CN107308415A - One group is used to treat Chinese medicine composition of cad pig and preparation method thereof - Google Patents

One group is used to treat Chinese medicine composition of cad pig and preparation method thereof Download PDF

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Publication number
CN107308415A
CN107308415A CN201710590275.9A CN201710590275A CN107308415A CN 107308415 A CN107308415 A CN 107308415A CN 201710590275 A CN201710590275 A CN 201710590275A CN 107308415 A CN107308415 A CN 107308415A
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parts
chinese medicine
medicine composition
grams
pig
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张义清
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Ji'nan Golden Animal Biotechnology Co Ltd
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Ji'nan Golden Animal Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract

There is provided one group is used to treat Chinese medicine composition of cad pig and preparation method thereof, Chinese medicine composition 1 of the present invention has inducing sweat and dispelling exogenous evils, expelling pathognic wind from muscles, warming meridian, the effects such as helps yang transforming qi, Chinese medicine composition 2 has clearing heat and detoxicating, the effects such as cool blood purging intense heat, the middle benefit gas dispelling cold of Chinese medicine composition 3, tonifying Qi Tianjin spleen, the effects such as helping transporting, full root according to Chinese veterinarian's theory organic conception and diagnosis and treatment, tonifying middle-Jiao and Qi is used for the cad pig of " QIXUELIANGXU type " and " qi stagnation and blood stasis type ", dry spleen promotees stomach, the promoting flow of qi and blood, attack the principle of reatment of the urgent what of product, to causing stiff reason to carry out to because of symptomatic treatment, promote growing for pig, it is quick to repair damaged organ, and without medicament residue, it is uneasy to recur, strengthen the immunocompetence of swinery, self-repairing capability and adaptive capacity to environment.

Description

One group is used to treat Chinese medicine composition of cad pig and preparation method thereof
Technical field
The present invention relates to one group of Chinese medicine composition for treating cad pig and preparation method thereof, belong to herbal medicine technology neck Domain.
Background technology
Cad pig or dwarf pig, also known as " iron pig ", are commonly called as " old man pig ".Refer to the piggy for being in growth and development stage having, It can eat food but longer term growthing lag, cause the economic loss of pig farmer.The reason for causing cad pig is a lot, mainly by pregnant It is improper that sow of being pregnent is raised, and lacks protein and some necessary trace elements and vitamin etc., causes fetus to lack nutrition and send out Educate and be obstructed, cause piglet small and weak；Or the sow postpartum milk secretion phase raises improper, miscarriage is fed after lactation amount deficiency or ablactation Piglet development is caused to stagnate；Or because of inbred, just with too early.In addition, piglet suffers from parasite and chronic swine fever disease etc. Chronic disease can all form cad pig.
Although cad pig food, body temperature are all normal, it is that bent rear arch waist, the small thin and weak, insanity of body are excited that it, which is mainly showed, good Run, slightly disorderly, skin is matt for dorsal body setae, and elasticity reduction, excrement is stiff, see to have sometimes and do not digest feed, some cad pigs have different thermophilic existing As liking gnawing wall soil etc..Feed for a long time, though pig age big individual still very little, extremely becomes thin, the death rate is very low.But Be that production target but to plant has extreme influence, and greatly waste feed, add aquaculture cost, reduce through Ji benefit.
The conventional Western medicine therapy to cad pig is mainly in feed plus feeds poultry tetracycline or terramycin, and every pig feeds daily Take 20~30 milligrams.Or vitamin B is injected after expelling parasite2Injection, injected once every 5~7 days or starts to use by 0.5 milligram every time Vitamin B12Intramuscular injection is carried out after the mixing of (500 microgram) 2 and inosine injection (2 milliliters every), connects note after 2 days, Atriphos (ATP) and vitamin B are used again12, inosine, each one of calcium colloidal et vit D, carry out hybrid injection.But, Western medicine is treated The curative effect that cad pig is treated in ruling by law is undesirable, and drug residue is big, course for the treatment of length and cost is higher.Factory is cultivated in order to pursue market interest, It is a large amount of to utilize western medicine cad pig, cause chemicals severe overweight, so as to cause food-safety problem, influence consumer's is strong Health.
Main point two types are said from the angle of Chinese veterinarian：
First, QIXUELIANGXU type
Symptom：Hair is thick disorderly unglazed, and pallor, abdominal circumference reduce, and bend over, mouth color is light white, and many stillnesss of night, cough, row step is slow Slowly, food less or it is many without changing, excrement is thin and has and does not digest food, do not taken effect person through expelling parasite,
Pathogensis：Spleen weakness or eak after being ill, nutrient QI and blood being insufficient, vim and vigour imbalance.
2nd, qi stagnation and blood stasis type：
Symptom：Mouthful color is crimson, conjunctival congestion, roars of laughter mouth flush, tripe bodice is thin, eat food less, excrement is stiff and it is few as rabbit excrement, Or stool band blood, thick unglazed, the slow-growing very day gradually thin person of hair.
Pathogensis：Invasion of pathogen toward the interior, is deposited on the interior disease for forming inner reality, is in fact greatly to see win shape；Or castrating is swatted, extravasated blood sinks Product is in inner, caused by retardance QI-blood circulation.
Chinese medicine cad pig, with it is pollution-free, pig immunity can be strengthened, fatten sick pig, control difficulty in relapse after healing, cost The low advantage of valency.Therefore, Chinese herbal medicine has catered to large market demand in terms of cad pig is treated, with highly important reality meaning Justice.But the general drug ingedient composition of existing Chinese medicine is complicated, application method be usually directly Chinese medicine is directly crushed or In the daily ration of pulvis addition after Chinese medicine is extracted, or it is brewed into oral liquid and gavages, it is impossible to obtains well-content curative effect.
The content of the invention
There is provided one group of Chinese medicine composition and its preparation for being used to treat cad pig for above-mentioned the deficiencies in the prior art by the present invention Method, Chinese medicine composition of the present invention is according to the organic conception and diagnosis and treatment of Chinese veterinarian's theory, for " QIXUELIANGXU type " and " gas The cad pig of stagnant blood stasis type " promotees stomach, the promoting flow of qi and blood using tonifying middle-Jiao and Qi, dry spleen, attacks the principle of reatment of the urgent what of product, to causing stiff reason to enter Row quickly repairs damaged organ to because of symptomatic treatment, promoting growing for pig, and without medicament residue, uneasy to recur, increasing Immunocompetence, self-repairing capability and the adaptive capacity to environment of strong swinery.
In order to realize foregoing invention target, the invention provides one group of Chinese medicine composition for being used to treat cad pig, including 3 groups Chinese medicine composition：
Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：15-25 parts of schizonepeta, windproof 15-25 parts, Radix Codonopsis 5-10 Part, 10-20 parts of Herba Andrographitis, 15-25 parts of rhizoma atractylodis, 15-25 parts of honeysuckle, 10-20 parts of root tuber of aromatic turmeric, 10-15 parts of rattletop, Fructus Aurantii 10-15 Part, 10-20 parts of Poria cocos, 10-20 parts of Ligusticum wallichii, 5-10 parts of radix glycyrrhizae, 5-10 parts of dried orange peel, 5-10 parts of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：100-150 parts of gypsum, 25-35 parts of the dried rhizome of rehmannia, rhinoceros horn 8- 12 parts, 10-20 parts of the Radix Astragali, 15-25 parts of Herba Andrographitis, 15-25 parts of the root bark of Chinese wolf-berry, 20-30 parts of kuh-seng, 20-30 parts of Radix Codonopsis, radix paeoniae rubrathe 20- 30 parts, 20-30 parts of bulb of thunberg fritillary, 25-35 parts of the wind-weed, 20-30 parts of honeysuckle, 20-30 parts of balloonflower root, 10-20 parts of radix glycyrrhizae, lophatherum gracile 20-30 Part；
Chinese medicine composition 3 is made up of the bulk drug of following parts by weight：28-32 parts of Radix Codonopsis, 280-350 parts of the Radix Astragali, rhizoma zingiberis 25- 35 parts, 25-30 parts of honey-fried licorice root, 50-60 parts of the bighead atractylodes rhizome, 8-12 parts of cooked aconite, 10-15 parts of pseudo-ginseng, 8-12 parts of wrinkled giant hyssop, dandelion 8-13 Part.
Preferably, the Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：20 parts of schizonepeta, windproof 20 parts, Radix Codonopsis 7 parts, 15 parts of Herba Andrographitis, 20 parts of rhizoma atractylodis, 20 parts of honeysuckle, 15 parts of root tuber of aromatic turmeric, 10 parts of rattletop, 10 parts of Fructus Aurantii, 15 parts of Poria cocos, Ligusticum wallichii 15 Part, 8 parts of radix glycyrrhizae, 7 parts of dried orange peel, 7 parts of pseudo-ginseng；
The Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：120 parts of gypsum, 30 parts of the dried rhizome of rehmannia, 10 parts of rhinoceros horn, 15 parts of the Radix Astragali, 20 parts of Herba Andrographitis, 20 parts of the root bark of Chinese wolf-berry, 25 parts of kuh-seng, 25 parts of Radix Codonopsis, 25 parts of the radix paeoniae rubrathe, 25 parts of bulb of thunberg fritillary, 30 parts of the wind-weed, 30 parts of honeysuckle, 25 parts of balloonflower root, 15 parts of radix glycyrrhizae, 25 parts of lophatherum gracile；
The Chinese medicine composition 3 is made up of the bulk drug of following parts by weight：30 parts of Radix Codonopsis, 300 parts of the Radix Astragali, 30 parts of rhizoma zingiberis, 30 parts of honey-fried licorice root, 60 parts of the bighead atractylodes rhizome, 10 parts of cooked aconite, 10 parts of pseudo-ginseng, 10 parts of wrinkled giant hyssop, 10 parts of dandelion.
Chinese medicine composition 1 (Antiphlogistic Powder of Schizonepetae and Ledebouriellae), function, inducing sweat and dispelling exogenous evils, expelling pathognic wind from muscles, warming meridian, helps yang transforming qi etc..Side Solution：Schizonepeta, windproof dispelling cold and removing dampness in side, benefiting qi for relieving superficies syndrome, windproof 5 rhizoma atractylodis are dispersed in chill, change gently, Herba Andrographitis removing toxic substances cool blood Match with windproof, rhizoma atractylodis, strengthen expelling cold, eliminating, damp dispelling and pain relieving closes and uses it, is altogether monarch drug in a prescription.The Ligusticum wallichii promoting flow of qi and blood circulation, and can dispel Wind, honeysuckle is clearing heat and detoxicating, and root tuber of aromatic turmeric expelling pathogenic factors from muscles and skin is thoroughly evil, and can promoting the circulation of qi, Radix Codonopsis blood-enrich, pseudo-ginseng blood stasis removing analgesic, you can principal drug assistance Inducing diaphoresis by heresy, again can promoting flow of qi and blood circulation benefiting qi and nourishing blood strengthen the power of diffusing impediment and relieving pain, be all ministerial drug.Rattletop, which rises, lifts yang-energy, Fructus Aurantii promoting the circulation of qi In width, turgor is eliminated, two medicines are reached the same goal the warp of taste two, cooperate with compatibility, one rise and one drop, yang-energy must rise, then essence of water and grain is able to defeated cloth； Stomach Qi is descending, then the turgor that stagnates can be eliminated.Poria cocos excreting dampness, with dissolving phlegm, is all adjutant.Radix glycyrrhizae, dried orange peel mediation property of medicine, and with benefit Gas is with.
Chinese medicine composition 2 (qingwen baidu powder), function：Clearing heat and detoxicating, cool blood purging intense heat.Cure mainly：Inside and outside the injection of pestilence heat toxin, It is vigorous heat at qi-blood phase.Fang Xie：We cure mainly heat toxin injection, vigorous heat at qi-blood phase disease.Due to heat toxinization fire, impairment of yin is contained long, therefore have big thirsty, heat Urgent blood is burnt, the disease for hair spot of spitting blood.So we focus on big clear positive bright qi leel epidemic disease heat, reuse gypsum and follow the example of white tiger with the wind-weed, radix glycyrrhizae Soup, it is intended that heat-clearing Bao Jin；Herba Andrographitis, the root bark of Chinese wolf-berry, the wind-weed, kuh-seng are reused, it is intended that three Jiao that remove heat by catharsis are burning hot；Rhinoceros horn, the dried rhizome of rehmannia, radix paeoniae rubrathe phase Match somebody with somebody, be to be set for clearing heat and detoxicating, cool blood dissipates the stasis of blood, to control syndrome of flaring heat in qifen and xuefen.The fire swum is dismissed with honeysuckle, bulb of thunberg fritillary again；Plus with party Ginseng, Radix Astragali benefiting qi and nourishing blood, to help QI-blood circulation；It is up that balloonflower root, the leaf of bamboo take it to carry medicine；This side is sweating antidote, therefore reuses stone Cream, " first put down notably and it is all through fire, from without uneasy ".Our big clear Yangming Channel heat, is equipped with purging intense heat, cool blood and complements each other, altogether Play the work(of heat-clearing and toxin-vanquishing.
Chinese medicine composition 3 (dissipates) in reason, suits the medicine to the illness：Deficiency-cold in middle-JIAO, diarrhea without thirst, vomiting abdomen carbuncle, loss of appetite, slow frightened, disease Saliva foam is slept in happiness afterwards.Cure mainly：The spleen has the function to transport and transform nutrients and rises clear, stomach receiving food and drink and drop turbid, modern cold in middle-JIAO, lifting imbalance, therefore tell sharp abdomen carbuncle, Loss of appetite.Control when middle benefit gas dispelling cold, tonifying Qi and Tianjin spleen, help transporting and multiple lifting, then all disease self-healing.Fang Xie：We are with hot dry Jiang Weijun, warm the middle warmer taste and interior cold of dispelling, Radix Codonopsis, Radix Astragali benefiting qi and nourishing blood and Tianjin taste, help transporting and are just lifting, be ministerial drug, Cooked aconite recuperating depleted yang, eliminating cold to stop pain mends fire supporing yang, pseudo-ginseng hemostatic, dissipate the stasis of blood, analgesic therapy, bighead atractylodes rhizome Tianjin spleen eliminating dampness, honey-fried licorice root QI invigorating and In be adjutant, wrinkled giant hyssop appetizing, dandelion cholagogic are to make medicine.All medicines share, the fiery of middle Jiao obtains pungent-warm and dispelled, and middle the empty of Jiao must be done Wen Erfu, clear sun rises and turbid yin drops, and strong and middle Jiao of transporting controls.
In order to which foregoing invention purpose is better achieved, present invention also offers the above-mentioned Chinese medicine composition for being used to treat cad pig Preparation method, comprise the following steps：
(1) culture of fermented bacterium：Bacillus subtilis, S. cervisiae, enterococcus faecalis, Monascus conventional method are expanded Big culture to viable bacteria reaches 1 × 109More than CFU/ml；
(2) fermentation medium prepares：
Chinese medicine material medicine needed for above-mentioned each group Chinese medicine composition is weighed, packet mixing is crushed to 20-80 mesh, using water extraction Method, obtains extract solution and Chinese medicine slag；
The wheat bran of gross weight 3%, 20% brown sugar, 10% mashed potatoes, 1.5% ammonium sulfate, 0.2% are added in the dregs of a decoction Potassium dihydrogen phosphate, 0.5% dipotassium hydrogen phosphate, 0.5% magnesium sulfate, stir, and are eventually adding one times of amount water, sterilizing cooling Dregs of a decoction fermentation medium is made；
Brown sugar, 5% glucose, 0.3% magnesium sulfate, 0.3% di(2-ethylhexyl)phosphate of gross weight 40% are added in extract solution Hydrogen potassium, 0.4% sodium nitrate, 3% glycerine, 3% yeast extract, 4% peptone, are stirred, and sterilizing cooling, which is made, to be carried Take liquid fermentation medium；
(3) ferment：
The bacillus subtilis after step (1) is cultivated, S. cervisiae, enterococcus faecalis are accessed in dregs of a decoction fermentation medium, Three is according to 1:2：0.5 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of training 48h is supported, every 6h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
The bacillus subtilis after step (1) is cultivated, S. cervisiae, Monascus are accessed in extract solution fermentation medium, Three is according to 1:1:2 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of culture 36h, every 4h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
Above-mentioned fermenting twice product is mixed.
The present invention prepares Chinese medicine preparation using the method for solid state fermentation and liquid state fermentation simultaneously, is inoculated with preferred zymophyte Kind, on the one hand effective component of chinese medicine can be subjected to biological conversion, by the macromolecular substances of Chinese medicine, by microorganism conversion into For the small molecule composition that can be directly absorbed by body enteron aisle, Chinese medicine is promoted to reach quick absorption, the purpose of quantitative curative effect.It is another Aspect accelerates fermenting speed, more conventional method is substantially reduced by the way of solid state fermentation and liquid state fermentation are carried out simultaneously Time.
Chinese medicine composition of the present invention is in use, program is as follows：Chinese medicine composition 1, addition 0.1%-0.5% (weight Than), feed 3 days；Then Chinese medicine composition 2, addition 0.1%-0.5% (weight ratio), feed 4 days；Finally Chinese medicine group is used again Compound 3, addition 0.1%-0.5% (weight ratio) is fed 28 days.Chinese medicine composition of the present invention, cure rate is high, pollution-free, can Strengthen pig immunity, fattening sick pig, non-relapse after healing, growth-promoting effect is good, and cost is low.With reference to the system of fermented tcm of the present invention Preparation Method, has started the New Times of cad pig treatment, is of great practical significance and historic significance in terms of cad pig is treated.
Therefore, the present invention also provides application of the Chinese medicine composition for being used to treat cad pig in cad pig feed is prepared.
The present invention also provides a kind of feed for treating cad pig, the feed include 0.1%-0.5% weight than Chinese medicine Composition 1 or Chinese medicine composition 2 or Chinese medicine composition 3.
The present invention has the advantages that：
(1) present invention is by the way that 3 groups of Chinese medicine compositions (being dissipated in Antiphlogistic Powder of Schizonepetae and Ledebouriellae, qingwen baidu powder, reason) are used cooperatively, altogether With tonifying middle-Jiao and Qi, dry spleen rush stomach, the promoting flow of qi and blood, the effect for attacking the urgent what of product is played, to causing stiff reason progress to because of symptomatic treatment.This Invention Chinese medicine composition include promotion hematopoietic cell, endothelial cell, femur cytothesis breeding Chinese medicine, have promotion skeleton development it Work(, can be obviously promoted animal body to bacterium, the phagocytic function of virus, improve animal autoimmunity ability, reduce disease, It is quick to repair damaged organ, promote growing for pig.
(2) Chinese medicine composition energy qi-regulating promoting digestion, invigorating spleen and promoting appetite of the present invention, liver protection shield kidney improves anti-virus ability, improves anti-answer Swash level；Strengthen Abwehrkraft des Koepers and immunity, reduce livestock and poultry because enteron aisle, respiratory tract and reproductive system 80% or so are fallen ill Rate, reduces death and culling rate.
(3) Chinese medicine is prepared using fermentation process, solves that simple " Chinese traditional medicine purification " function is single, weak curative effect weakness, protected The effect of the Chinese medicine of sufficiently complex chemical composition composition is demonstrate,proved.Solve the only unilateral of " Chinese herbal ultra-fine powder " and be directed to absorbing surface Product, uncertain therapeutic efficacy is cut, the shortcoming that pharmaceutical formulation can not effectively distil.The effective component of chinese medicine for solving " tradition fermentation comprehensively " is damaged The shortcoming of mistake.Solve the problems, such as the probiotics of " traditional powder+probiotics " and merging for Chinese medicine." traditional powder " is solved to be difficult The shortcomings of absorption, poor taste, strong toxicity, slow drug effect.Solving " traditional decocting medicine " wastes time and energy, complex procedures, is difficult what is grasped Defect.
(4) Chinese medicine of the present invention is prepared in fermentation, is employed preferred strain combination, on the one hand can effectively be repaired animal and bird intestines Damage (including intestinal tract injury caused by western medicine antibiotics), repair impaired intestinal villus and intestinal wall, regulation enteron aisle, recover machine rapidly Body function, effectively improves livestock and poultry resistance against diseases；Another aspect composite bacteria synergy can adjust animal and bird intestines colony balance, change Kind animal and bird intestines micro-ecological environment, in enteron aisle inwall formation beneficial bacterium film, sets up the infringement that biological barrier keeps out bacterial virus, presses down The growth and breeding of the harmful bacterias such as colibacillus processed, salmonella, can reduce by 6 0% or so medicine usage amounts, save a large sum of expenses for medicine Expenditure；And can also effectively break lps molecule chain, noxious material of degrading blocks the bound site of harmful toxins and intestines conjunctiva Point, improves the immunity of animal.
(5) added in feed after Chinese medicine composition of the present invention, feed digestion is thorough, excrement is fine and smooth, in reduction poultry house The concentration of the pernicious gases such as ammonia, hydrogen sulfide, reduces stool odor, improves feeding environment, reduces the hair of livestock and birds respiratory disease It is raw.Can produce the nutritional ingredients such as abundant protein, carbohydrate, fat after Chinese medicine and strain are fermented, alkaloid, general flavone, The active ingredients such as general anthraquinone, a variety of somatomedins such as bacteriocin, amylase, protease, significantly improve animal and feed are disappeared Rate and absorptivity, reduce by 8% or so feed cost, improve the speed of growth and improve meat quality simultaneously, improve local flavor.
Brief description of the drawings
Fig. 1 is plant's cad pig contrast before and after treatment in emirical cases 1.
Fig. 2 is plant's cad pig contrast before and after treatment in emirical cases 2.
Fig. 3 is plant's cad pig contrast before and after treatment in emirical cases 3.
Fig. 4 is plant's cad pig contrast before and after treatment in emirical cases 4.
Embodiment
Technical scheme and its produced technique effect are done further with reference to specific method and accompanying drawing Elaboration, the description below but is not any limitation as, based on present invention religion to the present invention merely to explain the present invention in any way Any conversion or replacement made are led, protection scope of the present invention is belonged to.The method of the invention unless otherwise specified, is This area conventional method.Agents useful for same unless otherwise specified, can be obtained from commercial channels.
1. 1 groups of embodiment is used for the Chinese medicine composition for treating cad pig, including 3 groups of Chinese medicine compositions：
Chinese medicine composition 1 is made up of the bulk drug of following weight：20 grams of schizonepeta, windproof 20 grams, 7 grams of Radix Codonopsis, Herba Andrographitis 15 Gram, 20 grams of rhizoma atractylodis, 20 grams of honeysuckle, 15 grams of root tuber of aromatic turmeric, 10 grams of rattletop, 10 grams of Fructus Aurantii, 15 grams of Poria cocos, 15 grams of Ligusticum wallichii, 8 grams of radix glycyrrhizae, 7 grams of dried orange peel, 7 grams of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following weight：120 grams of gypsum, 30 grams of the dried rhizome of rehmannia, 10 grams of rhinoceros horn, the Radix Astragali 15 Gram, 20 grams of Herba Andrographitis, 20 grams of the root bark of Chinese wolf-berry, 25 grams of kuh-seng, 25 grams of Radix Codonopsis, 25 grams of the radix paeoniae rubrathe, 25 grams of bulb of thunberg fritillary, 30 grams of the wind-weed, honeysuckle 30 Gram, 25 grams of balloonflower root, 15 grams of radix glycyrrhizae, 25 grams of lophatherum gracile；
Chinese medicine composition 3 is made up of the bulk drug of following weight：30 grams of Radix Codonopsis, 300 grams of the Radix Astragali, 30 grams of rhizoma zingiberis, honey-fried licorice root 30 grams, 60 grams of the bighead atractylodes rhizome, 10 grams of cooked aconite, 10 grams of pseudo-ginseng, 10 grams of wrinkled giant hyssop, 10 grams of dandelion.
Preparation method：
(1) culture of fermented bacterium：Bacillus subtilis, S. cervisiae, enterococcus faecalis, Monascus conventional method are expanded Big culture to viable bacteria reaches 1 × 109More than CFU/ml；
(2) fermentation medium prepares：
Chinese medicine material medicine needed for above-mentioned each group Chinese medicine composition is weighed, packet mixing is crushed to 20-80 mesh, using water extraction Method, obtains extract solution and Chinese medicine slag；
The wheat bran of gross weight 3%, 20% brown sugar, 10% mashed potatoes, 1.5% ammonium sulfate, 0.2% are added in the dregs of a decoction Potassium dihydrogen phosphate, 0.5% dipotassium hydrogen phosphate, 0.5% magnesium sulfate, stir, and are eventually adding one times of amount water, sterilizing cooling Dregs of a decoction fermentation medium is made；
Brown sugar, 5% glucose, 0.3% magnesium sulfate, 0.3% di(2-ethylhexyl)phosphate of gross weight 40% are added in extract solution Hydrogen potassium, 0.4% sodium nitrate, 3% glycerine, 3% yeast extract, 4% peptone, are stirred, and sterilizing cooling, which is made, to be carried Take liquid fermentation medium；
(3) ferment：
The bacillus subtilis after step (1) is cultivated, S. cervisiae, enterococcus faecalis are accessed in dregs of a decoction fermentation medium, Three is according to 1:2：0.5 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of training 48h is supported, every 6h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
The bacillus subtilis after step (1) is cultivated, S. cervisiae, Monascus are accessed in extract solution fermentation medium, Three is according to 1:1:2 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of culture 36h, every 4h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
Above-mentioned product by solid-state fermentation and liquid state fermentation product are mixed.
2. 1 groups of embodiment is used for the Chinese medicine composition for treating cad pig, including 3 groups of Chinese medicine compositions：
Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：25 grams of schizonepeta, windproof 17 grams, 7 grams of Radix Codonopsis, Herba Andrographitis 12 grams, 22 grams of rhizoma atractylodis, 18 grams of honeysuckle, 17 grams of root tuber of aromatic turmeric, 18 grams of rattletop, 10 grams of Fructus Aurantii, 20 grams of Poria cocos, 18 grams of Ligusticum wallichii, radix glycyrrhizae 7 Gram, 8 grams of dried orange peel, 8 grams of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：130 grams of gypsum, 28 grams of the dried rhizome of rehmannia, 9 grams of rhinoceros horn, the Radix Astragali 12 Gram, 20 grams of Herba Andrographitis, 25 grams of the root bark of Chinese wolf-berry, 26 grams of kuh-seng, 28 grams of Radix Codonopsis, 22 grams of the radix paeoniae rubrathe, 25 grams of bulb of thunberg fritillary, 30 grams of the wind-weed, honeysuckle 25 Gram, 26 grams of balloonflower root, 26 grams of radix glycyrrhizae, 28 grams of lophatherum gracile；
Chinese medicine composition 3 is made up of the bulk drug of following weight：28 grams of Radix Codonopsis, 350 grams of the Radix Astragali, 35 grams of rhizoma zingiberis, honey-fried licorice root 30 grams, 50 grams of the bighead atractylodes rhizome, 8 grams of cooked aconite, 10 grams of pseudo-ginseng, 8 grams of wrinkled giant hyssop, 8 grams of dandelion.
Preparation method be the same as Example 1.
3. 1 groups of embodiment is used for the Chinese medicine composition for treating cad pig, including 3 groups of Chinese medicine compositions：
Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：15 grams of schizonepeta, windproof 25 grams, 10 grams of Radix Codonopsis, Herba Andrographitis 20 grams, 25 grams of rhizoma atractylodis, 25 grams of honeysuckle, 20 grams of root tuber of aromatic turmeric, 15 grams of rattletop, 15 grams of Fructus Aurantii, 20 grams of Poria cocos, 20 grams of Ligusticum wallichii, radix glycyrrhizae 9 Gram, 7 grams of dried orange peel, 6 grams of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：140 grams of gypsum, 33 grams of the dried rhizome of rehmannia, 9 grams of rhinoceros horn, the Radix Astragali 12 Gram, 23 grams of Herba Andrographitis, 15 grams of the root bark of Chinese wolf-berry, 30 grams of kuh-seng, 27 grams of Radix Codonopsis, 22 grams of the radix paeoniae rubrathe, 25 grams of bulb of thunberg fritillary, 25 grams of the wind-weed, honeysuckle 25 Gram, 25 grams of balloonflower root, 18 grams of radix glycyrrhizae, 28 grams of lophatherum gracile；
Chinese medicine composition 3 is made up of the bulk drug of following weight：32 grams of Radix Codonopsis, 280 grams of the Radix Astragali, 28 grams of rhizoma zingiberis, honey-fried licorice root 28 grams, 55 grams of the bighead atractylodes rhizome, 10 grams of cooked aconite, 15 grams of pseudo-ginseng, 12 grams of wrinkled giant hyssop, 13 grams of dandelion.
Preparation method be the same as Example 1.
4. 1 groups of embodiment is used for the Chinese medicine composition for treating cad pig, including 3 groups of Chinese medicine compositions：
Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：15 grams of schizonepeta, windproof 15 grams, 5 grams of Radix Codonopsis, Herba Andrographitis 10 grams, 15 grams of rhizoma atractylodis, 15 grams of honeysuckle, 10 grams of root tuber of aromatic turmeric, 10 grams of rattletop, 10 grams of Fructus Aurantii, 10 grams of Poria cocos, 10 grams of Ligusticum wallichii, radix glycyrrhizae 5 Gram, 5 grams of dried orange peel, 5 grams of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：100 grams of gypsum, 25 grams of the dried rhizome of rehmannia, 8 grams of rhinoceros horn, the Radix Astragali 10 Gram, 15 grams of Herba Andrographitis, 15 grams of the root bark of Chinese wolf-berry, 20 grams of kuh-seng, 20 grams of Radix Codonopsis, 20 grams of the radix paeoniae rubrathe, 20 grams of bulb of thunberg fritillary, 25 grams of the wind-weed, honeysuckle 20 Gram, 20 grams of balloonflower root, 10 grams of radix glycyrrhizae, 20 grams of lophatherum gracile；
Chinese medicine composition 3 is made up of the bulk drug of following weight：30 grams of Radix Codonopsis, 330 grams of the Radix Astragali, 33 grams of rhizoma zingiberis, honey-fried licorice root 27 grams, 60 grams of the bighead atractylodes rhizome, 12 grams of cooked aconite, 10 grams of pseudo-ginseng, 8 grams of wrinkled giant hyssop, 8 grams of dandelion.
Preparation method be the same as Example 1.
Test example one, toxicity test
1 materials and methods
1.1 material
1.1.1 medicine
3 groups of Chinese medicine compositions prepared by above-described embodiment 1, are concentrated by the way of freeze-drying, before use with steaming Distilled water is made into the solution of every milliliter of crude drug containing 0.4g.
1.1.2 animal
ICR mouse 120,18~22g of body weight, male and female half and half.Purchased from experimental animal Co., Ltd.
1.2 method
1.2.1 animal feeding condition
Room temperature:22 DEG C ± 3 DEG C, relative humidity:55%~60%, no convection current wind, manually round the clock (12 daytime, 12h nights). 12h fasting before experiment packet administration.
1.2.2 administering mode
Healthy mice 80 is taken according to herbal pharmacology experimental method, 4 groups are randomly divided into, male and female half and half, every group 20, through 1 Secondary gastric infusion, dosage and observation the results are shown in Table 1- tables 3, to the toxic reaction of observation post administration animal, Continuous Observation 7d.
The dosage of 1. Chinese medicine composition of table 1 and result
The dosage of 2. Chinese medicine composition of table 2 and result
The dosage of 3. Chinese medicine composition of table 3 and result
2 results
2.1 mouse median lethal doses (LD50) are determined
It is normal in the same day mouse activity of administration, the state of mind, diet from experimental observation and table 1- tables 3,1 week it Dead mouse and other generations extremely are inside had no, each mouse heart of seen at post-mortem, liver, spleen, lung, kidney are not revealed any abnormalities and changed after execution Become.Therefore experiment can not measure the median lethal dose (LD50) of the fermented preparation of Chinese herb, therefore carry out maximal tolerance dose experiment.
2.2 mouse maximal tolerance doses (MTD) are determined
Healthy ICR mouse 40 are taken, 2 groups, male and female half and half are randomly divided into.The medicine of 0.4g/mL concentration is used (for medicine Maximum concentration), according to 0.4mL/10g gastric infusions 3 times, every 8 hours, 1 time (accumulation was equivalent daily, and dose is:48 000mg/ Kg body weight).Continuous Observation 7d.7th day whole mouse take off neck and put to death, cut open inspection, the record heart, liver, spleen, lung, the pathological change of kidney.Knot Fruit shows that mouse spirit, appetite, activity are showed no anomalous variation compared with control group, and internal organs are not shown any abnormalities.
3 conclusions
Acute toxicity test is once given after experimental animal certain tested material, observes in a short time to experimental animal institute The test method of the toxic reaction of generation.The Chinese medicinal composition preparation of the present invention is according to 16000mg/kg body weight gastric infusions, nothing Method measures median lethal dose (LD50) value.Maximal tolerance dose (MTD) experiment is carried out under the acceptable maximum volume of mouse, as a result Show, mouse is to the maximal tolerance dose of Chinese medicine preparation of the present invention more than 48000mg/kg body weight.It is generally acknowledged that, by batheroom scale Calculate, mouse maximum dosage-feeding on the 1st is then safer equivalent to more than 100 times of the clinical consumption per day of pig.And this experiment MTD is converted into Pig clinic consumption per day is 430 times.Therefore it can be assumed that said preparation is in a short time using safety, toxicity level should belong to " actual nothing Malicious level ", is a kind of safe preparation of comparison.
Test example 2, clinical trial
1.1 experimental animal
Qingdao Sheng Xinyue herding ecologic breeding Co., Ltds are carried out prolonged and repeated in August, 2014 in September, 2016 Experiment, selection cad pig 180 is used as experiment swinery.Cad pig shows as：Slightly disorderly, physique is modest for hair, circle belly, sharp hip, greatly Head, hogback contracting abdomen only eats not long, and vaccine immunity mortality is high, and part cad pig is also with cough or symptom of diarrhea.
1.2 experimental program
Using 180 cad pigs as trying animal, random fashion is taken to be divided into three groups, every group of 60 cad pigs are respectively this hair Bright group, conventional medicament group, blank group carry out contrast experiment.Wherein present invention group feeds journey using the Chinese medicine composition of embodiment 1 Sequence is as follows：Chinese medicine composition 1 is first used, addition 0.5% is fed 3 days；Then Chinese medicine composition 2, addition 0.5%, feed 4 My god；Chinese medicine composition 3 is finally used again, and addition 0.5% is fed 28 days；Free choice feeding.Conventional medicament group：Dimension is injected after expelling parasite Raw element B2Injection, injected once every 5~7 days or starts to use vitamin B by 0.5 milligram every time12(500 microgram) 2 and inosine are noted Penetrate and intramuscular injection is carried out after the mixing of liquid (2 milliliters every) one, even note after 2 days, then with atriphos (ATP) and vitamin B12, inosine, each one of calcium colloidal et vit D, carry out hybrid injection, free choice feeding；Blank group：Without any medicine.
1.3 efficacy determination
Substantially (600g/d), the state of mind is good for piglet daily gain, and hair color recovers, and is determined as effective；Piglet daily gain compared with Substantially (100g/d), hair color is normal, is determined as effectively；Piglet daily gain has no change (below 100g/d) substantially, hair The symptoms such as color are not recovered, and it is invalid to be determined as.
1.4 result
Present invention group 60 cad pigs for the treatment of, 7 days effectively, and rehabilitation in 15 days is normal, and total effective rate is 98.7%；Conventional medicament group 60 cad pigs are treated, treatment time is longer, average 40 days effectively, total effective rate 32.8%, as a result such as table 4
The comparitive study of 4. 3 kinds for the treatment of methods of table
It was found from the data of table 4：Compared with control group, cad pig is treated using the present invention, high with curative effect, the cycle is short, cures The high advantage of rate.
Emirical cases 1
Time：On 03 22nd, 2017.Place：Jinan, Shandong Province.Real example factory title：Wen Zuzhong prints plant.Suprapubic arch sling 170.
According to pig farm data cases, cad pig 33 is tested.
Experimental method：According to 3 days Chinese medicine composition 1 (0.5% addition)+4 days Chinese medicine compositions 2 " (0.5% addition), then With Chinese medicine composition 3 (0.1% addition) 28 days.Statistics after medication 35 days, the results are shown in Table 5 and accompanying drawing 1.
The Jinan Wen Zuzhong of table 5. prints plant cad pig treatment results
Before treatment After treatment Primitive pit pig
Average weight 6.3kg 17.8kg 18kg
Average age in days 38 days 75 days 75 days
Cad pig quantity 33 0 35
Diarrhea rate 8% 0 4%
Test result indicates that：
1st, respiratory disorder phenomenon is obviously improved, diarrhea rate is substantially reduced after medication 3 days.
2nd, after medication 7 days, feed intake increase, spiritual depressed situation improves obvious.
3rd, after medication 15 days, the state of mind is good, and body weight substantially increases.
4th, after medication 36 days, weigh, experiment cad pig group body weight is close to normal swinery.
5th, ammonia taste is obviously improved in column circle, and stink is reduced.
6th, period progress aftosa vaccine is immunized, and an aftosa case is not found.
Emirical cases 2
Time：On 03 06th, 2017.Place：Laiwu in Shandong province.Real example factory title：Laiwu is after aquaculture cooperative society.Through production Sow 420.
According to pig farm data cases, cad pig 32 is tested
Experimental method：According to 3 days Chinese medicine composition 1 (0.5% addition)+4 days Chinese medicine compositions 2 " (0.5% addition), then With Chinese medicine composition 3 (0.1% addition) 28 days.Statistics after medication 35 days, the results are shown in Table 6 and Fig. 2.
The Laiwu of table 6. is after aquaculture cooperative society cad pig treatment results
Before treatment After treatment Primitive pit pig
Average weight 5.8kg 14.8kg 15kg
Average age in days 32 days 68 days 68 days
Cad pig quantity 32 0 36
Diarrhea rate 8% 0 5%
Experimental result：
1st, a diarrhoea case is had no during medication.
2nd, after medication 7 days, feed intake increase, spiritual depressed situation improves obvious.
3rd, after medication 15 days, the state of mind is good, and body weight substantially increases.
4th, after medication 36 days, weigh, experiment cad pig group body weight is close to normal swinery.
5th, ammonia taste is obviously improved in column circle, and stink is reduced.
6th, period progress aftosa vaccine is immunized, and an aftosa case is not found.
7th, feedstuff-meat ratio results of measuring 1:1.19 (whole audience child care phase feedstuff-meat ratios 1:1.27).
Emirical cases 3
Time：On 02 18th, 2017.Place：Laiwu in Shandong province.Real example factory title：The green source breeding stock Breeding Center in Laiwu.Through Produce sow 310；
According to pig farm data cases, cad pig 41 is tested
Experimental method：According to 3 days Chinese medicine composition 1 (0.4% addition)+4 days Chinese medicine compositions 2 " (0.5% addition), then With Chinese medicine composition 3 (0.1% addition) 28 days.Statistics after medication 35 days, the results are shown in Table 7 and Fig. 3.
The green source breeding stock Breeding Center cad pig treatment results in the Laiwu of table 7.
Before treatment After treatment Primitive pit pig
Average weight 5.4kg 14.5kg 14.6kg
Average age in days 27 days 63 days 62 days
Cad pig quantity 41 0 45
Diarrhea rate 27% 3% 7%
Experimental result：
1st, after medication 7 days, feed intake increase, spiritual depressed situation improves obvious.
2nd, after medication 15 days, the state of mind is good, and body weight substantially increases.
3rd, after medication 36 days, weigh, experiment cad pig group body weight is close to normal swinery.
4th, ammonia taste is obviously improved in column circle, and stink is reduced.
5th, period progress aftosa vaccine is immunized, and an aftosa case is not found.
6th, feedstuff-meat ratio results of measuring 1:1.18 (whole audience child care phase feedstuff-meat ratios 1:1.25).
Emirical cases 4
Time：On 03 07th, 2017.Place：Taian Shandong.Real example factory title：Cooperative society is cultivated in the Piao of Tai'an.Through production Sow 340.
According to pig farm data cases, cad pig 30 is tested
Experimental method：According to 3 days Chinese medicine composition 1 (0.5% addition)+4 days Chinese medicine compositions 2 " (0.4% addition), then With Chinese medicine composition 3 (0.2% addition) 28 days.Statistics after medication 35 days, the results are shown in Table 8 and Fig. 4.
Cultivation cooperative society cad pig treatment results in the Piao of the Tai'an of table 8.
Experimental result：
1st, diarrhea rate is substantially reduced, hair color light.
2nd, after medication 7 days, feed intake increase, spiritual depressed situation improves obvious.
3rd, after medication 15 days, the state of mind is good, and body weight substantially increases.
4th, after medication 36 days, weigh, experiment cad pig group body weight is close to normal swinery.
5th, ammonia taste is obviously improved in column circle, and stink is reduced.
6th, cool suddenly during medication, swinery shows no obvious abnormalities and fallen ill
7th, feedstuff-meat ratio results of measuring 1:1.16 (whole audience child care phase feedstuff-meat ratios 1:1.23).

Claims (9)

1. one group of Chinese medicine composition for being used to treat cad pig, it is characterized in that, including 3 groups of Chinese medicine compositions：
Chinese medicine composition 1 is made up of the bulk drug of following parts by weight：15-25 parts of schizonepeta, windproof 15-25 parts, 5-10 parts of Radix Codonopsis, wears 10-20 parts of heart lotus, 15-25 parts of rhizoma atractylodis, 15-25 parts of honeysuckle, 10-20 parts of root tuber of aromatic turmeric, 10-15 parts of rattletop, 10-15 parts of Fructus Aurantii, Fu 10-20 parts of Siberian cocklebur, 10-20 parts of Ligusticum wallichii, 5-10 parts of radix glycyrrhizae, 5-10 parts of dried orange peel, 5-10 parts of pseudo-ginseng；
Chinese medicine composition 2 is made up of the bulk drug of following parts by weight：100-150 parts of gypsum, 25-35 parts of the dried rhizome of rehmannia, 8-12 parts of rhinoceros horn, 10-20 parts of the Radix Astragali, 15-25 parts of Herba Andrographitis, 15-25 parts of the root bark of Chinese wolf-berry, 20-30 parts of kuh-seng, 20-30 parts of Radix Codonopsis, 20-30 parts of the radix paeoniae rubrathe, 20-30 parts of bulb of thunberg fritillary, 25-35 parts of the wind-weed, 20-30 parts of honeysuckle, 20-30 parts of balloonflower root, 10-20 parts of radix glycyrrhizae, 20-30 parts of lophatherum gracile；
Chinese medicine composition 3 is made up of the bulk drug of following parts by weight：28-32 parts of Radix Codonopsis, 280-350 parts of the Radix Astragali, rhizoma zingiberis 25-35 Part, 25-30 parts of honey-fried licorice root, 50-60 parts of the bighead atractylodes rhizome, 8-12 parts of cooked aconite, 10-15 parts of pseudo-ginseng, 8-12 parts of wrinkled giant hyssop, dandelion 8-13 Part.
2. the as claimed in claim 1 Chinese medicine composition for being used to treat cad pig, it is characterized in that, the Chinese medicine composition 1 by with The bulk drug of lower parts by weight is made：20 parts of schizonepeta, windproof 20 parts, 7 parts of Radix Codonopsis, 15 parts of Herba Andrographitis, 20 parts of rhizoma atractylodis, honeysuckle 20 Part, 15 parts of root tuber of aromatic turmeric, 10 parts of rattletop, 10 parts of Fructus Aurantii, 15 parts of Poria cocos, 15 parts of Ligusticum wallichii, 8 parts of radix glycyrrhizae, 7 parts of dried orange peel, 7 parts of pseudo-ginseng.
3. the as claimed in claim 1 Chinese medicine composition for being used to treat cad pig, it is characterized in that, the Chinese medicine composition 2 by with The bulk drug of lower parts by weight is made：120 parts of gypsum, 30 parts of the dried rhizome of rehmannia, 10 parts of rhinoceros horn, 15 parts of the Radix Astragali, 20 parts of Herba Andrographitis, the root bark of Chinese wolf-berry 20 Part, 25 parts of kuh-seng, 25 parts of Radix Codonopsis, 25 parts of the radix paeoniae rubrathe, 25 parts of bulb of thunberg fritillary, 30 parts of the wind-weed, 30 parts of honeysuckle, 25 parts of balloonflower root, 15 parts of radix glycyrrhizae is light 25 parts of the leaf of bamboo.
4. the as claimed in claim 1 Chinese medicine composition for being used to treat cad pig, it is characterized in that, the Chinese medicine composition 3 by with The bulk drug of lower parts by weight is made：30 parts of Radix Codonopsis, 300 parts of the Radix Astragali, 30 parts of rhizoma zingiberis, 30 parts of honey-fried licorice root, 60 parts of the bighead atractylodes rhizome, cooked aconite 10 Part, 10 parts of pseudo-ginseng, 10 parts of wrinkled giant hyssop, 10 parts of dandelion.
5. the method for being used to treat the Chinese medicine composition of cad pig described in claim 1 is prepared, it is characterized in that, comprise the following steps：
(1) culture of fermented bacterium：Bacillus subtilis, S. cervisiae, enterococcus faecalis, Monascus conventional method are expanded into training Support to viable bacteria and reach 1 × 109More than CFU/ml；
(2) fermentation medium prepares：
Chinese medicine material medicine needed for above-mentioned each group Chinese medicine composition is weighed, packet mixing is crushed to 20-80 mesh, using water extraction, obtained Obtain extract solution and Chinese medicine slag；
Wheat bran, 20% brown sugar, 10% mashed potatoes, 1.5% ammonium sulfate, 0.2% phosphoric acid of gross weight 3% are added in the dregs of a decoction Potassium dihydrogen, 0.5% dipotassium hydrogen phosphate, 0.5% magnesium sulfate, stir, and are eventually adding one times of amount water, and sterilizing cooling is made Dregs of a decoction fermentation medium；
Added in extract solution the brown sugar of gross weight 40%, 5% glucose, 0.3% magnesium sulfate, 0.3% potassium dihydrogen phosphate, 0.4% sodium nitrate, 3% glycerine, 3% yeast extract, 4% peptone, stir, and extract solution hair is made in sterilizing cooling Ferment culture medium；
(3) ferment：
The bacillus subtilis after step (1) is cultivated, S. cervisiae, enterococcus faecalis, three are accessed in dregs of a decoction fermentation medium According to 1:2：0.5 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of culture 48h, every 6h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
The bacillus subtilis after step (1) is cultivated, S. cervisiae, Monascus, three are accessed in extract solution fermentation medium According to 1:1:2 ratio inoculation, total inoculum concentration is 10%, stirs, is fitted into sterile fermentation tank, 25-30 DEG C of culture 36h, Every 4h stirrings once；Fermentation ends dry, pulverize after 30-40 DEG C, sieve；
Above-mentioned fermenting twice product is mixed.
6. for treating application of the Chinese medicine composition of cad pig in cad pig feed is prepared described in claim 1.
7. a kind of feed for treating cad pig, it is characterized in that, the feed include 0.1%-0.5% weight than Chinese medicine composition 1。
8. a kind of feed for treating cad pig, it is characterized in that, the feed include 0.1%-0.5% weight than Chinese medicine composition 2。
9. a kind of feed for treating cad pig, it is characterized in that, the feed include 0.1%-0.5% weight than Chinese medicine composition 3。
CN201710590275.9A 2017-07-19 2017-07-19 One group is used to treat Chinese medicine composition of cad pig and preparation method thereof Pending CN107308415A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109043167A (en) * 2018-07-06 2018-12-21 江西江农生物营养技术有限公司 A kind of feeding composition and preparation method thereof improving meat
CN109105649A (en) * 2018-07-06 2019-01-01 江西江农生物营养技术有限公司 A kind of prevention and treatment sow weight tire phase and the feeding composition of postpartum anemia and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109043167A (en) * 2018-07-06 2018-12-21 江西江农生物营养技术有限公司 A kind of feeding composition and preparation method thereof improving meat
CN109105649A (en) * 2018-07-06 2019-01-01 江西江农生物营养技术有限公司 A kind of prevention and treatment sow weight tire phase and the feeding composition of postpartum anemia and preparation method thereof

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Application publication date: 20171103