury to the pathomycete of skin and fingernail and suppress gastric secretion and reduce effect such as pancreatic amylase; Cellulase can destroy plant cell wall, decomposes lignin, and the effective ingredient in the plant cell is dissolved out faster, and carry with simple water and comparing, the extraction ratio height, the clarity of resulting composition is good.
Clinical trial example 1:
Lee of Weifang City, Shandong Province, raise AA broiler 5000 plumages, find during 32 ages in days that disease chicken essence god is depressed, feather tarnish, loss of appetite, dysentery such as water sample, feces is yellow back and is canescence, foul smelling flavor, mortality rate 2%, have 4726 chickens during treatment, dead chicken is cutd open the visible pericarditis of inspection, perihepatitis, peritonitis.Take pathological material of disease to diagnose through test chamber, be judged to escherichia coli, in drinking-water, add the pharmaceutical composition that the embodiment of the invention 2 is made, logotype 3 days by every chicken 1.5ml, feed intake obviously rises, it is normal that feces recovers, and death stops, dead 27 altogether from medication to recovery, 11 of symptom chickens were arranged after 3 days, effective percentage reaches 99.4%, and body weight obviously increases, and obtains good result; After one week the sick chicken of medication is detected, do not find drug residue in the body.
Clinical trial example 2:
Wuqing, Tianjin one raiser Wang raises AA broiler chicken 3000 plumages, and 18 ages in days the feather pine occurs disorderly, respiratory symptom is arranged individually, feed intake descends, mortality rate 12%, and total trouble chicken is 2573 when seeing and treating patients, draw yellow-white stench feces, cut open inspection visible trachea, bronchus and slight bleeding is arranged, air bag muddiness, pericarditis, perihepatitis, intestinal mucosa comes off, and the foul smelling flavor.Take pathological material of disease to diagnose, be judged to avian colibacillosis, in drinking-water, add the pharmaceutical composition that the embodiment of the invention 2 is made by every chicken 1.5ml through test chamber, logotype 3 days, death stops, and feed intake rises, finish to be total to 154 of dead chickens to drug treatment, cure rate reaches 94%.
Above-mentioned clinical trial shows that pharmaceutical composition of the present invention can reach more than 90% the cure rate height to the effective percentage of the intestinal tract disease that escherichia coli cause; Simultaneously pharmaceutical composition of the present invention has overcome Chinese medicine powder effective ingredient and has been difficult to the shortcoming that stripping, spice are wasted time and energy, dissolubility is good, absorption is fast, toxicity is little, and cost is lower, and is easy to use, can directly be added in the drinking-water, thereby better bring into play diseases prevention, the resistant effect of medicine; And the chicken body weight obviously increases in the healing period, resistance strengthens, go back the anti-adversity ability of enhancing body simultaneously, is not easy to produce drug resistance, more drug residue free in the chicken body of back.
Above-mentioned detailed description of this a kind of pharmaceutical composition that prevents and treat chicken colibacillosis and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (10)
- One kind the prevention and the treatment chicken colibacillosis pharmaceutical composition, it is characterized in that: comprise Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae and cellulase, by 5～20 parts of its parts by weight Rhizoma Coptidis, 20～40 parts of Cortex Phellodendris, 20～40 parts of Radix Scutellariaes, 15～30 parts of Fructus Gardeniaes, 0.3～1 part of cellulase.
- 2. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 15 parts of its parts by weight Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 25 parts of Fructus Gardeniaes, 0.5 part of cellulase.
- 3. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 10 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 20 parts of Fructus Gardeniaes, 0.5 part of cellulase.
- 4. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 20 parts of its parts by weight Rhizoma Coptidis, 40 parts of Cortex Phellodendris, 40 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 1 part of cellulase.
- 5. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 15 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 0.7 part of cellulase.
- 6. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 5 parts of its parts by weight Rhizoma Coptidis, 20 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes, 0.3 part of cellulase.
- 7. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 18 parts of its parts by weight Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 20 parts of Radix Scutellariaes, 15 parts of Fructus Gardeniaes, 0.6 part of cellulase.
- 8. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment chicken colibacillosis is characterized in that: by 10 parts of its parts by weight Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 25 parts of Radix Scutellariaes, 30 parts of Fructus Gardeniaes, 0.8 part of cellulase.
- 9. according to the pharmaceutical composition of described a kind of prevention of one of claim 1～8 and treatment chicken colibacillosis, it is characterized in that: be brown liquid, bitter in the mouth.
- 10. the preparation of drug combination method of described a kind of prevention of one of claim 1～8 and treatment chicken colibacillosis, it is characterized in that: concrete preparation process is as follows:(1) each component in the compositions is crushed into the thick slag of 0.05-0.5cm, takes by weighing by above-mentioned parts by weight;(2) with above-mentioned composition total weight 8-15 doubly, temperature is 50 ℃, aqueous solution soaking 60-120 minute of pH5.0, filter, extracting solution A;(3) residue with above-mentioned composition total weight 5-10 doubly, temperature is 50 ℃, aqueous solution soaking 30-60 minute of pH5.0, filter, extracting solution B;(4) above-mentioned extracting solution A, B are mixed, get C liquid, leave standstill, get supernatant, filter and promptly get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009100687747A CN101879238A (en) | 2009-05-08 | 2009-05-08 | Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof |
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| CN2009100687747A CN101879238A (en) | 2009-05-08 | 2009-05-08 | Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof |
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| CN2009100687747A Pending CN101879238A (en) | 2009-05-08 | 2009-05-08 | Medicinal composition for preventing and controlling chicken colibacillosis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403996A (en) * | 2019-09-10 | 2019-11-05 | 华南农业大学 | The three yellow applications in the bird flu secondary bacterial infection drug of preparation prevention and treatment chicken |
| CN111450157A (en) * | 2020-03-31 | 2020-07-28 | 四川金坤动物药业有限公司 | Veterinary oral liquid for clearing plague and removing toxicity and preparation method thereof |
| CN112618664A (en) * | 2020-12-19 | 2021-04-09 | 杭州爱力迈动物药业有限公司 | Preparation process of enzyme-extracted coptis chinensis detoxification powder |
-
2009
- 2009-05-08 CN CN2009100687747A patent/CN101879238A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110403996A (en) * | 2019-09-10 | 2019-11-05 | 华南农业大学 | The three yellow applications in the bird flu secondary bacterial infection drug of preparation prevention and treatment chicken |
| CN110403996B (en) * | 2019-09-10 | 2021-09-14 | 华南农业大学 | Application of three-yellow in preparation of medicine for preventing and treating avian influenza secondary bacterial infection of chicken |
| CN111450157A (en) * | 2020-03-31 | 2020-07-28 | 四川金坤动物药业有限公司 | Veterinary oral liquid for clearing plague and removing toxicity and preparation method thereof |
| CN112618664A (en) * | 2020-12-19 | 2021-04-09 | 杭州爱力迈动物药业有限公司 | Preparation process of enzyme-extracted coptis chinensis detoxification powder |
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Application publication date: 20101110 |