CN104208294B - It is a kind of to be used to treat Chinese medicine composition of piglet yellow-white dysentery and preparation method thereof - Google Patents
It is a kind of to be used to treat Chinese medicine composition of piglet yellow-white dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for being used to treat piglet yellow-white dysentery and preparation method thereof, belong to technical field of Chinese medicine for animals.The Chinese medicine composition is mainly made up of the bulk drug of following parts by weight：100 parts of poplar flower, 9~15 parts of the coptis, 20~40 parts of the Chinese bulbul, 15~30 parts of purslane, 15~30 parts of golden cypress, 15~30 parts of the bark of ash, 15~30 parts of Herba Andrographitis, 15~30 parts of folium isatidis.The present invention according to monarch principle composition of prescription, Chinese bulbul bitter cold in side and enter blood system, be monarch drug in a prescription, energy is clearing heat and detoxicating, removes heat from the blood and relieve diarrhea；Coptis bitter cold, purging intense heat and detonicating, eliminating dampness thickness intestines, to control dysentery key medicine, the clear damp-heat in lower-JIAO of golden cypress, principal drug assistance is clearing heat and detoxicating altogether for two medicines, and energy eliminating dampness especially controls dysentery, is altogether ministerial drug；The bark of ash, Herba Andrographitis, poplar flower, purslane, folium isatidis are bitter and tremble with fear, clearing heat and detoxicating and simultaneous with inducing astrigency stop dysentery, are adjuvant；All medicines share, clearing heat and detoxicating, to remove heat from the blood and relieve diarrhea work(is played altogether, be mainly used in treating piglet yellow-white dysentery.
Description
Technical field
Present invention relates particularly to a kind of Chinese medicine composition for being used to treat piglet yellow-white dysentery, and the system of the Chinese medicine composition
Preparation Method, belong to technical field of Chinese medicine for animals.
Background technology
Piglet yellow-white dysentery is the enteric infectious disease of the pig as caused by enteropathogenic E. Coli.Yellow dysentery is mainly within 1 week old
Suckling pig, 1~3 age in days is the most common, and the morbidity of more than 7 ages in days sucking pig is few.Yellow dysentery is with discharge yellow or the sallow of suffering from diarrhoea
Color water sample loose stool, morbidity is anxious, and rapid dehydration is weak, dead to be characterized, and generally more than 90%, the death rate may be up to the incidence of disease
100%.The incidence of disease gradually reduces with the increase of age in days.Dysentery characterized by white mucous stool typically betides 7~30 age in days piglets, causes diarrhoea, and 1~2
The piglet of age in days or so easily causes enteritis and septicemia.Clinically with diarrhea, discharge milky or the sticky stench excrement of canescence
It is characterized, cut open inspection is characterized by enteritis.Dysentery characterized by white mucous stool easily causes piglet death or retarded growth.The incidence of disease is generally 10~30%,
The death rate is 10%.For a long time, piglet yellow-white dysentery brings serious economic loss to pig industry.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for being used to treat piglet yellow-white dysentery.
Meanwhile the present invention also provides a kind of preparation method for being used to treat the Chinese medicine composition of piglet yellow-white dysentery.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for being used to treat piglet yellow-white dysentery, is mainly made up of the bulk drug of following parts by weight：Poplar
Tree spend 100 parts, 9~15 parts of the coptis, 20~40 parts of the Chinese bulbul, 15~30 parts of purslane, 15~30 parts of golden cypress, the bark of ash 15~30
Part, 15~30 parts of Herba Andrographitis, 15~30 parts of folium isatidis.
Preferably, a kind of Chinese medicine composition for being used to treat piglet yellow-white dysentery, mainly by the bulk drug of following parts by weight
Composition：100 parts of poplar flower, 9 parts of the coptis, 24 parts of the Chinese bulbul, 21 parts of purslane, 18 parts of golden cypress, 18 parts of the bark of ash, 30 parts of Herba Andrographitis,
30 parts of folium isatidis.
Each bulk drug effect is summarized as follows：
Poplar flower：For Salicaceae poplar Chinese white poplar, eugene poplar or the male inflorescence for belonging to several plants together；It is bitter in taste,
It is cold；Can clearing heat and detoxicating, dampness elimination stop dysentery；Cure mainly bacillary dysentery, enteritis.
The coptis：For the rhizome of the hair root section coptis plant coptis, the triangle leaf coptis or rhizoma coptidis teetoidis；Containing alkaloids such as
The various active composition such as jamaicin, coptisine, epiberberine, obakunone；The coptis is bitter in taste, trembles with fear, the thoughts of returning home, liver, stomach, large intestine channel；
Energy clearing heat-fire, eliminating dampness, removing toxic substances；The high fever that pyreticosis heresy enters the heart channel of Hang-Shaoyin is cured mainly, irritated, the damp and hot feeling of stuffiness in chest, diarrhea, dysentery, heart-fire hyperactivity
Vexed insomnia, gastropyretic vomiting, rapid digestion of food and polyorexia, irascibility red eye, swell pain, and pathopyretic ulcer, serious case of furuncle septicemia, swelling and aching of gum, dispute
Raw sore, hemorrhoid blood, eczema, scald etc.；Modern pharmacology proves that the coptis has an impact to the circulatory system, nervous system, also has anti-
The effect such as microorganism, antiprotozoan, antiulcer, antiviral, anti-inflammatory, antitumor, hypoglycemic, suppression platelet aggregation.
The Chinese bulbul：For the root of the Ranunculaceae Pulsatilla plant Chinese bulbul；Contain triterpenoid such as Anemonin, white birch fat
The plurality of active ingredients such as acid, 3- oxos resin acid, Pulsatilla saponin A, B, C, D；It is bitter in taste, cold, return stomach, large intestine channel；Can heat-clearing solution
Poison, remove heat from the blood and relieve diarrhea, removing dampness and destroying parasites；Cure mainly dysentery, nosebleed epistaxis, bleeding, fever and chills a kind of malaria, scrofula, eczema ulcerative carbuncle, eye conjunctival congestion with ophthalmalgia
Deng；Modern pharmacology proves that the Chinese bulbul has resisting pathogenic microbes, anti-Amoeba, anti-other pathogens, antitumor, anti-inflammatory
And the effect such as enhancing immunologic function.
Purslane：For the herb of Portulacaceae portulaca purslane；Contain a large amount of norepinephrines and volume
Sylvite（Including potassium nitrate, potassium chloride, potassium sulfate and other sylvite）, also containing DOPA, dopamine, betanidin, isobetanidin, sweet tea
Dish glycosides etc., amino acids such as glutamic acid, aspartic acid, alanine, polysaccharide and other multiple active components；Nature and flavor are sour, cold, return large intestine,
Liver Channel；Can heat-clearing, removing toxic substances, cool blood, detumescence；Cure mainly heat toxin rush down dysentery, heat gonorrhea blood strangury, erysipelas scrofula etc.；Modern pharmacology proves horse
Bitterroot has the effect such as antibacterial, reducing blood lipid, antiatherosclerosis.
Golden cypress：For the bark of Rutaceae cork tree platymiscium wampee or cork tree；Contain alkaloids such as jamaicin, golden cypress
Alkali, magnoflorine, jateorrhizine etc., also containing plurality of active ingredients such as limonin, obakunone, campesterol, stigmasterol；Nature and flavor
It is bitter, cold, return kidney, bladder, large intestine channel；Can heat-clearing and damp-drying drug, purging intense heat and detonicating；Cure mainly damp-heat dysentery, diarrhea, jaundice, hectic fever due to yin labor heat, mouth
Tongue life sore, red eye, swell pain, skin sore etc.；Modern pharmacology proves that golden cypress has resisting pathogenic microbes, antipyretic and anti-inflammatory, resisted
Platelet aggregation and other effects, there is facilitation to cardiovascular system, digestive system and maincenter kidney channel system.
The bark of ash：For the bark of Oleaceae Chinese ash platymiscium great Ye Ash, sharp leaf Ash, Chinese ash and Pax ash；Contain horse-chestnut
Bark glycosides, aesculetin, also containing the Coumarins such as various active composition such as aesculetin, fraxetin and alkaloid；Nature and flavor
It is bitter, puckery, tremble with fear, Return liver, courage, large intestine channel；Energy heat-clearing and damp-drying drug, clear liver and improve vision；Cure mainly damp-heat dysentery, red eye, swell pain, lung heat asthma cough
Cough；Modern pharmacology proves that the bark of ash has the effect such as antibacterial, cough-relieving apophlegmatic.
Herba Andrographitis：For the herb of Acanthaceae punching nelumbium Herba Andrographitis；Leaf contains Diterpenes such as andrographolide etc., yellow
Ketone such as oroxylin A, wogonin, also containing Polyphenols such as caffeic acid, chlorogenic acid etc., it is yellow that root contains flavonoids such as Herba Andrographitis
Ketone, andrographin glycosides A, B, C, D, E and F, also containing the various active composition such as α- Sitosterol；It is bitter in taste, contain, it is the thoughts of returning home, lung, big
Intestines, bladder warp；Can clearing heat and detoxicating, purging intense heat, eliminating dampness；Cure mainly anemopyretic cold, warm disease heating, cough with lung heat, pertussis, lung carbuncle, pharynx
Larynx swelling and pain, gastropyretic toothache, acute bacillary dysentery, jaundice with damp-heat pathogen, sore carbuncle swells etc.；It is antipyretic, anti-that modern pharmacology proves that Herba Andrographitis has
Inflammation, anticancer, D-dimer, antithrombotic, hepatic cholagogic, decompression, antioxidant protection Endothelial Cell Function etc..
Folium isatidis：For the leaf of Cruciferae woaded blue platymiscium woaded blue；Contain indigo, woaded blue glycosides, indigo red, rosasterol etc.
Plurality of active ingredients；It is bitter in taste, tremble with fear；The thoughts of returning home, stomach, liver, lung channel；Can clearing heat and detoxicating, blood cooling and ecchymoses removing；Warm heat disease high fever is cured mainly to be tired of
Yearningly, coma, macula, spit blood, bleeding from five sense organs or subcutaneous tissue, jaundice, rush down dysentery, erysipelas, larynx numbness, aphtha, mumps etc.；Modern pharmacology proves folium isatidis tool
There is the effect such as resisting pathogenic microbes, antiendotoxin, anti-oxidant.
It is a kind of to be used to treat the Chinese medicine composition of piglet yellow-white dysentery, can be prepared into using conventional method granule, pulvis,
The common veterinary dosage form such as solution, injection.The present invention only provides a kind of preparation method of solution, comprises the following steps：
（1）Each taste bulk drug is accurately taken according to parts by weight, by poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the Qin
Skin, folium isatidis add water to cook 2 times, merge 2 decocting liquids, and it is 50~80% to add ethanol to alcohol content, and it is standby that recovery ethanol obtains extractum A；
（2）Take Herba Andrographitis ethanol to extract 2 times, merge 2 filtrates, it is standby that recovery ethanol obtains medicinal extract B；
（3）Merge extractum A and medicinal extract B, add Tween-80, regulation solution ph is 5~7, filters and produces.
The step（1）Middle decoct adds 8~10 times of amount water, decocts 1~2 hour.
The step（2）Middle ethanol extraction plus 6~8 times of amount ethanol.
The step（3）The addition of middle Tween-80 is 1~5 parts by weight.
The step（3）Mended after middle regulation pH value with purified water to 100 parts by weight.
Usage and dosage：Horse, 50~100ml of ox, sheep, 10~20ml of pig, rabbit, 1~2ml of fowl.
Beneficial effects of the present invention：
According to traditional Chinese veterinary medicine theoretical and clinical treatment by Chinese herbs practice, treatment piglet yellow-white dysentery is preferably clearing heat and detoxicating, remove heat from the blood and relieve diarrhea,
Heat moves back malicious solution, then dysentery is only then weighed and removed certainly.
The present invention uses poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, Herba Andrographitis, the folium isatidis pure day of totally 8 tastes
Right Chinese herbal medicine, according to monarch principle composition of prescription.Bitter cold in side and the Chinese bulbul that enters blood system is monarch drug in a prescription, it is clearing heat and detoxicating, cool
Blood stop dysentery.Coptis bitter cold, purging intense heat and detonicating, eliminating dampness thickness intestines, to control dysentery key medicine；The clear damp-heat in lower-JIAO of golden cypress, the principal drug assistance heat-clearing altogether of two medicines
Removing toxic substances, especially energy eliminating dampness control dysentery, are altogether ministerial drug.The bark of ash, Herba Andrographitis, poplar flower, purslane, folium isatidis are bitter and tremble with fear, clearing heat and detoxicating
And it is simultaneous with inducing astrigency stop dysentery, it is adjuvant.All medicines share, work(that is clearing heat and detoxicating, removing heat from the blood and relieve diarrhea is played altogether, be mainly used in treating piglet Huang
Dysentery characterized by white mucous stool.
The present invention use pure natural Chinese herbal medicine, bulk drug is easy to get, cheap and safety, noresidue, to livestock and poultry body without
Any toxic side effect.Above-mentioned Chinese medicine composition is prepared into solution by the present invention, and method is simple, easily operated, suitable for extensive
Production application.
Embodiment
Following embodiments are only described in further detail to the present invention, but do not form any limitation of the invention.
Embodiment 1
It is used for the Chinese medicine composition for treating piglet yellow-white dysentery in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：It is 100 parts of poplar flower, 15 parts of the coptis, 20 parts of the Chinese bulbul, 30 parts of purslane, 30 parts of golden cypress, 15 parts of the bark of ash, 15 parts of Herba Andrographitis, big
15 parts of leafiness.
It is used for the preparation method for treating the Chinese medicine composition of piglet yellow-white dysentery in the present embodiment, comprises the following steps：
（1）Poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, folium isatidis are accurately taken according to parts by weight, adds 8
Amount water again, decoct 2 times, decoct 1.5 hours every time, 2 decocting liquids of merging, it is 60% to add ethanol to alcohol content, and recovery ethanol obtains medicinal extract
A is standby；
（2）Herba Andrographitis is accurately taken according to parts by weight, 6 times of amount ethanol is added, alcohol extracting 2 times, merges 2 filtrates, reclaim second
It is standby that alcohol obtains medicinal extract B；
（3）Merge extractum A and medicinal extract B, in terms of parts by weight, add 1 part of Tween-80, regulation solution ph is 7, supplement
Purified water is to 100 parts, filling to produce then with 0.45 μm of membrane filtration.
Usage and dosage：Horse, 50~100ml of ox, sheep, 10~20ml of pig, rabbit, 1~2ml of fowl.
Embodiment 2
It is used for the Chinese medicine composition for treating piglet yellow-white dysentery in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：It is 100 parts of poplar flower, 9 parts of the coptis, 24 parts of the Chinese bulbul, 21 parts of purslane, 18 parts of golden cypress, 18 parts of the bark of ash, 30 parts of Herba Andrographitis, big
30 parts of leafiness.
It is used for the preparation method for treating the Chinese medicine composition of piglet yellow-white dysentery in the present embodiment, comprises the following steps：
（1）Poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, folium isatidis are accurately taken according to parts by weight, adds 8
Amount water again, decoct 2 times, decoct 1.5 hours every time, 2 decocting liquids of merging, it is 65% to add ethanol to alcohol content, and recovery ethanol obtains medicinal extract
A is standby；
（2）Herba Andrographitis is accurately taken according to parts by weight, 8 times of amount ethanol is added, alcohol extracting 2 times, merges 2 filtrates, reclaim second
It is standby that alcohol obtains medicinal extract B；
（3）Merge extractum A and medicinal extract B, in terms of parts by weight, add 2 parts of Tween-80s, regulation solution ph is 7, supplement
Purified water is to 100 parts, filling to produce then with 0.45 μm of membrane filtration.
Usage and dosage：Horse, 50~100ml of ox, sheep, 10~20ml of pig, rabbit, 1~2ml of fowl.
Embodiment 3
It is used for the Chinese medicine composition for treating piglet yellow-white dysentery in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：It is 100 parts of poplar flower, 12 parts of the coptis, 30 parts of the Chinese bulbul, 18 parts of purslane, 21 parts of golden cypress, 21 parts of the bark of ash, 24 parts of Herba Andrographitis, big
24 parts of leafiness.
It is used for the preparation method for treating the Chinese medicine composition of piglet yellow-white dysentery in the present embodiment, comprises the following steps：
（1）Poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, folium isatidis are accurately taken according to parts by weight, is added
10 times of amount water, decoct 2 times, decoct 1.5 hours every time, merge 2 decocting liquids, and it is 65% to add ethanol to alcohol content, and recovery ethanol must soak
Cream A is standby；
（2）Herba Andrographitis is accurately taken according to parts by weight, 8 times of amount ethanol is added, alcohol extracting 2 times, merges 2 filtrates, reclaim second
It is standby that alcohol obtains medicinal extract B；
（3）Merge extractum A and medicinal extract B, in terms of parts by weight, add 5 parts of Tween-80s, regulation solution ph is 7, supplement
Purified water is to 100 parts, filling to produce then with 0.45 μm of membrane filtration.
Usage and dosage：Horse, 50~100ml of ox, sheep, 10~20ml of pig, rabbit, 1~2ml of fowl.
Embodiment 4
It is used for the Chinese medicine composition for treating piglet yellow-white dysentery in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：It is 100 parts of poplar flower, 12 parts of the coptis, 25 parts of the Chinese bulbul, 15 parts of purslane, 15 parts of golden cypress, 30 parts of the bark of ash, 24 parts of Herba Andrographitis, big
24 parts of leafiness.
It is used for the preparation method for treating the Chinese medicine composition of piglet yellow-white dysentery in the present embodiment, comprises the following steps：
（1）Poplar flower, the coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, folium isatidis are accurately taken according to parts by weight, adds 8
Amount water again, decoct 2 times, decoct 1.5 hours every time, 2 decocting liquids of merging, it is 65% to add ethanol to alcohol content, and recovery ethanol obtains medicinal extract
A is standby；
（2）Herba Andrographitis is accurately taken according to parts by weight, 8 times of amount ethanol is added, alcohol extracting 2 times, merges 2 filtrates, reclaim second
It is standby that alcohol obtains medicinal extract B；
（3）Merge extractum A and medicinal extract B, in terms of parts by weight, add 3 parts of Tween-80s, regulation solution ph is 7, then is used
0.45 μm of membrane filtration, it is filling to produce.
Usage and dosage：Horse, 50~100ml of ox, sheep, 10~20ml of pig, rabbit, 1~2ml of fowl.
Test example
1st, trial drug：Test group uses solution prepared by embodiment 1~3, and control group can using commercially available Enrofloxacin
Dissolubility powder, is provided by Zhengzhou Houyi Pharmaceutical Co., Ltd., and product batch number is：20110110.
2nd, Antigen isolation and identification：With sterile cotton swabs from the frank sick pig rectum collection excrement of dysentery characterized by white mucous stool, wheat is inoculated in
On Kang Kai flat boards, 37 DEG C of 24~48h of culture, the smooth brick-red bacterium colony of picking, after isolating and purifying for several times, common meat is inoculated in
On soup nutrient solution and nutrient agar panel.Picking pure culture smear, microscopy, and carry out biochemical test and the examination of mouse pathogenicity
Test.
3rd, suppression mattress experiment in vitro
（1）The extracorporeal bacteria inhibitor test of Chinese medicine：Punched on the agar medium of coating pathogen, and in the solubilization of hole bottom
Sterilizing agar it is a little, to seal hole bottom, be separately added into hole embodiment 1~3 preparation solution, with fill it up with do not spill over for
Preferably, put after cultivating 24h in 37 DEG C of incubators, measure antibacterial circle diameter.
（2）The drug sensitive test of antimicrobial：From Enrofloxacin, Ciprofloxacin, cefotaxime, rifampin, cephazolin,
Furazolidone, ampicillin, Ceftriaxone Sodium, spectinomycin, orfloxacin carry out drug sensitive test.
Criterion：Antibacterial circle diameter≤10mm, it is resistance；L0~15mm, it is medium sensitivity；>=15mm, it is highly quick
Sense.
4th, test method
Experimental animal：Choose 10~30 ages in days and dysentery characterized by white mucous stool and the obvious piglet of clinical symptoms 400 occurs, during according to morbidity
Between, the relatively uniform principle of age in days, severity extent, body condition, using the method being grouped in nest, the piglet for suffering from dysentery characterized by white mucous stool is randomly divided into
4 groups, every group 100.Test group 1~3 gavages the solution of the preparation of embodiment 1~3, every each 10ml, 2 times a day, is used in conjunction 3
My god；Control group is treated using commercially available pig with specific drug Enrofloxacin soluble powder, every pig 1.2g, is dissolved in 5ml warm water and being gavaged,
2 times a day, it is used in conjunction 3 days.
Curative effect determinate standard：
Cure：After testing sick pig 1 course for the treatment of of medication, excrement, spirit, appetite recover normal；
Effectively：After testing sick pig 1 course for the treatment of of medication, pellet morphology is taken a turn for the better, and number of having loose bowels is reduced, and appetite takes a turn for the better；
It is invalid：After testing sick pig 1 course for the treatment of of medication, symptom is not improved, or even exacerbation or dead.
5th, data processing：The significance test of data is carried out with statistical method, cure rate, total effective rate are examined with card side
Test.
6th, result of the test
（1）Antigen isolation and identification
Through test for identification, the bacterium being separated to from morbidity piglet excrement is pathogenic ETEC.
（2）The extracorporeal bacteria inhibitor test of Chinese medicine
The diameter that embodiment 1~3 prepares the inhibition zone of solution is respectively 12.0mm, 12.7mm and 11.5mm, according to mark
Standard is determined as medium sensitivity.Result of the test shows that the Chinese Medicines agent of the present invention has certain suppression to make to ETEC
With.
（3）The drug sensitive test of antimicrobial
As it can be seen from table 1 Enrofloxacin, Ceftriaxone Sodium, ring receive the third husky star, cephazolin Gao Min；Cephalo he
Pyridine, ampicillin, spectinomycin, orfloxacin are quick in being；Rifampin is resistance.Therefore treated as a control group from Enrofloxacin
Medicine.
Fungistatic effect of the antibacterials of table 1 to separation Enteropathogenic Escherichia coli
（4）Therapeutic effect of the Chinese medicine to piglet yellow-white dysentery
From table 2 it can be seen that the total effective rate of test group is up to more than 95%.Statistical analysis shows that the cure rate of test group shows
Work is higher than control group（P ＜ 0.01）, without significant difference between total effective rate（P ＞ 0.05）.The total effective rate of test group 1~3 it
Between also without significant difference（P ＞ 0.05）.
Therapeutic effect of the 2 each treatment group of table to piglet yellow-white dysentery
Discuss：
For the white scour of piglet mainly as caused by pathogenic ETEC, the infection sources is typically the sow that carries disease germs.It is pathogenic big
Intestines Escherichia intersperses among colony house after sow excretes, and pollutes the nipple and skin of sow, and piglet is sucked the breast or licks sow
During skin, The book of Changes mouth infection.The In Vitro Bacteriostasis result that embodiment 1~3 prepares solution shows that Chinese medicine of the invention is to causing a disease
Property ETEC has certain inhibitory action.From the point of view of fungistatic effect, the cure rate of test group 1~3 is apparently higher than grace
Promise sand star（P ＜ 0.01）, and Enrofloxacin is also easy to produce resistant strains.Result of the test is also shown that Chinese herbal and crude drugs preparations except having antibacterial
Beyond effect, moreover it is possible to by other approach, such as enterotoxin caused by confrontation ETEC, egg is sticked with intestinal mucosa surface
It is white to form diaphragm, adjust physiological function of biological organs etc..
Claims (4)
- A kind of 1. Chinese Medicines agent for being used to treat piglet yellow-white dysentery, it is characterised in that：By the bulk drug system of following parts by weight Into：100 parts of poplar flower, 9~15 parts of the coptis, 20~40 parts of the Chinese bulbul, 15~30 parts of purslane, 15~30 parts of golden cypress, the bark of ash 15 ~30 parts, 15~30 parts of Herba Andrographitis, 15~30 parts of folium isatidis；Preparation method comprises the following steps：（1）Each taste bulk drug is accurately taken according to parts by weight, by the poplar flower, coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, big Leafiness adds water to cook 2 times, merges 2 decocting liquids, and it is 50~80% to add ethanol to alcohol content, and it is standby that recovery ethanol obtains extractum A；（2）Take Herba Andrographitis ethanol to extract 2 times, merge 2 filtrates, it is standby that recovery ethanol obtains medicinal extract B；（3）Merge extractum A and medicinal extract B, add Tween-80, regulation solution ph is 5~7, filters and produces；Step（2）Middle ethanol extraction plus 6~8 times of amount ethanol；Step（3）The addition of middle Tween-80 is 1~5 parts by weight.
- 2. the Chinese Medicines agent according to claim 1 for being used to treat piglet yellow-white dysentery, it is characterised in that：By following weight The bulk drug of number is made：100 parts of poplar flower, 9 parts of the coptis, 24 parts of the Chinese bulbul, 21 parts of purslane, 18 parts of golden cypress, 18 parts of the bark of ash, 30 parts of Herba Andrographitis, 30 parts of folium isatidis.
- 3. a kind of preparation method as claimed in claim 1 or 2 for being used to treat the Chinese Medicines agent of piglet yellow-white dysentery, its feature It is：Comprise the following steps：（1）Each taste bulk drug is accurately taken according to parts by weight, by the poplar flower, coptis, the Chinese bulbul, purslane, golden cypress, the bark of ash, big Leafiness adds water to cook 2 times, merges 2 decocting liquids, and it is 50~80% to add ethanol to alcohol content, and it is standby that recovery ethanol obtains extractum A；（2）Take Herba Andrographitis ethanol to extract 2 times, merge 2 filtrates, it is standby that recovery ethanol obtains medicinal extract B；（3）Merge extractum A and medicinal extract B, add Tween-80, regulation solution ph is 5~7, filters and produces；Step（2）Middle ethanol extraction plus 6~8 times of amount ethanol；Step（3）The addition of middle Tween-80 is 1~5 parts by weight.
- 4. the preparation method according to claim 3 for being used to treat the Chinese Medicines agent of piglet yellow-white dysentery, it is characterised in that： The step（1）Middle decoct adds 8~10 times of amount water, decocts 1~2 hour.
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| CN104840695A (en) * | 2015-05-18 | 2015-08-19 | 山东新希望六和集团有限公司 | Medicine combination for treating white scour of piglet and preparation method thereof |
| CN105055614A (en) * | 2015-08-25 | 2015-11-18 | 河南省睿兰特生物制药有限公司 | Preparation process of Chinese herbal medicine concentrated medicine for treating livestock and poultry intestinal diseases |
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