CN104000049B - A kind of composition and application thereof preventing and treating lamb dysentery - Google Patents
A kind of composition and application thereof preventing and treating lamb dysentery Download PDFInfo
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Abstract
The invention discloses a kind of composition and the application thereof that prevent and treat lamb dysentery, composition comprises the bulk drug of following weight portion: leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU.The present composition can also make feed addictive and external application sterilized solution.Chinese herbal medicine and microorganism formulation combine by the present composition, and preparation method is simple, low in raw material price, safe and harmless, and improve mouthfeel by material matching, facilitate lamb appetite, enhance lamb resistance, have good preventive and therapeutic effect to lamb dysentery.
Description
Technical field
The present invention relates to a kind of composition preventing and treating lamb dysentery, be specifically related to that a kind of lamb is special, feed addictive that lamb dysentery can be prevented and treated or lamb dysentery external medicinal liquid.
Background technology
At present due to the extensive use of antibiotics, particularly in recent years because vast plant, the head of a household use antibacterials the phase in a large number or unreasonably, many antibody-resistant bacterium are caused to create stronger drug resistance, thus the disease making originally curable some diseases become intractable to be difficult to cure, or control repeatly and send out repeatly, dosage is increasing, curative effect worse and worse, cause the production performance of animal to decline, expenses for medicine remains high, and plant's economic benefit is declined.Simultaneously along with the increase of drug dose, medicament residue is on the rise, and have impact on the health of the people and the foreign exchange earning of animal products.Particularly in feeding process, due to the abusing of additive, unordered, animal products security incident is caused more and more to receive the concern of people, livestock and poultry caused by food pollution and product security incident are also risen one after another, and are that typical case still exists so far on the impact that market is caused with melamine, tonyred, clenbuterol hydrochloride.The people that make of above food safety affair recognize, feed safety is exactly food security, more and more high to the cry of feed addictive.
The emphasis that additive is invented has been turned to high-quality, the exploitation invention of novel fodder additive of efficient, safety, low dosage and application by current developed country.Develop livestock and poultry compound nuisance free feed supplement product, significant for animal products upgrading.Compound nuisance free feed supplement refers to pollution-free, noresidue, anti-disease, somatotrophic natural additive, and it comprises three layers of meaning: one is to livestock and poultry nonhazardous effect; Two is noresidues in animal products, to human health without damaging effect; Three is the effects of farm animal excrement environmentally safe.Compound nuisance free feed supplement mainly comprises: Chinese herbal and crude drugs preparations, probiotics, chemical probiotic, enzyme preparation etc.China starts extensively invention exploitation Chinese herb feed additive product in late 1980s, makes some progress, and is widely used in husbandry sector.According to incompletely statistics, successively oneself has more than 200 to plant Chinese herbal medicine for additive of livestock and poultry.Chinese herbal and crude drugs preparations, as green additive, has the features such as natural sex, security, noresidue and medicine source popularity.Some Chinese herbal medicine inherently containing rich in protein, vitamin and mineral element, has drug effect and nutrition dual-use function concurrently.Long-Time Service can improve animal production performance, improve carcass quality and meat.
Lamb dysentery is caused by multiple pathogenic microorganisms, wherein mainly Escherichia coli, C.perfringens, salmonella, rotavirus, bovine diarrhea virus etc.Lamb dysentery is common disease and the frequently-occurring disease of lamb, and ill lamb can show lassitude, does not have appetite, diarrhoea, the phenomenon of becoming thin gradually.The lamb dysentery incidence of disease is high, particularly early stage lamb dysentery, and the incidence of disease is high, and indivedual sheep fields incidence of disease accounts for 60% ~ 80% of lamb, carrys out huge economic loss to sheep raising industrial belt.But because pathological change is slight, sometimes there is no obvious clinical symptoms, often by people are ignored.And lamb dysentery common antibiotics treatment clinically, due to irrational prolonged application antibiotic, antibody-resistant bacterium is got more and more, thus bring difficulty for clinical treatment.Medicine also can be caused simultaneously to remain in vivo, and affect food hygiene, harm people ' s health.
In addition, the having a low resistance of lamb, stomach are fragile, to the applicable ability of medicine not as adult goat, and therefore should be more prudent when treating.If add the feed addictive with relevant resistant effect when feeding, then greatly can reduce the incidence of lamb dysentery, reduce the loss.
Summary of the invention
The invention provides a kind of composition preventing and treating lamb dysentery, Chinese herbal medicine and microorganism formulation combine by said composition, safe and harmless, and improve mouthfeel by material matching, facilitate lamb appetite, enhance lamb resistance, have good preventive and therapeutic effect to lamb dysentery.
Present invention also offers with above-mentioned composition is feed addictive and the external application sterilized solution of raw material.During as feed addictive, can directly add feeding in lamb feed, during as external application sterilized solution, lamb anus place can be directly acted on, all can play the effect preventing and treating lamb dysentery.
Present invention also offers the preparation method of this external application sterilized solution.
Find under study for action, the main cause of lamb dysentery is that lamb early growth and development is rapid, be badly in need of nutrition, but its digestive function has certain limit, thus easily produces diarrhoea.For this reason, inventor, according to animal nutrition, Animal physiology and feed addictive feature, is studied prescription, and the composition of regulating the flow of vital energy containing invigorating the spleen in prescription, promoting digestion, absorbing, can strengthen lamb digestive function, pre-anti-diarrhea; In addition containing clearing heat and detoxicating, antipathogenic composition, play the effect for the treatment of timely when dysentery occurs.
The present invention is achieved by the following measures:
Prevent and treat a composition for lamb dysentery, it is characterized in that the bulk drug comprising following weight portion: leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU.
The present composition has screened that medicine source is enriched, the raw material of cheap, drug residue free, uses for reference pilot production simultaneously and assists, adjust each raw material dosage relation, additive is reached remarkably productive, the target that taste is suitable.
In above-mentioned composition, preferably include the bulk drug of following weight portion: leaves of plants 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, valerian 50 parts, phytase 50 parts, B family vitamin 100IU.
In the present invention's formula, leaves of plants, dandelion have clearing heat and detoxicating, anti-inflammation, dispersing swelling and dissipating binds, Huoxue San " what, clearing and activating the channels and collaterals effect; The effect that Cortex Bulbus Allii has restraining and sterilizing bacteria, stops dysentery stomach invigorating, improves feed local flavor, improves immunity; Valerian has effect that is calm, antibacterial, pain relieving of calming the nerves; Phytase, as microorganism formulation, can improve the effect of above Chinese herbal medicine with B family vitamin, and the aid digestion absorption of stomach invigorating, can improve abilities of digestive and absorption and the non-specific immunity of lamb.All material coordinates the effect with clearing heat and detoxicating, bacteriostasis antibiosis, calmness of releiving, stomach invigorating, aid digestion absorption.
On the basis of above-mentioned formula, the present composition can also add sodium bicarbonate, jerusalem artichoke, caraway root.Appropriate sodium bicarbonate can strengthen lamb appetite, promote lamb growth; Jerusalem artichoke energy clearing heat for detumescence, Effective multiplication, to the Bifidobacterium of animal health, improve immunity, but consumption will control proper, otherwise can affect mouthfeel; Caraway root crisp taste, can improve feed local flavor, promotes lamb appetite, can also urge digestion.
After adding sodium bicarbonate, jerusalem artichoke, caraway root, the composite formula of new formation is (weight portion): leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU, sodium bicarbonate 1-3 part, jerusalem artichoke 40-60 part, caraway root 80-120 part.Preferred: leaves of plants 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, valerian 50 parts, phytase 50 parts, B family vitamin 100IU, 2 parts, sodium bicarbonate, jerusalem artichoke 50 parts, caraway root 100 parts.
In above-mentioned composition, described leaves of plants is the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of drying after the light salt brine of 0.5wt% soaks 4-6h.Wherein, the mass ratio of leaf of Broussonetia papyrifera(L.) Vent, sweet potato leaves, grape leaf is 10:3-5:0.5-1, preferred 10:4:0.7.
With compound composition of the present invention for raw material, namely feed addictive can be made, external application sterilized solution can be made again, both is prevent and treat in lamb dysentery can be with the use of, namely add the ability that feed addictive of the present invention increases its appetite, digestion resistance against diseases and treatment dysentery in lamb feed, external application sterilized solution is injected lamb anus simultaneously, make drug ingedient in local directly onset, work along both lines, effect is better.When the present composition is as feed addictive, the addition in feed is 0.5-1%.
When the present composition makes feed addictive, pulverize after each raw material drying, mixing, cross 60 mesh sieves.
When the present composition makes external application sterilized solution, following methods can be adopted to obtain: pulverized by raw material, cross 60 mesh sieves, boiling twice, first time decocts 20 ~ 30min, and second time decocts 20min, merge decoction liquor, be concentrated into every milliliter contained 1 gram, obtain external application sterilized solution.
Inventor, through the invention tackling key problem more than 3 years, obtains formula of the present invention.Great many of experiments has been carried out in research, experimental result shows, in formula, single raw material is all undesirable to the fungistatic effect of dysentery, the fungistatic effect that pulp furnish difference shows is also different, greatly fungistatic effect could be improved after only being coordinated by proper proportion by all raw materials according to the present invention's magnitude relation, reach the object that be even better than conventional ablastins identical with conventional antibiotic bacteriostasis, better for animal body anaphase effect, the profound meaning that this fully shows " medicine has the speciality of individual character, and there is gregarious magical effect side ".Meanwhile, said composition mainly adds in feed with the form of feed addictive and uses, and also needs to consider that lamb is to the acceptance level of this feed addictive while consideration fungistatic effect.In optimum formula of the present invention, by the collocation of raw material dosage, not only make its fungistatic effect give prominence to, also make the taste of additive better, lamb appetite can better be promoted after adding, promote Lamb Growth.
The present invention has the following advantages:
1, the present invention is from Chinese veterinarian is theoretical, Animal nutrition is theoretical, animal physiological theory, in conjunction with clinical practice, Chinese herbal medicine and microorganism formulation are applied to lamb cultivation aspect, solve the various disadvantages such as the generation of medicament residue and the antibody-resistant bacterium using antibiotic to cause because of long-term a large amount of.
The composition of the present invention's formula all has good bacteriostasis in body in vitro, not only can treat lamb lamb dysentery, and be better than the antibiotic commonly used, solving feed addictive in the past can only as problem for health care, particularly in anus, administration can give full play to the local action of prescription, improves cure rate.Meanwhile, the present invention uses can also improve mouthfeel as additive, increases lamb appetite, promotes Lamb Growth.
Preparation method of the present invention is simple, the raw material selected all wide material sources, cheap, some are had to be all directly abandoned as rubbish at ordinary times, these raw materials are turned waste into wealth by the present invention, achieve their value, namely prevent waste to turn avoid rubbish and abandon brought environmental pollution, there is good economic and social benefit.
Detailed description of the invention
Explain the present invention further below by specific embodiment and related experiment, prove advantage of the present invention simultaneously, following content should not play the effect of restriction to protection scope of the present invention.If no special instructions, following raw material medicaments is weight portion.
The present invention's phytase used and B family vitamin all can have been bought from market.
Embodiment 1
The composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, valerian 50 parts, phytase 50 parts, B family vitamin 100IU.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:4:0.7, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, normal temperature dries, and the leaves of plants after drying adds the raw material as composition in formula.
By the following method above-mentioned composition is made feed addictive: take each bulk drug by said ratio, pulverize, cross 60 mesh sieves, put into vertical mixer and mix, dress plastic bag sealing is for subsequent use, every bag of 500g packing.
By the following method above-mentioned composition is made external application sterilized solution: take each bulk drug by said ratio, pulverize, cross 60 mesh sieves, put into vertical mixer and mix, dress plastic bag sealing is for subsequent use; Get said mixture, add water boil 20 ~ 30min, elimination liquid, then boiling 20min filters, by twice liquid Hybrid Heating, be concentrated into every milliliter contained 1 gram, bottled by above-mentioned liquid, autoclaving is for subsequent use.
Embodiment 2
The composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 100 parts, dandelion 120 parts, Cortex Bulbus Allii 100 parts, valerian 60 parts, phytase 40 parts, B family vitamin 150IU.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:3:1, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, dry after soaking 5h, the leaves of plants after drying adds the raw material as composition in formula.
According to the method for embodiment 1, said composition is made feed addictive and external application sterilized solution respectively.
Embodiment 3
The composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 150 parts, dandelion 80 parts, Cortex Bulbus Allii 160 parts, valerian 30 parts, phytase 80 parts, B family vitamin 80IU.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:5:0.5, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, dry after soaking 5h, the leaves of plants after drying adds the raw material as composition in formula.
According to the method for embodiment 1, said composition is made feed addictive and external application sterilized solution respectively.
Embodiment 4
The composition material medicine composition preventing and treating lamb dysentery is: the composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, valerian 50 parts, phytase 50 parts, B family vitamin 100IU, 2 parts, sodium bicarbonate, jerusalem artichoke 50 parts, caraway root 100 parts.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:4:0.7, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, dry after soaking 5h, the leaves of plants after drying adds the raw material as composition in formula.
According to the method for embodiment 1, said composition is made feed addictive and external application sterilized solution respectively.
Embodiment 5
The composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 100 parts, dandelion 120 parts, Cortex Bulbus Allii 100 parts, valerian 60 parts, phytase 40 parts, B family vitamin 150IU, 1 part, sodium bicarbonate, jerusalem artichoke 60 parts, caraway root 80 parts.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:3:1, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, dry after soaking 5h, the leaves of plants after drying adds the raw material as composition in formula.
According to the method for embodiment 1, said composition is made feed addictive and external application sterilized solution respectively.
Embodiment 6
The composition material medicine composition preventing and treating lamb dysentery is: leaves of plants 150 parts, dandelion 80 parts, Cortex Bulbus Allii 160 parts, valerian 30 parts, phytase 80 parts, B family vitamin 80IU, 3 parts, sodium bicarbonate, jerusalem artichoke 40 parts, caraway root 120 parts.The mixture of the leaf of Broussonetia papyrifera(L.) Vent of described leaves of plants to be mass ratio be 10:5:0.5, grape leaf and sweet potato leaves, leaves of plants is before use through following process: the light salt brine mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, dry after soaking 5h, the leaves of plants after drying adds the raw material as composition in formula.
Comparative example
The composition material medicine composition preventing and treating lamb dysentery is: sweet potato leaves 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, phytase 50 parts, B family vitamin 100IU.Described sweet potato leaves is fresh sweet potato leaves, before use through following process: the light salt brine fresh sweet potato leaves being put into concentration 0.5wt%, and after soaking 5h, normal temperature dries, and adds in formula as raw material after drying.
According to the method for embodiment 1, above-mentioned formula is made feed addictive and external application sterilized solution respectively.
Below by the advantage of the present invention of the results show in research process.
One, to the research of the preventive and therapeutic effect of lamb dysentery
1, lamb dysentery controlling experiment among a small circle
1.1 test drug
The embodiment of the present invention 1,2,4,5 made feed addictives or external application sterilized solution: it is precious that commodity are called scorching health;
The feed addictive that reference examples of the present invention is made or external application sterilized solution;
Ciprofloxacin injection: produced by Co., Ltd of Qilu Pharmaceutical Factory, specification 100ml:0.2g, is purchased from Linyi City pharmaceuticals.
1.2 experimental animal
Test and provided by the prosperous field, sheep field in great Feng mutton sheep field, Linyi and Linyi with lamb.
1.3 test method
1.3.1 recessive lamb dysentery test: diagnose and use conventional scatoscopy, choose the lamb 70 of the recessive lamb dysentery positive, be divided into 7 groups at random, 1st group is not medication control group, and the 2nd group is embodiment 1 feed addictive group, and the 3rd group is embodiment 2 feed addictive group, 4th group is embodiment 4 feed addictive group, 5th group is embodiment 5 feed addictive group, and the 6th group is comparative example feed addictive group, and the 7th group is Ciprofloxacin Lactate group.Duration of test rearing conditions is basically identical.
Feed addictive using method is: the feed additive powder agent each embodiment and comparative example prepared adds in feed carry out feeding according to the addition of 1%, and additive every lamb once a day, is used in conjunction 6 days.
Ciprofloxacin Lactate using method: extracting lactic acid ciprofloxacin injection 50ml, cleans around ill lamb afterbody, injects anus through conduit, anus jog is pinched for several times with hand after administration, so that liquid spreads and ensures no longer to flow out, every lamb once a day, is used in conjunction 6 days.
1.3.2 clinical type lamb dysentery test: clinical type lamb dysentery mainly causes obvious lamb diarrhea, poor appetite, the clinical symptoms such as anus is red and swollen, choose the obvious ill lamb 50 of clinical symptoms, be divided into 5 groups at random, 1st group is embodiment 1 feed addictive+external application sterilized solution group, 2nd group is the alone feed addictive group of embodiment 1, 3rd group is embodiment 2 feed addictives+external application sterilized solution group, 4th group is embodiment 4 feed addictives+external application sterilized solution group, 5th group is embodiment 5 feed addictives+external application sterilized solution group, 6th group is comparative example feed addictive+external application sterilized solution group, 7th group is Ciprofloxacin Lactate group.Duration of test strengthens feeding and management, and duration of test rearing conditions is basically identical.
Feed addictive+external application sterilized solution using method is: the feed additive powder agent each embodiment prepared adds in feed carry out feeding according to the addition of 1%, and additive every lamb once a day, is used in conjunction 6 days; Cleaned by ill lamb afterbody simultaneously, inject anus with sterilized solution 100ml through conduit, pinch anus jog for several times with hand after administration, so that liquid spreads and ensures no longer to flow out, every lamb once a day, is used in conjunction 4 days.
Ciprofloxacin Lactate using method is the same, once a day, is used in conjunction 4 days.
Observe in above-mentioned process of the test, record treatment situation, carries out diagnositc decision.
1.4 efficacy determination
1.4.1 recessive lamb dysentery efficacy determination: cure: through being diagnosed as feminine gender after treatment; Effective: through test diagnosis after treatment, its positive findings reduces more than one "+"; Invalid: through test diagnosis after treatment, its positive findings is front unchanged with treatment, even increases the weight of or transfers clinical type lamb dysentery to.
1.4.2 clinical type lamb dysentery efficacy determination: cure: obviously, under appetite degradation clinical symptoms disappear completely for the heating of its anus redness, afterbody diarrhea; Effective: its clinical symptoms substantially disappear or are clearly better; Invalid: its clinical symptoms continue to worsen.
Result
1.5.1 the result for the treatment of of recessive lamb dysentery is in table 1.
Observation experimentally in process and experimental result are seen, control group without improvement, and has an example to transfer clinical type lamb dysentery on the 4th day in test the sick sheep of duration of test; Diagnosis after the test of various embodiments of the present invention group, its positive findings has reduction in various degree, and wherein the result for the treatment of of embodiment 4 is best, and efficient and cure rate all reaches 100%.Ciprofloxacin Lactate is to the cure rate of recessive lamb dysentery and efficient not ideal enough, and cure rate is 30%, and efficient is 50%, and comparative example is also not ideal enough to the therapeutic action of recessive lamb dysentery, and cure rate is 30%, and efficient is 60%, and invalid is 40%.From result, the embodiment of the present invention is respectively organized and is compared with Ciprofloxacin Lactate group, significant difference (P < 0.05), illustrate that formula of the present invention has good therapeutic action to recessive lamb dysentery, the selection of raw material of the present invention and raw material dosage all has considerable influence to treatment results.As coordinated rectal, result for the treatment of is by even more ideal.
1.5.2 the result for the treatment of of clinical type lamb dysentery is in table 2.
As can be seen from the above results, the present invention's for oral administration mode of administration in anus that coordinates of filling a prescription has good therapeutic action to clinical type lamb dysentery, the wherein best results of embodiment 4, cure rate and efficiently all reach 100%.And Ciprofloxacin Lactate is also not ideal enough to the therapeutic action of clinical type lamb dysentery, cure rate is 40%, and efficient is 60%, invalid is 40%, and comparative example is also not ideal enough to the therapeutic action of clinical type lamb dysentery, and cure rate is 40%, efficient is 70%, and invalid is 30%.From result, the embodiment of the present invention is respectively organized and is compared with Ciprofloxacin Lactate group, and significant difference (P < 0.05), illustrates that formula of the present invention also has good therapeutic action to clinical type lamb dysentery.In addition, the selection of raw material of the present invention and raw material dosage all has considerable influence to treatment results.
Lamb dysentery is controlling experiment on a large scale
In order to study the effect of the present composition as feed addictive further, in March, 2012, in Yimeng, large red Yang Chang makees the scorching health treasured of the present invention to the clinical expanding test of lamb.
2.1 test drug
The embodiment of the present invention 1, embodiment 4: it is precious that commodity are called scorching health;
The feed addictive that comparative example is made.
2.2 test method
Test is provided by the large red Yang Chang in Yimeng with lamb.Selection lamb lactation 200 points 4 groups, wherein precious 30 days of the scorching health of the 1st group 50 embodiments 1 of feeding continuously, precious 30 days of the scorching health of 2nd group 50 embodiments 4 of feeding continuously, 3rd group 50 the comparative example feed addictives 30 days of feeding continuously, 4th group (control group) 50 feeding patternses with front 3 groups identical, just not feeding feed stuff additive.
The Feeding way of the 1st group, the 2nd group and the 3rd group is: the feed additive powder agent of Example 1,4 and comparative example formula respectively, then they be evenly mixed in feed respectively and feed, additive addition is 1%.Be used in conjunction 1 month.
2.3, result
Continuous nursing is after one month, and a situation arises sees the following form 3 for each group lamb dysentery.
Test proves, group of usually feeding obviously raises than scorching health treasured group dysentery incidence of feeding, and this illustrates that additive of the present invention comparatively effectively can suppress the generation of lamb dysentery.In addition, can be found out by the contrast of the embodiment of the present invention and comparative example, the feed addictive effect of embodiment is better.
Two, product of the present invention is promoted to the research of Lamb Growth and resistance against diseases
1, experimental animal
With Small-fat-tail sheep field, white sand Bu Zhen great Dun village, Linyi City Lanshan District for subjects, choose 120 3 the monthly age Small-fat-tail sheep lamb, be divided into 4 groups, often organize 30.
2, test method
1st group according to 1% addition, the embodiment of the present invention of feeding every day 1 feed addictive, is used in conjunction 60 days; 2nd group according to 1% addition, the embodiment of the present invention of feeding every day 4 feed addictive, is used in conjunction 60 days; 3rd group according to 1% addition, comparative example feed addictive of the present invention of feeding every day, is used in conjunction 60 days; 4th group is not added additive of the present invention, according to normally feeding; In process of the test, other each rearing conditions is all consistent, inspection record every day 4 groups of sheep upgrowth situation only.Weigh after feeding 60 days.
3, result of the test
After feeding 60 days, each group lamb diarrhoea and growing state see the following form 4.
Prove through test, the additive of the embodiment of the present invention 1 and 4 all has better prevention effect to Small-fat-tail sheep lamb diarrhoea, also can promote the appetite of lamb simultaneously and grow, and more effective than comparative example, and wherein the effect of the additive of embodiment 4 is optimum.
By testing above and can finding out, prescription of the present invention is simple, cheap, give full play to the characteristic of the bidirectional modulation body of Chinese herbal medicine and probiotics, all components matching application improve the nonspecific mental retardation of body, enhance the premunition of lamb, to lamb epidemic disease resistivity, promote that the aspects such as Lamb Growth all have comparatively ideal effect.The present composition is better than Ciprofloxacin Lactate as additive to the therapeutic action for the treatment of lamb dysentery, has good promotion prospect.
Claims (9)
1. prevent and treat a composition for lamb dysentery, it is characterized in that the bulk drug comprising following weight portion: leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU; Described leaves of plants is the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of drying after the light salt brine of 0.5wt% soaks 4-6h.
2. composition according to claim 1, is characterized in that the bulk drug comprising following weight portion: leaves of plants 120 parts, dandelion 100 parts, Cortex Bulbus Allii 150 parts, valerian 50 parts, phytase 50 parts, B family vitamin 100IU.
3. composition according to claim 1, is characterized in that the bulk drug also comprising following weight portion: sodium bicarbonate 1-3 part, jerusalem artichoke 40-60 part, caraway root 80-120 part.
4. composition according to claim 3, is characterized in that the bulk drug also comprising following weight portion: 2 parts, sodium bicarbonate, jerusalem artichoke 50 parts, caraway root 100 parts.
5. the composition according to any one of claim 1-4, is characterized in that: the mass ratio of leaf of Broussonetia papyrifera(L.) Vent, sweet potato leaves, grape leaf is 10:3-5:0.5-1.
6. composition according to claim 5, is characterized in that: the mass ratio of leaf of Broussonetia papyrifera(L.) Vent, sweet potato leaves, grape leaf is 10:4:0.7.
7. prevent and treat a feed addictive for lamb dysentery, it is characterized in that: with the composition preventing and treating lamb dysentery according to any one of claim 1-6 for raw material.
8. prevent and treat an external application sterilized solution for lamb dysentery, it is characterized in that: with the composition preventing and treating lamb dysentery according to any one of claim 1-6 for raw material.
9. the preparation method preventing and treating the external application sterilized solution of lamb dysentery according to claim 8, it is characterized in that: raw material is pulverized, cross 60 mesh sieves, boiling twice, first time decocts 20 ~ 30min, and second time decocts 20min, merges decoction liquor, be concentrated into every milliliter contained 1 gram, obtain external application sterilized solution.
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| CN104225551A (en) * | 2014-09-26 | 2014-12-24 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine oral liquid for treating lamb dysentery and preparation method thereof |
| CN105194579A (en) * | 2015-11-09 | 2015-12-30 | 马英臣 | Medicament for preventing and treating lamb dysentery |
| CN105412761A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating lamb dysentery and preparation method thereof |
| CN105412860A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating weak and limp symptom of lambs and preparation method thereof |
| CN105475645A (en) * | 2016-01-18 | 2016-04-13 | 肖华 | Ecological and health sheep feed additive |
| CN114343061B (en) * | 2022-01-13 | 2023-07-25 | 山东益得来生物科技有限公司 | Composition for improving quality of livestock and poultry bone and meat |
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| CN1235030A (en) * | 1998-05-07 | 1999-11-17 | 史灯 | Composite oral liquid of Gaolining and preparing method thereof |
| CN102550823A (en) * | 2012-01-01 | 2012-07-11 | 张奎昌 | Garlic skin biological feed additive |
| CN103202899A (en) * | 2013-04-01 | 2013-07-17 | 陈鹏举 | Traditional Chinese medicine feed additive for preventing and curing livestock and poultry diarrhea |
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|---|---|---|---|---|
| CN1235030A (en) * | 1998-05-07 | 1999-11-17 | 史灯 | Composite oral liquid of Gaolining and preparing method thereof |
| CN102550823A (en) * | 2012-01-01 | 2012-07-11 | 张奎昌 | Garlic skin biological feed additive |
| CN103202899A (en) * | 2013-04-01 | 2013-07-17 | 陈鹏举 | Traditional Chinese medicine feed additive for preventing and curing livestock and poultry diarrhea |
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| 蒲公英煎汁预防治疗羔羊痢疾;张祯;《内蒙古畜牧科学》;20031231(第3期);21 * |
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| CN104000049A (en) | 2014-08-27 |
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