CN104147586A - Chinese herbal medicine composition and fodder for preventing and treating cold irritable enteritis of quails - Google Patents
Chinese herbal medicine composition and fodder for preventing and treating cold irritable enteritis of quails Download PDFInfo
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- CN104147586A CN104147586A CN201410459875.8A CN201410459875A CN104147586A CN 104147586 A CN104147586 A CN 104147586A CN 201410459875 A CN201410459875 A CN 201410459875A CN 104147586 A CN104147586 A CN 104147586A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention relates to a Chinese herbal medicine composition and fodder for preventing and treating cold irritable enteritis of quails and belongs to the technical field of fodders. The compatibility of drugs of the Chinese herbal medicine composition is based on the principle that different drugs play different roles, all the drugs complement one another in drug property, through iterative trial and verification, the type and the best optimal dosage of the drugs are determined innovatively at last, and all Chinese herbal medicinal ingredients take synergetic effects, promote one another, and have an unexpected technical effect that 1 plus 1 is equal to or greater than 2 in treatment of cold irritable enteritis of quails; meanwhile, the immunity and the resistance to disease of quails are increased. The composition is extensive in material taking, low in cost, safe, and low in cost, has no toxic or side effects, and has the effects of clearing away heat and toxic materials, recovering intestinal functions and enhancing immunity of the organism.
Description
Technical field
The feedstuff that the present invention relates to the special-purpose cold-resistant growth promotion Chinese medicine composition of a kind of Carnis Coturnicis japonicae and preparation thereof, belongs to field of feed additive technology.
Background technology
Carnis Coturnicis japonicae is the special fowl that economic worth is very high, and China has become the first in the world and supported Carnis Coturnicis japonicae big country, have the good reputation of " animal Radix Ginseng ".Carnis Coturnicis japonicae intensive farm is the important component part of modern poultry production, Carnis Coturnicis japonicae because its investment is little, take up an area less, fertility performance is high, is put into one of national Spark Program project, raise in the area and the rural area that are applicable to very much limited fund; Domestic Carnis Coturnicis japonicae aquaculture mainly concentrates on east and central China area, the Northeast because of region cold and low temperature time remaining long, ambient temperature is starkly lower than the required optimum temperature of Feeding Quails, Carnis Coturnicis japonicae is responsive, strong to cold stress (Cold stress) reaction, especially the intestinal of digestive system reaction, the cultivation of Carnis Coturnicis japonicae is extremely restricted, the bowel problems being caused by cold stress is not also effectively solved, technical staff feels simply helpless, technical staff also attempts treating or preventing with Western medicine, Chinese herbal medicine or other material, but has no resolution so far.
At present, for the research of Carnis Coturnicis japonicae cold stress, report seldom both at home and abroad, especially there is no the corresponding research for the special cold environment in northeast.Domestic correlational study focuses mostly at present and reduces the various stress of animal, for example patent CN1564692 A disclose a kind of take antiviral that Radix Scutellariae, Flos Lonicerae, Herba Menthae be composition, bring down a fever, the preparation of enhancing immunity; It usings pure natural Chinese herbal medicine as feed additive, but lacks specific aim; Patent CN 1596733 A disclose that a kind of to take vitamin C, vitamin E, glutaminase, tryptophan, chromium, zinc be component, can effectively improve stress adaptive capacity compositions, but this research is also only for all stress, completely inapplicable for the cold stress situation under the environment of northeast.Also have patent and bibliographical information for heat stress, yet above-mentioned research does not all have specially for the reaction of Carnis Coturnicis japonicae intestinal cold stress, therefore, how effectively to utilize Chinese herbal medicine and obtain prevention, treatment Carnis Coturnicis japonicae cold stress enteritis, just become one of current industry problem demanding prompt solution.Intestinal, as the organ of body and external environment contact area maximum, more easily suffers damage under cold stress state.Carnis Coturnicis japonicae is had relatively high expectations to ambient temperature, and has special physiological property, and digestive tract is shorter, is therefore more easily subject to the impact of cold stress.Inventor's early-stage Study is found: cold stress can cause that Carnis Coturnicis japonicae Intestinal Morphology damages, imbalance occurs enteric microorganism flora and then make Carnis Coturnicis japonicae intestinal produce inflammation, the lighter occurs that the decline of Carnis Coturnicis japonicae feed intake, diarrhoea, fertility performance decline, and serious appearance is dead.As everyone knows, feeding antibiotic causes drug resistance problem and drug residue problem are very large to the mankind's threat.Therefore, extensive with drawing materials, with low cost, Chinese herbal medicine replaces antibiotic imperative safely and effectively.
Also not yet have be at present specifically designed under the weather condition of northeast, for preventing, treat herbal composite, feed additive and the feedstuff report of Carnis Coturnicis japonicae cold stress enteritis.
Summary of the invention
Object of the present invention: provide a kind of and have that cost is low, technique is simple, easy operating, without herbal composite and the feedstuff thereof of complex device, a kind of prevention that is applicable to the advantages such as large-scale breeding, treatment Carnis Coturnicis japonicae cold stress enteritis.
The technical problem that the present invention solves: solve that current the Northeast Carnis Coturnicis japonicae cold stress enteritis takes place frequently and serious common problem.Herbal composite and the feedstuff thereof of a kind of prevention, treatment Carnis Coturnicis japonicae cold stress enteritis are provided.
Technical scheme of the present invention: provide
oneplant the herbal composite for the treatment of Carnis Coturnicis japonicae cold stress enteritis, it is characterized in that this herbal composite is prepared from by following raw material, in weight portion: Herba Taraxaci 1-3 part, Cortex Eucommiae 2-4 part, Herba Portulacae 2-4 part, Herba Houttuyniae 3-6 part, Radix Astragali 5-10 part, Fructus Foeniculi 3-5 part, Flos Chrysanthemi Indici 2-4 part, Rhizoma Osmundae 3-6 part, Radix Angelicae Sinensis 3-5 part, Fructus Hordei Germinatus 3-5 part, Rhizoma Atractylodis Macrocephalae 3-5 part, Radix Glycyrrhizae 3-5 part, Folium Isatidis 3-5 part, Fructus Oryzae Germinatus 3-5 part, Galla Chinensis 3-5 part, Rhizoma Zingiberis Recens 3-5 part.
The present invention also provides a kind of preparation method for the treatment of the herbal composite of Carnis Coturnicis japonicae cold stress enteritis, concrete preparation method is for to be mixed and made into the trickle powder of 600 object by Herba Taraxaci, the Cortex Eucommiae, Herba Portulacae, Herba Houttuyniae, the Radix Astragali, Fructus Foeniculi, Flos Chrysanthemi Indici, Rhizoma Osmundae, Radix Angelicae Sinensis, Fructus Hordei Germinatus, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis, Fructus Oryzae Germinatus, Galla Chinensis, Rhizoma Zingiberis Recens, the herbal composite of the Carnis Coturnicis japonicae enteritis that obtains medical treatment.
The present invention also provides a kind of feedstuff that prevents the Carnis Coturnicis japonicae enteritis that cold stress causes, it is characterized in that, in weight portion: said herbal medicine compositions 1-10 part, Semen Maydis 50-60 part, bean cake 20-30, fish flour 2-4 part, bone meal 1-2 part, tryptophan 1-2 part, glutamic acid 0.5-1 part, lysine 0.5-1 part, arginine 0.5-1 part, methionine 0.5-1 part, threonine 0.5-1 part, premix material 0.2-0.5 part.Wherein herbal composite can be also without the simple mixing of extracting.
The present invention also provides a kind of simultaneously and has further facilitation, is exclusively used in the premix material of Carnis Coturnicis japonicae cold stress reaction, in weight portion: vitamin C 0.5-0.8 part, vitamin A 0.5-0.8 part, vitamin D
30.01-0.3 part, vitamin E 0.7-2.0 part, vitamin B
10.05-0.07 part, vitamin B
20.5-1 part, vitamin B
60.1-0.6 part, vitamin B
120.08-0.1 part, folic acid 0.06-0.18 part, biotin 0.02-0.25 part, nicotinic acid 0.8-1.2 part; Manganese sulfate 0.3-0.7 part, zinc sulfate 0.02-0.05 part, ferrous sulfate 0.1-0.5 part, copper sulfate 0.2-0.6 part, choline chloride 1.5-2.1 part, calcium carbonate 18-26 part, calcium hydrogen phosphate 24-31 part.
Herba Taraxaci: having another name called Herba crotalariae albidae, is the kind that health ministry is listed medicine-food two-purpose recently in.According to < < Compendium of Materia Medica > >, record, Herba Taraxaci can heat clearing away poison, relieving dyspepsia is malicious, disappear that it is swollen to dislike.The successive dynasties Medical monographs such as < < Tang materia medica > >, < < Sheng Nong's herbal classic > >, < < Chinese medicine voluminous dictionary > > are all given high evaluation.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, hypertension.
Herba Portulacae: there is heat-clearing and toxic substances removing, the effect such as treating stranguria, antibacterial of stopping blooding, the inhibitory action that escherichia coli, Bacillus proteus, dysentery bacterium, typhoid fever, Salmonella paratyphi is had to height, also has inhibitory action in various degree to staphylococcus aureus, fungus as Austria Du big belly microspore tinea bacterium, tubercule bacillus.Cure mainly acute, subacute dermatitis and enteritis, bacillary dysentery, treatment pyogenic infections from tumour or sore.
Herba Houttuyniae: acrid in the mouth; Cold nature; Return lung meridian.Effect heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria.
Flos Chrysanthemi: have Herba Dendranthematis indici and family chrysanthemum minute, family's chrysanthemum liver heat removing and eyesight improving wherein, the loose fire of Herba Dendranthematis indici toxic removing, sweetness and bitterness is slightly cold, heat-clearing and toxic substances removing all has certain effectiveness to eyes strain, headache, hypertension etc.In < < Compendium of Materia Medica > >, the drug effect of chrysanthemum scented tea is also documented in detail: property is sweet, be slightly cold, there is the effect of loose wind heat, suppressing the hyperactive liver improving eyesight.< < Sheng Nong's herbal classic > > thinks, Flos Chrysanthemi scented tea can " main all dizziness due to wind, swell and ache, order wish is de-, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen, takes for a long time promoting the circulation of QI, she making light of one's life by commiting suicide endures hardships prolongs life.
Radix Angelicae Sinensis: moisturize laxation, enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, cure mainly weight after all cards of blood deficiency, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, bloody dysentery, ulcer sores, injury from falling down.
The Rhizoma Atractylodis Macrocephalae: there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.
Rhizoma Zingiberis Recens: property and flavor of peppery and warm, has the multiple efficacies such as cold expelling diaphoresis, preventing phlegm from forming and stopping coughing, stomach function regulating, preventing or arresting vomiting.
Fructus Foeniculi: have the effect of regulating the stomach to normalize QI, warming kidney for dispelling cold, gas when active component Oleum Anisi Stellati wherein can be discharged abdominal distention, promotes intestinal peristalsis promoting, also has certain antibacterial action.
Fructus Oryzae Germinatus: have another name called Fructus Setariae Germinatus, have spleen benefiting and stimulating the appetite and in the effect that helps digestion, can solve Carnis Coturnicis japonicae indigestion, the symptom of tripe distention and fullness in the abdomen;
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing.
Folium Isatidis: heat clearing away, removing toxic substances, removing heat from blood, hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Rhizoma Osmundae: there is heat-clearing and toxic substances removing, kill the effect of ascarid, cestode, pinworm;
Galla Chinensis: there is the effect of the astringing intestine to stop diarrhea of astringing the lung, hemostasis removing toxic substances, also staphylococcus aureus, streptococcus pneumoniae, typhoid fever, paratyphoid fever, dysentery etc. are had to obvious inhibition and killing effect.
Beneficial effect of the present invention:
(1) Chinese medicine in Chinese prescription of the present invention is by the principle compatibility of " monarch ", each taste property of medicine brings out the best in each other, through repetition test and final kind and the optimum amount of having determined Chinese herbal medicine of innovating of checking, make wherein Synergistic between various Chinese medicine ingredients, mutually promote, treatment Carnis Coturnicis japonicae cold stress enteritis has been produced to the unexpected technique effect of 1+1 >=2, increased Carnis Coturnicis japonicae immunity and premunition simultaneously.It is monarch that antibacterial Herba Portulacae, the heat-clearing and toxic substances removing removing heat from blood Folium Isatidis of Herba Taraxaci, heat-clearing and toxic substances removing of heat-clearing and toxic substances removing take in the present invention, minister with the Galla Chinensis with the astringing intestine to stop diarrhea of astringing the lung, the Herba Houttuyniae of the Rhizoma Osmundae of removing toxic substances parasite killing, treatment hematodiarrhoea malaria, assistant is with the Rhizoma Atractylodis Macrocephalae of benefiting QI for strengthening the superficies, the Radix Astragali that holds in the palm skin ulcer granulation promoting and invigorating the spleen and benefiting QI, dampness diuretic, with have invigorating the spleen and replenishing QI Radix Glycyrrhizae, spleen benefiting and stimulating the appetite and in the Fructus Foeniculi of Fructus Oryzae Germinatus, the regulating the stomach to normalize QI, the warming kidney for dispelling cold that help digestion for making coordinating the actions of various ingredients in a prescription, further add Rhizoma Zingiberis Recens mediation effect and played unforeseeable technique effect being in harmonious proportion medicine.
(2) on the basis of Rhizoma Osmundae and Galla Chinensis special ratios, then be aided with mixing Herba Houttuyniae jointly as ministerial drug, acting on of high monarch drug is provided greatly.
(3) in multivitamin use, inventor finds unexpectedly, vitamin C 0.5-0.8 part, vitamin A 0.5-0.8 part are used in conjunction with preventing Carnis Coturnicis japonicae cold stress enteritis to have unforeseeable effect, especially aspect whole prevention effect with the ratio of 1:1.In prior art, vitamin C stress play an important role under situation at cold resistance, think that vitamin C is the cofactor of synthetic catecholamine and glucocorticoid necessity, under stressed condition, animal synthetic vitamin C ability reduces, in cold stress lower body, synthetic vitamin can not meet the needs of organism metabolism, supplements a certain amount of vitamin C to adapt to the weather that turns cold.Vitamin C and vitamin A have synergism, may come from the biosynthesis that vitamin A can Promote immunity globulin, promote increment and the growth of cell, further promote the auxiliary synthetic catecholamine of vitamin C and glucocorticoid.
the specific embodiment
Embodiment 1: a kind of herbal composite for the treatment of Carnis Coturnicis japonicae cold stress enteritis, it is characterized in that this herbal composite is prepared from by following raw material, in weight portion: Herba Taraxaci 1-3 part, Cortex Eucommiae 2-4 part, Herba Portulacae 2-4 part, Herba Houttuyniae 3-6 part, Radix Astragali 5-10 part, Fructus Foeniculi 3-5 part, Flos Chrysanthemi Indici 2-4 part, Rhizoma Osmundae 3-6 part, Radix Angelicae Sinensis 3-5 part, Fructus Hordei Germinatus 3-5 part, Rhizoma Atractylodis Macrocephalae 3-5 part, Radix Glycyrrhizae 3-5 part, Folium Isatidis 3-5 part, Fructus Oryzae Germinatus 3-5 part, Galla Chinensis 3-5 part, Rhizoma Zingiberis Recens 3-5 part.
Embodiment 2: a kind of herbal composite for the treatment of Carnis Coturnicis japonicae cold stress enteritis, it is characterized in that this herbal composite is prepared from by following raw material, in weight portion: 3 parts of Herba Taraxacis, 2 parts of the Cortexs Eucommiae, 4 parts of Herba Portulacaes, 5 parts of Herba Houttuyniae, 8 parts of the Radixs Astragali, 3 parts of Fructus Foeniculi, 3 parts of Flos Chrysanthemi Indicis, 5 parts of Rhizoma Osmundae, 4 parts of Radix Angelicae Sinensis, 4 parts, Fructus Hordei Germinatus, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts, Radix Glycyrrhizae, 5 parts of Folium Isatidiss, 4 parts of Fructus Oryzae Germinatus, 4 parts of Galla Chinensiss, 5 parts, Rhizoma Zingiberis Recens.
Embodiment 3: a kind of feedstuff that prevents the Carnis Coturnicis japonicae enteritis that cold stress causes, 10 parts of herbal composites, 60 parts of Semen Maydiss, bean cake 30,4 parts of fish flour, 2 parts of bone meal, 2 parts of tryptophans, 1 part, glutamic acid, 1 part of lysine, 1 part of arginine, 1 part of methionine, 1 part of threonine, 0.5 part of premix material; Wherein, herbal composite is in weight portion: 3 parts of Herba Taraxacis, 4 parts of the Cortexs Eucommiae, 4 parts of Herba Portulacaes, 6 parts of Herba Houttuyniae, 10 parts of the Radixs Astragali, 5 parts of Fructus Foeniculi, 4 parts of Flos Chrysanthemi Indicis, 6 parts of Rhizoma Osmundae, 5 parts of Radix Angelicae Sinensis, 5 parts, Fructus Hordei Germinatus, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Radix Glycyrrhizae, 5 parts of Folium Isatidiss, 5 parts of Fructus Oryzae Germinatus, 5 parts of Galla Chinensiss, 5 parts, Rhizoma Zingiberis Recens.The concrete preparation method of Chinese herbal medicine is for to be mixed and made into the trickle powder of 600 object by the Herba Taraxaci of described weight portion, the Cortex Eucommiae, Herba Portulacae, Herba Houttuyniae, the Radix Astragali, Fructus Foeniculi, Flos Chrysanthemi Indici, Rhizoma Osmundae, Radix Angelicae Sinensis, Fructus Hordei Germinatus, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis, Fructus Oryzae Germinatus, Galla Chinensis, Rhizoma Zingiberis Recens, the herbal composite of the Carnis Coturnicis japonicae enteritis that obtains medical treatment.
Embodiment 4: a kind of feedstuff that prevents the Carnis Coturnicis japonicae enteritis that cold stress causes, 8 parts of herbal composites, 50 parts of Semen Maydiss, bean cake 20,2 parts of fish flour, 1 part of bone meal, 1 part of tryptophan, 0.5 part, glutamic acid, 0.5 part of lysine, 0.5 part of arginine, 0.5 part of methionine, 0.5 part of threonine, 0.2 part of premix material; Wherein, herbal composite is in weight portion: 1 part of Herba Taraxaci, 2 parts of the Cortexs Eucommiae, 2 parts of Herba Portulacaes, 3 parts of Herba Houttuyniae, 5 parts of the Radixs Astragali, 3 parts of Fructus Foeniculi, 2 parts of Flos Chrysanthemi Indicis, 3 parts of Rhizoma Osmundae, 3 parts of Radix Angelicae Sinensis, 3 parts, Fructus Hordei Germinatus, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts, Radix Glycyrrhizae, 3 parts of Folium Isatidiss, 3 parts of Fructus Oryzae Germinatus, 3 parts of Galla Chinensiss, 3 parts, Rhizoma Zingiberis Recens.The concrete preparation method of Chinese herbal medicine is for to be mixed and made into the trickle powder of 600 object by the Herba Taraxaci of described weight portion, the Cortex Eucommiae, Herba Portulacae, Herba Houttuyniae, the Radix Astragali, Fructus Foeniculi, Flos Chrysanthemi Indici, Rhizoma Osmundae, Radix Angelicae Sinensis, Fructus Hordei Germinatus, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis, Fructus Oryzae Germinatus, Galla Chinensis, Rhizoma Zingiberis Recens, the herbal composite of the Carnis Coturnicis japonicae enteritis that obtains medical treatment; Consisting of of premix material, in weight portion: 0.6 part of vitamin C, 0.6 part of vitamin A, vitamin D
30.1 part, 0.8 part of vitamin E, vitamin B
10.06 part, vitamin B
20.8 part, vitamin B
60.5 part, vitamin B
120.09 part, 0.08 part, folic acid, 0.1 part of biotin, 0.9 part, nicotinic acid; 0.6 part of manganese sulfate, 0.03 part, zinc sulfate, 0.3 part, ferrous sulfate, 0.5 part, copper sulfate, 1.5 parts of choline chlorides, 18 parts of calcium carbonate, 24 parts of calcium hydrogen phosphate.
Therapeutic effect
1 materials and methods
1.1 laboratory samples: Chinese medicine composition of the present invention, by formula of the present invention and method preparation.
1.2 laboratory animal
Experimental animal is the meat Carnis Coturnicis japonicae of the Sha Weimate of 1 age in days, and totally 360, routine is used for test while raising to 7 age in days.
1.3 experimental design
1.3.1 experiment grouping
Routine is raised to 360 Carnis Coturnicis japonicaes to 7 ages in days, carry out cold stress processing in 12 ± 1 ℃, stress time 7d.In whole process of the test, equal free choice feeding and drinking-water.The clinical manifestation of keeper's observed and recorded.In experimentation, choose and occur that the Carnis Coturnicis japonicae (symptom of digestive tract such as all appearance are depressed, suffer from diarrhoea, have blood in stool, dysentery be all considered as disease quail) of clinical symptoms carries out therapeutic test.Specifically be grouped as follows:
Choose altogether 141 of disease Carnis Coturnicis japonicaes, be divided equally at random 3 groups, be respectively 1 group of traditional Chinese medicine composition for treating (drinking-water administration), traditional Chinese medicine composition for treating 2 groups of (spice administration) and not administration matched groups.
1.3.2 medication administration method
The sick Carnis Coturnicis japonicae of making a definite diagnosis is divided into after 3 groups, and according to the routine dose of administration, the administration of 1 group of drinking-water (is mixed in medicine in drinking-water, after control water, freely drink), 2 groups of spice administrations (medicine being mixed in feedstuff to free choice feeding), successive administration 7 days, not administration matched group is conventional raises.Except medication, it is all consistent that each organizes other conditions such as feeding and management method.
1.3.3 medication efficacy determination
Recovery from illness: after medication 3-5 days, sick Carnis Coturnicis japonicae stops diarrhoea, recovers normal, energetic without hemafecia, feed intake.And after drug withdrawal, in 1 week, nothing recurs again.
Effective: after medication after 6-7 days Carnis Coturnicis japonicae diarrhoea situation alleviate, appetite and spirit compared with their early stage, take a turn for the better to some extent, and after drug withdrawal in 1 week recurrence.
Invalid: in medication process, to occur that improvement does not appear 7 days above (comprising 7 days) in dead and medication yet.
Recurrence: drug withdrawal was recurred in 1 week.
1.4 data analysiss are processed
Test data adopts the GLM module in SAS (Release6.12) statistical software, and the data between processing are carried out to statistical analysis.
Results and analysis
Table 1 clinical test results
| Group | Cure rate | Effective percentage | Inefficiency | Spontaneous recovery rate |
| Chinese medicine drinking-water treatment group | 82.98%(39/47) | 89.36%(42/49) | 10.64%(5/47) | ? |
| Chinese medicine spice administration group | 91.48%(43/47) | ?95.74% (45/47) | 4.26% (2/47) | ? |
| Not administration matched group | ? | ? | ? | 17.02%(8/47) |
Through significance test of difference, group difference is (P < 0.05) significantly.
As can be seen from Table 1, Chinese medicine drinking-water treatment group is 82.98% to the cure rate of Carnis Coturnicis japonicae, and effective percentage is 89.36%, and inefficiency is 10.64%; Chinese medicine spice administration group is 91.48% to the cure rate of Carnis Coturnicis japonicae, and effective percentage is 95.74%, and inefficiency is 4.26%; In not administration matched group, the spontaneous recovery rate of sick quail is 17.02%.Statistic analysis result shows, the cure rate of this compositions and effective percentage are significantly higher than ill not administration group.Illustrate that medicine of the present invention all has obvious curative effects to the Carnis Coturnicis japonicae all kinds enteritis being caused by cold stress, spice administration curative effect is better than drinking-water.
Preventive effect
2 materials and methods
2.1 laboratory samples: the feedstuff that the present invention contains Chinese medicine composition, by formulated of the present invention; Conventional Carnis Coturnicis japonicae diet feed.
2.2 laboratory animal
Experimental animal is the meat Carnis Coturnicis japonicae of the Sha Weimate of 1 age in days, totally 220, during raising to 7 age in days, be divided at random matched group and stress group, every group 110, matched group is that Normal group (feed routinely by Carnis Coturnicis japonicae diet feed, containing normal conventional premix material), stress group is fed, and (by prevention feedstuff of the present invention, prepare is spice administration to the feedstuff that contains Chinese medicine composition, containing normal conventional premix material), other conditions such as two groups of feeding and management methods are all consistent, in whole process of the test, each organizes the equal free choice feeding of young Carnis Coturnicis japonicae and drinking-water, during raising to 16 age in days, carry out prophylactic tria.
Carnis Coturnicis japonicae is carried out to cold stress stimulation: get above-mentioned two groups of equal healthy Carnis Coturnicis japonicaes, get respectively 100 for every group, carry out cold stress processing respectively at 12 ± 1 ℃, stress the time 10d respectively.In whole process of the test, each organizes the equal free choice feeding of young Carnis Coturnicis japonicae and drinking-water, control group fed conventional feed, and stress group is fed and is contained Chinese medicine composition feedstuff, and other feeding and management condition is consistent.The clinical manifestation of keeper's observed and recorded.In experimentation, choose and occur that the Carnis Coturnicis japonicae (symptom of digestive tract such as all appearance are suffered from diarrhoea, had blood in stool, dysentery, lassitude be all considered as disease quail) of enteritis condition of illness counts.
Results and analysis
Table 2 clinical test results
| Group | Morbidity number | Healthy number | Sickness rate | Spontaneous recovery rate |
| Matched group | 39 | 61 | 39% | 7% |
| Stress group | 4 | 96 | 4% | 60% |
Table 2 analysis result shows, illustrates that feedstuff of the present invention all has obvious preventive effect to the Carnis Coturnicis japonicae all kinds enteritis being caused by cold stress.
Preventive effect
3 materials and methods
3.1 laboratory samples: the feedstuff that the present invention contains Chinese medicine composition, by formulated of the present invention; Conventional Carnis Coturnicis japonicae diet feed.
3.2 laboratory animal
Experimental animal is the meat Carnis Coturnicis japonicae of the Sha Weimate of 1 age in days, totally 220, during raising to 7 age in days, be divided at random 2 groups, every group 110, matched group is that Normal group (feed routinely by Carnis Coturnicis japonicae diet feed, containing normal conventional premix material), the stress group feedstuff that contains Chinese medicine composition of feeding (is prepared by prevention feedstuff of the present invention, containing the application's premix material), other condition such as feeding and management method is all consistent, in whole process of the test, each organizes the equal free choice feeding of young Carnis Coturnicis japonicae and drinking-water, raises to 16 ages in days.
To carrying out the stimulation of Carnis Coturnicis japonicae cold stress: get above-mentioned two groups of equal healthy Carnis Coturnicis japonicaes, get respectively 100 for every group, carry out cold stress processing respectively at 12 ± 1 ℃, stress the time 10d respectively.In whole process of the test, each organizes the equal free choice feeding of young Carnis Coturnicis japonicae and drinking-water, searches for food as the conventional daily ration of Carnis Coturnicis japonicae.The clinical manifestation of keeper's observed and recorded.In experimentation, choose and occur that the Carnis Coturnicis japonicae (symptom of digestive tract such as all appearance are suffered from diarrhoea, had blood in stool, dysentery, lassitude be all considered as disease quail) of enteritis condition of illness counts.
Results and analysis
Table 3 clinical test results
| Group | Morbidity number | Healthy number | Sickness rate | Spontaneous recovery rate |
| 1 group | 28 | 72 | 28% | 7% |
| 2 groups | 3 | 97 | 3% | 70% |
Table 3 analysis result shows, illustrates that the specific premix material of the present invention has significantly, further facilitation, has obtained unforeseeable technique effect.
Toxicological test
Experiment one this safety of medicine dosage experiments
Choose 196 of the meat Carnis Coturnicis japonicaes of healthy 1 age in days Sha Weimate, during raising to 7 age in days, be divided at random 2 groups, every group 98,1 group is Normal group (Carnis Coturnicis japonicae diet feed is fed routinely, containing normal conventional premix material), and all the other the 1 group feedstuff that contains Chinese medicine composition of feeding (is prepared with reference to example 4 of the present invention, containing the application's premix material, wherein the metering of Chinese medicine composition is 3 times of example 4).Feed 28 days, within 24 hours after last is fed, weigh, cut open and kill.Duration of test is observed the mental status, feed intake, body weight, the calculating feedstuff-meat ratio of Carnis Coturnicis japonicae, detects blood parameters, liver function, the calculating organ coefficient of Carnis Coturnicis japonicae while butchering.Result shows: the Carnis Coturnicis japonicae mental status of feedstuff of taking Chinese medicine composition dosage and be 3 multiple doses in embodiment 4 is good, feed intake, body weight etc. are all without ANOMALOUS VARIATIONS; Blood parameters, liver function all with matched group without significant difference.This Chinese medicine composition safe without toxic side effect is described.
Test two toxicological experiments
Select 30 of SD rats, take the feedstuff of the embodiment of the present invention 4 preparations, continuous 120 days, after last administration, 24 hours each groups were lived and are killed 1/2 animal, wherein, male and female half and half, all the other 1/2 animals continuation are observed after 2 weeks and are lived and kill.Duration of test is observed outward appearance, behavior, food ration, the body weight of animal, takes feedstuff 120 days and cuts out feedstuff and within 10 weeks, carry out the index checkings such as hematology and blood biochemical, urine biochemistry, organ coefficient, histopathology.Result shows: the animal general state of feedstuff of taking embodiment 4 preparation is good, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Hematological examination, blood biochemical, urine biochemical analysis are all in normal range; Main organs histopathological examination shows no obvious abnormalities.These parameters cuts out feedstuff and after 10 days, also has no change.This test has no significant effect rat with feedstuff 1 for continuous 120 days, and without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the safety of feedstuff 4 clinical practices of the present invention fine.Also can adopt other method of this area to carry out toxicological test.
Claims (7)
1. a herbal composite for the treatment of Carnis Coturnicis japonicae cold stress enteritis, it is characterized in that this herbal composite is prepared from by following raw material, in weight portion: Herba Taraxaci 1-3 part, Cortex Eucommiae 2-4 part, Herba Portulacae 2-4 part, Herba Houttuyniae 3-6 part, Radix Astragali 5-10 part, Fructus Foeniculi 3-5 part, Flos Chrysanthemi Indici 2-4 part, Rhizoma Osmundae 3-6 part, Radix Angelicae Sinensis 3-5 part, Fructus Hordei Germinatus 3-5 part, Rhizoma Atractylodis Macrocephalae 3-5 part, Radix Glycyrrhizae 3-5 part, Folium Isatidis 3-5 part, Fructus Oryzae Germinatus 3-5 part, Galla Chinensis 3-5 part, Rhizoma Zingiberis Recens 3-5 part (preferably Rhizoma Zingiberis Recens is 4 parts).
2. a herbal composite for the treatment of Carnis Coturnicis japonicae cold stress enteritis, it is characterized in that this herbal composite is prepared from by following raw material, in weight portion: 2 parts of Herba Taraxacis, 3 parts of the Cortexs Eucommiae, 3 parts of Herba Portulacaes, 5 parts of Herba Houttuyniae, 7 parts of the Radixs Astragali, 4 parts of Fructus Foeniculi, 3 parts of Flos Chrysanthemi Indicis, 4 parts of Rhizoma Osmundae, 4 parts of Radix Angelicae Sinensis, 4 parts, Fructus Hordei Germinatus, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts, Radix Glycyrrhizae, 4 parts of Folium Isatidiss, 4 parts of Fructus Oryzae Germinatus, 4 parts of Galla Chinensiss, 4 parts, Rhizoma Zingiberis Recens.
3. the preparation method of the herbal composite of a treatment as claimed in claim 1 or 2 Carnis Coturnicis japonicae cold stress enteritis, concrete preparation method is for to be mixed and made into the trickle powder of 600 object by the Herba Taraxaci of described weight portion, the Cortex Eucommiae, Herba Portulacae, Herba Houttuyniae, the Radix Astragali, Fructus Foeniculi, Flos Chrysanthemi Indici, Rhizoma Osmundae, Radix Angelicae Sinensis, Fructus Hordei Germinatus, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis, Fructus Oryzae Germinatus, Galla Chinensis, Rhizoma Zingiberis Recens, the herbal composite of the Carnis Coturnicis japonicae enteritis that obtains medical treatment.
4. the application in the feedstuff of the Carnis Coturnicis japonicae enteritis that the herbal composite of a treatment Carnis Coturnicis japonicae cold stress enteritis as claimed in claim 1 or 2 causes at preparation prevention cold stress.
5. the application in the feedstuff of the Carnis Coturnicis japonicae enteritis that the herbal composite of method acquisition causes at preparation prevention cold stress as claimed in claim 3.
6. the feedstuff of the Carnis Coturnicis japonicae enteritis that the prevention cold stress that prepared by the herbal composite being obtained by method described in claim 3 causes, it is characterized in that, in weight portion: herbal composite 1-10 part, Semen Maydis 50-60 part, bean cake 20-30, fish flour 2-4 part, bone meal 1-2 part, tryptophan 1-2 part, glutamic acid 0.5-1 part, lysine 0.5-1 part, arginine 0.5-1 part, methionine 0.5-1 part, threonine 0.5-1 part, premix material 0.2-0.5 part.
7. feedstuff according to claim 6, wherein, has the consisting of of premix material of further important function to prevention cold stress, in weight portion: vitamin C 0.5-0.8 part, vitamin A 0.5-0.8 part, vitamin D
30.01-0.3 part, vitamin E 0.7-2.0 part, vitamin B
10.05-0.07 part, vitamin B
20.5-1 part, vitamin B
60.1-0.6 part, vitamin B
120.08-0.1 part, folic acid 0.06-0.18 part, biotin 0.02-0.25 part, nicotinic acid 0.8-1.2 part; Manganese sulfate 0.3-0.7 part, zinc sulfate 0.02-0.05 part, ferrous sulfate 0.1-0.5 part, copper sulfate 0.2-0.6 part, choline chloride 1.5-2.1 part, calcium carbonate 18-26 part, calcium hydrogen phosphate 24-31 part.
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Application publication date: 20141119 |