CN105106394A - Chinese herb preparation for preventing and treating animal digestive canal infection and preparing method and application thereof - Google Patents
Chinese herb preparation for preventing and treating animal digestive canal infection and preparing method and application thereof Download PDFInfo
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Abstract
The invention relates to a Chinese herb preparation for preventing and treating animal digestive canal infection and a preparing method and application thereof. The Chinese herb preparation is prepared from, by weight, 2.5-7.5 parts of scutellaria baicalensis, 4-11 parts of pericarpium granati, 9-28 parts of Chinese pulsatilla roots, 2-6 parts of radix sophorae flavescentis, 4-11 parts of coptis chinensis, 7.5-22.5 parts of cortex fraxini, 5.5-16.5 parts of golden cypress and 2.5-7.5 parts of poplar flowers. The preparing method includes the steps that during preparation, 1-5 kinds of Chinese herb components are taken by weight, soaked in ethyl alcohol for 10-12 h, and filtered to obtain first leach liquor; the remaining Chinese herb components are decocted with water, concentrated and filtered to obtain concentrated liquor, and the concentrated liquor is added into ethyl alcohol to obtain second leach liquor through precipitating and filtering; the first leach liquor and the second leach liquor are mixed, the ethyl alcohol is separated and removed, and the Chinese herb preparation is obtained through forming. Compared with the prior art, the Chinese herb preparation can effectively prevent and treat animal digestive canal infection without causing drug resistance, and is free from residues or toxic and side effects, and capable of being widely used for preventing and treating digestive canal infection of livestock and poultry, and the preparing method is simple.
Description
Technical field
The invention belongs to field of veterinary medicine preparation, relate to for Chinese medicine preparation preventing and treating animal digestive canal infection and preparation method thereof and application.
Background technology
Along with the development of livestock breeding industry, cultivation scale is at expanding day, and cultivation density is also improving constantly.Especially now along with the raising of social environment consciousness, the plant that some small scales, unable increase expenses of environmental protection drop into is eliminated gradually, and this facilitates cultivation scale and intensive development process more.The new problem that scale and intensivization development bring is exactly control and prevention of disease, because cultivation density increases, animal individual vivosphere is reducing, and animal disease is in increase, and the probability of disease propagation is also in increase simultaneously.Therefore, the medicine that exploitation is efficient, applicable is also applied to clinical, is one of effective means improving control and prevention of disease ability.
Digestive tract infection, respiratory tract infection, this is the two large class diseases that breeding enterprise faces.Such as, pig breeding enterprise wants high efficiency, and sow piglet will be supported, and this is the basic law of enterprise of raising pigs, because sow is basic, piglet is source, improves litter size, improves piglet survival rate, is the basic guarantee of enterprise of raising pigs.Equally, effectively improving chickling survival rate, is the target that poultry farming is laying siege to always.And digestive tract infection piglet, young fowl stage the most incident disease just, such as, in a brood of piglet, HUANGBAI(sic) dysentery sickness rate can reach 80%, and young pullorum disease sickness rate is higher, sometimes even can reach 100%.Although digestive tract infection causes young stock, young fowl mortality rate not high, but its meeting appreciable impact individual health level, and then affect total quality, sometimes also very large trouble can be brought to the raising in later stage, so exploitation active drug, in order to control digestive tract infection, concerning breeding enterprise, then seem especially important.
Many medicines all have good inhibitory action to causing the escherichia coli of digestive tract infection, Salmonella, but if singlely for a long time reuse same medicine, this is just easy to the drug resistance causing antibacterial.Some medicines be exactly because exist drug resistance serious, dosage is increased, residual risk increases and the problem such as side effect increase, and to be eliminated gradually.For this point, Chinese medicine preparation has relative advantage, and first, overall medication is particular about by Chinese medicine, and in prescribed preparation, effective ingredient is various, not easily produces drug resistance; Secondly, Chinese medicine preparation derives from herbaceous plant, has no side effect.
But can Chinese medicine preparation bring into normal play curative effect, is also affect by many factors.One is prescription, has the Chinese medicine of identical function, and prescription is different, and curative effect is also different; Two is extract, if extraction process is improper, effective ingredient can not propose, and this not only wastes natural resources of Chinese medicinal materials, and the preparation curative effect made also can be made to have a greatly reduced quality; Three is purification, and purification directly affects preparation active constituent content, and content is also one of factor affected the treatment; Finally dosage form, if extraction purification do good again, do not have suitable dosage form, animal can not effectively be diluted, and still can not play the drug action of medicine.
For the problems referred to above, Authorization Notice No. is the Chinese medicine composition that the Chinese invention patent of CN102846838B discloses that piglet digestive bacterial disease prevented and treated by a kind of alternative antibiotic, composed of the following components according to parts by weight: Radix Ranunculi Ternati 12 parts, Radix Sophorae Flavescentis 13 parts, medicated cigarette silk 3 parts, Flos Chrysanthemi 7 parts, Herba Asari 18 parts, Rhizoma Coptidis 32 parts, Herba Houttuyniae 28 parts.In the component of above-mentioned patent, Radix Ranunculi Ternati is sweet, pungent, tepor, returns liver, lung meridian, has dissipating phlegm and resolving masses, effect of removing toxic substances and promoting subsidence of swelling; Radix Sophorae Flavescentis, for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; Medicated cigarette silk has subduing swelling and detoxicating, disinsection efficiency, for furuncle swelling toxin, and tinea capitis, tinea alba, tinea alba, venom; Flos Chrysanthemi has heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver effect, cures mainly furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc.; Herba Asari has XIAOFENG SAN gas expelling summer-heat, and inducing diuresis for treating stranguria syndrome goes the effect amassed, and cures mainly sandstone and drenches, dysuria, hematuria, edema caused by wind-dampness, anemogenous headache, cough due to common cold, stomachache, for a long time long-pending disease; Rhizoma Coptidis, the fire of the stomach that clears away heart-fire, and it is damp and hot to control the intestines and stomach, be applicable to the damp and hot caused diarrhoea of the intestines and stomach, dysentery, vomiting, the high fever caused by calentura intenseness of heat is irritated; Herba Houttuyniae heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, cure mainly the main lung abscess vomiting pus of pyretic stranguria, expectorant dyspnea of heat type coughed, larynx Oh, hematodiarrhoea, carbuncle sore tumefacting virus, pyretic stranguria etc.Above-mentioned patent component formula has heat-clearing toxin-expelling functions widely, and what lay particular emphasis on digestive tract disease only has Radix Sophorae Flavescentis, Rhizoma Coptidis two taste Chinese medicine.Relative to above-mentioned patent, the present invention has following characteristics: 1) every in formula Chinese medicine ingredients is alone simply, all has therapeutical effect to digestive tract bacterial disease; 2) in formula, each Chinese medicinal components combinationally uses, and by controlling suitable consumption, plays synergism each other, more excellent to the bactericidal effect of digestive tract antibacterial; 3) owing to adopting Chinese medicinal components to be used in conjunction with each other, effectively can also reduce pathogen in digestive tract and produce the probability of drug resistance.Therefore, technical solution of the present invention more lays particular emphasis on treatment digestive tract bacterial infection, and curative effect can be more remarkable.
Summary of the invention
Object of the present invention be exactly in order to overcome above-mentioned prior art exist defect and provide one effectively can prevent and treat animal digestive canal infection, drug resistance can not be produced, noresidue, have no side effect for Chinese medicine preparation preventing and treating animal digestive canal infection and preparation method thereof and application.
Object of the present invention can be achieved through the following technical solutions:
For preventing and treating the Chinese medicine preparation of animal digestive canal infection, this Chinese medicine preparation adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 2.5-7.5 part, Pericarpium Granati 4-11 part, Radix Pulsatillae 9-28 part, Radix Sophorae Flavescentis 2-6 part, Rhizoma Coptidis 4-11 part, Cortex Fraxini 7.5-22.5 part, Cortex Phellodendri 5.5-16.5 part and flower of poplar 2.5-7.5 part.
Further, described raw material also comprises Radix Isatidis 2.5-7.5 part, Folium Isatidis 2-6 part.
Further, described raw material also comprises Rhizoma Dryopteris Crassirhizomatis 2-5 part.
For preventing and treating the preparation method of the Chinese medicine preparation of animal digestive canal infection, the method specifically comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get 1-5 kind Chinese medicinal components in step (1) by weight, and be placed in ethanol and soak 10-12h, filter, i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
Further, the raw material in step (1) also comprises Radix Isatidis 2.5-7.5 part, Folium Isatidis 2-6 part.
Further, the raw material in step (1) also comprises Rhizoma Dryopteris Crassirhizomatis 2-5 part.
The mass concentration of described ethanol is 50-95%.
The quality of the concentrated solution described in step (3) is the 25-50% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second described lixiviating solution is 50-80%.
Chinese medicine preparation described in step (4) is the one in powder preparation, liquid preparation, ointment preparation, paste-like preparation or granular formulations.
When practical application, described Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 0.1-1%, feeding animals.
In formula of Chinese materia medica preparation of the present invention:
Radix Scutellariae, master enters part of the body cavity above the diaphragm housing the heart and lungs lung meridian, to rush down clearly part of the body cavity above the diaphragm housing the heart and lungs lung-fire, and has clearing heat and preventing abortion, the merit of pathogenic fire purging hemostasis, also has good effect to the frequent fetal movement etc. caused by interior-heat.
Pericarpium Granati, relieving diarrhea with astringents, hemostasis, anthelmintic, dysentery, discharging fresh blood stool, metrorrhagia, leukorrhagia, insect, cure mainly chronic diarrhea, chronic dysentery, have blood in stool, abdominal pain due to worm stagnation, and it all has good antibacterial action to the four clock dysentery bacteriums such as in will he, Amur, Fu Shi and Song.
The Radix Pulsatillae, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, diarrhea due to damp-heat, dysentery pus and blood, cure mainly toxic-heat and blood stasis, tenesmus, damp-heat vaginal discharge, pyrexial malaria cold and heat.
Radix Sophorae Flavescentis, for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Rhizoma Coptidis, clear away heart-fire the fire of stomach, and it is damp and hot to control the intestines and stomach, be applicable to the damp and hot caused diarrhoea of the intestines and stomach, dysentery, vomiting, high fever caused by calentura intenseness of heat is irritated, it has good antiinflammatory, antiviral, stomach-invigorating and gall bladder-invigorating effect, and its antiinflammatory action is the most obvious with dysentery bacterium, thus has good therapeutical effect to acute enteritis, bacillary dysentery.
Cortex Fraxini, heat clearing and damp drying, liver heat removing and eyesight improving, astringent therapy dysentery relieving, leukorrhagia stopping, cure mainly pyretic toxicity dysentery, leukorrhagia pudendal pruritus, liver-heat conjunctival congestion and swelling pain, the raw cataracta of order.
Cortex Phellodendri, specially enters kidney of lower warmer, urinary bladder channel, is good at clearing away damp-heat from lower-JIAO, and Cortex Phellodendri can not only control excess-fire, but also can control asthenic fire.
Flower of poplar, heat and toxic materials clearing away medicine, removing dampness antidysenteric, but directly can kill pathogen, improve the resistance of body, antagonism immunosuppressant, regulates the immunologic function of body, various stress between effective alleviation poultry period of disease, make animal intestines and stomach flesh and sphincter tone improve.
Folium Isatidis and Radix Isatidis can work in coordination with performance heat-clearing and toxic substances removing, effect of blood cooling and ecchymoses removing, have good resisting pathogenic microbes, improve body's immunity and the pharmacological action such as to protect the liver.
Rhizoma Dryopteris Crassirhizomatis, heat-clearing and toxic substances removing, hemostasis, parasite killing, cure mainly epidemic disease flu, headache due to pathogenic wind-heat, maculae caused by violent heat pathogen, sore swollen toxin, metrostaxis, abdominal pain due to worm stagnation.
In the formula of Chinese medicine preparation of the present invention, the Radix Pulsatillae, for controlling dysentery key medicine, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, is monarch drug; Radix Sophorae Flavescentis, Radix Scutellariae, Pericarpium Granati, Rhizoma Coptidis, Cortex Phellodendri, flower of poplar heat-clearing and toxic substances removing, removing dampness dysentery relieving are ministerial drug altogether; Cortex Fraxini, Radix Isatidis, Folium Isatidis, Rhizoma Dryopteris Crassirhizomatis heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery are adjuvant drug altogether.All medicines share, and play effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery altogether.
Chinese medicine preparation of the present invention, all meets the quality standard of " Chinese people's republicanism veterinary drug allusion quotation two " (version in 2010) inspection regulation.
Compared with prior art, the present invention has following characteristics:
1) adopt plurality of Chinese component, be particular about overall medication, there is between each component the synergism of drug effect of mutually promoting, while effectively preventing and treating animal digestive canal infection, also not easily produce drug resistance, have no side effect;
2) in preparation process, by soak extraction and water boiling and extraction, concentratedly to combine, the high efficiency extraction of Effective Component of Chinese Medicine can be ensured, while saving raw material of Chinese medicine, effectively can also ensure the Stability of preparation;
3) formed machining adopts diversified dosage form, can be applicable to different types of domestic animal, poultry, ensures Chinese medicine preparation effective dilution in vivo, and then plays the drug action of medicine;
4) overall preparation technology is simple, and condition is controlled, and the curative effect of the Chinese medicine preparation made is excellent, good stability, is applicable to extension and produces, have good application prospect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
In the present embodiment, Chinese medicine preparation adopts the raw material of following Chinese medicinal components and weight portion content to make:
Radix Scutellariae 5 parts, Pericarpium Granati 7.5 parts, the Radix Pulsatillae 19 parts, Radix Sophorae Flavescentis 4 parts, Radix Isatidis 5 parts, Rhizoma Dryopteris Crassirhizomatis 3 parts, Folium Isatidis 4 parts, Rhizoma Coptidis 7.5 parts, Cortex Fraxini 15 parts, Cortex Phellodendri 11.25 parts, flower of poplar 5 parts.
Processing technique is as follows:
1, by Radix Isatidis, Folium Isatidis mixing, with 80% soak with ethanol 12h of Radix Isatidis and Folium Isatidis gross mass 10 times amount, filtration, filtrate is for subsequent use.
2, Chinese medicine mixing will be remained, decoct with water extraction twice, first time 2h, second time 1.5h, merge extractive liquid, being concentrated into relative density is 1.2-1.25 (60 DEG C), obtained concentrated solution, add 95% ethanol of concentrated solution quality 3 times amount again, precipitation 12h, filters.
3, by 1,2 step gained filtrate mixing, reclaim ethanol, gained runny plaste adds the adjuvant such as glucose, starch and makes granule, and every 1g is equivalent to crude drug in whole 2g.
Clinical trial is carried out with made granule:
Select 30 age in days ablactational baby pig totally 60 on pig farm, Jinggangshan one, be divided into 3 groups at random.One group is blank group, does not add any medicine, normally raises; One group is test group, to add in feedstuff feed with above-mentioned granule by 0.5%; One group is matched group, to add in feedstuff feed with 10% colistin sulphate pre-mixing agent by 0.2%.
Administration frequency is every 15 days continuous uses 5 days.Test is from turning group's same day, and Continuous Observation 30 days, occurs that namely dysentery or symptom of diarrhea carry out record, and isolates disease pig and treat separately.Result of the test is as shown in table 1.
Table 1 result of the test
| Grouping | Test head number | Morbidity head number | Sickness rate |
| Blank group | 20 | 9 | 45％ |
| Test group | 20 | 1 | 5％ |
| Matched group | 20 | 2 | 10％ |
Conclusion: ablactational baby pig in the stage of turn-taking because environmental change or feedstuff change, occur stress and occur that the situation of dysentery is very general, in production, common drug prevents, colistin sulfate pre-mixing agent is as common drug, and preventive effect is remarkable, as can be seen from result of the test., also reach and colistin sulfate pre-mixing agent effect same with the granule prevention made by Chinese medicine composition meanwhile, visible, this granule prevention digestive tract infection definite effect.
Embodiment 2
In the present embodiment, Chinese medicine preparation adopts the raw material of following Chinese medicinal components and weight portion content to make:
Radix Scutellariae 7.5 parts, Pericarpium Granati 11 parts, the Radix Pulsatillae 25 parts, Radix Sophorae Flavescentis 2 parts, Radix Isatidis 7.5 parts, Rhizoma Dryopteris Crassirhizomatis 5 parts, Folium Isatidis 5 parts, Rhizoma Coptidis 10 parts, Cortex Fraxini 7.5 parts, Cortex Phellodendri 7.5 parts, flower of poplar 7 parts.
Processing technique is as follows:
1, by Radix Isatidis, Folium Isatidis, Radix Pulsatillae mixing, with Radix Isatidis, Folium Isatidis, Radix Pulsatillae gross mass 10 times amount 70% soak with ethanol 12h, filter, filtrate is for subsequent use.
2, Chinese medicine mixing will be remained, decoct with water extraction twice, first time 3h, second time 2h, merge extractive liquid, being concentrated into relative density is 1.2 ~ 1.25 (60 DEG C), obtained concentrated solution, add 95% ethanol of concentrated solution quality 3 times amount again, precipitation 12h, filters.
3, by 1,2 step gained filtrate mixing, reclaim ethanol, gained runny plaste adds 4 times of water gagings, and cold preservation precipitation 12h, filter, add tween 80, sodium benzoate is mixed with solution, every 1ml is equivalent to crude drug in whole 2g.
Clinical trial is carried out with made solution:
Select 7 age in days dysentery chickling totally 150 plumages in certain broiler field, be divided into 3 groups at random.One group is blank group, need not any drug quality, normally raises; One group is test group, to add in drinking-water treat with above-mentioned solution by 0.25%; One group is matched group, to add in drinking-water treat with 10% amoxicillin powder by 0.1%.Test period is 5 days.Result of the test is as shown in table 2.
Table 2 result of the test
| Grouping | Experiment quantity | Cure quantity | Cure rate | Dead quantity | Mortality rate |
| Blank group | 50 plumages | 5 plumages | 10％ | 36 plumages | 72％ |
| Test group | 50 plumages | 38 plumages | 76％ | 3 plumages | 6％ |
| Matched group | 50 plumages | 40 plumages | 80％ | 8 plumages | 16％ |
Conclusion: white scour of chicken sickness rate is high, if taken drugless medication, mortality rate is very high.In this test, test group and matched group cure rate are respectively 76% and 80%, although test group does not have matched group cure rate high, the therapeutic effect of Chinese medicine composition clearly.
Embodiment 3
The present embodiment, for preventing and treating the Chinese medicine preparation of animal digestive canal infection, adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 2.5 parts, Pericarpium Granati 4 parts, the Radix Pulsatillae 9 parts, Radix Sophorae Flavescentis 2 parts, Rhizoma Coptidis 4 parts, Cortex Fraxini 7.5 parts, Cortex Phellodendri 5.5 parts and flower of poplar 2.5 parts.
Concrete preparation method comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get Radix Scutellariae, Pericarpium Granati, the Radix Pulsatillae by weight, and be placed in ethanol and soak 10h, filter, be i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
Wherein, the mass concentration of ethanol is 50%.
In step (3), the quality of concentrated solution is 50% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second lixiviating solution is 80%.
The Chinese medicine preparation that the present embodiment obtains is powder preparation, and when practical application, obtained Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 1%, feeding animals.
Embodiment 4
The present embodiment, for preventing and treating the Chinese medicine preparation of animal digestive canal infection, adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 7.5 parts, Pericarpium Granati 11 parts, the Radix Pulsatillae 28 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 11 parts, Cortex Fraxini 22.5 parts, Cortex Phellodendri 16.5 parts, flower of poplar 7.5 parts, Radix Isatidis 7.5 parts and Folium Isatidis 6 parts.
Concrete preparation method comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get Radix Scutellariae, Rhizoma Coptidis, Cortex Fraxini, Cortex Phellodendri, flower of poplar by weight, and be placed in ethanol and soak 12h, filter, be i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
Wherein, the mass concentration of ethanol is 95%.
In step (3), the quality of concentrated solution is 25% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second lixiviating solution is 50%.
The Chinese medicine preparation that the present embodiment obtains is granular formulations, and when practical application, obtained Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 0.1%, feeding animals.
Embodiment 5
The present embodiment, for preventing and treating the Chinese medicine preparation of animal digestive canal infection, adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 6 parts, Pericarpium Granati 8 parts, the Radix Pulsatillae 16 parts, Radix Sophorae Flavescentis 4 parts, Rhizoma Coptidis 7 parts, Cortex Fraxini 15 parts, Cortex Phellodendri 9 parts, flower of poplar 5 parts, Radix Isatidis 2.5 parts, Folium Isatidis 2 parts and Rhizoma Dryopteris Crassirhizomatis 5 parts.
Concrete preparation method comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get Radix Sophorae Flavescentis, Cortex Fraxini by weight, and be placed in ethanol and soak 11h, filter, be i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
Wherein, the mass concentration of ethanol is 80%.
In step (3), the quality of concentrated solution is 40% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second lixiviating solution is 65%.
The Chinese medicine preparation that the present embodiment obtains is paste-like preparation, and when practical application, obtained Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 0.6%, feeding animals.
Embodiment 6
The present embodiment, for preventing and treating the Chinese medicine preparation of animal digestive canal infection, adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 3 parts, Pericarpium Granati 9 parts, the Radix Pulsatillae 24 parts, Radix Sophorae Flavescentis 3 parts, Rhizoma Coptidis 5 parts, Cortex Fraxini 13 parts, Cortex Phellodendri 6 parts, flower of poplar 3 parts, Radix Isatidis 5 parts, Folium Isatidis 5 parts and Rhizoma Dryopteris Crassirhizomatis 2 parts.
Concrete preparation method comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get Radix Sophorae Flavescentis, Cortex Fraxini by weight, and be placed in ethanol and soak 10h, filter, be i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
Wherein, the mass concentration of ethanol is 60%.
In step (3), the quality of concentrated solution is 35% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second lixiviating solution is 55%.
The Chinese medicine preparation that the present embodiment obtains is ointment preparation, and when practical application, obtained Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 0.3%, feeding animals.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1. for preventing and treating the Chinese medicine preparation of animal digestive canal infection, it is characterized in that, this Chinese medicine preparation adopts the raw material of following Chinese medicinal components and weight portion content to make: Radix Scutellariae 2.5-7.5 part, Pericarpium Granati 4-11 part, Radix Pulsatillae 9-28 part, Radix Sophorae Flavescentis 2-6 part, Rhizoma Coptidis 4-11 part, Cortex Fraxini 7.5-22.5 part, Cortex Phellodendri 5.5-16.5 part and flower of poplar 2.5-7.5 part.
2. the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 1, is characterized in that, described raw material also comprises Radix Isatidis 2.5-7.5 part, Folium Isatidis 2-6 part.
3. the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 2, is characterized in that, described raw material also comprises Rhizoma Dryopteris Crassirhizomatis 2-5 part.
4. as claimed in claim 1 for preventing and treating the preparation method of the Chinese medicine preparation of animal digestive canal infection, it is characterized in that, the method specifically comprises the following steps:
(1) get the raw materials ready by the raw material of following Chinese medicinal components and weight portion content:
(2) get 1-5 kind Chinese medicinal components in step (1) by weight, and be placed in ethanol and soak 10-12h, filter, i.e. obtained first lixiviating solution;
(3) Chinese medicinal components soak by water will be remained, concentrated after, filter, obtained concentrated solution, then concentrated solution joined in ethanol, by precipitation, filter, be i.e. obtained second lixiviating solution;
(4) the first lixiviating solution is mixed with the second lixiviating solution, be separated removing ethanol, then through formed machining, i.e. obtained described Chinese medicine preparation.
5. the preparation method of the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 4, is characterized in that, the raw material in step (1) also comprises Radix Isatidis 2.5-7.5 part, Folium Isatidis 2-6 part.
6. the preparation method of the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 5, is characterized in that, the raw material in step (1) also comprises Rhizoma Dryopteris Crassirhizomatis 2-5 part.
7. the preparation method of the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 4, is characterized in that, the mass concentration of described ethanol is 50-95%.
8. the preparation method of the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 4, it is characterized in that, the quality of the concentrated solution described in step (3) is the 25-50% of residue Chinese medicinal components gross mass, and the mass content of concentrated solution in the second described lixiviating solution is 50-80%.
9. the preparation method of the Chinese medicine preparation for preventing and treating animal digestive canal infection according to claim 4, it is characterized in that, the Chinese medicine preparation described in step (4) is the one in powder preparation, liquid preparation, ointment preparation, paste-like preparation or granular formulations.
10. as claimed in claim 1 for preventing and treating the application of the Chinese medicine preparation of animal digestive canal infection, it is characterized in that, described Chinese medicine preparation adds in feedstuff or drinking-water by the mass percent of 0.1-1%, feeding animals.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497878A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Compound preparation for treating animal diarrhea and preparation method of compound preparation |
| CN112022934A (en) * | 2020-09-14 | 2020-12-04 | 沈阳农业大学 | Traditional Chinese medicine preparation for treating infectious proventriculitis of poultry and preparation method thereof |
| CN112056461A (en) * | 2020-10-14 | 2020-12-11 | 江苏威泰龙生物科技有限公司 | Natural feed containing crude extract of poplar flower |
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| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN104208294A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof |
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| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN104208294A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497878A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Compound preparation for treating animal diarrhea and preparation method of compound preparation |
| CN112022934A (en) * | 2020-09-14 | 2020-12-04 | 沈阳农业大学 | Traditional Chinese medicine preparation for treating infectious proventriculitis of poultry and preparation method thereof |
| CN112056461A (en) * | 2020-10-14 | 2020-12-11 | 江苏威泰龙生物科技有限公司 | Natural feed containing crude extract of poplar flower |
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Effective date of registration: 20170106 Address after: 363000 Fujian province Zhangzhou Jinzhu Xiangcheng Jinfeng Economic Development Zone area of gold and stone Po Road Road intersection Applicant after: FUJIAN AONONG BIOTECHNOLOGY GROUP CO., LTD. Applicant after: JIANGXI AOXIN BIOTECHNOLOGY CO., LTD. Address before: 363000 Fujian province Zhangzhou Jinzhu Xiangcheng Jinfeng Economic Development Zone area of gold and stone Po Road Road intersection Applicant before: FUJIAN AONONG BIOTECHNOLOGY GROUP CO., LTD. |
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