CN102716214A - Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia - Google Patents
Veterinary medicine composition for preventing and treating mycotoxin pathopoiesia Download PDFInfo
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- CN102716214A CN102716214A CN2012102200291A CN201210220029A CN102716214A CN 102716214 A CN102716214 A CN 102716214A CN 2012102200291 A CN2012102200291 A CN 2012102200291A CN 201210220029 A CN201210220029 A CN 201210220029A CN 102716214 A CN102716214 A CN 102716214A
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Abstract
The invention relates to a veterinary medicine composition for preventing and treating mycotoxin pathopoiesia. The veterinary medicine composition is prepared from the follow ingredients in parts by weight: 5 to 25 parts of mildew preventive, 5 to 25 parts of sodium humate, 5 to 25 parts of montmorillonite, 5 to 25 parts of rheum officinale, 5 to 25 parts of scutellaria baicalensis, 5 to 25 parts of coptis chinensis, 5 to 15 parts of liquorice and 5 to 25 parts of radix isatidis. The veterinary medicine composition has the advantages that the specific adsorption capacity is realized, various mycotoxins can be directionally and effectively eliminated, the veterinary medicine composition effectively aims at zearalenone, vomitoxin, aflatoxin, ochratoxin, fumitremorgin, T-2 toxin and the like, the detoxification capability of the liver per se on the toxin can be improved, and the toxin injury to animal bodies is eliminated.
Description
Technical field
The present invention relates to animal medicinal composition, be specifically related to the morbific animal medicinal composition of a kind of control mycotoxin.
Background technology
Mycotoxin be mycete in growth course, produce animal, the mankind and crop are had bigger toxic secondary metabolites.Present known mycotoxin kind surpasses kind more than 300.The toxin that various mycete produced has nothing in common with each other, and the extent of injury that causes is also inequality.What wherein, toxicity was maximum has: flavacin, ochratoxin, anguidin, rotten horse toxin, the rare ketone of Gibberella zeae, vomitoxin, T2 toxin etc.These toxin have all caused immeasurable harm to the development and even the human beings'health of whole herding industry.The main harm that mycotoxin causes pig is:
1. the sickness rate of various diseases rises: reproductive and respiratory syndrome, porcine circovirus, pseudorabies, swine fever, chlamydiosis, bow blood worm disease etc. are puzzlement often; 2. fertility performance descends: feed intake descends or refusing to eat, causes the swinery poor growth, and the price of deed reduces, and lean meat percentage also reduces greatly; 3. the body tissue organ is impaired: intestinal injury, and diarrhoea increases; Nephropathy, hematuria water is just; Hepar damnification, function reduction; Lungs are impaired, and acute lung edema increases etc.; 4. swinery immunity degradation: the protection of vaccine reduces greatly, and the swinery union dyeing is serious, and medication effect is poor, and mortality rate increases greatly.
Mycete and mycotoxin are of a great variety, and different types of mycete and toxin there are differences the infringement of body, and the pathogenic situation of each system, tissue, organ also is not quite similar.The form of expression differs after causing clinical onset, and it is widely different to cut open inspection back pathological change, and this brings great difficulty for clinical veterinary personnel's diagnosis and disposing task.
Most of people think, add mildew removing agent in the feedstuff and just can thoroughly prevent feed mold, or pig can not occur unusually after eating the feedstuff that goes mouldy that adds mildew removing agent.In fact, mildew removing agent can only be sloughed a part of mycete, and effect is not removed and removed to mycotoxin and most mycete.
Summary of the invention
The technical problem that the present invention will solve provides a kind of detoxification ability that has specific adsorption ability, the various mycotoxins of orientable efficient elimination, can improve the contratoxin of liver own, eliminates the control mycotoxin morbific animal medicinal composition of toxin to the animal body infringement.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is:
The morbific animal medicinal composition of a kind of control mycotoxin, process by the raw material of following weight parts:
5～25 parts of antifungus agents, 5～25 parts of sodium humates, 5～25 parts of Montmorillonitums, 5～25 parts of Radix Et Rhizoma Rhei, 5～25 parts of Radix Scutellariaes, 5～25 parts of Rhizoma Coptidis, 5～15 parts in Radix Glycyrrhizae, 5～25 parts of Radix Isatidis.
Said animal medicinal composition is processed by the raw material of following weight parts:
10～20 parts of antifungus agents, 10～20 parts of sodium humates, 10～20 parts of Montmorillonitums, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Coptidis, 6～12 parts in Radix Glycyrrhizae, 10～20 parts of Radix Isatidis.
Said antifungus agent is at least a in sodium diacetate, propanoic acid and salt thereof, sorbic acid and salt thereof, fumaric acid and esters thereof, p-Hydroxybenzoate, the deoxidation acetic acid.
The method for preparing of said veterinary drug is following:
Screen each raw material, dry back pulverize separately is crossed 60～120 mesh sieves, takes by weighing each raw material by said weight portion, and packing gets final product behind the mix homogeneously.
Usage and dosage: the feedstuff that every 1000kg slightly goes mouldy is mixed with above-mentioned veterinary drug 1000g; The feedstuff that every 500kg moderate is gone mouldy is mixed with above-mentioned veterinary drug 1000g; Feedstuff suggestion for severe is gone mouldy need not.
The present invention has actively useful effect:
In the side raw materials used blending the east and the west, have complementary advantages, maximize favourable factors and minimize unfavourable ones; The active adsorption surface area of these article of per kilogram is equivalent to 5000 square metres of sizes; Has the specific adsorption ability, the various mycotoxins of orientable efficient elimination, the strong effect to 6-(10-hydroxy-6-oxo-trans-1-undecenyl)-.beta.-resorcylic acid lactone, vomitoxin, aflatoxin, Toxins,ochra., the bent toxin of cigarette and T-2 toxin etc.; Can improve the detoxification ability of the contratoxin of liver own, eliminate the infringement of toxin animal body.
All medicines share in the side: 1. protect the liver and protect gallbladder, clearing away heat-damp and promoting diuresis, the subcutaneous ulcer that disappears jaundice eliminating, nest is protected in YIN nourishing, strengthens resistance against diseases, guarantees the poultry total health, reduces M & M; 2. multiplely take off mould composition associating onset, the mould fungus inhibition growth is removed mycotoxin to immune inhibition, improves immunity, reduces the susceptibility of disease; 3. can efficiently remove mycotoxin, and the nutrient substance in the adsorption feed not; 4. green, safety, efficient, noresidue does not in animal body have bad stimulation, does not influence the absorption of nutrient substance; 5. stable in properties has good thermostability.
The pharmacological effect brief introduction of each raw material is following in the side:
Sodium humate is multi-functional macromolecular compound, contains hydroxyl, quinonyl, and the active group that carboxyl etc. are more has very big internal surface area, and stronger absorption is arranged, exchange, complexation, sequestering power.Convergence, hemostasis, antidiarrheal.Be used for spitting blood, have blood in stool, have loose bowels, vomiting, epigastric pain.
Montmorillonitum has lamellar structure and heterogeneity CHARGE DISTRIBUTION, and the toxin of the virus in the digestive tract, pathogenic bacteria and generation thereof is had fixing and inhibitory action; Gastrointestinal mucosal is had covering power, and through mutually combining with MGP, reparation and raising gastrointestinal mucosa are to the defense function of virulence factor.
Radix Et Rhizoma Rhei, hardship, cold.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Rhizoma Coptidis is used for diseases such as retention of damp-heat in the interior, the intestines and stomach are damp and hot, vomiting, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., control the card of retention of damp-heat in the interior.
Radix Isatidis, heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving.The tool antibiosis and antiviral functions.
Radix Glycyrrhizae has antiinflammatory, antiviral and effects such as protecting liver and detoxication and raise immunity.Contained glycyrrhizin has adsorption to poisonous substance, and glycyrrhizin hydrolyzate glucuronic acid can combine with poisonous substance, and GLYCYRRHIN have the effect of adrenocortical hormone appearance, the result of the aspect combined factors effects such as detoxification ability of enhancing liver.
The specific embodiment
Further set forth the present invention below in conjunction with specific embodiment.Related various raw materials among the following embodiment if no special instructions, are commercially available.
Embodiment 1: be used to prevent sow owing to taking the veterinary drug that the feedstuff that goes mouldy causes disease, processed by the raw material of following weight portion:
15 parts of antifungus agents (sodium diacetate), 15 parts of sodium humates, 15 parts of Montmorillonitums, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 10 parts in Radix Glycyrrhizae, 15 parts of Radix Isatidis; Cross 80 mesh sieves after getting above-mentioned clear wood material drying, pulverizing, get final product by said ratio weigh batching, mixing, the inspection uniformity, packing again.
Method for using: for the feedstuff that slightly goes mouldy, the present invention is according to 1000g spice 1000kg; Go mouldy for moderate, the present invention is according to 1000g spice 500kg; Feedstuff suggestion for severe is gone mouldy need not.
Above-mentioned veterinary drug has carried out the clinical practice test at large-scale pig farm:
Test material: about 600 of large scale of pig farm field, Puyang sow livestock on hand.50 of the healthy sows of random choose are divided into two groups at random, 1 group 30 of random experiments, 2 groups 20 of tests, and all sows all carry out feeding and management under identical trophic level and management condition.
The medicated premix amount: the edible moderate of adding medicine of the present invention of the 1st group of sow feedstuff that goes mouldy inserts in the feedstuff for 500 kilograms according to every 1000g spice and feeds, second group of edible moderate of not adding medicine of the present invention of sow feedstuff that goes mouldy.
Test method: test 1 group with the test 2 groups of matched groups all undertaken by conventional feeding and management.Test duration carried out 10 days.Test is in charge of by the special messenger, observes spirit, body temperature and feces situation with the record sow at any time; During off-test, according to the incidence and mortality of the conventional statistical method statistics of Animal Science sow.
Result of the test: through 10 days test, and through the sorting-out in statistics of test data, this test obtained result preferably, sees table 1.
Table 1 test contrast situation
| ? | Test 1 group | Test 2 groups |
| A sow number (head) | 30 | 20 |
| Sickness rate (%) | 16.7 | 75 |
| Mortality rate (%) | 0 | 10 |
Visible by last table: add the said medicine group of feeding in the feedstuff that moderate is gone mouldy, its average attack rate does not add feeding with medicine group of the present invention and reduces by 58.3%, and mortality rate hangs down 10%.Add above-mentioned veterinary drug in the feedstuff, can obviously reduce the sickness rate of sow, reduce mortality rate.
Embodiment 2: be used to treat piglet owing to taking the veterinary drug that the feedstuff that goes mouldy causes disease, processed by the raw material of following weight portion:
10 parts of antifungus agents, 20 parts of sodium humates, 5 parts of Montmorillonitums, 10 parts of Radix Et Rhizoma Rhei, 20 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae, 20 parts of Radix Isatidis.Method for preparing and method for using are with embodiment 1.
90 of piglets are raised on the pig farm, Henan, beginning at the beginning of 2011 6 months; Identical symptom all appears in piglet successively: extremity split, vomiting, diarrhoea, paralysis etc., and dead symptom has appearred successively, and take many places to treat the commentaries on classics of also not getting better; The applicant located to go to a doctor afterwards, and discovery is that feedstuff has produced moderate and goes mouldy and cause, adopts the every 1000g spice of present embodiment to insert in the feedstuff for 500 kilograms afterwards and feeds; Cooperate measures such as improving feeding and management simultaneously; Use after 7 days continuously, the state of an illness of piglet obtains obvious control, and survival rate also obviously improves.
Embodiment 3: be used to treat growing and fattening pigs owing to taking the veterinary drug that the feedstuff that goes mouldy causes disease, this drug main will comprise the raw material of following parts by weight: 20 parts of antifungus agents, 25 parts of sodium humates, 15 parts of Montmorillonitums, 25 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 25 parts of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae, 25 parts of Radix Isatidis.Method for preparing and method for using are with embodiment 1.
Above-mentioned veterinary drug has carried out the clinical practice test at large-scale pig farm, and test specific embodiments result sees following test report.
Supply the examination pig to select: about 450 of Shandong large scale of pig farm field growing and fattening pigs pig livestock on hand; Wherein 89 growing and fattening pigs all occur panting, the performance of enteritis; Discovery after diagnosing is that the mycotoxin in the feedstuff causes; Be divided into two groups at random, 1 group 50 of random experiments, 2 groups 39 of tests, feeding and management is all carried out in all growing and fattening pigs under identical trophic level and management condition.
The medicated premix amount: the 1st group of morbidity growing and fattening pigs interpolation the present invention inserts in the feedstuff for 500 kilograms according to every 1000g spice and feeds, and second group of morbidity growing and fattening pigs interpolation peace also appropriate (Antitox) powder inserts in the feedstuff according to its operation instruction and feed.
Test method: test 1 group with the test 2 groups of matched groups all undertaken by conventional feeding and management.Tested continuous 15 days.Test is in charge of by the special messenger, observes spirit, body temperature and feces situation with the record growing and fattening pigs at any time; During off-test, according to the cure rate and the mortality rate of the conventional statistical method statistics of Animal Science growing and fattening pigs.
Result of the test: through 15 days test, and through the sorting-out in statistics of test data, this test obtained result preferably, sees table 2.
Table 2 is taken the comparative effectiveness of adding medicine of the present invention and other medicine of interpolation because mycotoxin causes the growing and fattening pigs of morbidity
| ? | Test 1 group | Test 2 groups |
| Fatten pig's head number (head) | 50 | 39 |
| Cure rate (%) | 86 | 76.9 |
| Mortality rate (%) | 4 | 7.6 |
Visible by last table: add feeding with medicine group of the present invention in the feedstuff that moderate is gone mouldy, its average cure rate adds disease medicament that other treatment mycotoxin the causes group of feeding and improves 1.12%, and mortality rate reduces by 3.6%.Add said medicine in the feedstuff, can obviously improve the cure rate of growing and fattening pigs, reduce mortality rate.Increase economic efficiency.
Claims (4)
1. prevent and treat the morbific animal medicinal composition of mycotoxin for one kind, process by the raw material of following weight parts:
5～25 parts of antifungus agents, 5～25 parts of sodium humates, 5～25 parts of Montmorillonitums, 5～25 parts of Radix Et Rhizoma Rhei, 5～25 parts of Radix Scutellariaes, 5～25 parts of Rhizoma Coptidis, 5～15 parts in Radix Glycyrrhizae, 5～25 parts of Radix Isatidis.
2. the morbific animal medicinal composition of control mycotoxin according to claim 1 is characterized in that said animal medicinal composition is processed by the raw material of following weight parts:
10～20 parts of antifungus agents, 10～20 parts of sodium humates, 10～20 parts of Montmorillonitums, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Coptidis, 6～12 parts in Radix Glycyrrhizae, 10～20 parts of Radix Isatidis.
3. the morbific animal medicinal composition of control mycotoxin according to claim 1; It is characterized in that said antifungus agent is at least a in sodium diacetate, propanoic acid and salt thereof, sorbic acid and salt thereof, fumaric acid and esters thereof, p-Hydroxybenzoate, the deoxidation acetic acid.
4. the morbific animal medicinal composition of control mycotoxin according to claim 1 is characterized in that the method for preparing of said veterinary drug is following:
Screen each raw material, dry back pulverize separately is crossed 60～120 mesh sieves, takes by weighing each raw material by said weight portion, packing behind the mix homogeneously.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103169823A (en) * | 2013-04-18 | 2013-06-26 | 四川农业大学 | Veterinary drug composition for preventing and controlling mycotoxicoses as well as application, preparation and preparation method of veterinary drug composition |
| CN103583823A (en) * | 2013-11-07 | 2014-02-19 | 北京大北农科技集团股份有限公司 | Mold removal agent for feed and preparation method and feed additive thereof |
| CN103875916A (en) * | 2012-12-20 | 2014-06-25 | 信宜市金方子生物科技有限公司 | Chinese herbal medicine-type feed mildew inhibitor |
| CN105749244A (en) * | 2016-04-12 | 2016-07-13 | 浙江艾杰斯生物科技有限公司 | Antidote for preventing and treating livestock aflatoxicosis |
| CN113827600A (en) * | 2021-11-11 | 2021-12-24 | 湖南农业大学 | Application of betulinic acid in preparation of antidote for F-2 toxin poisoning, antidote and application of antidote |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103875916A (en) * | 2012-12-20 | 2014-06-25 | 信宜市金方子生物科技有限公司 | Chinese herbal medicine-type feed mildew inhibitor |
| CN103875916B (en) * | 2012-12-20 | 2016-01-27 | 信宜市金方子生物科技有限公司 | Chinese herbal medicine type feed mould inhibitor |
| CN103169823A (en) * | 2013-04-18 | 2013-06-26 | 四川农业大学 | Veterinary drug composition for preventing and controlling mycotoxicoses as well as application, preparation and preparation method of veterinary drug composition |
| WO2014169542A1 (en) * | 2013-04-18 | 2014-10-23 | 四川农业大学 | Veterinary drug composition for preventing and treating mycotoxin poisoning, and use, formulation and preparation method thereof |
| CN103583823A (en) * | 2013-11-07 | 2014-02-19 | 北京大北农科技集团股份有限公司 | Mold removal agent for feed and preparation method and feed additive thereof |
| CN105749244A (en) * | 2016-04-12 | 2016-07-13 | 浙江艾杰斯生物科技有限公司 | Antidote for preventing and treating livestock aflatoxicosis |
| CN105749244B (en) * | 2016-04-12 | 2019-02-05 | 浙江艾杰斯生物科技有限公司 | A kind of antidote for preventing and treating poultry aflatoxicosis disease |
| CN113827600A (en) * | 2021-11-11 | 2021-12-24 | 湖南农业大学 | Application of betulinic acid in preparation of antidote for F-2 toxin poisoning, antidote and application of antidote |
| CN113827600B (en) * | 2021-11-11 | 2024-01-26 | 湖南农业大学 | Application of betulinic acid in preparing antidote for F-2 toxin poisoning, antidote and application thereof |
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Owner name: HENAN ZHONGYA SHENPENG PHARMACEUTICAL TECHNOLOGY C Free format text: FORMER NAME: HENAN ZHONGYA SHENPENG ANIMAL MEDICINE CO., LTD. |
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