CN102716214B - Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia - Google Patents
Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia Download PDFInfo
- Publication number
- CN102716214B CN102716214B CN2012102200291A CN201210220029A CN102716214B CN 102716214 B CN102716214 B CN 102716214B CN 2012102200291 A CN2012102200291 A CN 2012102200291A CN 201210220029 A CN201210220029 A CN 201210220029A CN 102716214 B CN102716214 B CN 102716214B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- mycotoxin
- medicine composition
- veterinary medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The invention relates to a veterinary medicine composition for preventing and treating mycotoxin pathopoiesia. The veterinary medicine composition is prepared from the follow ingredients in parts by weight: 5 to 25 parts of mildew preventive, 5 to 25 parts of sodium humate, 5 to 25 parts of montmorillonite, 5 to 25 parts of rheum officinale, 5 to 25 parts of scutellaria baicalensis, 5 to 25 parts of coptis chinensis, 5 to 15 parts of liquorice and 5 to 25 parts of radix isatidis. The veterinary medicine composition has the advantages that the specific adsorption capacity is realized, various mycotoxins can be directionally and effectively eliminated, the veterinary medicine composition effectively aims at zearalenone, vomitoxin, aflatoxin, ochratoxin, fumitremorgin, T-2 toxin and the like, the detoxification capability of the liver per se on the toxin can be improved, and the toxin injury to animal bodies is eliminated.
Description
Technical field
The present invention relates to animal medicinal composition, be specifically related to a kind of animal medicinal composition that mycotoxin causes a disease of preventing and treating.
Background technology
Mycotoxin is mycete produces in growth course the secondary metabolites that animal, the mankind and crop are had to larger toxicity.At present known mycotoxin kind surpasses kind more than 300.The toxin that various mycetes produce is different, and the extent of injury caused is not identical yet.Wherein, the toxicity maximum has: flavacin, ochratoxin, anguidin, rotten horse toxin, the rare ketone of Gibberella zeae, vomitoxin, T2 toxin etc.These toxin have all caused immeasurable harm to the development of whole livestock and even the mankind's health.The main harm that mycotoxin causes pig is:
1. the sickness rate of various diseases rises: reproductive and respiratory syndrome, porcine circovirus, pseudorabies, swine fever, chlamydiosis, bow blood worm disease etc. are puzzlement often; 2. fertility performance descends: feed intake descends or refusing to eat, causes the swinery poor growth, and the price of deed reduces, and lean meat percentage also reduces greatly; 3. the body tissue organ is impaired: intestinal injury, and diarrhoea increases; Nephropathy, hematuria water is just; Hepar damnification, function reduction; Lungs are impaired, and acute lung edema increases etc.; 4. Swinery immunity power descends: the protection of vaccine reduces greatly, and the swinery union dyeing is serious, and medication effect is poor, and mortality rate increases greatly.
Mycete and mycotoxin are of a great variety, and different types of mycete and toxin there are differences the infringement of body, and the pathogenic situation of each system, tissue, organ also is not quite similar.After causing clinical onset, the form of expression differs, and cuts open the rear pathological change of inspection widely different, and this brings great difficulty for diagnosis and disposing task of clinical veterinary personnel.
Most people thinks, in feedstuff, add mildew removing agent and just can thoroughly prevent feed mold, or pig not there will be extremely after eating the feedstuff that goes mouldy that adds mildew removing agent.In fact, mildew removing agent can only be sloughed a part of mycete, and effect is not removed and removed to mycotoxin and most mycete.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of detoxification ability that has specific adsorption ability, the various mycotoxins of orientable efficient elimination, can improve the contratoxin of liver own, eliminates the control mycotoxin pathogenic animal medicinal composition of toxin to the animal body infringement.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of pathogenic animal medicinal composition of mycotoxin of preventing and treating, by the raw material of following weight parts, made:
5～25 parts of antifungus agents, 5～25 parts of sodium humates, 5～25 parts of Montmorillonitums, 5～25 parts of Radix Et Rhizoma Rhei, 5～25 parts of Radix Scutellariaes, 5～25 parts of Rhizoma Coptidis, 5～15 parts, Radix Glycyrrhizae, 5～25 parts of Radix Isatidis.
Described animal medicinal composition is made by the raw material of following weight parts:
10～20 parts of antifungus agents, 10～20 parts of sodium humates, 10～20 parts of Montmorillonitums, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Coptidis, 6～12 parts, Radix Glycyrrhizae, 10～20 parts of Radix Isatidis.
Described antifungus agent is at least a in sodium diacetate, propanoic acid and salt thereof, sorbic acid and salt thereof, fumaric acid and esters thereof, p-Hydroxybenzoate, deoxidation acetic acid.
The preparation method of described veterinary drug is as follows:
Screen each raw material, after drying, pulverized respectively 60～120 mesh sieves, take each raw material by described weight portion, after mix homogeneously, packing gets final product.
Usage and dosage: the feedstuff that every 1000kg slightly goes mouldy is mixed with above-mentioned veterinary drug 1000g; The feedstuff that every 500kg moderate is gone mouldy is mixed with above-mentioned veterinary drug 1000g; Need not for the feedstuff suggestion that severe is gone mouldy.
The present invention has actively useful effect:
In side raw materials used blending the east and the west, have complementary advantages, maximize favourable factors and minimize unfavourable ones, the active adsorption surface area of per kilogram this product is equivalent to 5000 square metres of sizes, has the specific adsorption ability, the various mycotoxins of orientable efficient elimination, potent for 6-(10-hydroxy-6-oxo-trans-1-undecenyl)-.beta.-resorcylic acid lactone, vomitoxin, aflatoxin, Toxins,ochra., the bent toxin of cigarette and T-2 toxin etc., can improve the detoxification ability of the contratoxin of liver own, eliminate the infringement of toxin to animal body.
In side, all medicines share: 1. protect the liver and protect gallbladder, clearing away heat-damp and promoting diuresis, the subcutaneous ulcer that disappears jaundice eliminating, YIN nourishing is protected nest, strengthens resistance against diseases, guarantees the poultry total health, reduces M & M; 2. multiple de-mould composition associating onset, the mould fungus inhibition growth, remove mycotoxin to immune inhibition, improves immunity, reduces the susceptibility of disease; 3. can high-efficient cleaning except mycotoxin, and the nutrient substance in adsorption feed not; 4. green, safe, efficient, noresidue in animal body, without bad stimulation, do not affect the absorption of nutrient substance; 5. stable in properties, have good thermostability.
In side, the pharmacological effect brief introduction of each raw material is as follows:
Sodium humate is multi-functional macromolecular compound, contains hydroxyl, quinonyl, and the active group that carboxyl etc. are more, have very large internal surface area, and stronger absorption is arranged, exchange, complexation, sequestering power.Convergence, hemostasis, antidiarrheal.For spitting blood, have blood in stool, have loose bowels, vomiting, epigastric pain.
Montmorillonitum has lamellar structure and heterogeneity CHARGE DISTRIBUTION, and the toxin of the virus in digestive tract, pathogenic bacteria and generation thereof is had to fixing and inhibitory action; Gastrointestinal mucosal is had to covering power, and by with mucous glycoprotein, mutually combining, reparation and the raising gastrointestinal mucosa defense function to virulence factor.
Radix Et Rhizoma Rhei, hardship, cold.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Rhizoma Coptidis, the disease such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., control the card of retention of damp-heat in the interior.
Radix Isatidis, heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.The tool antibiosis and antiviral functions.
Radix Glycyrrhizae has antiinflammatory, antiviral, and the effects such as protecting liver and detoxication and enhancing immunologic function.Contained glycyrrhizin has adsorption to poisonous substance, and glycyrrhizin hydrolyzate glucuronic acid can be combined with poisonous substance, and glycyrrhizin have the effect of adrenocortical hormone sample, the result of the aspect combined factors effects such as detoxification ability of enhancing liver.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Related various raw materials in following embodiment, if no special instructions, be commercially available.
Embodiment 1: be used to preventing sow due to the veterinary drug of taking the feedstuff that goes mouldy and cause disease, made by the raw material of following weight portion:
15 parts of antifungus agents (sodium diacetate), 15 parts of sodium humates, 15 parts of Montmorillonitums, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 10 parts, Radix Glycyrrhizae, 15 parts of Radix Isatidis, get above-mentioned clear wood material drying, pulverize rear 80 mesh sieves of crossing, then get final product by said ratio weigh batching, mixing, the inspection uniformity, packing.
Using method: for the feedstuff slightly gone mouldy, the present invention is according to 1000g spice 1000kg; For moderate, go mouldy, the present invention is according to 1000g spice 500kg; Need not for the feedstuff suggestion that severe is gone mouldy.
Above-mentioned veterinary drug has carried out the clinical practice test at large-scale pig farm:
Test material: approximately 600 of large scale of pig farm field, Puyang sow livestock on hands.50 of the healthy sows of random choose, be divided into two groups at random, 1 group 30 of random experiments, 2 groups 20 of tests, and all sows all carry out feeding and management under identical trophic level and management condition.
The medicated premix amount: the edible moderate of adding medicine of the present invention of the 1st group of sow feedstuff that goes mouldy inserts in feedstuff and feeds according to 500 kilograms of every 1000g spices, second group of edible moderate of not adding medicine of the present invention of sow feedstuff that goes mouldy.
Test method: test 1 group and 2 groups of matched groups of test all routinely feeding and management carry out.Test duration carried out 10 days.Test is in charge of by the special messenger, observes at any time and the spirit that records sow, body temperature and feces situation; During off-test, according to the incidence and mortality of the conventional statistical method statistics of Animal Science sow.
Result of the test: through the test of 10 days, and through the sorting-out in statistics of test data, this test obtained result preferably, in Table 1.
Table 1 Experimental Comparison situation
| ? | Test 1 group | Test 2 groups |
| A sow number (head) | 30 | 20 |
| Sickness rate (%) | 16.7 | 75 |
| Mortality rate (%) | 0 | 10 |
As seen from the above table: in the feedstuff that moderate is gone mouldy, add the said medicine group of feeding, its average attack rate does not add feeding with medicine group of the present invention and reduces by 58.3%, mortality rate low 10%.In feedstuff, add above-mentioned veterinary drug, can obviously reduce the sickness rate of sow, reduce mortality rate.
Embodiment 2: be used for the treatment of piglet due to the veterinary drug of taking the feedstuff that goes mouldy and cause disease, made by the raw material of following weight portion:
10 parts of antifungus agents, 20 parts of sodium humates, 5 parts of Montmorillonitums, 10 parts of Radix Et Rhizoma Rhei, 20 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 15 parts, Radix Glycyrrhizae, 20 parts of Radix Isatidis.Preparation method and using method are with embodiment 1.
The pig farm, Henan, raise 90 of piglets, at the beginning of 2011 6 months, start, identical symptom all appears in piglet successively: extremity split, vomiting, diarrhoea, paralysis etc., dead symptom has appearred successively, take the many places treatment also to have no improvement, the applicant located to go to a doctor afterwards, discovery is that feedstuff has produced moderate and goes mouldy and cause, adopt afterwards 500 kilograms of the every 1000g spices of the present embodiment to insert in feedstuff and feed, coordinate simultaneously measures such as improving feeding and management, after using continuously 7 days, the state of an illness of piglet is significantly controlled, and survival rate also obviously improves.
Embodiment 3: be used for the treatment of growing and fattening pigs due to the veterinary drug of taking the feedstuff that goes mouldy and cause disease, this drug main will comprise the raw material of following parts by weight: 20 parts of antifungus agents, 25 parts of sodium humates, 15 parts of Montmorillonitums, 25 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 25 parts of Rhizoma Coptidis, 15 parts, Radix Glycyrrhizae, 25 parts of Radix Isatidis.Preparation method and using method are with embodiment 1.
Above-mentioned veterinary drug has carried out the clinical practice test at large-scale pig farm, and the test specific embodiments the results are shown in following test report.
For the examination pig, select: approximately 450 of Shandong large scale of pig farm field growing and fattening pigs pig livestock on hands; wherein 89 growing and fattening pigs all occur panting, the performance of enteritis; discovery after diagnosing is that the mycotoxin in feedstuff causes; be divided at random two groups; 1 group 50 of random experiments, 2 groups 39 of tests, feeding and management is all carried out in all growing and fattening pigs under identical trophic level and management condition.
The medicated premix amount: the 1st group of morbidity growing and fattening pigs are added the present invention and are inserted in feedstuff and feed according to 500 kilograms of every 1000g spices, and second group of morbidity growing and fattening pigs interpolation pacified also appropriate (Antitox) powder and inserted in feedstuff and feed according to its operation instruction.
Test method: test 1 group and 2 groups of matched groups of test all routinely feeding and management carry out.Tested continuous 15 days.Test is in charge of by the special messenger, observes at any time and the spirit that records growing and fattening pigs, body temperature and feces situation; During off-test, according to cure rate and the mortality rate of the conventional statistical method statistics of Animal Science growing and fattening pigs.
Result of the test: through the test of 15 days, and through the sorting-out in statistics of test data, this test obtained result preferably, in Table 2.
Table 2 is taken the comparative effectiveness of adding medicine of the present invention and adding other medicine because mycotoxin causes the growing and fattening pigs of morbidity
| ? | Test 1 group | Test 2 groups |
| Fatten pig's head number (head) | 50 | 39 |
| Cure rate (%) | 86 | 76.9 |
| Mortality rate (%) | 4 | 7.6 |
As seen from the above table: in the feedstuff that moderate is gone mouldy, add feeding with medicine group of the present invention, its average cure rate adds disease medicament that other treatment mycotoxin the causes group of feeding and improves 1.12%, and mortality rate reduces by 3.6%.In feedstuff, add said medicine, can obviously improve the cure rate of growing and fattening pigs, reduce mortality rate.Increase economic efficiency.
Claims (4)
1. prevent and treat the animal medicinal composition that mycotoxin causes a disease for one kind, made by the raw material of following weight parts:
5～25 parts of antifungus agents, 5～25 parts of sodium humates, 5～25 parts of Montmorillonitums, 5～25 parts of Radix Et Rhizoma Rhei, 5～25 parts of Radix Scutellariaes, 5～25 parts of Rhizoma Coptidis, 5～15 parts, Radix Glycyrrhizae, 5～25 parts of Radix Isatidis.
2. the pathogenic animal medicinal composition of control mycotoxin according to claim 1, is characterized in that, described animal medicinal composition is made by the raw material of following weight parts:
10～20 parts of antifungus agents, 10～20 parts of sodium humates, 10～20 parts of Montmorillonitums, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Coptidis, 6～12 parts, Radix Glycyrrhizae, 10～20 parts of Radix Isatidis.
3. the animal medicinal composition that causes a disease of control mycotoxin according to claim 1, it is characterized in that, described antifungus agent is at least a in sodium diacetate, propanoic acid and salt thereof, sorbic acid and salt thereof, fumaric acid and esters thereof, p-Hydroxybenzoate, deoxidation acetic acid.
4. the pathogenic animal medicinal composition of control mycotoxin according to claim 1, is characterized in that, the preparation method of described veterinary drug is as follows:
Screen each raw material, after drying, pulverized respectively 60～120 mesh sieves, take each raw material by described weight portion, packing after mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102200291A CN102716214B (en) | 2012-06-29 | 2012-06-29 | Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102200291A CN102716214B (en) | 2012-06-29 | 2012-06-29 | Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102716214A CN102716214A (en) | 2012-10-10 |
| CN102716214B true CN102716214B (en) | 2013-11-27 |
Family
ID=46942169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102200291A Expired - Fee Related CN102716214B (en) | 2012-06-29 | 2012-06-29 | Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102716214B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103875916B (en) * | 2012-12-20 | 2016-01-27 | 信宜市金方子生物科技有限公司 | Chinese herbal medicine type feed mould inhibitor |
| CN103169823B (en) * | 2013-04-18 | 2014-09-24 | 四川农业大学 | Veterinary drug composition for preventing and controlling mycotoxicoses as well as application, preparation and preparation method of veterinary drug composition |
| CN103583823A (en) * | 2013-11-07 | 2014-02-19 | 北京大北农科技集团股份有限公司 | Mold removal agent for feed and preparation method and feed additive thereof |
| CN105749244B (en) * | 2016-04-12 | 2019-02-05 | 浙江艾杰斯生物科技有限公司 | A kind of antidote for preventing and treating poultry aflatoxicosis disease |
| CN113827600B (en) * | 2021-11-11 | 2024-01-26 | 湖南农业大学 | Application of betulinic acid in preparing antidote for F-2 toxin poisoning, antidote and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008585B (en) * | 2009-09-08 | 2011-12-14 | 河南惠通天下动物药业有限公司 | Sihuang anti-dysentery effervescent particle and preparation method thereof |
-
2012
- 2012-06-29 CN CN2012102200291A patent/CN102716214B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102716214A (en) | 2012-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102716214B (en) | Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia | |
| CN103893272A (en) | Pharmaceutical composition for treating livestock diarrhea and preparation method thereof | |
| CN103006916A (en) | Pure traditional Chinese medicine recipe for curing various animal diarrhoeal diseases and preparation method of pure traditional Chinese medicine recipe | |
| CN105685476A (en) | Grouper feed and preparing method thereof | |
| CN103006892A (en) | Medicine composition for preventing and treating porcine viral diseases, and premix and batch with composition | |
| CN102078522A (en) | Chinese medicine composition for treating enterovirus syndrome in chicken | |
| CN111789190A (en) | Traditional Chinese medicine feed additive for improving animal organism immunity, feed and preparation method | |
| CN102743657B (en) | Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof | |
| CN104543576B (en) | Prevent and treat composite vegetables extractive feed addictive and its preparation method application of grice diarrhoea | |
| CN103623121B (en) | A kind of for thousand order Chinese veterinary drug preparation of preventing and treating livestock and birds respiratory disease and preparation method thereof | |
| WO2014134846A1 (en) | Traditional chinese medicine composition for treating dairy cow laminitis and preparation method for same | |
| CN105168807A (en) | Traditional Chinese medicine composition for treating porcine reproductive and respiratory syndrome and preparation method thereof | |
| CN109999117A (en) | Prevent and treat enteritis, bacillary dysentery, dysentery, intractable diarrhea Chinese medicine composition | |
| CN113181317B (en) | Traditional Chinese medicine composition, preparation method thereof and application thereof in preventing diarrhea or resisting diarrhea | |
| CN105250972A (en) | Traditional Chinese medicine composition for preventing and treating poultry proventriculitis and preparation method and application thereof | |
| CN104147586A (en) | Chinese herbal medicine composition and fodder for preventing and treating cold irritable enteritis of quails | |
| CN104083729A (en) | Medicine for preventing and treating mixed infection of fur-bearing animals as well as preparation method and application of medicine | |
| CN110812389B (en) | Soluble granule for improving pig immunity and preparation method thereof | |
| CN107308415A (en) | One group is used to treat Chinese medicine composition of cad pig and preparation method thereof | |
| CN103768453A (en) | Traditional Chinese medicine composite having effects of strengthening stomach, promoting digestion and relaxing bowels, and preparation method of traditional Chinese medicine composite | |
| CN102885927A (en) | Traditional Chinese medicine composition for treating pullorum disease and preparation method thereof | |
| CN105724831A (en) | Grouper feed and preparation method thereof | |
| CN110755604A (en) | Pharmaceutical composition for preventing and treating poultry adenofibromyositis and application thereof | |
| CN114191510B (en) | Chinese herbal compound preparation for preventing and treating diarrhea of piglets and preparation method thereof | |
| CN103263538A (en) | Traditional Chinese medicine combination with nourishing, anti-inflammation, antidiarrheal, hemostatic and analgesic effects for livestock and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HENAN ZHONGYA SHENPENG PHARMACEUTICAL TECHNOLOGY C Free format text: FORMER NAME: HENAN ZHONGYA SHENPENG ANIMAL MEDICINE CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 450061 eighteen Li River town, Zhengzhou City, Henan Province Patentee after: HENAN ZHONGYA SHENPENG MEDICAL TECHNOLOGY CO., LTD. Address before: 450061 eighteen Li River town, Zhengzhou City, Henan Province Patentee before: Henan Zhongya Shenpeng Animal Medicine Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131127 Termination date: 20190629 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |