CN101214311B - Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof - Google Patents
Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof Download PDFInfo
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- CN101214311B CN101214311B CN2007100510767A CN200710051076A CN101214311B CN 101214311 B CN101214311 B CN 101214311B CN 2007100510767 A CN2007100510767 A CN 2007100510767A CN 200710051076 A CN200710051076 A CN 200710051076A CN 101214311 B CN101214311 B CN 101214311B
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Abstract
The present invention discloses a compound scutellaria injection for curing infectious diseases in livestock and poultry, characterized in that the injection is prepared from the following raw materials with the weight portions: 10 to 50 portions of scutellaria, 30 to 100 portions of radix bupleuri, 30 to 100 portions of honeysuckle, 30 to 100 portions of cordate houttuynia, 30 to 100 portions ofdyers woad root, 30 to 100 portions of Daqing leaf, 10 to 15 portions of tween 80 and 10 to 15 of benzyl alcohol; and the water for injection is appropriately confected to 1,000. The present invention is a pure Chinese medicine injection with quick effect, high curing effect, rare recurrence after cure and no drug resistance of bacteria. The present invention with no side effect on livestock and poultry and safe use has the curing rate of virus and bacterial infectious diseases in poultry up to 95 percent and of toxic epidemic diseases and bacterial diseases in other livestock up to 82 percent.
Description
Technical field
The present invention relates to the zoonotic Chinese medicine composition of a kind of treatment, especially a kind of compound scutellaria injection for the treatment of the poultry infectious disease and preparation method thereof.
Background technology
In recent years, China's livestock and poultry breeding industry is subjected to external and traditional multiple infectious disease puzzlement, especially fowl poultry kind viral infectious kind and quantity obviously increase, up to the present, lack the animal viral disease medicine, cause bigger harm to aquaculture, traditional Chinese herbal medicine powder or decoction curative effect are slower, treatment time is long, antibiotic Western medicine is only effective to bacterial infectious disease in the prior art, then effect is bad to virosis, simultaneously long-term abuse of antibiotics, sulfonamides and some chemical drugss make antibacterial produce behind the drug resistance that dosage can increase widely and curative effect descends.Not only increased feeding cost, also increased antibiotic and chemical veterinary drug in of the harm of the intravital residual and toxic and side effects of poultry to the mankind.
Summary of the invention
The objective of the invention is to overcome the prior art deficiency, a kind of curative effect height is provided, treatment time is short, have no side effect, the whole animal immune ability that improves, compound scutellaria injection of the treatment poultry infectious disease that antibacterial is difficult to develop immunity to drugs and preparation method thereof, the present invention realizes that by following technical proposals the present invention is formulated by following raw materials according component and weight ratio:
Radix Scutellariae 10-50 Radix Bupleuri 30-100
Flos Lonicerae 30-100 Herba Houttuyniae 30-100
Radix Isatidis 30-100 Folium Isatidis 30-100
Tween 80 10-15 benzyl alcohol 10-15
Water for injection is mixed with 1000 in right amount
The present invention prepares by following step:
1, Flos Lonicerae, Radix Bupleuri and Herba Houttuyniae are cleaned and are put in the distil container, carry out steam distillation with the way of distillation, collect 2-4 times of raw material weight of distillate, the distillate of collecting is carried out the 2nd distillation concentrate, and collect re-distilled liquid, and collecting amount is that crude drug 1-2 is doubly standby;
2, Flos Lonicerae, Radix Bupleuri, Herba Houttuyniae distillation test residue and Radix Scutellariae, Radix Isatidis, Folium Isatidis merging are put in the decoction device, add water and cross powder 5-10 centimetre, decoct 2 times, decocting time was respectively 45 minutes to 1 hour, filtration, merging filtrate, the 0.8-1.1 that is concentrated into raw material weight doubly is cooled to room temperature, adds 95% ethanol the 1st time, the adjustment concentration of alcohol is 60-70%, the limit edged stirs, and leaves standstill more than 24 hours, filters.Reclaim the ethanol in the filtrate, reconcentration to the 0.8-1.1 of raw material doubly, add 95% ethanol the 2nd time, making solution contain the alcohol amount is about 70%, the limit edged stirs, and leaves standstill more than 24 hours, filters.Reclaim the ethanol in the filtrate, reconcentration is to raw material weight 0.4-0.6 times, merge distillation filtrate and concentrated solution, add Tween 80 and benzyl alcohol, addition is the 1-1.5/100 weight portion of injection total amount separately, stirring and dissolving, add active carbon, amount is 0.1/100 injection total amount, and 100 ℃ were boiled cooled and filtered 10 minutes.Regulate the medicinal liquid pH value to 7.0-7.5 with sodium hydroxide solution, add the injection water and be equivalent to crude drug 0.16-0.55 gram to every milliliter, wherein Radix Scutellariae 0.01-0.05, Radix Bupleuri, Flos Lonicerae, Herba Houttuyniae, Radix Isatidis, each 0.03-0.1 of Folium Isatidis restrain, mixing is filtered to clear and bright with No. 3 sintered glass funnels or other filter filter materials.Embedding, 100 ℃ of sterilizations got final product in 30 minutes.
Radix Scutellariae contains baicalin, baicalin, wogonin, wogonoside and neobaicalein etc. in the present invention's prescription, has analgesic antibiotic (Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, influenza virus, dermatophytes etc. are had inhibition and killing action), antiinflammatory function of gallbladder promoting, can effectively improve the poultry immunity of organisms; Flos Lonicerae contains chlorogenic acid, isochlorogenic acid, sweet-scented osmanthus element etc., and dysentery bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, staphylococcus, streptococcus, Diplococcus pneumoniae and influenza etc. are had inhibitory action; Radix Bupleuri contains bupleurumol, fatty oil, plant sterol etc., has the effect of analgesic, calm, analgesia, function of gallbladder promoting and anti-liver injury, and effective human body immunity improving ability has plasmodium, tubercule bacillus, influenza virus and to suppress and killing action; Radix Isatidis and Folium Isatidis contain indigo glycoside, β-sitosterol, isatin, Radix Isatidis second, third, fourth element and aminoacid, resin, saccharide etc., and viruses such as Gram-positive, negative bacteria and influenza are all had inhibitory action; The diuresis of Herba Houttuyniae heat-clearing and toxic substances removing, itself and Radix Bupleuri share, antiviral effect is better, more than 6 the flavor Chinese medicines, compatibility is scientific and reasonable, supplements and complements each other, and plays anti-inflammation altogether, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, dredge the meridian passage is moisturized the cooperative effect of nourishing YIN; Mixed sense to various animal viruss and antibacterial has good especially curative effect.Soil temperature 80 among the present invention is solubilizing agent, and benzyl alcohol is an analgesic, environmental protection of the present invention, and noresidue is difficult for making pathogen to produce drug resistance.The objective of the invention is as can be known to realize from above-mentioned situation, through clinical and correlation test, the present invention has higher curative effect to the poultry infectious disease.
Clinical observation result is as follows:
(1) extracorporeal bacteria inhibitor test
1, the antibacterial scraps of paper are made: get injection 0.5 milliliter of the present invention and add sterile saline and be mixed standby, matched group, it is standby that the acid of pyrrole group adds sterile saline 10ml dissolving with 32 milligrams, methylbenzyl oxygen Aminometradine adds sterile saline 10ml for 8 milligrams and dissolves standby, pyrrole first mixture is respectively got 32 milligrams and 8 milligrams, and to add sterile saline dissolving back standby, it is standby that the reuse diameter is that 6 millimeters test-paper soaks completely above drug solution oven dry back respectively, and the antibacterial scraps of paper of penicillin and streptomycin market is purchased.
2, test strain
Strain: nine kinds of antibacterials such as staphylococcus aureus, pasteurellosis bacillus, Bacillus proteus, bacillus typhi murium, bacillus enteritidis, escherichia coli, shigella flexneri, hog cholera bacillus, Pullorum Disease bacillus, above strain is provided by microorganism teaching and research room of veterinary university.
3, experimental technique: antibacterial was cultivated 24 hours in ordinary broth and serum broth, getting this culture evenly coats on the plain agar culture medium, above-mentioned pastille test-paper is placed a plate culture medium centre respectively, each plate placed in the 37 degree constant incubators cultivated 24 hours, take out the inhibition zone diameter (mm) of each medicine of observed and recorded each bacterium.Its result such as following table:
Can know that by above result fungistatic effect of the present invention respectively contrasts medicine apparently higher than other, through relatively differing highly significant (P＜0.01) with other each medicine inhibition zone diameter.
(2) the present invention is to suppressing the bacterium test in the body of zoopery chicken Bacillus pasteurii disease:
1, with 120 of her sandgrouses of three monthly ages, be divided into four groups at random, 30 every group, prevention group promptly of the present invention, treatment experimental group, fowl cholera spirit treatment matched group, blank group.
2, the pasteurellosis bacillus freeze-drying lactobacillus that provides by China Veterinery Drug Inspection Office of strain, get strain one oese, place 20 milliliters of broth mediums to put in the 37 degree calorstats and cultivated 24 hours, calculating this bacterium liquid bacteria containing amount with a times times dilution method is every milliliter 32 * 10
8Individual antibacterial bottling sealing, refrigerator is preserved standby.
3, prevention group of the present invention: organize 20 chicken intramuscular injection with the dosage of 0.5ml to this by per kilogram of body weight earlier, every day secondary, logotype drug withdrawal after three days, give every subcutaneous injection bacterium liquid 0.5ml then, cause a disease for all the other animal subcutaneous injections to other the three groups dosage of all pressing 0.5ml bacterium liquid, connect behind the bacterium two hours, of the present invention group and chicken cholera spirit group are promptly treated, and dosage is the dosed administration of 10ml/kg body weight of the present invention and fowl cholera spirit group 0.1g/kg body weight; Logotype three days, drug withdrawal was observed two to three days, and matched group is drug treatment not, observes four to five days.Observed result such as following table:
| The example number | Prevention group of the present invention | Treatment group of the present invention | Chicken cholera spirit treatment group | The blank group |
| The inoculation number | 20? | 20? | 20? | 20? |
| Cure number | 18? | 19? | 14? | 1? |
| Death toll | 2? | 1? | 6? | 19? |
| Survival number (%) | 90? | 95? | 70? | 5? |
By above table prevention group of the present invention as can be known medication drug withdrawal in three days, see after the bacterial injection that the morbidity of 3 chickens is arranged is dead, survive 27, preventing protective rate is 90%, and 28 of 30 chicken deaths of blank group are survived 2, survival rate is 6.7%, two group and relatively differs remarkable.
(p＜0.01) shows that the present invention has the good preventing effect to chicken cholera.Treatment group of the present invention is cured 29, and dead one, survival rate 96.7%, the chicken cholera spirit is cured 21, and dead 9, survival rate relatively differs significantly (p＜0.05) for 70%, two group, and treatment of the present invention is apparently higher than the chicken cholera spirit.
(3) treatment of infectious bursal disease:
1 monthly age of a group that Nanchong City Pengan County in 2006 raises in glad emerging chicken farm, body weight 1.4-1.8 jin meat chicken group, clinical manifestation is that appetite subtracts greatly, fulminant diarrhoea occurs, is canescence and celadon loose stool; Be reluctant the walking of standing, feather is fluffy for sleeping inly, and two wings are sagging, after death cut open inspection and see that lower limb, chest muscle have hemorrhage speckle, hepatosplenomegaly, that gallbladder elongate to become is big, glandular stomach is hemorrhage, fabricius bursa edema, volume increase 1-3 doubly, be full of brown cheese sample thing in the hemorrhage capsule of gauffer in the capsule, appearance is the Cera Flava color, and clinical diagnosis is an infectious bursal disease, with the present invention this chicken group is treated, Therapeutic Method: severe disease disease chicken is used intramuscular injection of the present invention, every each 1 milliliter, once-a-day, logotype 5 days.The sick chicken of light disease is used intramuscular injection of the present invention, every each 0.5ml, and once-a-day, logotype is 3 days continuously, observed result such as following table:
| ? | Severe cases | Light disease case | Add up to |
| The treatment number | 48? | 357? | 405? |
| Cure number | 48? | 357? | 405? |
| Mortality rate | 0? | 0? | 0? |
| Cure rate (%) | 100? | 100? | 100? |
By in the table as can be known, the present invention treats infectious bursal disease and all cures, do not see because of primary disease and secondary disease dead.
(4) the present invention is to the curative effect such as the following table of other infectious disease:
| The sick kind | Avian infectious larynx trachea fire | Fowl cholera | Yellow scour of piglet | Baby swine paratyphoid | Canine distemper | Equine influenza |
| The treatment number | 400? | 5000? | 120? | 91? | 50? | 40? |
| Cure number | 385? | 4770? | 104? | 85? | 41? | 37? |
| More do not count | 15? | 230? | 16? | 6? | 9? | 3? |
| Cure rate (%) | 96.25? | 95.40? | 86.66? | 93.40? | 82.00? | 92.50? |
The present invention all has better curative effect to treatment some infectious disease of pig such as chronic swine fever, pig lung plague, Schweineseuche, swine enzootic pneumonia, baby pig edema, Medulla sus domestica inflammation etc.
The present invention is a kind of pure injections of Chinese medicine, and effect is fast, and the curative effect height is cured the back and is difficult for recurrence, and antibacterial is difficult to develop immunity to drugs; The present invention has no side effect to poultry, and is safe in utilization, and the cure rate of avian viral and bacterial infection sexually transmitted disease (STD) is reached more than 95%; To other livestock disease toxicity eqpidemic disease and bacterial disease cure rate more than 82%.
The specific embodiment:
The invention will be further described below in conjunction with instantiation:
Embodiment 1, presses the column weight amount and gets the raw materials ready:
Radix Scutellariae 100g Radix Bupleuri 1000g Flos Lonicerae 500g
Herba Houttuyniae 1000g Radix Isatidis 500g Folium Isatidis 1000g
Tween 100g benzyl alcohol 100g
Water for injection adds 10000 milliliters in right amount to.
Compound method is as follows:
(1) Flos Lonicerae, Radix Bupleuri and Herba Houttuyniae are cleaned and are put in the container, carry out steam distillation with the way of distillation, collect 8000 milliliters of distillates.Distillate is carried out the 2nd distillation, collect 4000 milliliters of re-distilled liquids.
(2) Flos Lonicerae, Radix Bupleuri, Herba Houttuyniae distillation test residue and Radix Scutellariae, Radix Isatidis, Folium Isatidis merging are put and decocted in the device, add water and cross powder 5-10 centimetre, present embodiment is the 10cm first time, 5cm decocts 2 times for the second time, and decocting time was respectively 45 minutes to 1 hour, filter, merging filtrate is concentrated into and puts coldly about 4000 milliliters, adds 95% ethanol the 1st time, the limit edged stirs, make solution contain the alcohol amount, leave standstill more than 24 hours, filter 60%.Reclaim the ethanol in the filtrate, about reconcentration to 4000 milliliter.Add 95% ethanol the 2nd time, making solution contain the alcohol amount is about 70%, and the limit edged stirs, and leaves standstill more than 24 hours, filters.Reclaim the ethanol in the filtrate, about reconcentration to 2000 milliliter, be concentrated solution.
(3) merge above-mentioned redistillation filtrate and concentrated solution, add Tween 80, each 100 gram of benzyl alcohol, stirring and dissolving adds active carbon 10g, and 100 ℃ were boiled cold filtration 10 minutes.Regulate the medicinal liquid pH value to 7.0-7.5 with sodium hydroxide solution, add injection water to 10000 milliliter, be filtered to clear and bright with No. 3 sintered glass funnels or other filter filter materials.Embedding, 100 ℃ of sterilizations got final product in 30 minutes.
Embodiment 2, press the column weight amount and get the raw materials ready:
Radix Scutellariae 500g Radix Bupleuri 300g Flos Lonicerae 1000g
Herba Houttuyniae 500g Radix Isatidis 1000g Folium Isatidis 700g
Tween 150g benzyl alcohol 120g
Water for injection adds 10000 milliliters in right amount to.
Preparation method is with embodiment 1.
Embodiment 3, press the column weight amount and get the raw materials ready:
Radix Scutellariae 250g Radix Bupleuri 800g Flos Lonicerae 750g
Herba Houttuyniae 800g Radix Isatidis 750g Folium Isatidis 700g
Tween 120g benzyl alcohol 150g
Water for injection adds 10000 milliliters in right amount to.
Preparation method is with embodiment 1.
Embodiment 4, press the column weight amount and get the raw materials ready:
Radix Scutellariae 500g Radix Bupleuri 600g Flos Lonicerae 750g
Herba Houttuyniae 300g Radix Isatidis 750g Folium Isatidis 300g
Tween 100g benzyl alcohol 100g
Water for injection adds 10000 milliliters in right amount to.
Preparation method is with embodiment 1.
Embodiment 5, press the column weight amount and get the raw materials ready:
Radix Scutellariae 250g Radix Bupleuri 800g Flos Lonicerae 750g
Herba Houttuyniae 800g Radix Isatidis 300g Folium Isatidis 800g
Tween 100g benzyl alcohol 100g
Water for injection adds 10000 milliliters in right amount to.
Preparation method is with embodiment 1.
Claims (2)
1. compound scutellaria injection for the treatment of the poultry infectious disease is characterized in that: formulated by following material component and weight ratio:
Radix Scutellariae 10-50 Radix Bupleuri 30-100
Flos Lonicerae 30-100 Herba Houttuyniae 30-100
Radix Isatidis 30-100 Folium Isatidis 30-100
Tween 80 10-15 benzyl alcohol 10-15
Water for injection is an amount of
Be mixed with 1000.
2. the described a kind of compound scutellaria injection preparation method for the treatment of the poultry infectious disease of claim 1 is characterized in that, follows these steps to carry out:
(1) Flos Lonicerae, Radix Bupleuri and Herba Houttuyniae are cleaned and are put in the distil container, carry out steam distillation with the way of distillation, collect 2-4 times of raw material weight of distillate, the distillate of collecting is carried out the 2nd distillation concentrate, and collect re-distilled liquid, and collecting amount is that crude drug 1-2 is doubly standby;
(2) with Flos Lonicerae, Radix Bupleuri, Herba Houttuyniae distillation test residue and Radix Scutellariae, Radix Isatidis, Folium Isatidis merges puts in the decoction device, add water and cross powder 5-10 centimetre, decoct 2 times, decocting time was respectively 45 minutes to 1 hour, filter, merging filtrate, the 0.8-1.1 that is concentrated into raw material weight doubly, be cooled to room temperature, add 95% ethanol the 1st time, the adjustment concentration of alcohol is 60-70%, the limit edged stirs, leave standstill more than 24 hours, filter, reclaim the ethanol in the filtrate, reconcentration to the 0.8-1.1 of raw material doubly, add 95% ethanol the 2nd time, making solution contain the alcohol amount is 70%, the limit edged stirs, leave standstill more than 24 hours, filter, reclaim the ethanol in the filtrate, reconcentration is to raw material weight 0.4-0.6 times, merge distillate and concentrated solution, add Tween 80 and benzyl alcohol, addition is the 1-1.5/100 weight portion of injection total amount separately, stirring and dissolving, add active carbon, measure the injection into 0.1g/100ml, 100 ℃ were boiled 10 minutes, cooled and filtered, regulate the medicinal liquid pH value to 7.0-7.5 with sodium hydroxide solution, add the injection water and be equivalent to crude drug 0.16-0.55 gram to every milliliter, wherein Radix Scutellariae 0.01-0.05 gram, Radix Bupleuri, Flos Lonicerae, Herba Houttuyniae, Radix Isatidis, each 0.03-0.1 gram of Folium Isatidis, mixing, be filtered to No. 3 sintered glass funnels or other filter filter materials clear and bright, embedding, 100 ℃ of sterilizations got final product in 30 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100510767A CN101214311B (en) | 2007-12-27 | 2007-12-27 | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof |
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| CN2007100510767A CN101214311B (en) | 2007-12-27 | 2007-12-27 | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof |
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| CN101214311B true CN101214311B (en) | 2010-12-08 |
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Families Citing this family (11)
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| CN101574430B (en) * | 2009-06-15 | 2011-08-10 | 金陵科技学院 | Chinese medicinal composition for resisting trichomonas columbae disease and method for preparing oral liquid thereof |
| CN102698193B (en) * | 2012-05-31 | 2014-02-05 | 四川金瑞克动物药业有限公司 | Traditional Chinese medicine injection for preventing and controlling pig exogenous febrile diseases and preparation method thereof |
| CN102793789B (en) * | 2012-08-23 | 2015-07-22 | 郑州后羿制药有限公司 | Compound houttuynia injection for animals and preparation method thereof |
| CN102940722B (en) * | 2012-12-03 | 2015-11-18 | 北京大北农动物保健科技有限责任公司 | A kind ofly treat Chinese medicine composition of fowl bacterial disease and preparation method thereof |
| CN103341154B (en) * | 2013-07-21 | 2014-08-20 | 山东中牧兽药有限公司 | Compound veterinary injection for clearing heat and removing toxin |
| CN104288317A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine veterinary injection with antiviral, antibacterial and anti-inflammatory effects and preparation method thereof |
| CN104784327B (en) * | 2015-05-07 | 2018-05-18 | 成都乾坤动物药业有限公司 | A kind of Chinese veterinary medicinal composition for treating chicken respiratory tract disease and preparation method thereof |
| CN105148216B (en) * | 2015-07-14 | 2019-05-03 | 襄汾县育凤鑫养殖场 | A kind of laying hen eliminating pestilence and relieving toxicity liquid preparation and preparation method thereof |
| CN105816563B (en) * | 2016-05-20 | 2019-07-23 | 山东德州神牛药业有限公司 | A kind of Chinese medicine composition improves the application in sow reproductive performance drug in preparation |
| CN107439478A (en) * | 2017-08-30 | 2017-12-08 | 贵州杨老奶食品有限公司 | A kind of black pig ecological cultivation method |
| CN109125625A (en) * | 2018-09-11 | 2019-01-04 | 安徽万士生物制药有限公司 | A kind of injection and its preparation, application method for improving piglet immunity |
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| CN1879745A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | A veterinary Chinese medicinal powder for treating avian viral disease |
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| CN1879745A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | A veterinary Chinese medicinal powder for treating avian viral disease |
Non-Patent Citations (1)
| Title |
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| 刘振湘.浅谈禽流感的综合防制.畜牧兽医科技信息2004年第2期.2004,2004年第2期70-71. * |
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