CN103099812A - Medicine for treating porcine reproductive and respiratory syndrome and preparation method thereof - Google Patents
Medicine for treating porcine reproductive and respiratory syndrome and preparation method thereof Download PDFInfo
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- CN103099812A CN103099812A CN2013100192558A CN201310019255A CN103099812A CN 103099812 A CN103099812 A CN 103099812A CN 2013100192558 A CN2013100192558 A CN 2013100192558A CN 201310019255 A CN201310019255 A CN 201310019255A CN 103099812 A CN103099812 A CN 103099812A
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Abstract
The invention relates to a medicine for treating porcine reproductive and respiratory syndrome and a preparation method thereof. According to production batch and in a 1000 ml container, The medicine comprises 50-100g of tilmicosin phosphate, 1-3g of chlorpheniramine maleate, 10-40g of taurine, 50-80g of glycerin methylal, 100-200g of polyethylene glycol, 1-3g of sodium bisulfate, 0.1-0.3g of ethylene diamine tetraacetic acid and the balance of water for injection. The veterinary medicine composition provided by the invention is simple in process, stable in quality, low in cost, less in toxic and side effects, can adjust the function of macrophage, protect liver and cholecyst, improve the immunity of pigs, and inhibit the reduction of total white blood cells in the blood of the pigs with porcine reproductive and respiratory syndrome, and has significant effect in the treatment of porcine reproductive and respiratory syndrome, and great market potential.
Description
Technical field
The invention belongs to the veterinary drug preparation field, be specifically related to a kind of medicine for the treatment of pig blue-ear disease and preparation method thereof.
Background technology
Pig blue-ear disease has another name called pig breeding and respiratory disorder syndrome (PRRS), and 1987 at first at U.S.'s report, begin to be called as mysterious sick, to PRRS rapid spread whole Europe in 1991.PRRS is widely current in worldwide at present.PRRS and the mid-90 in last century are imported China into, and China classifies them as two class animal epidemics.This disease M ﹠ M in the pig farm at home is high, directly affects the sound development of China's pig industry, has caused the great attention of official.
To macrophage, particularly pulmonary alveolar macrophage has extremely strong close preferendum because of reproductive and respiratory syndrome virus, and massive duplication within it, destroys macrophage and causes immunosuppressant.Relevantly studies show that histamine is the important inflammatory mediator of body, can discharge histamine when being subject to the infection such as antibacterial, virus at body, histamine can increase venule and telangiectasis and permeability by H1 receptor and H2 receptor, causes the pathological changes such as pulmonary circulation disorder and injury of lung.The diffuse interstitial pneumonia occurs in reproductive and respiratory syndrome trouble Pulmonis Sus domestica section, small intestinal, the serious hyperemia of lymph node, hemorrhage, the pathological changes such as spleen degeneration, necrosis.
The reproductive and respiratory syndrome of veterinary drug market treatment at present antibacterials add ntipyretic analgesic medicine and come symptomatic treatment, but effect is all not satisfactory.Generally select cephalo-type, quinolones or disulfonamide thing, add that dexamethasone, dipyrone or aminophenazone come symptomatic treatment.These medicines are all larger to Liver and kidney toxicity, can cause the leukopenia of body, the side effect that immunity reduces, and being difficult to focus on pulmonary alveolar macrophage after drug absorption kills or suppresses the reproductive and respiratory syndrome poison, also be difficult to reduce or in and the histamine that discharges of body, be difficult to solve the pathological changes such as the disorderly and injury of lung of pulmonary circulation.These pharmaceutical preparation cure rates are low, and the prevention and control of reproductive and respiratory syndrome are produced little effect.Given this, a kind of medicine that can effectively treat reproductive and respiratory syndrome of research and development makes and has very much the production practices meaning.
Summary of the invention
The problem to be solved in the present invention be to provide a kind of therapeutic effect significantly, the medicine of instant effect, steady quality, safe and reliable treatment pig blue-ear disease and preparation method thereof.
For solving the problems of the technologies described above; the technical solution used in the present invention is: a kind of medicine for the treatment of pig blue-ear disease; it is characterized in that: press production batch in the container of 1000 ml, the component of required medicine is: phosphoric acid tilmicosin 50-100g, chlorphenamine maleate 1-3g; taurine 10-40g; glycerin methylal 50-80g, Polyethylene Glycol 100-200g, sodium sulfite 1-3g; disodiumedetate 0.1-0.3g, surplus is water for injection.
Improvement to such scheme is: press production batch in the container of 1000 ml; the component of required medicine is: phosphoric acid tilmicosin 70g; chlorphenamine maleate 1.5g; taurine 25g, glycerin methylal 60g, Polyethylene Glycol 150g; sodium sulfite 2g; disodiumedetate 0.2g, surplus is water for injection, water for injection adds to 1000 ml.
Undertaken by the method for being prepared as follows:
(1) take by weight phosphoric acid tilmicosin, chlorphenamine maleate, taurine, glycerin methylal, Polyethylene Glycol, sodium sulfite, disodiumedetate;
(2) with glycerin methylal, the Polyethylene Glycol mix homogeneously, then the phosphoric acid tilmicosin is added wherein, be heated to 65-80 degree centigrade of stirring and dissolving;
(3) take 500-700g water for injection, be heated to 70-80 degree centigrade, add successively bisulfite, disodiumedetate, chlorphenamine maleate, taurine, respectively stirring and dissolving.
(4) medicinal liquid of combining step (2) and (3) preparation, add water for injection to 1000ml, stirs, filter, and the inflated with nitrogen embedding, 115-120 degree centigrade of flowing steam sterilization 30 minutes, lamp inspection, labeling, packing gets final product.
Beneficial effect:
1. this product can protect the liver and protect gallbladder, in and the histamine that discharges of body, solve the cases variations such as the disorderly and injury of lung of pulmonary circulation;
2. solved and be difficult to reach pulmonary alveolar macrophage after general drug absorption and kill or suppress the reproductive and respiratory syndrome poison.But the tilmicosin targeting of this pharmaceutical composition is gathered in pulmonary alveolar macrophage, and pulmonary alveolar macrophage is also the main host cell of reproductive and respiratory syndrome poison, multinomial studies show that: tilmicosin is inhibited to copying of reproductive and respiratory syndrome virus.
3. solved after most of drug absorption greatlyr to Liver and kidney toxicity, can cause the leukopenia of body, the side effect that immunity reduces, this product can protect the liver protects gallbladder, suppresses the decline that reproductive and respiratory syndrome is suffered from total white blood cells in pig blood.
In component, the pharmacological effect brief introduction of each raw material is as follows:
Tilmicosin: belong to large lopps esters medicine, the special-purpose antibiotic of poultry, its has a broad antifungal spectrum, have very strong antibacterial activity and unique characteristics of pharmacokinetics, that body absorbs is fast, apparent volume of distribution is large, selective enrichment function etc., the characteristics such as, long half time high in lung tissue and Ruzhong drug level all have inhibitory action to all gram positive bacterias and part gram negative bacteria, mycoplasma, spirillum etc., have the activity stronger than tylosin.Simultaneously, but the tilmicosin targeting is gathered in pulmonary alveolar macrophage, and pulmonary alveolar macrophage is also the main host cell of reproductive and respiratory syndrome poison.Tilmicosin is inhibited to copying of reproductive and respiratory syndrome virus.Tilmicosin can effectively be controlled reproductive and respiratory syndrome virus (PRRSV) and infect pig breeding dysfunction and the immunosuppressant that causes.
Chlorphenamine maleate: antihistaminic.Can reduce the release of histamine, can stablize and suffer from pig leucocyte quantity, adjust impaired immune system, increase the compactness of blood capillary, minimizing is oozed out.Have and alleviate or suppress pig blue-ear disease and suffer from the effects such as the genesis of inflammation in the pig body, hyperemia, hemorrhage, pulmonary lesion, suffer from the pig clinical symptoms thereby alleviate.
Taurine: belong to the maincenter inhibitory transmitter, can regulate nervous tissue's irritability and body temperature, antipyretic-antalgic is arranged, the antiinflammatory rheumatism, anticonvulsant action also has the heart tonifying antiarrhythmic effect, promotes lipid to absorb, and cholesterol reducing, function of gallbladder promoting is arranged, protect the liver and Detoxication.
(1) analgesic and antiinflammatory action: this product may reduce body temperature by the effect to maincenter 5-ht system or catecholamine system
(2) Mechanisms of Taurine on Cardiaovascular System has stronger protective effect, and effects such as strengthening the myocardial cell function is arranged.
(3) strong liver choleretic effect: Cavia porcellus experiment showed, that taurine can remove cholestasis, is choleretic effect.Taurine and cholic acid combination can increase the bile permeability, and relevant with the backflow of bile.Taurine also can reduce cholesterol level in liver, reduces the formation of cholesterol calculus, and liver is shielded.
Above all medicines share, and kill or suppress the reproductive and respiratory syndrome poison but the tilmicosin targeting is gathered in pulmonary alveolar macrophage; Chlorphenamine maleate can reduce the release of histamine, have and alleviate or suppress pig blue-ear disease and suffer from the effects such as the genesis of inflammation in the pig body, hyperemia, hemorrhage, pulmonary lesion, suffer from the pig clinical symptoms thereby alleviate, and can suppress the decline that reproductive and respiratory syndrome is suffered from total white blood cells in pig blood, improve the immunity of suffering from pig; The strong liver function of gallbladder promoting of taurine, antipyretic and anti-inflammatory solve tilmicosin and absorb rear toxicity to Liver and kidney, and can have reduction body temperature to the high heat that reproductive and respiratory syndrome causes, remove the effect of clinical symptoms.
The specific embodiment
A kind of medicine for the treatment of pig blue-ear disease, made by the raw material of following weight parts:
Press production batch in the container of 1000 ml; the component of required medicine is: phosphoric acid tilmicosin 50-100g; chlorphenamine maleate 1-3g; taurine 10-40g; glycerin methylal 50-80g, Polyethylene Glycol 100-200g, sodium sulfite 1-3g; disodiumedetate 0.1-0.3g, surplus is water for injection.
Embodiment one:
Press production batch in the container of 1000 ml, the component of required medicine is: phosphoric acid tilmicosin 70g, chlorphenamine maleate 1.5g; taurine 25g, glycerin methylal 60g, Polyethylene Glycol 150g; sodium sulfite 2g, disodiumedetate 0.2g, water for injection add to 1000 ml.
Undertaken by the method for being prepared as follows:
(1) take by weight phosphoric acid tilmicosin, chlorphenamine maleate, taurine, glycerin methylal, Polyethylene Glycol, sodium sulfite, disodiumedetate;
(2) with glycerin methylal, the Polyethylene Glycol mix homogeneously, then the phosphoric acid tilmicosin is added wherein, be heated to 65-80 degree centigrade of stirring and dissolving;
(3) take 500-700g water for injection, be heated to 70-80 degree centigrade, add successively bisulfite, disodiumedetate, chlorphenamine maleate, taurine, respectively stirring and dissolving;
(4) medicinal liquid of combining step (2) and (3) preparation, add water for injection to 1000ml, stirs, filter, and the inflated with nitrogen embedding, 115-120 degree centigrade of flowing steam sterilization 30 minutes, lamp inspection, labeling, packing gets final product.
With the prepared injection of the present invention according to the pig body weight, 0.1 milliliter/kg body weight of intramuscular injection, inject once every day, is used in conjunction 3 days and can obtains good result.
One, the acute toxicity test of the veterinary drug preparation of preparation to rat
1, materials and methods
1.1 animal: rat Wister system, Hebei North institute animal center provides body weight 180-200g.
1.2 method: get 50 of rat, be divided at random 5 groups, 10 every group, male and female half and half are raised a week under controlled condition before experiment, are in a good state of health.This veterinary drug preparation is by the grouping of different dosing dosage, and gavage is for oral administration once a day, Continuous Observation 7 days.
Result: after rat this veterinary drug preparation for oral administration, the viewing duration at 7 days, drinking-water and feed intake are all normal, any clinical poisoning symptom and death do not occur.
The acute toxicity test of table 1 veterinary drug preparation to rat
Conclusion: oral formulation dosage of rat reaches 16(ml/kg), clinical recommendering folder preparation consumption is 0.1ml/kg, exceeded clinical recommendation consumption and still do not occurred any poisoning symptom and death more than 100 times, according to the toxicological evaluation standard, thought that this preparation belongs to innocuous substance.
Two, a kind of result of the test of medicaments injection aspect the raising immunity of organisms for the treatment of pig blue-ear disease of the present invention:
1 materials and methods
1.1 test drug
(1) injection 10ml*10 of the present invention props up;
(2) astragalin injection 10ml*10 props up content 10ml: the 0.2g lot number: 20120501, and Sichuan animal pharmaceutical estate company produces, and it is qualified to detect through our company;
(3) sterile saline.
45 of the piglets of 35 ages in days, be divided into test group, positive controls and negative control group at random 1.2 experimental animal and grouping animal subject, nest three way cross past the breast; Every group 15.
1.3 test method
35 ages in days ablactational baby pig, respectively to test group, positive controls and blank group difference intramuscular injection injection of the present invention, astragalin injection and sterile saline, 0.1 milliliter/kg body weight of above each intramuscular injection of three groups, inject once every day, is used in conjunction 3 days.The test piglet carries out routine according to the pig farm management and raises.
Three experimental results are as follows: each group test piglet of blank group (injecting normal saline), test group (injecting injection of the present invention), positive controls (injection astragalin injection) detects blood middle leukocytes quantity (unit: ten thousand/m
3)
Table 2
Reproductive and respiratory syndrome belongs to a kind of immunosuppressive disease, and after organism infection reproductive and respiratory syndrome poison (PRRSV), the quantity of leucocyte in blood can be by normal 12000-15000/m
3Be reduced to 10000/m
3, when the body quantity of leucocyte at 10000/m
3When following, the ability of opposing exotic disease substance and the function of specific immune response all can reduce.
Results and analysis
As can be seen from the above table, after the present invention treats the medicine composition injection injection body of pig blue-ear disease, the leukocyte that produces is obviously more than blank group (injecting normal saline) and positive controls (injection astragalin injection), and difference is (P＜0.01) extremely significantly.The immunity of body improves rapidly, thereby reaches the purpose of eliminating pathogen.
Three, a kind of medicine composition injection for the treatment of pig blue-ear disease of the present invention is as follows to the clinical trial of manual-induced pig blue-ear disease:
1 materials and methods
1.1 material
1.1.1 for the reagent product
(1) injection of the present invention, specification: 10ml * 10, content: 10ml: phosphoric acid tilmicosin 0.7g+ chlorphenamine maleate 0.15g+ taurine 0.25g;
(2) compound Radix Astragali polysaccharide injection 10ml*10 props up content 10ml: astragalus polysaccharides 0.2g+ lincomycin hydrochloride 3g lot number: 20120501, and Sichuan animal pharmaceutical estate company produces, and it is qualified to detect through our company;
(3) compound interferon injection 10ml*10 props up content 10ml: interferon 0.2g+ lincomycin hydrochloride 3g lot number: 20120301, and Henan animal pharmaceutical estate company produces, and it is qualified to detect through our company.
1.1.2 strain pig blue-ear disease strain Europe (1 type) is available from Chinese Animal diseases prevention and control center.
1.1.3 age in animal subject 8 week, health pig was 200, was provided by Chongqing Agricultural University Of Southwest herding institute, was used for pig blue-ear disease strain Europe (1 type) and infected.
1.1.4 experimental animal grouping and processing
Experimental animal divides four groups: injection group of the present invention, 50; The compound Radix Astragali polysaccharide group, 50; The compound interferon group, 50; Negative control group (injecting normal saline), 50.The counteracting toxic substances sample carries out filtration sterilization by 0.22 micron microporous filter membrane, the injection of ear back muscles, every pig 2ml.Counteracting toxic substances was respectively injected the 0.1ml/ kg body weight with above four groups after 48 hours, injected every day 1 time, injected continuously 3 days.Raise routinely after counteracting toxic substances, observe body temperature, the spirit of respectively organizing test pig, search for food, drink water, the clinical manifestation such as breathing.
1.1.5 general symptom after infecting
After counteracting toxic substances, the clinical symptoms such as fervescence (more than 41 ℃), loss of appetite, dyspnea, skin cyanosis appear in test group in succession.
1.1.6 dissection symptom
1. congested serious 2. bronchus of larynx joint are congested serious, in be full of foam and mucus.3. pulmonary congestion is serious, and enlargement occurs, but matter broadening between not occurring significantly.4. cardiac muscle is congested serious.5. the spleen enlargement is more than 2 times, and color and luster shades.6. at the bottom of stomach, ulcer is serious.7. the serious enlargement of liver, the bottom blackout.8. serious dispersivity petechia appears in intestine and small intestine.9. the kidney quality is more crisp, and there is the tip-like petechia on the surface.10 cystohemias are serious, the .11. inguinal lymph nodes enlargement of color strong tea sample and the hyperemia of interior urine.12. subcutaneous hemorrhage point is purple dark serious with blackout.
1.1.7 index of assessment of curative effect is cured: clinical symptoms disappears fully after the medication treatment, and it is to cure that spirit and diet recover normal, and statistics is cured number, calculates cure rate.Produce effects: clinical symptoms obviously alleviates after the medication treatment, and what spirit and diet took a turn for the better is the treatment produce effects, and statistics produce effects number calculates obvious effective rate.Effectively: be cure rate and obvious effective rate sum.Invalid: through after medication treatment, clinical symptoms does not disappear, the state of an illness does not take a turn for the better and treat during because of primary disease death all be considered as invalidly, the statistics invalid number calculates inefficiency.
2 results
The significance test of data is carried out in the statistical disposition of data with biometrics.
The clinical trial of table 3 different pharmaceutical injection to manual-induced pig blue-ear disease
As seen from the above table, a kind of medicine composition injection for the treatment of pig blue-ear disease of the present invention is to manual-induced pig blue-ear disease cure rate and effective percentage and compound Radix Astragali polysaccharide injection group, compound interferon injection group, negative control group heteropole significantly (P＜0.01).
3 conclusions
To treat the medicaments injection of pig blue-ear disease remarkable to the pig blue-ear disease therapeutic effect 3.1 the present invention is a kind of, significantly is better than compound Radix Astragali polysaccharide group and compound interferon injection group.
3.2 according to this result of the test, recommend a kind of medicine composition injection for the treatment of pig blue-ear disease by the 0.1ml/kg body weight, be used in conjunction 3d, can obtain good therapeutic effect to the treatment pig blue-ear disease.
Claims (3)
1. medicine for the treatment of pig blue-ear disease; it is characterized in that: press production batch in the container of 1000 ml; the component of required medicine is: phosphoric acid tilmicosin 50-100g; chlorphenamine maleate 1-3g, taurine 10-40g, glycerin methylal 50-80g; Polyethylene Glycol 100-200g; sodium sulfite 1-3g, disodiumedetate 0.1-0.3g, surplus is water for injection.
2. a kind of medicine for the treatment of pig blue-ear disease according to claim 1; it is characterized in that: press production batch in the container of 1000 ml; the component of required medicine is: phosphoric acid tilmicosin 70g; chlorphenamine maleate 1.5g, taurine 25g, glycerin methylal 60g; Polyethylene Glycol 150g; sodium sulfite 2g, disodiumedetate 0.2g, surplus is water for injection.
3. preparation method for the treatment of the medicine of pig blue-ear disease, undertaken by the method for being prepared as follows:
(1) take by weight phosphoric acid tilmicosin, chlorphenamine maleate, taurine, glycerin methylal, Polyethylene Glycol, sodium sulfite, disodiumedetate;
(2) with glycerin methylal, the Polyethylene Glycol mix homogeneously, then the phosphoric acid tilmicosin is added wherein, be heated to 65-80 degree centigrade of stirring and dissolving;
(3) take 500-700g water for injection, be heated to 70-80 degree centigrade, add successively bisulfite, disodiumedetate, chlorphenamine maleate, taurine, respectively stirring and dissolving;
(4) medicinal liquid of combining step (2) and (3) preparation, add water for injection to 1000ml, stirs, filter, and the inflated with nitrogen embedding, 115-120 degree centigrade of flowing steam sterilization 30 minutes, lamp inspection, labeling, packing gets final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272068A (en) * | 2013-05-20 | 2013-09-04 | 广东大华农动物保健品股份有限公司 | Chinese and western medicine compound preparation containing tilmicosin and preparation method thereof |
| CN106389454A (en) * | 2016-08-30 | 2017-02-15 | 瑞普（天津）生物药业有限公司 | Compound erythromycin thiocyanate soluble powder for livestock and preparation method therefor |
-
2013
- 2013-01-21 CN CN2013100192558A patent/CN103099812A/en active Pending
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| 刘芳等: "组胺受体拮抗剂对高致病性猪蓝耳病血液学的影响", 《贵州农业科学》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103272068A (en) * | 2013-05-20 | 2013-09-04 | 广东大华农动物保健品股份有限公司 | Chinese and western medicine compound preparation containing tilmicosin and preparation method thereof |
| CN106389454A (en) * | 2016-08-30 | 2017-02-15 | 瑞普（天津）生物药业有限公司 | Compound erythromycin thiocyanate soluble powder for livestock and preparation method therefor |
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Application publication date: 20130515 |