CN102743657B - Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing piglet dysentery and a preparation method thereof. The traditional Chinese medicine composition, by weight, comprises 5-20 parts of bulk pharmaceutical chemicals hawthorn, 5-20 parts of malt, 5-25 parts of pericarpium citri reticulatae, 5-25 parts of medicated leaven, 10-30 parts of radix bupleuri, 10-30 parts of root of Chinese pulsatilla and 10-30 parts of root of common peony. Firstly needed bulk pharmaceutical chemicals are processed to be clean, then drying and smashing are carried out, various bulk pharmaceutical chemical powder are weighted to be sufficiently and evenly mixed, finally split charging is carried out. The traditional Chinese medicine composition can effectively prevent and treat various irritability diarrheas, trophism diarrheas and yellow and white dysentery caused by escherichia coli, has obvious effects on viral diarrheas, can protect and repair intestinal mucosa and recovers digestion capability of piglets.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition and method of making the same of preventing and treating piglet diarrhoea.
Background technology
Piglet diarrhea is a kind of typical ubiquitous multifactor property disease, is to threaten at present one of the most serious disease of piglet growth, is also the major reason that causes piglet death.The Alimentary growth of ablactational baby pig is not perfect, after weaned piglet owing to being subject to various impacts that stress (daily ration changes, maternal antibody disappearance, turn group and wean etc.), intestinal villi is easy to be subject to the destruction of antibacterial and normal wean measure, thereby affects effective absorption of nutrient substance.When nutrient substance can not obtain fine digesting and assimilating, dysbacteriosis and toxin poisoning that harmful colibacillary breeding causes are extremely serious to the harm of ablactational baby pig, then there is take the serial disease of ablactational baby pig that diarrhoea, edema are cardinal symptom: as feed intake decline, gastric acid deficiency, poor growth, stagnation, negative growth, the generation postweaning multisystemic wasting syndrome even having and death.
In recent years, because the dead piglet of suffering from diarrhoea accounts for 39.8% of the dead sum of piglet.In China, because pig industry practitioner's technical merit, management level are lower, aquaculture model mostly is raises scattered or cultivation on a small scale, causes the sickness rate of piglet diarrhea higher.The annual sickness rate of piglet is 46.5%, and mortality rate is 10～15%, to pig industry, causes larger economic loss.
At present, herding is produced, and control suckling pig diarrhoea is mainly by improving feeding and management condition, with measures such as antibiotics, reduces the generation of suckling pig diarrhoeal diseases, and piglet is mainly to make a living with breast milk, oral administration difficulty, what intramuscular administration strengthened again piglet stress.Antibiotic is invalid to viral disease, and the antibacterials such as escherichia coli, Salmonella very easily produce drug resistance to antibiotic, and antibacterial drug therapy often effect is bad or invalid.Life-time service or abuse of antibiotics, can cause pathogen Drug resistance to increase gradually, causes the use amount of antibiotics increasing.And the long-term a large amount of antibacterials of using easily cause archenteric flora imbalance, be diarrhoeal diseases more refractory more, easily form cad pig.Simultaneously antibiotic residual, have a strong impact on the mankind's health and bio-safety etc., livestock-raising is produced and brought huge pressure.
Summary of the invention
The object of the invention is the weak point for existing control piglet diarrhea medicine and method existence, a kind of Chinese medicine composition and method of making the same of preventing and treating piglet diarrhoea is provided.Chinese medicine composition of the present invention prevents and treats the HUANGBAI(sic) dysentery that various irritability diarrhoea, trophism diarrhea and escherichia coli cause, comparatively obvious to viral diarrhea effect; And can protect and repair intestinal mucosa, recover the digestion power of piglet.
In order to address the above problem, the technical scheme that the present invention takes is:
The invention provides a kind of Chinese medicine compositions of preventing and treating piglet diarrhoea, with weight portion, represent, described Chinese medicine composition is by 5～20 parts of crude drug Fructus Crataegis, 5～20 parts, Fructus Hordei Germinatus, 5～25 parts of Pericarpium Citri Reticulataes, 5～25 parts of Massa Medicata Fermentata, 10～30 parts of Radix Bupleuri, 10～30 parts of the Radix Pulsatillaes and 10～30 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, described Chinese medicine composition is by 5～10 parts of crude drug Fructus Crataegis, 5～10 parts, Fructus Hordei Germinatus, 5～10 parts of Pericarpium Citri Reticulataes, 5～10 parts of Massa Medicata Fermentata, 10～15 parts of Radix Bupleuri, 10～15 parts of the Radix Pulsatillaes and 10～15 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, described Chinese medicine composition is by 10～15 parts of crude drug Fructus Crataegis, 10～15 parts, Fructus Hordei Germinatus, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Massa Medicata Fermentata, 15～25 parts of Radix Bupleuri, 15～25 parts of the Radix Pulsatillaes and 15～25 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, described Chinese medicine composition is by 15～20 parts of crude drug Fructus Crataegis, 15～20 parts, Fructus Hordei Germinatus, 20～25 parts of Pericarpium Citri Reticulataes, 20～25 parts of Massa Medicata Fermentata, 25～30 parts of Radix Bupleuri, 25～30 parts of the Radix Pulsatillaes and 25～30 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, the preparation method of described Chinese medicine compositions is: according to the required crude drug of above-mentioned control piglet diarrhoea Chinese medicine compositions, prepare various raw materials, first required various crude drug are processed clean, then be dried successively, pulverize, after pulverizing, cross 80 mesh sieves, after pulverizing, obtain the medicated powder of various crude drug; Proportioning ratio according to above-mentioned control piglet diarrhoea Chinese medicine compositions takes the crude drug medicated powder after various pulverizing, then the various crude drug medicated powder that take is mixed, and fully mix homogeneously, finally carries out subpackage.
The pharmacological action of the present invention's various crude drug used:
Fructus Crataegi: this product sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.Effect: this product has appetite-stimulating indigestion-relieving, changes stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the effects such as circulation of qi promoting of reducing phlegm.Be usually used in carnivorous stagnant amassing, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, has loose bowels, the cards such as discharging fresh blood stool.
Modern medicine study: this product, containing materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum, has the effects such as blood fat reducing, blood pressure lowering, heart tonifying and arrhythmia.Flavone compound vitexin in Fructus Crataegi, is the medicine that a kind of antitumaous effect is stronger, and Fructus Crataegi extract all has certain inhibitory action to cancerous cell tumor growth, propagation and infiltration metastasis.Fructus Crataegi energy prevention and cure of cardiovascular disease, has blood vessel dilating, heart tonifying, increase coronary flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also helpful to senile heart disease.
Fructus Hordei Germinatus: this product sweet in the mouth, property is flat; Return spleen, stomach warp.Effect: this product has promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effects such as newborn relieving distension.Be usually used in food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, women's ablactation, Fructus Hordei Germinatus invigorating the spleen and regulating the stomach lactogenesis.
Modern medicine study: the main amylase-containing of this product, conversion carbohydrase, vitamin B, fat, phospholipid, dextrin, maltose, glucose etc.There is the effects such as digestion-aid effect, hypoglycemic activity, antifungic action, inhibition prolactin antagonist are released into, also have radioactive protective action.
Pericarpium Citri Reticulatae: this product acrid in the mouth, hardship, warm in nature; Enter spleen, stomach, lung meridian.Effect: this product has regulating qi-flowing for strengthening spleen, in tune, dampness, the effect such as reduce phlegm; The conventional distension and fullness in the abdomen of controlling stagnation of QI in spleen and stomach or pain, dyspepsia, abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance, phlegm-damp is stopped up the cards such as cough and asthma of lung.
Modern medicine study: main containing volatile oil in this product, separately containing flavones ingredient, hesperidin, the compositions such as Nobiletin and Neosynephrine.
Contained volatile oil in Pericarpium Citri Reticulatae, has gentle stimulation to gastrointestinal tract, and pneumatosis in intestinal tube is got rid of in secretion that can facilitating digestion liquid, has shown the effectiveness of fragrant stomach invigorating and the therapeutic method to keep the adverse QI flowing downwards of dispeling the wind; The arteriosclerosis that pectin in Pericarpium Citri Reticulatae causes high fat diet has certain preventive effect; In Pericarpium Citri Reticulatae, the irritant passive phlegm-dispelling functions of contained volatile oil, makes the easy expectoration of sputum; Pericarpium Citri Reticulatae decoct has faint dilating effect to bronchus, and it is higher that the relievining asthma of its ethanol extract tired; Pericarpium Citri Reticulatae decoct can make kidney vasoconstriction, makes hypourocrinia; Pericarpium Citri Reticulatae has the effects such as antiinflammatory.
Massa Medicata Fermentata: this product bitter in the mouth, warm in nature, enters spleen, stomach, large intestine channel.Effect: this product has strengthening the spleen to promote digestion, regulating QI to expel dampness, the effect such as induce sweat; The conventional food feeling of stuffiness in chest of controlling, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, children's hinders hungry full grade for the card that loses.
Modern medicine study: contain yeast in Massa Medicata Fermentata, its composition has volatile oil, glycoside, fatty oil and vitamin B etc.This product has the effect of vitamin B group sample, as appetite stimulator, maintains normal stool function etc.
Radix Bupleuri: this product bitter in the mouth, pungent, cold nature; Enter Liver Channel, gallbladder meridian.Effect: this product has expelling pathogenic factors from the exterior and expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, the cards such as elevate a turnable ladder yang-energy; The conventional heating that cures cold, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.
Modern medicine study: its composition of Radix Bupleuri mainly contains saikoside, sterol, volatile oil (bupleurumol, eugenol etc.), fatty acid (oleic acid, linoleic acid, Palmic acid, stearic acid etc.) and polysaccharide etc.This product has antipyretic, antiinflammatory, Promote immunity function, anti-liver injury, the effects such as Antiradiation injury.
The Radix Pulsatillae: this product bitter in the mouth, cold in nature; Enter stomach, large intestine channel.Effect: this product has heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, the effects such as removing dampness and killing parasites; Commonly use and control pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, the cards such as scrofula.
Modern medicine study: Radix Pulsatillae root master is containing anemoside.This product has anti-ameba effect, anti-trichomonas vaginitis effect, antibacterial action, the effects such as antiviral.
Radix Paeoniae Rubra: this product is containing peoniflorin, lactone glucoside of Radix Paeoniae, oxypaeoniflorin, benzoylpaeoniflorin, the lucky ketone of Radix Paeoniae, lacdtlorin Ⅲ, gallotannin, benzoic acid, volatile oil, fatty oil, resin etc.This product energy coronary artery dilator, increase coronary flow; Radix Paeoniae Rubra water extraction liquid, Radix Paeoniae Rubra glycosides, Radix Paeoniae Rubra composition and derivant thereof have anticoagulant effect; The outer thrombus formation time of its water decoction energy extension body, alleviates thrombosis dry weight; Contained peoniflorin has calmness, anti-inflammatory analgesic effect; Radix Paeoniae fluid extract, peoniflorin have anticonvulsant action; Radix Paeoniae Rubra, peoniflorin have spasmolysis; Radix Paeoniae Rubra has obvious potentiation to hepatocyte DNA synthetic, and multiple sex pheromone is had to stronger inhibitory action.
The compatibility mechanism of medicament composing prescription of the present invention: in prescription of the present invention, reuse Radix Bupleuri, can be antipyretic, antiinflammatory, Promote immunity, anti-liver injury, the functions such as Antiradiation injury, are monarch drug; Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, Radix Paeoniae Rubra has stronger inhibitory action to multiple pathogenic microorganisms, is ministerial drug; Fructus Crataegi appetite-stimulating indigestion-relieving, changes stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, and the circulation of qi promoting of reducing phlegm, Fructus Hordei Germinatus promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effects such as newborn relieving distension, is adjuvant drug; Pericarpium Citri Reticulatae, Massa Medicata Fermentata have regulating qi-flowing for strengthening spleen, adjust medium effect, can coordinating the actions of various ingredients in a prescription, and for making medicine.All medicines share, can antipyretic and anti-inflammatories, and Promote immunity.
In medicine of the present invention, various crude drug compatibilities are reasonable, all medicines share there is dampness, spleen invigorating, protect the liver, the function such as intestine moistening, after mixing, to piglet, take, better to the diarrhoeal diseases therapeutic effect of piglet, need not use other all antibacterials, the pathology that is particularly useful for antibiotic therapy DeGrain, can fully demonstrate organic conception and the advantage of Chinese medicine, make drug effect and function reach treating both the principal and secondary aspects of a disease more comprehensively, practical, evident in efficacy, the scope of application is wide.
positive beneficial effect of the present invention:
1, Chinese medicine composition of the present invention prevents and treats the HUANGBAI(sic) dysentery that various irritability diarrhoea, trophism diarrhea and escherichia coli cause, comparatively obvious to viral diarrhea effect; And can protect and repair intestinal mucosa, recover the digestion power of piglet.
2, medicine of the present invention is by adhesion and package action; effectively solve escherichia coli and the further destruction of toxin to small intestinal of new breeding; solving ablactational baby pig, to take diarrhoea, edema be the serial disease of leading; recover the pH value of intestinal and supplement the nutrition that generates antibody, intestinal is effectively protected, making impaired intestinal villi be repaired and unfold; thereby raising abilities of digestive and absorption; the generation of enhancing antibody, suppresses pathogen, particularly suppresses harmful colibacillary breeding.
3, Chinese medicine composition compatibility of the present invention is reasonable, and all medicines share, and has anti-inflammation, protection and reparation intestinal mucosa, recovers digestion power, the relieving diarrhea with astringents of piglet, supplement the nutrients and disappearance sodium potassium ion, and the effect of control dehydration.
4, utilize Chinese medicine composition of the present invention can effectively prevent and treat the diarrhoeal diseases that piglet a variety of causes causes, prevention effect is remarkable, has significant economic benefit (referring to concrete clinical test results).
utilize the clinical trial data of Chinese medicine composition control piglet diarrhoea of the present invention:
The present invention prevents and treats the using method of the Chinese medicine composition of piglet diarrhoea: in feedstuff, add Chinese medicine composition of the present invention and eat; According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Easily there is the syndromic pig farm of diarrhea of weaned piglets: before suckling pig wean, progressively increase the forage volume of supplementary feeding, adopt the method that weans gradually, the sucking number of times that reduces every day and the amount of sucking, with wean in 3-5 days, wean starts not reload, wean after 5 days, start to change feedstuff, adopt and mix gradually the method for reloading, with 5-7 days replacing feedstuffs, in the feedstuff of changing, add Chinese medicine composition of the present invention simultaneously and finish latter 3 days to reloading; As what adopt, be direct wean, change feedstuff simultaneously, from changing feedstuff to reloading 10 days, in feedstuff, add Chinese medicine composition of the present invention and use continuously.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out clinical practice test at large-scale pig farm, and test specific embodiments the results are shown in following test report.
first group of clinical trial data:
The proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
With weight portion, represent, by 15 parts of crude drug Fructus Crataegis, 18 parts, Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 18 parts of Radix Bupleuri, 18 parts of the Radix Pulsatillaes and 22 parts of compositions of Radix Paeoniae Rubra.
Experiment situation: ablactational baby pig is added Chinese medicine composition of the present invention and un-added comparative effectiveness:
1, test material:
1.1 select for examination pig: approximately 500 of large scale of pig farm field, Nanyang sow livestock on hands, delivery room piglet is easily suffered from diarrhoea.Random choose is 400 of ablactational baby pig not, are divided at random two groups, 1 group 200 of random experiments, 2 groups 200 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2 medicated premix amounts: test 1 group of preventing post-weaning diarrhea and add Chinese medicine composition of the present invention, Chinese medicine composition of the present invention inserts in feedstuff and feeds according to 250 kilograms of every 1000g spices; Testing 2 groups is blank group.
2, test method:
2.1, for examination pig, process: test 1 group except adding Chinese medicine composition beyond the region of objective existence of the present invention, other and test 2 groups of matched groups all routinely feeding and management carry out.Test finishes to weaning 5 days from weaned piglet for 15 days, carries out altogether 10 days.
2.2 test data statistical dispositions:
Test is in charge of by special messenger, observes at any time and the spirit that records piglet, body temperature and feces situation; During off-test, to all, for examination piglet, weigh, and according to the conventional statistical method of Animal Science, calculate average weight gain, the incidence and mortality of simultaneously adding up piglet.
3, result of the test:
Through the test of 10 days, and through the sorting-out in statistics of test data, this test obtained good result.Now that result of the test list 1 is as follows:
Table 1 utilizes the therapeutic effect of medical treatment piglet diarrhoea of the present invention
Known by table 1 result of the test data: in pig starter feed, add the Chinese medicine composition of the present invention group of feeding, its average weight gain improves 1.24 kilograms compared with matched group, improves 24.9%; Piglet sickness rate is lower by 11.5% than matched group, and mortality rate is low by 9%.
4, conclusion:
In ablactational baby pig feedstuff, add the Chinese medicine composition that the present invention prevents and treats piglet diarrhoea, can obviously reduce the sickness rate of diarrhea of weaned piglets, reduce mortality rate, improve weight gain of piglets amount, increase economic efficiency.
second group of clinical trial data:
the proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
With weight portion, represent, by 13 parts of crude drug Fructus Crataegis, 14 parts, Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 20 parts of Radix Bupleuri, 20 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Using method: 1/3 of the original feed intake of feeding after 10 hours to plant, later every day, dosage, recovered former scale of feeding after 3-5 days, added Chinese medicine composition of the present invention in feedstuff simultaneously, was used in conjunction 10 days.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out clinical practice test at large-scale pig farm, and test specific embodiments the results are shown in following test report.
Experiment situation: newly purchase piglet and add Chinese medicine composition of the present invention and un-added comparative effectiveness:
1, test material:
1.1 select for examination pig: approximately 600 of large scale of pig farm field, Shandong sow livestock on hands, and newly purchase piglet and easily suffer from diarrhoea.Random choose is newly purchased 200 of piglets, is divided at random two groups, 1 group 100 of random experiments, 2 groups 100 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2 medicated premix amounts: test 1 group of prevention and newly purchase piglet diarrhea interpolation Chinese medicine composition of the present invention, insert in feedstuff and feed according to 250 kilograms of every 1000g Chinese medicine composition spices of the present invention, testing 2 groups is blank group.
2, test method:
2.1, for examination pig, process: test 1 group except adding Chinese medicine composition beyond the region of objective existence of the present invention, other and test 2 groups of matched groups all routinely feeding and management carry out.Test, from newly purchasing piglet day end on the same day to 10, is carried out 10 days altogether.
2.2 test data statistical dispositions: test is in charge of by special messenger, observes at any time and the spirit that records piglet, body temperature and feces situation; During off-test, to all, for examination piglet, weigh, and according to the conventional statistical method of Animal Science, calculate average weight gain, the incidence and mortality of simultaneously adding up piglet.
3, result of the test: through the test of 10 days, and through the sorting-out in statistics of test data, this test obtained good result.Now that result of the test list 2 is as follows:
Second group of clinical experiment statistical result of table 2
Known by upper table 2 result of the test data: newly purchase and in pig starter feed, add the Chinese medicine composition of the present invention group of feeding, its average weight gain improves 0.86 kilogram compared with matched group, improves 16.4%, and piglet sickness rate is lower by 9% than matched group, and mortality rate is low by 5%.
4, conclusion: newly purchase in pig starter feed and add Chinese medicine composition of the present invention, can obviously reduce the sickness rate of newly purchasing piglet diarrhea, reduce mortality rate, improve weight gain of piglets amount, increase economic efficiency.
the 3rd group of clinical trial data:
the proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
With weight portion, represent, by 13 parts of crude drug Fructus Crataegis, 14 parts, Fructus Hordei Germinatus, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 23 parts of Radix Bupleuri, 24 parts of the Radix Pulsatillaes and 23 parts of compositions of Radix Paeoniae Rubra.
Using method: slight diarrhoea, adopt Chinese medicine composition spice of the present invention to be used in conjunction 3-5 days; For cacatory, adopt Chinese medicine composition spice of the present invention to use continuously 7-15 days.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out clinical practice test at large-scale pig farm, and test specific embodiments the results are shown in following test report.
Experiment situation: newly purchase the comparative effectiveness that piglet and ablactational baby pig are added Chinese medicine composition of the present invention and add other medicine.
1, test material:
1.1, for examination pig, select: approximately 450 of large scale of pig farm field, Hebei sow livestock on hands, newly purchase piglet and ablactational baby pig is all suffered from diarrhoea.Draw yellow water sample loose stool, the course of disease is longer, the piglet death of finally dewatering.35 of random choose morbidity piglets, are divided into two groups at random, 1 group 17 of random experiments, 2 groups 18 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2, medicated premix amount: test 1 group of morbidity piglet diarrhea and add Chinese medicine composition of the present invention, insert in feedstuff and feed according to 250 kilograms of every 1000g Chinese medicine composition spices of the present invention; Testing 2 groups of morbidity piglet diarrhea oxytetracyclines inserts in feedstuff and feeds according to 250 kilograms of every 1000g oxytetracycline spices.
2, test method:
2.1, for examination pig, process: test 1 group and test 2 groups of matched groups all routinely feeding and management carry out.Test continuous 15 days.
2.2, test data statistical disposition: test is in charge of by special messenger, observes at any time and the spirit that records piglet, body temperature and feces situation; During off-test, according to the conventional statistical method of Animal Science, cure rate and the mortality rate of statistics piglet.
3, result of the test: through the test of 15 days, and through the sorting-out in statistics of test data, this test obtained good result.Now that result of the test list 3 is as follows:
The 3rd group of clinical test results of table 3
Known by upper table 3 result of the test data: the Chinese medicine composition of the present invention group of feeding is added in morbidity in pig starter feed, and its average cure rate improves 21.3% compared with oxytetracycline matched group, and morbidity piglet mortality rate is lower by 5.2% than oxytetracycline matched group.
4, conclusion: add Chinese medicine composition of the present invention in morbidity pig starter feed, can obviously cure morbidity piglet diarrhea and reduce mortality rate.
five, the specific embodiment:
Below in conjunction with embodiment, further set forth the present invention, but do not limit content of the present invention.
Embodiment 1:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 13 parts of crude drug Fructus Crataegis, 14 parts, Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 20 parts of Radix Bupleuri, 20 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Embodiment 2:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 15 parts of crude drug Fructus Crataegis, 18 parts, Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 18 parts of Radix Bupleuri, 18 parts of the Radix Pulsatillaes and 22 parts of compositions of Radix Paeoniae Rubra.
Embodiment 3:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 20 parts of crude drug Fructus Crataegis, 20 parts, Fructus Hordei Germinatus, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Massa Medicata Fermentata, 30 parts of Radix Bupleuri, 30 parts of the Radix Pulsatillaes and 30 parts of compositions of Radix Paeoniae Rubra.
Embodiment 4:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 10 parts of crude drug Fructus Crataegis, 10 parts, Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 13 parts of Massa Medicata Fermentata, 12 parts of Radix Bupleuri, 14 parts of the Radix Pulsatillaes and 13 parts of compositions of Radix Paeoniae Rubra.
Embodiment 5:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 5 parts of crude drug Fructus Crataegis, 5 parts, Fructus Hordei Germinatus, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Massa Medicata Fermentata, 10 parts of Radix Bupleuri, 10 parts of the Radix Pulsatillaes and 10 parts of compositions of Radix Paeoniae Rubra.
Embodiment 6:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 8 parts of crude drug Fructus Crataegis, 16 parts, Fructus Hordei Germinatus, 8 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 7:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 18 parts of crude drug Fructus Crataegis, 7 parts, Fructus Hordei Germinatus, 22 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 22 parts of the Radix Pulsatillaes and 26 parts of compositions of Radix Paeoniae Rubra.
Embodiment 8:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 16 parts of crude drug Fructus Crataegis, 17 parts, Fructus Hordei Germinatus, 24 parts of Pericarpium Citri Reticulataes, 28 parts of Massa Medicata Fermentata, 27 parts of Radix Bupleuri, 26 parts of the Radix Pulsatillaes and 28 parts of compositions of Radix Paeoniae Rubra.
Embodiment 9:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 5 parts of crude drug Fructus Crataegis, 5 parts, Fructus Hordei Germinatus, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Massa Medicata Fermentata, 11 parts of Radix Bupleuri, 10 parts of the Radix Pulsatillaes and 10 parts of compositions of Radix Paeoniae Rubra.
Embodiment 10:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 10 parts of crude drug Fructus Crataegis, 10 parts, Fructus Hordei Germinatus, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 11:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 8 parts of crude drug Fructus Crataegis, 7 parts, Fructus Hordei Germinatus, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Massa Medicata Fermentata, 12 parts of Radix Bupleuri, 13 parts of the Radix Pulsatillaes and 12 parts of compositions of Radix Paeoniae Rubra.
Embodiment 12:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 6 parts of crude drug Fructus Crataegis, 8 parts, Fructus Hordei Germinatus, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Massa Medicata Fermentata, 10 parts of Radix Bupleuri, 12 parts of the Radix Pulsatillaes and 14 parts of compositions of Radix Paeoniae Rubra.
Embodiment 13:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 12 parts of crude drug Fructus Crataegis, 13 parts, Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 21 parts of Radix Bupleuri, 19 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Embodiment 14:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 10 parts of crude drug Fructus Crataegis, 11 parts, Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 16 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 15:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 13 parts of crude drug Fructus Crataegis, 14 parts, Fructus Hordei Germinatus, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 23 parts of Radix Bupleuri, 24 parts of the Radix Pulsatillaes and 23 parts of compositions of Radix Paeoniae Rubra.
Embodiment 16:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 15 parts of crude drug Fructus Crataegis, 15 parts, Fructus Hordei Germinatus, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 25 parts of the Radix Pulsatillaes and 25 parts of compositions of Radix Paeoniae Rubra.
Embodiment 17:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 13 parts of crude drug Fructus Crataegis, 10 parts, Fructus Hordei Germinatus, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 17 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 16 parts of compositions of Radix Paeoniae Rubra.
Embodiment 18:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 16 parts of crude drug Fructus Crataegis, 16 parts, Fructus Hordei Germinatus, 20 parts of Pericarpium Citri Reticulataes, 22 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 26 parts of the Radix Pulsatillaes and 25 parts of compositions of Radix Paeoniae Rubra.
Embodiment 19:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 18 parts of crude drug Fructus Crataegis, 18 parts, Fructus Hordei Germinatus, 22 parts of Pericarpium Citri Reticulataes, 23 parts of Massa Medicata Fermentata, 28 parts of Radix Bupleuri, 27 parts of the Radix Pulsatillaes and 28 parts of compositions of Radix Paeoniae Rubra.
Embodiment 20:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 20 parts of crude drug Fructus Crataegis, 20 parts, Fructus Hordei Germinatus, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Massa Medicata Fermentata, 30 parts of Radix Bupleuri, 30 parts of the Radix Pulsatillaes and 30 parts of compositions of Radix Paeoniae Rubra.
Embodiment 21:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 15 parts of crude drug Fructus Crataegis, 19 parts, Fructus Hordei Germinatus, 24 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 26 parts of Radix Bupleuri, 25 parts of the Radix Pulsatillaes and 27 parts of compositions of Radix Paeoniae Rubra.
Embodiment 22:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, with weight portion, represents, and by 19 parts of crude drug Fructus Crataegis, 15 parts, Fructus Hordei Germinatus, 23 parts of Pericarpium Citri Reticulataes, 21 parts of Massa Medicata Fermentata, 27 parts of Radix Bupleuri, 28 parts of the Radix Pulsatillaes and 26 parts of compositions of Radix Paeoniae Rubra.
The preparation method that above-described embodiment 1-22 the present invention prevents and treats the Chinese medicine composition of piglet diarrhoea is: according to preventing and treating the required crude drug of piglet diarrhoea Chinese medicine compositions described in above-described embodiment, prepare various crude drug, first required various crude drug are processed clean, then be dried successively, pulverize, after pulverizing, cross 80 mesh sieves, after pulverizing, obtain the medicated powder of various crude drug; Then according to the proportioning ratio of preventing and treating piglet diarrhoea Chinese medicine compositions in each embodiment, take the crude drug medicated powder after various pulverizing, then the various crude drug medicated powder that take are mixed, fully mix homogeneously, finally carries out subpackage.
Claims (5)
1. a Chinese medicine compositions of preventing and treating piglet diarrhoea, is characterized in that: with weight portion, represent, described Chinese medicine composition is by 5～20 parts of crude drug Fructus Crataegis, 5～20 parts, Fructus Hordei Germinatus, 5～25 parts of Pericarpium Citri Reticulataes, 5～25 parts of Massa Medicata Fermentata, 10～30 parts of Radix Bupleuri, 10～30 parts of the Radix Pulsatillaes and 10～30 parts of compositions of Radix Paeoniae Rubra.
2. the Chinese medicine compositions of control piglet diarrhoea according to claim 1, is characterized in that: described Chinese medicine composition is by 5～10 parts of crude drug Fructus Crataegis, 5～10 parts, Fructus Hordei Germinatus, 5～10 parts of Pericarpium Citri Reticulataes, 5～10 parts of Massa Medicata Fermentata, 10～15 parts of Radix Bupleuri, 10～15 parts of the Radix Pulsatillaes and 10～15 parts of compositions of Radix Paeoniae Rubra.
3. the Chinese medicine compositions of control piglet diarrhoea according to claim 1, it is characterized in that: described Chinese medicine composition is by 10～15 parts of crude drug Fructus Crataegis, 10～15 parts, Fructus Hordei Germinatus, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Massa Medicata Fermentata, 15～25 parts of Radix Bupleuri, 15～25 parts of the Radix Pulsatillaes and 15～25 parts of compositions of Radix Paeoniae Rubra.
4. the Chinese medicine compositions of control piglet diarrhoea according to claim 1, it is characterized in that: described Chinese medicine composition is by 15～20 parts of crude drug Fructus Crataegis, 15～20 parts, Fructus Hordei Germinatus, 20～25 parts of Pericarpium Citri Reticulataes, 20～25 parts of Massa Medicata Fermentata, 25～30 parts of Radix Bupleuri, 25～30 parts of the Radix Pulsatillaes and 25～30 parts of compositions of Radix Paeoniae Rubra.
5. according to the Chinese medicine compositions of the control piglet diarrhoea described in claim 1～4 any one, it is characterized in that, the preparation method of described Chinese medicine compositions is: according to preventing and treating the required crude drug of piglet diarrhoea Chinese medicine compositions described in claim 1～4 any one, prepare various raw materials, first required various crude drug are processed clean, then be dried successively, pulverize, after pulverizing, cross 80 mesh sieves, after pulverizing, obtain the medicated powder of various crude drug; According to the proportioning ratio of preventing and treating piglet diarrhoea Chinese medicine compositions described in claim 1～4 any one, take the crude drug medicated powder after various pulverizing, then the various crude drug medicated powder that take are mixed, fully mix homogeneously, finally carries out subpackage.
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| CN103432228A (en) * | 2013-09-09 | 2013-12-11 | 刘水石 | Porcine antidiarrheal traditional Chinese medicine and preparation method thereof |
| CN104351514A (en) * | 2014-10-23 | 2015-02-18 | 吴咏梅 | Piglet low-residue green feed additive and manufacturing method thereof |
| CN105796715B (en) * | 2016-05-19 | 2019-11-22 | 丽水市农业科学研究院 | A kind of Chinese herbal medicine formula and preparation method thereof for treating pig stomach enteritis disease |
| CN106692917A (en) * | 2016-11-18 | 2017-05-24 | 钱峰 | Traditional Chinese medicine feed additive for preventing and treating piglet diarrhea and preparation method thereof |
| CN108541809A (en) * | 2018-04-11 | 2018-09-18 | 浙江博信药业股份有限公司 | A kind of livestock and poultry Chinese herb feed additive and its preparation method and application |
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Effective date of registration: 20161128 Address after: 450000 eighteen Mile River, Guan Cheng District, Henan, Zhengzhou Patentee after: HENAN ZHONGYA SHENPENG MEDICAL TECHNOLOGY CO., LTD. Address before: 451164 Henan province Zhengzhou city Xinzheng Port Development Zone, Taiwan investment Patentee before: Henan Guangtai Animal Pharmaceutical Co., Ltd. |
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