CN101829257B - Traditional Chinese medicine oral liquid for treating chicken colibacillosis and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for treating chicken colibacillosis and preparation method thereof Download PDFInfo
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- CN101829257B CN101829257B CN2010101769361A CN201010176936A CN101829257B CN 101829257 B CN101829257 B CN 101829257B CN 2010101769361 A CN2010101769361 A CN 2010101769361A CN 201010176936 A CN201010176936 A CN 201010176936A CN 101829257 B CN101829257 B CN 101829257B
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Abstract
The invention discloses a traditional Chinese medicine oral liquid for treating chicken colibacillosis and a preparation method thereof. The traditional Chinese medicine oral liquid comprises the following effective components in parts by weight: 20-100 parts of Chinese bulbul, 10-80 parts of golden cypress, 10-50 parts of radix scutellariae, 20-100 parts of purslane, 10-50 parts of elecampane and 5-25 parts of areca-nut. The traditional Chinese medicine oral liquid has characteristics of high healing effect and non-toxic and side-effect, and can promote the recovery and the growth of organism and increase weight. The traditional Chinese medicine oral liquid is pure Chinese medicine preparation without drug fastness for long term use. Especially, the invention adopts preparation of oral liquid, thereby having characteristics of high absorption speed and high absorption rate.
Description
Technical field
The present invention relates to a kind of veterinary drug, especially a kind of Chinese medicine oral liquid for the treatment of chicken colibacillosis and preparation method thereof.
Background technology
Chicken colibacillosis is one of clinical common fowl disease of China, has the characteristics of rapid onset, mortality rate height, course of disease length, has caused great harm to poultry husbandry.Adopt antibacterial drug therapy for colibacillosis at present more, but because the unreasonable use of this type of medicine, caused colibacillary drug resistance spectrum constantly to enlarge, prevention effect descends, antibacterials are intravital residual at machine simultaneously, reduce meat egg product quality, influenced human health and public health security.Clinical practice shows that Chinese medicine has the better prevention effect to chicken colibacillosis, and has low-residual, hypotoxicity, cure rate height, is difficult for producing characteristics such as drug resistance, meets the industry requirement of the green cultivation that current society advocates, and vast potential for future development is arranged.The control prescription that uses on the veterinary clinic mostly is powder, administering mode inconvenience; And the intestinal of poultry is shorter, and the time that medicine retains in vivo is shorter, absorbs relatively poor.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicine oral liquid for the treatment of chicken colibacillosis; The present invention also provides the preparation method of the Chinese medicine oral liquid of treatment chicken colibacillosis.
For solving the problems of the technologies described above, the components by weight percent of Chinese medicine oral liquid effective ingredient of the present invention is: 5～25 parts of 20～100 parts of the Radix Pulsatillaes, 10～80 parts of Cortex Phellodendris, 10～50 parts of Radix Scutellariaes, 20～100 parts of Herba Portulacaes, 10～50 parts of the Radix Aucklandiae and Semen Arecaes.
As a preferred embodiment of the present invention, the components by weight percent of effective ingredient is: 15 parts of 60 parts of the Radix Pulsatillaes, 45 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 60 parts of Herba Portulacaes, 30 parts of the Radix Aucklandiae and Semen Arecaes.
The preparation method of Chinese medicine oral liquid of the present invention is: (1), take by weighing Chinese medicine by compatibility dosage, add the distilled water of 8～12 times of weight, soak 20～40min;
(2), the drug decocting that soaks, boil back 10～30min at a simmer, filter, obtain medicinal liquid and medicinal residues;
(3), medicinal residues add the distilled water of 5～8 times of weight, boil back 10～30min at a simmer, filter and obtain the secondary medicinal liquid;
(4), merge medicinal liquid and secondary medicinal liquid, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, can obtain finished product after the sterilization.
China is accumulating rich experience aspect the Chinese herb prevention bacterial disease, according to the dialectical theory of Chinese veterinarian, avian colibacillosis is the interior-heat syndrome that the long-pending intestinal of damp and hot heap soil or fertilizer over and around the roots causes, control suitable heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping, monarch cooperates, coordinate mutually to be usefulness, can reach the effect for the treatment of both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors.
Wherein, the Radix Pulsatillae has effects such as heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, and escherichia coli etc. are had inhibitory action, is we's principal agent; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging removes the effect of steaming, cures mainly hygropyretic dysentery and has loose bowels, and its main antipathogenic composition is a berberine; Radix Scutellariae has the effect of heat clearing and damp drying, eliminating fire and detoxication, and modern pharmacology studies show that Radix Scutellariae contains compositions such as baicalin and neobaicalein, and its antimicrobial spectrum is wider, and various bacteria, dermatophytes, leptospira etc. are all had inhibitory action; Herba Portulacae is all good wild plants of a kind of medical, edible, and the flavone compound that wherein contains is better to colibacillary fungistatic effect; Cortex Phellodendri, Radix Scutellariae and Herba Portulacae are we's ministerial drug; The Radix Aucklandiae has the dual regulation of excitement or inhibition to gastrointestinal tract, but also facilitating digestion liquid secretion has the effect of regulating QI to relieve pain; Semen Arecae has effects such as dyspepsia and intestinal stasis relieving, parasite killing; The Radix Aucklandiae and Semen Arecae are we's adjuvant drugs.
Adopt the beneficial effect that technique scheme produced to be: the characteristics that Chinese medicine oral liquid of the present invention has the curative effect height, has no side effect the chicken colibacillosis of control, and can promote the recovery and the growth of body to improve weightening finish.Chinese medicine oral liquid of the present invention is a pure Chinese medicinal preparation, and life-time service can not develop immunity to drugs; Especially adopt the dosage form of oral liquid, have the advantages that infiltration rate is fast, absorbance is high.
The specific embodiment
The present invention is further detailed explanation below in conjunction with specific embodiment.
Embodiment 1:
The Chinese medicine oral liquid of this treatment chicken colibacillosis adopts the raw material of Chinese medicine of following weight: Radix Pulsatillae 60g, Cortex Phellodendri 45g, Radix Scutellariae 30g, Herba Portulacae 60g, Radix Aucklandiae 30g and Semen Arecae 15g.
Preparation method: take by weighing Chinese medicine by compatibility dosage, the distilled water that adds 10 times of weight decocts behind the immersion 30min, boils back 20min at a simmer, four layers of filtered through gauze medicine, medicinal residues add the distilled water of 5 times of weight again, boil back 20min at a simmer, filter, merge medicinal liquid twice, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, autoclaving can obtain this Chinese medicine oral liquid.
Embodiment 2:
This Chinese medicine oral liquid adopts the raw material of Chinese medicine of following weight: Radix Pulsatillae 20g, Cortex Phellodendri 30g, Radix Scutellariae 40g, Herba Portulacae 100g, Radix Aucklandiae 10g and Semen Arecae 20g.
Preparation method: take by weighing Chinese medicine by compatibility dosage, the distilled water that adds 8 times of weight decocts behind the immersion 40min, boils back 10min at a simmer, four layers of filtered through gauze medicine, medicinal residues add the distilled water of 8 times of weight again, boil back 30min at a simmer, filter, merge medicinal liquid twice, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, autoclaving can obtain this Chinese medicine oral liquid.
Embodiment 3:
This Chinese medicine oral liquid adopts the raw material of Chinese medicine of following weight: Radix Pulsatillae 100g, Cortex Phellodendri 80g, Radix Scutellariae 50g, Herba Portulacae 20g, Radix Aucklandiae 50g and Semen Arecae 25g.
Preparation method: take by weighing Chinese medicine by compatibility dosage, the distilled water that adds 9 times of weight decocts behind the immersion 20min, boils back 25min at a simmer, four layers of filtered through gauze medicine, medicinal residues add the distilled water of 5 times of weight again, boil back 15min at a simmer, filter, merge medicinal liquid twice, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, autoclaving can obtain this Chinese medicine oral liquid.
Embodiment 4:
This Chinese medicine oral liquid adopts the raw material of Chinese medicine of following weight: Radix Pulsatillae 40g, Cortex Phellodendri 20g, Radix Scutellariae 20g, Herba Portulacae 80g, Radix Aucklandiae 40g and Semen Arecae 5g.
Preparation method: take by weighing Chinese medicine by compatibility dosage, the distilled water that adds 12 times of weight decocts behind the immersion 25min, boils back 30min at a simmer, four layers of filtered through gauze medicine, medicinal residues add the distilled water of 6 times of weight again, boil back 25min at a simmer, filter, merge medicinal liquid twice, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, autoclaving can obtain this Chinese medicine oral liquid.
Embodiment 5:
This Chinese medicine oral liquid adopts the raw material of Chinese medicine of following weight: Radix Pulsatillae 80g, Cortex Phellodendri 70g, Radix Scutellariae 10g, Herba Portulacae 40g, Radix Aucklandiae 20g and Semen Arecae 10g.
Preparation method: take by weighing Chinese medicine by compatibility dosage, the distilled water that adds 11 times of weight decocts behind the immersion 35min, boils back 15min at a simmer, four layers of filtered through gauze medicine, medicinal residues add the distilled water of 6 times of weight again, boil back 10min at a simmer, filter, merge medicinal liquid twice, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, autoclaving can obtain this Chinese medicine oral liquid.
This Chinese medicine oral liquid pharmacodynamic experiment:
1 material
1.1 300 of the brown laying hens of experimental animal 1 age in days Yi Sha are pressed layer breeding feeding standard to 15 age in days.
1.2 test strain escherichia coli O
1, available from China Veterinery Drug Inspection Office.
1.3 trial drug and 1 resulting Chinese medicine oral liquid of preparation method embodiment; Control drug is that florfenicol soluble powder (levy space pharmaceutical Co. Ltd and produce, lot number: 20090915) by Hebei.
2 methods
2.1 pharmacodynamics test
2.1.1 animal grouping situation and processing method
300 chickling are divided into 6 groups at random, 50 every group, test after waiting to stablize.Determine counteracting toxic substances bacterium amount according to the pilot study result.Except that negative control group, every group of chickling chest muscle injection chicken colibacillosis O
1(contain the bacterium number approximately is 10 to bacterium liquid 0.1ml
8CFU).Behind the counteracting toxic substances, the medication that will begin in a minute of I～IV group.Wherein the I～III group is with the treatment of this Chinese medicine oral liquid, respectively with high dose (I group, 1.5ml/kg body weight), middle dosage (II group, 1.0ml/kg body weight) and the administration of low dosage (III group, 0.5ml/kg body weight) drinking-water; The IV group uses florfenicol soluble powder with the administration of routine dose (20mg/kg body weight) drinking-water.The positive matched group of V group, not administration of counteracting toxic substances; The negative matched group of VI group, not administration of counteracting toxic substances.Medication therapy groups administration every day 2 times, continuous use 5 days.
2.1.2 evaluating drug effect
After the medication in 2 weeks, every day the observed and recorded test chicken clinical symptoms, death condition, dead chicken cutd open as pathology inspection separates with antibacterial, biochemical identification.Calculate effective percentage, cure rate, the mortality rate of each group, before inoculation, respectively organize the body weight of chicken, calculate the relative weight gain rate, and the These parameters between each group is carried out statistical analysis with off-test time-division another name amount.
2.2 data analysis
With SPSS11.5 software data are tested.Mortality rate, cure rate, protective rate adopt X
2The T check is adopted in check, the relative weight gain rate.
3 results
Negative control group chickling spirit, appetite are good, do not show any symptom and the phenomena of mortality; Other group chickling sagging, the minimizing of searching for food of wing successively occurs behind counteracting toxic substances 8h except that negative control group, draws symptoms such as yellow-white loose stool, and all occurs dead.Show as colibacillary typical cytopathic in various degree after dead chicken is cutd open inspection: the trachea mucus increases, and liver is dispersed in the petechia mostly, fiber disposition perihepatitis, pericarditis, and the intestinal mucosa plumpness, enteric cavity has the yellow foam of volume, and kidney is swollen slightly.Liver takes pathological material of disease to carry out the antibacterial separation and Culture, through being accredited as escherichia coli.The clinical symptoms of each group of medication is slighter than positive controls, and dead quantity is few.
Cure rate, protective rate, mortality rate and the relative weight gain rate of each group of test the results are shown in Table 1.
This Chinese medicine oral liquid of table 1 is to the curative effect of artificial challenge's chicken colibacillosis
| Group | Death toll | Mortality rate % | Cure rate % | Protective rate % | The relative weight gain rate % |
| I group (high dose group) | 8 | 16Bc | 76Aa | 84Aa | 85.85Bb |
| II group (middle dosage group) | 9 | 18Bc | 70ABa | 82Aa | 84.84Bb |
| III group (low dose group) | 15 | 30Bb | 56Bb | 70Ab | 74.19Bc |
| IV group (florfenicol group) | 10 | 20Bbc | 72ABa | 80Aab | 82.35Bb |
| V group (positive controls) | 26 | 52Aa | 8*Cc | 48*Bc | 10.54Cd |
| VI group (negative control group) | 0 | -- | -- | -- | 100.0Aa |
In the table, *: spontaneous recovery or symptom spontaneous remission
Annotate: the different group differences extremely significantly (p＜0.01) of representing of capitalization; The different group differences significantly (p＜0.05) of representing of lower case
The result shows: the therapeutic effect of three groups of this treatment by Chinese herbs, the relative weight gain rate and the poor heteropole of positive controls be (P＜0.01) significantly, Chinese medicine height, middle dosage group and florfenicol group comparing difference be significantly (P＞0.05) not, difference not significantly (P＞0.05) between two groups of high, the middle dosage.
Conclusion: this Chinese medicine oral liquid height, middle dosage group reach more than 80% artificial challenge's chicken colibacillosis protective rate, and prevention effect and florfenicol be (P＞0.05) quite, and can promote the recovery and the growth of body, improve weightening finish.Because high, two groups of there was no significant differences in every statistical indicator of middle dosage, so serve as the recommendation using dosage with middle dosage.
Claims (3)
1. Chinese medicine oral liquid for the treatment of chicken colibacillosis, it is characterized in that, make: 5～25 parts of 20～100 parts of the Radix Pulsatillaes, 10～80 parts of Cortex Phellodendris, 10～50 parts of Radix Scutellariaes, 20～100 parts of Herba Portulacaes, 10～50 parts of the Radix Aucklandiae and Semen Arecaes by the crude drug of following weight component.
2. the Chinese medicine oral liquid of treatment chicken colibacillosis according to claim 1 is characterized in that, the components by weight percent of described crude drug is: 15 parts of 60 parts of the Radix Pulsatillaes, 45 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 60 parts of Herba Portulacaes, 30 parts of the Radix Aucklandiae and Semen Arecaes.
3. the preparation method of the Chinese medicine oral liquid of claim 1 or 2 described treatment chicken colibacillosis is characterized in that, this method step is: (1), take by weighing the crude drug of respectively distinguishing the flavor of by described components by weight percent, add the distilled water of 8～12 times of weight, soak 20～40min;
(2), the drug decocting that soaks, boil back 10～30min at a simmer, filter, obtain medicinal liquid and medicinal residues;
(3), medicinal residues add the distilled water of 5～8 times of weight, boil back 10～30min at a simmer, filter and obtain the secondary medicinal liquid;
(4), merge medicinal liquid and secondary medicinal liquid, be concentrated into slow fire that crude drug content is 1g/ml in the medicinal liquid, can obtain finished product after the sterilization.
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